Sec61g (Sec61 translocon subunit gamma) - Rat Genome Database

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Gene: Sec61g (Sec61 translocon subunit gamma) Rattus norvegicus
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Symbol: Sec61g
Name: Sec61 translocon subunit gamma
RGD ID: 1596170
Description: Predicted to enable phospholipid binding activity; protein transmembrane transporter activity; and ribosome binding activity. Predicted to be involved in membrane docking and post-translational protein targeting to membrane, translocation. Predicted to be located in membrane. Predicted to be part of Ssh1 translocon complex. Orthologous to human SEC61G (SEC61 translocon subunit gamma); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; phagocytosis pathway; INTERACTS WITH 3-chloropropane-1,2-diol; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC689134; Sec61 translocon gamma subunit; SEC61, gamma subunit; similar to Protein transport protein SEC61 gamma subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Sec61g-ps1   Sec61g-ps4   Sec61g-ps8   Sec61g-ps9  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81495,113,083 - 95,119,458 (-)NCBIGRCr8
mRatBN7.21490,899,766 - 90,906,143 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl941,302,749 - 41,302,955 (-)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl1490,899,768 - 90,906,162 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1495,245,187 - 95,251,561 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01496,489,501 - 96,495,875 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01492,954,596 - 92,960,970 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01499,774,589 - 99,780,964 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1499,774,589 - 99,780,964 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01499,067,709 - 99,074,084 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41497,323,315 - 97,329,689 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1489,994,302 - 90,000,677 (-)NCBICelera
Cytogenetic Map14q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:8107851   PMID:8942632   PMID:12477932   PMID:16751776   PMID:22375059  


Genomics

Comparative Map Data
Sec61g
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81495,113,083 - 95,119,458 (-)NCBIGRCr8
mRatBN7.21490,899,766 - 90,906,143 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl941,302,749 - 41,302,955 (-)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl1490,899,768 - 90,906,162 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1495,245,187 - 95,251,561 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01496,489,501 - 96,495,875 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01492,954,596 - 92,960,970 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01499,774,589 - 99,780,964 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1499,774,589 - 99,780,964 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01499,067,709 - 99,074,084 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41497,323,315 - 97,329,689 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1489,994,302 - 90,000,677 (-)NCBICelera
Cytogenetic Map14q22NCBI
SEC61G
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38754,752,253 - 54,759,211 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl754,752,250 - 54,759,974 (-)EnsemblGRCh38hg38GRCh38
GRCh37754,819,946 - 54,826,904 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36754,787,434 - 54,794,433 (-)NCBINCBI36Build 36hg18NCBI36
Build 34754,594,149 - 54,601,148NCBI
Celera754,925,611 - 54,932,604 (-)NCBICelera
Cytogenetic Map7p11.2NCBI
HuRef754,657,603 - 54,664,596 (-)NCBIHuRef
CHM1_1754,822,457 - 54,829,452 (-)NCBICHM1_1
T2T-CHM13v2.0754,912,179 - 54,919,137 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2754,825,706 - 54,832,698 (-)NCBI
Sec61g
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391116,451,638 - 16,458,484 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1116,450,530 - 16,458,484 (-)EnsemblGRCm39 Ensembl
GRCm381116,501,638 - 16,508,484 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1116,500,530 - 16,508,484 (-)EnsemblGRCm38mm10GRCm38
MGSCv371116,401,641 - 16,408,487 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361116,401,641 - 16,408,156 (-)NCBIMGSCv36mm8
Celera1116,882,412 - 16,889,258 (-)NCBICelera
Cytogenetic Map11A2NCBI
cM Map119.41NCBI
Sec61g
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955456645,607 - 648,681 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955456645,607 - 651,764 (+)NCBIChiLan1.0ChiLan1.0
SEC61G
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2659,585,143 - 59,596,463 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17107,909,868 - 107,917,618 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0755,346,034 - 55,353,779 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1755,657,507 - 55,664,585 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl755,657,507 - 55,664,567 (-)Ensemblpanpan1.1panPan2
SEC61G
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1185,564,447 - 5,570,937 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl185,564,401 - 5,570,946 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha185,418,268 - 5,424,754 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0185,614,253 - 5,620,746 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl185,611,828 - 5,620,805 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1185,605,260 - 5,611,743 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0185,579,504 - 5,585,985 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0185,684,171 - 5,690,651 (-)NCBIUU_Cfam_GSD_1.0
Sec61g
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118109,106,431 - 109,112,600 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936678776,994 - 780,267 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936678776,979 - 783,125 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SEC61G
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9139,128,296 - 139,135,727 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19139,128,287 - 139,135,831 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29153,348,321 - 153,355,866 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SEC61G
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1214,114,914 - 4,122,117 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl214,114,916 - 4,122,123 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606218,374,761 - 18,381,653 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sec61g
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624740881,416 - 886,594 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624740881,339 - 886,686 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sec61g
43 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:16
Count of miRNA genes:16
Interacting mature miRNAs:16
Transcripts:ENSRNOT00000006906
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
1582236Gluco22Glucose level QTL 223.30.0164blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
631213Bw60Body weight QTL604.51retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)147995092195876975Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1582259Gluco23Glucose level QTL 233.10.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1470053989104886043Rat
1582197Gluco27Glucose level QTL 273.40.0006blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)147341532392554092Rat
634328Hc5Hypercalciuria QTL 52.3urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1458184885103184885Rat
1582250Gluco26Glucose level QTL 263.30.0009blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532395876975Rat
2317879Alcrsp27Alcohol response QTL 273.30.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1456631369101631369Rat
1641900Alcrsp11Alcohol response QTL 11alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)1470053989104886043Rat
4889951Bss92Bone structure and strength QTL 923.9tibia area (VT:1000281)tibia-fibula cortical bone total cross-sectional area (CMO:0001721)148205747195876975Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
1582255Gluco29Glucose level QTL 293.10.0025blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)147341532392554092Rat
9589034Epfw11Epididymal fat weight QTL 1160.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1455624247100624247Rat
1582209Gluco20Glucose level QTL 203.80.0005blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)147341532392554092Rat
1300136Rf22Renal function QTL 223.9renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)144226252995023211Rat
1549834Scl45Serum cholesterol level QTL 455.8blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)145002321195023211Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000006906   ⟹   ENSRNOP00000006906
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1490,899,768 - 90,906,162 (-)Ensembl
Rnor_6.0 Ensembl1499,774,589 - 99,780,964 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080060   ⟹   ENSRNOP00000089147
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl941,302,749 - 41,302,955 (-)Ensembl
RefSeq Acc Id: NM_001135020   ⟹   NP_001128492
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81495,113,083 - 95,119,458 (-)NCBI
mRatBN7.21490,899,768 - 90,906,143 (-)NCBI
Rnor_6.01499,774,589 - 99,780,964 (-)NCBI
Rnor_5.01499,067,709 - 99,074,084 (+)NCBI
RGSC_v3.41497,323,315 - 97,329,689 (-)RGD
Celera1489,994,302 - 90,000,677 (-)RGD
Sequence:
RefSeq Acc Id: XM_039092466   ⟹   XP_038948394
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81495,113,098 - 95,119,352 (-)NCBI
mRatBN7.21490,899,766 - 90,905,925 (-)NCBI
RefSeq Acc Id: NP_001128492   ⟸   NM_001135020
- UniProtKB: B5DEL7 (UniProtKB/TrEMBL),   F1LPB2 (UniProtKB/TrEMBL),   A6JPX6 (UniProtKB/TrEMBL),   A0A8I6AAZ9 (UniProtKB/TrEMBL),   B5DER8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006906   ⟸   ENSRNOT00000006906
RefSeq Acc Id: XP_038948394   ⟸   XM_039092466
- Peptide Label: isoform X1
- UniProtKB: F1LPB2 (UniProtKB/TrEMBL),   B5DEL7 (UniProtKB/TrEMBL),   A6JPX6 (UniProtKB/TrEMBL),   A0A8I6AAZ9 (UniProtKB/TrEMBL),   B5DER8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000089147   ⟸   ENSRNOT00000080060

