Kctd4 (potassium channel tetramerization domain containing 4) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Pathways
Gene: Kctd4 (potassium channel tetramerization domain containing 4) Rattus norvegicus
Analyze
Symbol: Kctd4
Name: potassium channel tetramerization domain containing 4
RGD ID: 1594637
Description: Predicted to be involved in protein homooligomerization. Orthologous to human KCTD4 (potassium channel tetramerization domain containing 4); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BTB/POZ domain-containing protein KCTD4; LOC691835; potassium channel tetramerisation domain containing 4; similar to Potassium channel tetramerisation domain-containing protein 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81557,675,024 - 57,686,816 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1557,673,741 - 57,687,798 (+)EnsemblGRCr8
mRatBN7.21551,263,664 - 51,278,030 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1551,274,295 - 51,277,499 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1555,432,568 - 55,435,772 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01556,550,889 - 56,554,093 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01553,373,392 - 53,376,592 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01558,006,288 - 58,021,166 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1558,016,238 - 58,019,442 (+)Ensemblrn6Rnor6.0
Rnor_5.01561,711,478 - 61,723,368 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41556,872,713 - 56,875,694 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1550,900,784 - 50,903,988 (+)NCBICelera
Cytogenetic Map15q11NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Kctd4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81557,675,024 - 57,686,816 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1557,673,741 - 57,687,798 (+)EnsemblGRCr8
mRatBN7.21551,263,664 - 51,278,030 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1551,274,295 - 51,277,499 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1555,432,568 - 55,435,772 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01556,550,889 - 56,554,093 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01553,373,392 - 53,376,592 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01558,006,288 - 58,021,166 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1558,016,238 - 58,019,442 (+)Ensemblrn6Rnor6.0
Rnor_5.01561,711,478 - 61,723,368 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41556,872,713 - 56,875,694 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1550,900,784 - 50,903,988 (+)NCBICelera
Cytogenetic Map15q11NCBI
KCTD4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381345,192,853 - 45,201,045 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1345,192,853 - 45,201,045 (-)Ensemblhg38GRCh38
GRCh371345,766,988 - 45,775,180 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361344,664,988 - 44,673,175 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341344,664,989 - 44,666,852NCBI
Celera1326,823,093 - 26,831,280 (-)NCBICelera
Cytogenetic Map13q14.12-q14.13NCBI
HuRef1326,568,652 - 26,576,838 (-)NCBIHuRef
CHM1_11345,734,533 - 45,742,720 (-)NCBICHM1_1
T2T-CHM13v2.01344,412,904 - 44,421,096 (-)NCBIT2T-CHM13v2.0
Kctd4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391476,192,443 - 76,202,657 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1476,192,449 - 76,203,646 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381475,955,003 - 75,965,217 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1475,955,009 - 75,966,206 (+)Ensemblmm10GRCm38
MGSCv371476,354,810 - 76,365,024 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361474,689,158 - 74,699,372 (+)NCBIMGSCv36mm8
Celera1473,456,212 - 73,466,277 (+)NCBICelera
Cytogenetic Map14D3NCBI
cM Map1440.3NCBI
Kctd4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555182,977,055 - 2,987,676 (-)Ensembl
ChiLan1.0NW_0049555182,977,055 - 2,987,676 (-)NCBIChiLan1.0ChiLan1.0
KCTD4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21444,713,419 - 44,721,382 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11335,775,417 - 35,780,282 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01326,361,483 - 26,369,687 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13197,702,121 - 197,710,303 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3197,708,590 - 197,709,369 (+)EnsemblpanPan2panpan1.1
KCTD4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1225,820,833 - 5,832,672 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl225,830,982 - 5,831,758 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha225,801,957 - 5,821,225 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0225,930,440 - 5,949,756 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl225,948,316 - 5,949,092 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1225,712,604 - 5,731,890 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0225,775,746 - 5,795,218 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0225,781,268 - 5,800,524 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Kctd4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945155,398,279 - 155,400,084 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367911,319,688 - 1,320,467 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049367911,318,756 - 1,320,794 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCTD4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1122,056,743 - 22,076,408 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11122,056,743 - 22,076,501 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
KCTD4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1323,285,993 - 23,347,315 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl323,286,681 - 23,287,460 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605720,774,921 - 20,776,818 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kctd4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247489,777,890 - 9,786,966 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247489,777,747 - 9,787,130 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Kctd4
43 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:841
Count of miRNA genes:293
Interacting mature miRNAs:376
Transcripts:ENSRNOT00000075786
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1544806773104695021Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
724545Niddm54Non-insulin dependent diabetes mellitus QTL 540.02blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)155720389580107161Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152852773273527732Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)154367724488677244Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)154367724488677244Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)154046315285463152Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151492659471614418Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)152233635167336351Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)154367724488677244Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)154367724488677244Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)154367724488677244Rat

