Prr22 (proline rich 22) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Prr22 (proline rich 22) Rattus norvegicus
Analyze
Symbol: Prr22
Name: proline rich 22
RGD ID: 1595447
Description: Orthologous to human PRR22 (proline rich 22); INTERACTS WITH 6-propyl-2-thiouracil; acetamide; amitrole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC680177; hypothetical protein LOC682170; LOC680177; proline-rich protein 22
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,686,295 - 1,688,129 (+)NCBIGRCr8
mRatBN7.291,599,169 - 1,601,003 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,599,148 - 1,601,416 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx92,033,326 - 2,035,160 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,382,426 - 7,384,260 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,338,522 - 6,340,356 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0910,286,755 - 10,289,340 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,287,086 - 10,290,035 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.099,284,180 - 9,286,387 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera96,915,746 - 6,917,566 (-)NCBICelera
Cytogenetic Map9q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Prr22
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,686,295 - 1,688,129 (+)NCBIGRCr8
mRatBN7.291,599,169 - 1,601,003 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,599,148 - 1,601,416 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx92,033,326 - 2,035,160 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,382,426 - 7,384,260 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,338,522 - 6,340,356 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0910,286,755 - 10,289,340 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,287,086 - 10,290,035 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.099,284,180 - 9,286,387 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera96,915,746 - 6,917,566 (-)NCBICelera
Cytogenetic Map9q11NCBI
PRR22
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38195,782,960 - 5,784,746 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl195,782,960 - 5,784,746 (-)EnsemblGRCh38hg38GRCh38
GRCh37195,782,971 - 5,784,757 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36195,733,971 - 5,735,610 (-)NCBINCBI36Build 36hg18NCBI36
Celera195,720,964 - 5,722,769 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef195,543,905 - 5,545,710 (-)NCBIHuRef
CHM1_1195,782,899 - 5,784,704 (-)NCBICHM1_1
T2T-CHM13v2.0195,769,757 - 5,771,543 (-)NCBIT2T-CHM13v2.0
Prr22
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391757,077,276 - 57,079,134 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1757,077,250 - 57,079,208 (+)EnsemblGRCm39 Ensembl
GRCm381756,770,276 - 56,772,134 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1756,770,250 - 56,772,208 (+)EnsemblGRCm38mm10GRCm38
MGSCv371756,909,705 - 56,911,560 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361756,909,699 - 56,911,557 (+)NCBIMGSCv36mm8
Celera1761,114,423 - 61,116,278 (+)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.5NCBI
Prr22
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554953,659,972 - 3,662,624 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554953,660,380 - 3,662,642 (+)NCBIChiLan1.0ChiLan1.0
PRR22
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22010,177,025 - 10,179,065 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1199,403,225 - 9,405,030 (-)NCBINHGRI_mPanPan1
PanPan1.1 Ensembl195,729,277 - 5,731,256 (-)Ensemblpanpan1.1panPan2
PRR22
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12054,256,356 - 54,258,341 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2054,255,609 - 54,258,322 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2053,983,566 - 53,985,782 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02054,908,481 - 54,910,721 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2054,903,238 - 54,910,706 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12053,974,780 - 53,976,996 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02054,455,329 - 54,457,542 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02054,652,571 - 54,654,786 (+)NCBIUU_Cfam_GSD_1.0
Prr22
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118214,503,428 - 214,505,206 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365883,329,593 - 3,331,348 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365883,329,577 - 3,331,883 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRR22
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.165,428,380 - 5,430,460 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl65,428,398 - 5,430,077 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660812,625,282 - 2,627,306 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prr22
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248284,437,925 - 4,439,736 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248284,437,612 - 4,439,748 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prr22
3 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:51
Count of miRNA genes:46
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000075201
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9114209783Rat
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7
Low 3 36 52 36 19 36 6 8 74 35 34 11 6
Below cutoff 7 5 5 5 2 3 2

Sequence


RefSeq Acc Id: ENSRNOT00000075201   ⟹   ENSRNOP00000066533
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl91,599,148 - 1,601,416 (+)Ensembl
Rnor_6.0 Ensembl910,287,086 - 10,290,035 (-)Ensembl
RefSeq Acc Id: NM_001126375   ⟹   NP_001119847
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,686,309 - 1,688,129 (+)NCBI
mRatBN7.291,599,183 - 1,601,003 (+)NCBI
Rnor_6.0910,287,100 - 10,288,920 (-)NCBI
Rnor_5.099,284,180 - 9,286,387 (-)NCBI
Celera96,915,746 - 6,917,566 (-)RGD
Sequence:
RefSeq Acc Id: NM_001399121   ⟹   NP_001386050
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,686,295 - 1,688,129 (+)NCBI
mRatBN7.291,599,169 - 1,601,003 (+)NCBI
RefSeq Acc Id: XM_039084199   ⟹   XP_038940127
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,686,375 - 1,688,129 (+)NCBI
mRatBN7.291,599,190 - 1,601,003 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001119847 (Get FASTA)   NCBI Sequence Viewer  
  NP_001386050 (Get FASTA)   NCBI Sequence Viewer  
  XP_038940127 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI61872 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000066533.3
RefSeq Acc Id: NP_001119847   ⟸   NM_001126375
- Peptide Label: isoform 2
- UniProtKB: B1WBS8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000066533   ⟸   ENSRNOT00000075201
RefSeq Acc Id: XP_038940127   ⟸   XM_039084199
- Peptide Label: isoform X1
- UniProtKB: M0RAI3 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001386050   ⟸   NM_001399121
- Peptide Label: isoform 1
- UniProtKB: M0RAI3 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RAI3-F1-model_v2 AlphaFold M0RAI3 1-417 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696460
Promoter ID:EPDNEW_R6975
Type:initiation region
Name:Prr22_1
Description:proline rich 22
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0910,288,934 - 10,288,994EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1595447 AgrOrtholog
BioCyc Gene G2FUF-28512 BioCyc
Ensembl Genes ENSRNOG00000047295 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075201.3 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7112899 IMAGE-MGC_LOAD
InterPro PRR22 UniProtKB/TrEMBL
KEGG Report rno:680177 UniProtKB/TrEMBL
MGC_CLONE MGC:187430 IMAGE-MGC_LOAD
NCBI Gene 680177 ENTREZGENE
PANTHER PROLINE-RICH PROTEIN 22 UniProtKB/TrEMBL
  PTHR37871 UniProtKB/TrEMBL
Pfam PRR22 UniProtKB/TrEMBL
PhenoGen Prr22 PhenoGen
RatGTEx ENSRNOG00000047295 RatGTEx
UniProt B1WBS8 ENTREZGENE, UniProtKB/TrEMBL
  M0RAI3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Prr22  proline rich 22  LOC682170  hypothetical protein LOC682170  Data merged from RGD:1586918 1643240 APPROVED
2010-04-21 Prr22  proline rich 22  LOC680177  hypothetical protein LOC680177  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC680177  hypothetical protein LOC680177      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC682170  hypothetical protein LOC682170      Symbol and Name status set to provisional 70820 PROVISIONAL