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B5DEL7-F1-model_v2 AlphaFold B5DEL7 1-68 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699500
Promoter ID:EPDNEW_R10022
Type:initiation region
Name:Sec61g_1
Description:Sec61 translocon gamma subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01499,780,940 - 99,781,000EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1596170 AgrOrtholog
BioCyc Gene G2FUF-14944 BioCyc
Ensembl Genes ENSRNOG00000005203 Ensembl
  ENSRNOG00000052328 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000080060.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.820 UniProtKB/TrEMBL
InterPro Prot_translocase_SecE_dom UniProtKB/TrEMBL
  Translocase_Sec61-g UniProtKB/TrEMBL
  Translocase_SecE/Sec61-g UniProtKB/TrEMBL
KEGG Report rno:689134 UniProtKB/TrEMBL
NCBI Gene 689134 ENTREZGENE
PANTHER PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT GAMMA UniProtKB/TrEMBL
  SEC61 GAMMA SUBUNIT UniProtKB/TrEMBL
Pfam SecE UniProtKB/TrEMBL
PhenoGen Sec61g PhenoGen
PROSITE SECE_SEC61G UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005203 RatGTEx
  ENSRNOG00000052328 RatGTEx
Superfamily-SCOP SecE_euk_arc UniProtKB/TrEMBL
UniProt A0A8I6AAZ9 ENTREZGENE, UniProtKB/TrEMBL
  A6JPX6 ENTREZGENE, UniProtKB/TrEMBL
  B5DEL7 ENTREZGENE
  B5DER8 ENTREZGENE, UniProtKB/TrEMBL
  F1LPB2 ENTREZGENE
UniProt Secondary B5DEL7 UniProtKB/TrEMBL
  F1LPB2 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-04-05 Sec61g  Sec61 translocon subunit gamma  Sec61g  SEC61 translocon subunit gamma  Name changed 629549 APPROVED
2019-12-06 Sec61g  SEC61 translocon subunit gamma  Sec61g  Sec61 translocon gamma subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-08-11 Sec61g  Sec61 translocon gamma subunit  Sec61g  SEC61, gamma subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-14 Sec61g  SEC61, gamma subunit  LOC689134  similar to Protein transport protein SEC61 gamma subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC689134  similar to Protein transport protein SEC61 gamma subunit  LOC681549  similar to Protein transport protein SEC61 gamma subunit  Data merged from RGD:1594087 1643240 APPROVED
2006-11-20 LOC689134  similar to Protein transport protein SEC61 gamma subunit      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC681549  similar to Protein transport protein SEC61 gamma subunit      Symbol and Name status set to provisional 70820 PROVISIONAL