Pole (DNA polymerase epsilon, catalytic subunit) - Rat Genome Database

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Gene: Pole (DNA polymerase epsilon, catalytic subunit) Rattus norvegicus
Analyze
Symbol: Pole
Name: DNA polymerase epsilon, catalytic subunit
RGD ID: 1594540
Description: Enables DNA-directed DNA polymerase activity. Involved in DNA biosynthetic process and embryonic organ development. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of epsilon DNA polymerase complex. Human ortholog(s) of this gene implicated in colorectal cancer (multiple); endometrial cancer (multiple); lung cancer (multiple); and mismatch repair cancer syndrome. Orthologous to human POLE (DNA polymerase epsilon, catalytic subunit); PARTICIPATES IN nucleotide excision repair pathway; base excision repair pathway; DNA replication pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DNA polymerase epsilon; DNA polymerase epsilon catalytic subunit A; DNA-directed DNA polymerase epsilon; POLE1; Pole_mapped; polymerase (DNA directed), epsilon; polymerase (DNA directed), epsilon (mapped); polymerase (DNA directed), epsilon, catalytic subunit; polymerase (DNA) epsilon, catalytic subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81252,005,155 - 52,053,761 (-)NCBIGRCr8
GRCr8 Ensembl1252,005,155 - 52,053,662 (-)EnsemblGRCr8 Ensembl
mRatBN7.21246,345,420 - 46,393,984 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1246,345,420 - 46,393,939 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1247,521,043 - 47,569,702 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01248,126,677 - 48,175,127 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01247,187,202 - 47,235,652 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01252,403,533 - 52,452,075 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1252,403,529 - 52,452,040 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01254,138,907 - 54,187,430 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41246,491,498 - 46,539,988 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1247,901,862 - 47,950,299 (-)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2'-Methylenebis(4-methyl-6-tert-butylphenol)  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
amphetamine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
coumestrol  (ISO)
curcumin  (EXP)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
ethanol  (ISO)
FR900359  (ISO)
furan  (EXP,ISO)
genistein  (EXP)
geraniol  (ISO)
glyphosate  (ISO)
imiquimod  (ISO)
ivermectin  (ISO)
lead diacetate  (ISO)
lidocaine  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
methimazole  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
quercetin  (ISO)
rotenone  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
xylitol  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
epsilon DNA polymerase complex  (IBA,IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)
plasma membrane  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The somatic POLE P286R mutation defines a unique subclass of colorectal cancer featuring hypermutation, representing a potential genomic biomarker for immunotherapy. Ahn SM, etal., Oncotarget. 2016 Oct 18;7(42):68638-68649. doi: 10.18632/oncotarget.11862.
2. Polymerase É› (POLE) mutations in endometrial cancer: clinical outcomes and implications for Lynch syndrome testing. Billingsley CC, etal., Cancer. 2015 Feb 1;121(3):386-94. doi: 10.1002/cncr.29046. Epub 2014 Sep 15.
3. Tenofovir diphosphate is a poor substrate and a weak inhibitor of rat DNA polymerases alpha, delta, and epsilon*. Birkus G, etal., Antimicrob Agents Chemother. 2002 May;46(5):1610-3.
4. Molecular Classification of Grade 3 Endometrioid Endometrial Cancers Identifies Distinct Prognostic Subgroups. Bosse T, etal., Am J Surg Pathol. 2018 May;42(5):561-568. doi: 10.1097/PAS.0000000000001020.
5. Risk of colorectal cancer for carriers of a germ-line mutation in POLE or POLD1. Buchanan DD, etal., Genet Med. 2018 Aug;20(8):890-895. doi: 10.1038/gim.2017.185. Epub 2017 Nov 9.
6. DNA polymerase ε and δ exonuclease domain mutations in endometrial cancer. Church DN, etal., Hum Mol Genet. 2013 Jul 15;22(14):2820-8. doi: 10.1093/hmg/ddt131. Epub 2013 Mar 24.
7. Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: a retrospective, pooled biomarker study. Domingo E, etal., Lancet Gastroenterol Hepatol. 2016 Nov;1(3):207-216. doi: 10.1016/S2468-1253(16)30014-0. Epub 2016 Jul 20.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Clinical impact of endometrial cancer stratified by genetic mutational profiles, POLE mutation, and microsatellite instability. Haruma T, etal., PLoS One. 2018 Apr 16;13(4):e0195655. doi: 10.1371/journal.pone.0195655. eCollection 2018.
10. Ultra-mutated colorectal cancer patients with POLE driver mutations exhibit distinct clinical patterns. Hu H, etal., Cancer Med. 2021 Jan;10(1):135-142. doi: 10.1002/cam4.3579. Epub 2020 Oct 30.
11. Increased incidence of FBXW7 and POLE proofreading domain mutations in young adult colorectal cancers. Kothari N, etal., Cancer. 2016 Sep 15;122(18):2828-35. doi: 10.1002/cncr.30082. Epub 2016 May 31.
12. DNA polymerases and repair synthesis in NER in human cells. Lehmann AR DNA Repair (Amst). 2011 Jul 15;10(7):730-3. doi: 10.1016/j.dnarep.2011.04.023. Epub 2011 May 20.
13. Favorable outcome of patients with lung adenocarcinoma harboring POLE mutations and expressing high PD-L1. Liu L, etal., Mol Cancer. 2018 Apr 12;17(1):81. doi: 10.1186/s12943-018-0832-y.
14. Frameshift mutational target gene analysis identifies similarities and differences in constitutional mismatch repair-deficiency and Lynch syndrome. Maletzki C, etal., Mol Carcinog. 2017 Jul;56(7):1753-1764. doi: 10.1002/mc.22632. Epub 2017 Mar 30.
15. Genetic variation in the DNA repair genes is predictive of outcome in lung cancer. Matakidou A, etal., Hum Mol Genet. 2007 Oct 1;16(19):2333-40.
16. High polymerase ε expression associated with increased CD8+T cells improves survival in patients with non-small cell lung cancer. Min KW, etal., PLoS One. 2020 May 20;15(5):e0233066. doi: 10.1371/journal.pone.0233066. eCollection 2020.
17. Somatic POLE exonuclease domain mutations elicit enhanced intratumoral immune responses in stage II colorectal cancer. Mo S, etal., J Immunother Cancer. 2020 Aug;8(2). pii: jitc-2020-000881. doi: 10.1136/jitc-2020-000881.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
20. DNA polymerase epsilon - more than a polymerase. Pospiech H and Syvaoja JE, ScientificWorldJournal. 2003 Mar 24;3:87-104.
21. DNA polymerases delta and epsilon in developing and aging rat brain. Prapurna DR and Rao KS, Int J Dev Neurosci. 1997 Feb;15(1):67-73.
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Comprehensive gene review and curation RGD comprehensive gene curation
25. A mutation in POLE predisposing to a multi-tumour phenotype. Rohlin A, etal., Int J Oncol. 2014 Jul;45(1):77-81. doi: 10.3892/ijo.2014.2410. Epub 2014 Apr 29.
26. POLD1 and POLE Gene Mutations in Jewish Cohorts of Early-Onset Colorectal Cancer and of Multiple Colorectal Adenomas. Rosner G, etal., Dis Colon Rectum. 2018 Sep;61(9):1073-1079. doi: 10.1097/DCR.0000000000001150.
27. Mutations in POLE and survival of colorectal cancer patients--link to disease stage and treatment. Stenzinger A, etal., Cancer Med. 2014 Dec;3(6):1527-38. doi: 10.1002/cam4.305. Epub 2014 Aug 1.
28. Adjuvant Treatment for POLE Proofreading Domain-Mutant Cancers: Sensitivity to Radiotherapy, Chemotherapy, and Nucleoside Analogues. Van Gool IC, etal., Clin Cancer Res. 2018 Jul 1;24(13):3197-3203. doi: 10.1158/1078-0432.CCR-18-0266. Epub 2018 Mar 20.