Markers in Region
RH144249  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21551,277,868 - 51,277,968 (+)MAPPERmRatBN7.2
Rnor_6.01558,019,812 - 58,019,911NCBIRnor6.0
Rnor_5.01561,722,724 - 61,722,823UniSTSRnor5.0
RGSC_v3.41556,876,064 - 56,876,163UniSTSRGSC3.4
Celera1550,904,358 - 50,904,457UniSTS
RH 3.4 Map15601.1UniSTS
Cytogenetic Map15q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 11 47 163 46 45 14 73 14 6 230 152 11 142 44 74 31 16 16

Sequence


Ensembl Acc Id: ENSRNOT00000075786   ⟹   ENSRNOP00000065668
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1557,673,741 - 57,687,798 (+)Ensembl
mRatBN7.2 Ensembl1551,274,295 - 51,277,499 (+)Ensembl
Rnor_6.0 Ensembl1558,016,238 - 58,019,442 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000126931   ⟹   ENSRNOP00000104238
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1557,675,099 - 57,684,712 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000157928   ⟹   ENSRNOP00000099809
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1557,676,056 - 57,684,712 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000161597   ⟹   ENSRNOP00000099336
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1557,676,062 - 57,684,712 (+)Ensembl
RefSeq Acc Id: NM_001109650   ⟹   NP_001103120
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81557,683,612 - 57,686,816 (+)NCBI
mRatBN7.21551,274,295 - 51,277,499 (+)NCBI
Rnor_6.01558,016,238 - 58,019,442 (+)NCBI
Rnor_5.01561,711,478 - 61,723,368 (+)NCBI
RGSC_v3.41556,872,713 - 56,875,694 (+)RGD
Celera1550,900,784 - 50,903,988 (+)RGD
Sequence:
RefSeq Acc Id: XM_006252330   ⟹   XP_006252392
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81557,675,024 - 57,685,204 (+)NCBI
mRatBN7.21551,263,664 - 51,278,030 (+)NCBI
Rnor_6.01558,006,288 - 58,021,166 (+)NCBI
Rnor_5.01561,711,478 - 61,723,368 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001103120 (Get FASTA)   NCBI Sequence Viewer  
  XP_006252392 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM02308 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000065668
  ENSRNOP00000065668.1
  ENSRNOP00000099809
RefSeq Acc Id: NP_001103120   ⟸   NM_001109650
- UniProtKB: D3ZXL9 (UniProtKB/TrEMBL),   A6HTU4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006252392   ⟸   XM_006252330
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000065668   ⟸   ENSRNOT00000075786
Ensembl Acc Id: ENSRNOP00000099336   ⟸   ENSRNOT00000161597
Ensembl Acc Id: ENSRNOP00000104238   ⟸   ENSRNOT00000126931
Ensembl Acc Id: ENSRNOP00000099809   ⟸   ENSRNOT00000157928
Protein Domains
BTB

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZXL9-F1-model_v2 AlphaFold D3ZXL9 1-259 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1594637 AgrOrtholog
BioCyc Gene G2FUF-13095 BioCyc
Ensembl Genes ENSRNOG00000050996 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075786 ENTREZGENE
  ENSRNOT00000075786.2 UniProtKB/TrEMBL
  ENSRNOT00000157928 ENTREZGENE
Gene3D-CATH Potassium Channel Kv1.1, Chain A UniProtKB/TrEMBL
InterPro BTB/POZ-like UniProtKB/TrEMBL
  BTB/POZ_fold UniProtKB/TrEMBL
  KCTD4_C UniProtKB/TrEMBL
  T1-type_BTB UniProtKB/TrEMBL
KEGG Report rno:691835 UniProtKB/TrEMBL
NCBI Gene 691835 ENTREZGENE
PANTHER BTB/POZ DOMAIN-CONTAINING PROTEIN KCTD4 UniProtKB/TrEMBL
  POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING UniProtKB/TrEMBL
Pfam K_tetra UniProtKB/TrEMBL
  KCTD4_C UniProtKB/TrEMBL
PhenoGen Kctd4 PhenoGen
RatGTEx ENSRNOG00000050996 RatGTEx
SMART BTB UniProtKB/TrEMBL
Superfamily-SCOP BTB/POZ_fold UniProtKB/TrEMBL
UniProt A6HTU4 ENTREZGENE, UniProtKB/TrEMBL
  D3ZXL9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-07-09 Kctd4  potassium channel tetramerization domain containing 4  Kctd4  potassium channel tetramerisation domain containing 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Kctd4  potassium channel tetramerisation domain containing 4  LOC691835  similar to Potassium channel tetramerisation domain-containing protein 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC691835  similar to Potassium channel tetramerisation domain-containing protein 4  LOC684884  similar to Potassium channel tetramerisation domain-containing protein 4  Data merged from RGD:1585514 1643240 APPROVED
2006-11-20 LOC691835  similar to Potassium channel tetramerisation domain-containing protein 4      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC684884  similar to Potassium channel tetramerisation domain-containing protein 4      Symbol and Name status set to provisional 70820 PROVISIONAL