Cyp3a62 (cytochrome P450, family 3, subfamily a, polypeptide 62) - Rat Genome Database

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Gene: Cyp3a62 (cytochrome P450, family 3, subfamily a, polypeptide 62) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Cyp3a62
Name: cytochrome P450, family 3, subfamily a, polypeptide 62
RGD ID: 1595919
Description: Predicted to enable testosterone 6-beta-hydroxylase activity. Predicted to be involved in oxidative demethylation and steroid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human CYP3A7-CYP3A51P (CYP3A7-CYP3A51P readthrough) and CYP3A7 (cytochrome P450 family 3 subfamily A member 7); INTERACTS WITH 1,2-dichlorobenzene; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CYP3; Cyp3a; Cyp3a_mapped; cytochrome P450, subfamily 3A, polypeptide 62; Cytochrome P450, subfamily IIA (niphedipine oxidase); cytochrome P450, subfamily IIIA (niphedipine oxidase); cytochrome P450, subfamily IIIA (niphedipine oxidase) (mapped)
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81221,511,763 - 21,547,598 (+)NCBIGRCr8
mRatBN7.21216,397,998 - 16,433,833 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1216,397,998 - 16,433,833 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1217,211,646 - 17,247,469 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01217,835,371 - 17,871,198 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01216,898,330 - 16,934,279 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01218,679,809 - 18,709,397 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1218,678,594 - 18,709,397 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01220,667,026 - 20,696,614 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1218,144,225 - 18,179,601 (+)NCBICelera
Cytogenetic Map12q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Lack of an effect of CYP3A4 and MDR1 gene polymorphisms on colchicine pharmacogenetics in the treatment of Familial Mediterranean fever. Dogruer D, etal., Genet Mol Res. 2013 Jan 24;12(3):3521-8. doi: 10.4238/2013.January.24.2.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. An integrated rat genetic map: analysis of linkage conservation with the mouse and human maps. Remmers EF, etal., Transplant Proc 1999 May;31(3):1549-54.
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Expression of P450 enzymes in rat whole skin and cultured epidermal keratinocytes. Zhu Z, etal., Biochem Biophys Res Commun 2002 Sep 13;297(1):65.
Additional References at PubMed
PMID:3259858   PMID:10620362   PMID:11695850   PMID:12231541   PMID:12626652   PMID:14559847   PMID:14642533   PMID:15004215   PMID:15039299   PMID:15256616   PMID:15288127   PMID:15327587  
PMID:15465924   PMID:15546903   PMID:15570024   PMID:15680923   PMID:16401082   PMID:16673044   PMID:16844145   PMID:17550236   PMID:18356043   PMID:18446064   PMID:18619574   PMID:19103281  
PMID:19219744   PMID:19237454   PMID:20819951   PMID:21103392   PMID:21311750   PMID:21351448   PMID:21351579   PMID:21425376   PMID:21467745   PMID:22870815   PMID:23012479   PMID:23304981  
PMID:25630049   PMID:25953268   PMID:27390106   PMID:36345268  


Genomics

Variants

.
Variants in Cyp3a62
199 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:108
Count of miRNA genes:88
Interacting mature miRNAs:95
Transcripts:ENSRNOT00000001863
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
61443Btemp2Thermal response to stress QTL 23.30.000094body temperature trait (VT:0005535)core body temperature (CMO:0001036)121502518320794014Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121107382524234895Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12683319017870186Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121363552330827399Rat
7204484Bp358Blood pressure QTL 3580.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121300829619212979Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382528064557Rat

Markers in Region
BF400282  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21216,424,715 - 16,424,853 (+)MAPPERmRatBN7.2
Rnor_6.01218,700,280 - 18,700,417NCBIRnor6.0
Rnor_5.01220,687,497 - 20,687,634UniSTSRnor5.0
Celera1218,170,484 - 18,170,621UniSTS
RH 3.4 Map12250.5UniSTS
AW529990  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21216,433,621 - 16,433,792 (+)MAPPERmRatBN7.2
Rnor_6.01218,709,186 - 18,709,356NCBIRnor6.0
Rnor_5.01220,696,403 - 20,696,573UniSTSRnor5.0
Celera1218,179,390 - 18,179,560UniSTS
RH 3.4 Map12254.4UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 8 15 69 82 80 53 21 53 6 135 55 49 11 32 27