29. Nucleotide excision repair gene expression in the rat conceptus during organogenesis. Vinson RK and Hales BF, Mutat Res. 2001 Jul 12;486(2):113-23.
Additional References at PubMed
PMID:1730053   PMID:10559260   PMID:10801849   PMID:16762037   PMID:20227374   PMID:22465957  


Genomics

Comparative Map Data
Pole
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81252,005,155 - 52,053,761 (-)NCBIGRCr8
GRCr8 Ensembl1252,005,155 - 52,053,662 (-)EnsemblGRCr8 Ensembl
mRatBN7.21246,345,420 - 46,393,984 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1246,345,420 - 46,393,939 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1247,521,043 - 47,569,702 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01248,126,677 - 48,175,127 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01247,187,202 - 47,235,652 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01252,403,533 - 52,452,075 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1252,403,529 - 52,452,040 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01254,138,907 - 54,187,430 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41246,491,498 - 46,539,988 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1247,901,862 - 47,950,299 (-)NCBICelera
Cytogenetic Map12q16NCBI
POLE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812132,623,762 - 132,687,342 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12132,623,753 - 132,687,376 (-)EnsemblGRCh38hg38GRCh38
GRCh3712133,200,348 - 133,263,928 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612131,710,421 - 131,774,018 (-)NCBINCBI36Build 36hg18NCBI36
Build 3412131,811,625 - 131,874,295NCBI
Celera12132,900,080 - 132,958,351 (-)NCBICelera
Cytogenetic Map12q24.33NCBI
HuRef12129,980,040 - 130,042,942 (-)NCBIHuRef
CHM1_112133,019,687 - 133,083,939 (-)NCBICHM1_1
T2T-CHM13v2.012132,673,921 - 132,737,569 (-)NCBIT2T-CHM13v2.0
Pole
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395110,434,185 - 110,485,319 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5110,434,172 - 110,485,340 (+)EnsemblGRCm39 Ensembl
GRCm385110,286,319 - 110,337,468 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5110,286,306 - 110,337,474 (+)EnsemblGRCm38mm10GRCm38
MGSCv375110,715,338 - 110,766,472 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365110,526,690 - 110,577,757 (+)NCBIMGSCv36mm8
Celera5107,409,945 - 107,462,118 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map553.45NCBI
Pole
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955482373,555 - 417,266 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955482373,467 - 418,000 (+)NCBIChiLan1.0ChiLan1.0
POLE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210140,734,114 - 140,796,597 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112140,730,631 - 140,793,174 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012129,975,750 - 130,038,402 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112134,695,976 - 134,758,650 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12134,695,976 - 134,758,650 (-)Ensemblpanpan1.1panPan2
POLE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.126433,990 - 481,018 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl26433,879 - 479,917 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha26470,023 - 522,861 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.026485,709 - 538,959 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl26485,793 - 537,892 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.126427,092 - 479,552 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.026514,096 - 567,155 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.026445,310 - 497,983 (+)NCBIUU_Cfam_GSD_1.0
Pole
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118122,098,149 - 122,145,825 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366602,575,360 - 2,622,852 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366602,575,255 - 2,622,867 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POLE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1422,798,192 - 22,853,547 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11422,798,146 - 22,852,818 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
