Myo18b (myosin XVIIIb) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Myo18b (myosin XVIIIb) Rattus norvegicus
Analyze
Symbol: Myo18b
Name: myosin XVIIIb
RGD ID: 1594542
Description: Predicted to enable actin filament binding activity. Predicted to be involved in actomyosin structure organization. Predicted to act upstream of or within cardiac muscle cell development; in utero embryonic development; and vasculogenesis. Predicted to be located in Z disc. Predicted to be part of filamentous actin; myosin II complex; and unconventional myosin complex. Predicted to be active in cytoplasm and myosin filament. Human ortholog(s) of this gene implicated in Klippel-Feil syndrome 4. Orthologous to human MYO18B (myosin XVIIIB); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; alpha-Zearalanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC103690078; LOC304551; similar to Myosin-18B (Myosin XVIIIb); unconventional myosin-XVIIIb; unconventional myosin-XVIIIb-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81249,421,062 - 49,614,127 (+)NCBIGRCr8
mRatBN7.21243,747,003 - 43,953,694 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1243,747,010 - 43,953,695 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01249,761,100 - 49,979,745 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1249,761,120 - 49,979,758 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01250,806,338 - 50,812,174 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01251,525,647 - 51,739,994 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1245,335,125 - 45,539,192 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12547197   PMID:18761673  


Genomics

Comparative Map Data
Myo18b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81249,421,062 - 49,614,127 (+)NCBIGRCr8
mRatBN7.21243,747,003 - 43,953,694 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1243,747,010 - 43,953,695 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01249,761,100 - 49,979,745 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1249,761,120 - 49,979,758 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01250,806,338 - 50,812,174 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01251,525,647 - 51,739,994 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1245,335,125 - 45,539,192 (+)NCBICelera
Cytogenetic Map12q16NCBI
MYO18B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382225,742,188 - 26,063,847 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2225,742,144 - 26,031,045 (+)EnsemblGRCh38hg38GRCh38
GRCh372226,138,155 - 26,427,011 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362224,468,120 - 24,757,007 (+)NCBINCBI36Build 36hg18NCBI36
Build 342224,462,673 - 24,751,561NCBI
Celera229,942,299 - 10,231,147 (+)NCBICelera
Cytogenetic Map22q12.1NCBI
HuRef229,085,589 - 9,374,875 (+)NCBIHuRef
CHM1_12226,097,561 - 26,386,572 (+)NCBICHM1_1
T2T-CHM13v2.02226,203,366 - 26,530,383 (+)NCBIT2T-CHM13v2.0
Myo18b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395112,836,742 - 113,044,311 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5112,836,742 - 113,044,228 (-)EnsemblGRCm39 Ensembl
GRCm385112,688,876 - 112,896,461 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5112,688,876 - 112,896,362 (-)EnsemblGRCm38mm10GRCm38
MGSCv375113,117,896 - 113,325,382 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365112,929,179 - 113,129,163 (-)NCBIMGSCv36mm8
Celera5109,812,620 - 110,004,309 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map554.8NCBI
Myo18b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955455437,291 - 696,376 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955455437,308 - 696,161 (+)NCBIChiLan1.0ChiLan1.0
MYO18B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22335,767,321 - 36,035,601 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12238,466,124 - 38,734,311 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0226,802,390 - 7,118,996 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12224,529,348 - 24,816,779 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2224,529,348 - 24,816,779 (+)Ensemblpanpan1.1panPan2
MYO18B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12619,520,287 - 19,776,007 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2619,536,778 - 19,773,326 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2619,386,332 - 19,641,385 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02619,886,407 - 20,141,753 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2619,902,908 - 20,141,753 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12619,591,181 - 19,846,792 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02619,856,813 - 20,112,437 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02619,926,312 - 20,181,928 (+)NCBIUU_Cfam_GSD_1.0
Myo18b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118115,106,453 - 115,334,938 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936657551,535 - 764,247 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYO18B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1443,468,514 - 43,687,727 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11443,467,823 - 43,687,729 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21446,276,886 - 46,514,866 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103223082
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1198,622,498 - 8,926,818 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl198,650,438 - 8,927,494 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045117,294,181 - 117,489,167 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myo18b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247472,338,528 - 2,578,637 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247472,337,892 - 2,630,397 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Myo18b
1484 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:137
Count of miRNA genes:101
Interacting mature miRNAs:107
Transcripts:ENSRNOT00000070961
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122308134044726024Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123210317445899022Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat

Markers in Region
BF414070  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21243,764,422 - 43,764,650 (+)MAPPERmRatBN7.2
Rnor_6.01249,778,531 - 49,778,758NCBIRnor6.0
Rnor_5.01251,543,059 - 51,543,286UniSTSRnor5.0
Celera1245,352,566 - 45,352,793UniSTS
RH 3.4 Map19156.7UniSTS
Cytogenetic Map12q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 11 49 112 75 75 44 25 44 6 197 96 93 41 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000070961   ⟹   ENSRNOP00000065213
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1243,747,010 - 43,953,695 (+)Ensembl
Rnor_6.0 Ensembl1249,761,120 - 49,979,758 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000086428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1249,029,184 - 49,035,295 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000098133   ⟹   ENSRNOP00000097315
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1243,760,381 - 43,953,695 (+)Ensembl
RefSeq Acc Id: XM_006249578   ⟹   XP_006249640
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81249,421,062 - 49,614,127 (+)NCBI
mRatBN7.21243,747,003 - 43,953,694 (+)NCBI
Rnor_6.01249,761,100 - 49,979,745 (+)NCBI
Rnor_5.01251,525,647 - 51,739,994 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001419354 (Get FASTA)   NCBI Sequence Viewer  
  XP_006249640 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM13988 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000065213.3
  ENSRNOP00000097315.1
RefSeq Acc Id: XP_006249640   ⟸   XM_006249578
- UniProtKB: A0A8I6GM05 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000065213   ⟸   ENSRNOT00000070961
Ensembl Acc Id: ENSRNOP00000097315   ⟸   ENSRNOT00000098133
Protein Domains
Myosin motor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R6Z9-F1-model_v2 AlphaFold M0R6Z9 1-2551 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698727
Promoter ID:EPDNEW_R9249
Type:multiple initiation site
Name:Myo18b_1
Description:myosin XVIIIb
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01249,761,168 - 49,761,228EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1594542 AgrOrtholog
BioCyc Gene G2FUF-18878 BioCyc
Ensembl Genes ENSRNOG00000048430 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000058414 Ensembl
Ensembl Transcript ENSRNOT00000070961.3 UniProtKB/TrEMBL
  ENSRNOT00000098133.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.820 UniProtKB/TrEMBL
  1.20.58.530 UniProtKB/TrEMBL
  3.40.850.10 UniProtKB/TrEMBL
  6.20.240.20 UniProtKB/TrEMBL
  Myosin VI head, motor domain, U50 subdomain UniProtKB/TrEMBL
  Myosin, subunit A UniProtKB/TrEMBL
InterPro IQ_motif_EF-hand-BS UniProtKB/TrEMBL
  Kinesin_motor_dom_sf UniProtKB/TrEMBL
  Myosin_head_motor_dom UniProtKB/TrEMBL
  MYSc_Myo18 UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene 304551 ENTREZGENE
PANTHER MYOSIN HEAVY CHAIN, NON-MUSCLE UniProtKB/TrEMBL
  PTHR45615:SF8 UniProtKB/TrEMBL
Pfam Myosin_head UniProtKB/TrEMBL
PhenoGen Myo18b PhenoGen
PRINTS MYOSINHEAVY UniProtKB/TrEMBL
PROSITE MYOSIN_MOTOR UniProtKB/TrEMBL
  PS50096 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000048430 RatGTEx
  ENSRNOG00000058414 RatGTEx
SMART MYSc UniProtKB/TrEMBL
  SM00015 UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
  Tropomyosin UniProtKB/TrEMBL
UniProt A0A8I6GM05 ENTREZGENE, UniProtKB/TrEMBL
  M0R6Z9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Myo18b  myosin XVIIIb  LOC103690078  unconventional myosin-XVIIIb-like  Data merged from RGD:9404043 737654 PROVISIONAL
2014-08-25 LOC103690078  unconventional myosin-XVIIIb-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-03-04 Myo18b  myosin XVIIIb  LOC304551  similar to Myosin-18B (Myosin XVIIIb)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC304551  similar to Myosin-18B (Myosin XVIIIb)      Symbol and Name status set to provisional 70820 PROVISIONAL