Sequence


Ensembl Acc Id: ENSRNOT00000001863   ⟹   ENSRNOP00000001863
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1216,403,996 - 16,433,833 (+)Ensembl
Rnor_6.0 Ensembl1218,679,789 - 18,709,397 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087229   ⟹   ENSRNOP00000073459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1216,397,998 - 16,433,833 (+)Ensembl
Rnor_6.0 Ensembl1218,678,594 - 18,709,188 (+)Ensembl
RefSeq Acc Id: NM_001024232   ⟹   NP_001019403
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81221,511,763 - 21,547,598 (+)NCBI
mRatBN7.21216,397,998 - 16,433,833 (+)NCBI
Rnor_6.01218,679,809 - 18,709,397 (+)NCBI
Rnor_5.01220,667,026 - 20,696,614 (+)NCBI
Celera1218,144,225 - 18,179,601 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001019403 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAC23085 (Get FASTA)   NCBI Sequence Viewer  
  BAC98413 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001863.6
  ENSRNOP00000073459.2
RefSeq Acc Id: NP_001019403   ⟸   NM_001024232
- UniProtKB: Q8CJF2 (UniProtKB/TrEMBL),   A0A0G2K5K4 (UniProtKB/TrEMBL),   A6K211 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073459   ⟸   ENSRNOT00000087229
Ensembl Acc Id: ENSRNOP00000001863   ⟸   ENSRNOT00000001863

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F7F0U1-F1-model_v2 AlphaFold F7F0U1 1-480 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1595919 AgrOrtholog
BioCyc Gene G2FUF-19844 BioCyc
Ensembl Genes ENSRNOG00000001379 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001863.6 UniProtKB/TrEMBL
  ENSRNOT00000087229.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/TrEMBL
  Cyt_P450_E_CYP3A UniProtKB/TrEMBL
  Cyt_P450_E_grp-II UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
  Cytochrome_P450_3A UniProtKB/TrEMBL
KEGG Report rno:170509 UniProtKB/TrEMBL
NCBI Gene 170509 ENTREZGENE
PANTHER CYTOCHROME P450 3A7 UniProtKB/TrEMBL
  CYTOCHROME P450 FAMILY 3 UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PhenoGen Cyp3a62 PhenoGen
PRINTS EP450II UniProtKB/TrEMBL
  EP450IICYP3A UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001379 RatGTEx
Superfamily-SCOP Cytochrome_P450 UniProtKB/TrEMBL
UniProt A0A0G2K5K4 ENTREZGENE, UniProtKB/TrEMBL
  A6K211 ENTREZGENE, UniProtKB/TrEMBL
  F7F0U1_RAT UniProtKB/TrEMBL
  Q8CJF2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-19 Cyp3a62  cytochrome P450, family 3, subfamily a, polypeptide 62  Cyp3a62  cytochrome P450, subfamily 3A, polypeptide 62  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-13 Cyp3a62  cytochrome P450, subfamily 3A, polypeptide 62  Cyp3a_mapped  cytochrome P450, subfamily IIIA (niphedipine oxidase) (mapped)  Data merged from RGD:68934 737654 APPROVED
2006-11-20 Cyp3a62  cytochrome P450, subfamily 3A, polypeptide 62      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Cyp3a_mapped  cytochrome P450, subfamily IIIA (niphedipine oxidase) (mapped)      Symbol and Name updated 1556543 APPROVED
2002-06-10 Cyp3a  cytochrome P450, subfamily 3A       Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression Cyp3a2 expressed only in skin and liver 625597
gene_expression Cyp3a1 is expressed in skin, liver, kidney, lung and small intestine 625597
gene_transcript two isoforms- Cyp3a1 and Cyp3a2 625597