POLE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111127,966,879 - 128,030,442 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11127,965,896 - 128,030,292 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037116,836,268 - 116,900,907 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pole
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474728,024,975 - 28,068,344 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474728,024,230 - 28,068,390 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:149
Count of miRNA genes:118
Interacting mature miRNAs:122
Transcripts:ENSRNOT00000067453
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122598935552308831Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)124413955852308831Rat

Markers in Region
Pole  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21246,384,834 - 46,385,578 (+)MAPPERmRatBN7.2
Rnor_6.01252,442,942 - 52,443,684NCBIRnor6.0
Rnor_5.01254,178,316 - 54,179,058UniSTSRnor5.0
RGSC_v3.41246,530,907 - 46,531,649UniSTSRGSC3.4
Celera1247,941,266 - 47,942,008UniSTS
Cytogenetic Map12q16UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 49 113 91 90 59 25 59 6 218 97 11 93 45 60 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001107152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005491633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005491634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005491635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005491637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005491638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005491639 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010056397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010056398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC120688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY176054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000067453   ⟹   ENSRNOP00000058920
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1252,005,155 - 52,053,662 (-)Ensembl
mRatBN7.2 Ensembl1246,345,420 - 46,393,939 (-)Ensembl
Rnor_6.0 Ensembl1252,403,529 - 52,452,040 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000153279   ⟹   ENSRNOP00000109464
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1252,005,155 - 52,053,662 (-)Ensembl
RefSeq Acc Id: NM_001107152   ⟹   NP_001100622
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81252,005,155 - 52,053,662 (-)NCBI
mRatBN7.21246,345,420 - 46,393,939 (-)NCBI
Rnor_6.01252,403,533 - 52,452,042 (-)NCBI
Rnor_5.01254,138,907 - 54,187,430 (-)NCBI
RGSC_v3.41246,491,498 - 46,539,988 (-)RGD
Celera1247,901,862 - 47,950,299 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039089516   ⟹   XP_038945444
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81252,013,550 - 52,053,761 (-)NCBI
mRatBN7.21246,353,816 - 46,393,984 (-)NCBI
RefSeq Acc Id: XM_039089517   ⟹   XP_038945445
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81252,015,708 - 52,053,761 (-)NCBI
mRatBN7.21246,355,927 - 46,393,984 (-)NCBI
RefSeq Acc Id: XM_063271395   ⟹   XP_063127465
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81252,013,728 - 52,053,761 (-)NCBI
RefSeq Acc Id: XM_063271396   ⟹   XP_063127466
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81252,013,545 - 52,053,761 (-)NCBI
RefSeq Acc Id: XR_005491633
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81252,006,853 - 52,053,761 (-)NCBI
mRatBN7.21246,347,118 - 46,393,984 (-)NCBI
RefSeq Acc Id: XR_005491634
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81252,007,964 - 52,053,761 (-)NCBI
mRatBN7.21246,348,227 - 46,393,984 (-)NCBI
RefSeq Acc Id: XR_005491635
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81252,007,910 - 52,053,761 (-)NCBI
mRatBN7.21246,348,175 - 46,393,984 (-)NCBI
RefSeq Acc Id: XR_005491637
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81252,013,550 - 52,053,761 (-)NCBI
mRatBN7.21246,350,102 - 46,393,984 (-)NCBI
RefSeq Acc Id: XR_005491638
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81252,015,356 - 52,053,761 (-)NCBI
mRatBN7.21246,355,625 - 46,393,984 (-)NCBI
RefSeq Acc Id: XR_005491639
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81252,013,726 - 52,053,761 (-)NCBI
mRatBN7.21246,354,716 - 46,393,984 (-)NCBI
RefSeq Acc Id: XR_010056397
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81252,013,550 - 52,053,761 (-)NCBI
RefSeq Acc Id: XR_010056398
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81252,013,727 - 52,053,761 (-)NCBI
RefSeq Acc Id: NP_001100622   ⟸   NM_001107152
- UniProtKB: D3Z8X4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000058920   ⟸   ENSRNOT00000067453
RefSeq Acc Id: XP_038945444   ⟸   XM_039089516
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038945445   ⟸   XM_039089517
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063127466   ⟸   XM_063271396
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063127465   ⟸   XM_063271395
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000109464   ⟸   ENSRNOT00000153279
Protein Domains
DNA polymerase epsilon catalytic subunit A C-

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z8X4-F1-model_v2 AlphaFold D3Z8X4 1-2283 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698737
Promoter ID:EPDNEW_R9262
Type:single initiation site
Name:Pole_1
Description:DNA polymerase epsilon, catalytic subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01252,452,044 - 52,452,104EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1594540 AgrOrtholog
BioCyc Gene G2FUF-18805 BioCyc
Ensembl Genes ENSRNOG00000037449 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000067453 ENTREZGENE
  ENSRNOT00000067453.4 UniProtKB/TrEMBL
Gene3D-CATH 1.10.132.60 UniProtKB/TrEMBL
  3.30.420.10 UniProtKB/TrEMBL
  3.90.1600.10 UniProtKB/TrEMBL
  DNA Polymerase, chain B, domain 1 UniProtKB/TrEMBL
InterPro DNA-dir_DNA_pol_B UniProtKB/TrEMBL
  DNA-dir_DNA_pol_B_exonuc UniProtKB/TrEMBL
  DNA/RNA_pol_sf UniProtKB/TrEMBL
  DNA_pol_B_C UniProtKB/TrEMBL
  DNA_pol_e_suA_C UniProtKB/TrEMBL
  DNA_pol_palm_dom_sf UniProtKB/TrEMBL
  POL2 UniProtKB/TrEMBL
  POL2_thumb UniProtKB/TrEMBL
  RNaseH-like_dom UniProtKB/TrEMBL
  RNaseH_sf UniProtKB/TrEMBL
  Znf-DPOE UniProtKB/TrEMBL
KEGG Report rno:304573 UniProtKB/TrEMBL
NCBI Gene 304573 ENTREZGENE
PANTHER DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A UniProtKB/TrEMBL
  PTHR10670 UniProtKB/TrEMBL
Pfam DNA_pol_B_exo1 UniProtKB/TrEMBL
  DUF1744 UniProtKB/TrEMBL
  POL2_thumb UniProtKB/TrEMBL
  zf-DPOE UniProtKB/TrEMBL
  zf_DPOE_2 UniProtKB/TrEMBL
PharmGKB POLE RGD
PhenoGen Pole PhenoGen
RatGTEx ENSRNOG00000037449 RatGTEx
SMART DUF1744 UniProtKB/TrEMBL
  POLBc UniProtKB/TrEMBL
Superfamily-SCOP RNaseH_fold UniProtKB/TrEMBL
  SSF56672 UniProtKB/TrEMBL
UniProt A6J2B5_RAT UniProtKB/TrEMBL
  D3Z8X4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-21 Pole  DNA polymerase epsilon, catalytic subunit  Pole  polymerase (DNA) epsilon, catalytic subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-03-09 Pole  polymerase (DNA) epsilon, catalytic subunit  Pole  polymerase (DNA directed), epsilon, catalytic subunit  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-10 Pole  polymerase (DNA directed), epsilon, catalytic subunit  Pole  polymerase (DNA directed), epsilon  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-13   polymerase (DNA directed), epsilon  Pole  polymerase (DNA directed), epsilon (mapped)  Name updated 737654 APPROVED
2007-04-13   polymerase (DNA directed), epsilon  Pole  polymerase (DNA directed), epsilon (mapped)  Name updated 737654 APPROVED
2007-04-11 Pole  polymerase (DNA directed), epsilon (mapped)  Pole_mapped  polymerase (DNA directed), epsilon (mapped)  Data merged from RGD:3364 737654 APPROVED
2006-11-20 Pole  polymerase (DNA directed), epsilon (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Pole_mapped  polymerase (DNA directed), epsilon (mapped)      Symbol and Name updated 1556543 APPROVED
2003-04-09 Pole  polymerase (DNA directed), epsilon    DNA polymerase epsilon  Name updated 629478 APPROVED
2002-06-10 Pole  DNA polymerase epsilon      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in neuronal and astroglial cell fractions at moderate levels in developing adult and aging brain cerebral cortex 734484
gene_function plays important role in long patch base excision repair as well as in other modes of DNA repair 734484
gene_function possesses 3'-5'-exonuclease activity 1303937