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Gene: Ocrl (OCRL, inositol polyphosphate-5-phosphatase) Rattus norvegicus

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Symbol:

Ocrl

Name:

OCRL, inositol polyphosphate-5-phosphatase

RGD ID:

1594526

Description:

Predicted to enable GTPase activator activity; phosphatase activity; and small GTPase binding activity. Predicted to be involved in cilium assembly. Predicted to act upstream of or within in utero embryonic development and phosphatidylinositol dephosphorylation. Predicted to be located in several cellular components, including cytoplasmic vesicle; photoreceptor outer segment; and trans-Golgi network. Predicted to be active in cytoplasm; membrane; and neuron projection. Human ortholog(s) of this gene implicated in Dent disease 2 and oculocerebrorenal syndrome. Orthologous to human OCRL (OCRL inositol polyphosphate-5-phosphatase); PARTICIPATES IN inositol phosphate metabolic pathway; phosphatidylinositol 3-kinase signaling pathway; INTERACTS WITH 2,6-dinitrotoluene; 6-propyl-2-thiouracil; acrylamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

inositol polyphosphate 5-phosphatase OCRL; inositol polyphosphate 5-phosphatase OCRL-1; OCRL-1; Ocrl_mapped; oculocerebrorenal syndrome of Lowe; oculocerebrorenal syndrome of Lowe (mapped); phosphatidylinositol 3,4,5-triphosphate 5-phosphatase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	131,955,775 - 132,018,298 (+)	NCBI		GRCr8
mRatBN7.2	X	127,089,508 - 127,140,362 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	127,089,590 - 127,140,362 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	129,215,952 - 129,266,773 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	132,786,279 - 132,837,107 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	130,313,088 - 130,363,915 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	134,742,226 - 134,793,411 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	134,742,356 - 134,792,618 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	134,814,622 - 134,865,807 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	134,271,916 - 134,322,751 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	126,040,210 - 126,091,039 (+)	NCBI		Celera
Cytogenetic Map	X	q35	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

Autosomal Dominant Intellectual Developmental Disorder 65 (ISO)

autosomal hemophilia A (ISO)

cataract (ISO)

Charcot-Marie-Tooth disease type X (ISO)

COVID-19 (ISO)

Dent disease (ISO)

Dent disease 2 (ISO)

factor VIII deficiency (ISO)

familial hypocalciuric hypercalcemia (ISO)

intellectual disability (ISO)

oculocerebrorenal syndrome (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

syndromic X-linked intellectual disability Raymond type (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,6-dinitrotoluene (EXP)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP,ISO)

amitrole (EXP)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

CGP 52608 (ISO)

choline (ISO)

clothianidin (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

Dibutyl phosphate (ISO)

endosulfan (EXP)

ethanol (ISO)

ethyl methanesulfonate (ISO)

folic acid (ISO)

ivermectin (ISO)

L-methionine (ISO)

lead(0) (ISO)

methimazole (EXP)

methotrexate (ISO)

methyl methanesulfonate (ISO)

pirinixic acid (ISO)

resveratrol (ISO)

sodium arsenite (ISO)

sulfadimethoxine (EXP)

sunitinib (ISO)

thapsigargin (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

troglitazone (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

cilium assembly (IEA,ISO)

in utero embryonic development (IEA,ISO)

phosphatidylinositol dephosphorylation (IEA,ISO)

signal transduction (IEA)

Cellular Component

centriolar satellite (IEA,ISO)

ciliary basal body (IEA,ISO)

cilium (ISO)

clathrin-coated pit (IEA)

clathrin-coated vesicle (IEA,ISO,ISS)

cytoplasm (IBA,ISO)

cytosol (IEA,ISO)

early endosome (ISO,ISS)

early endosome membrane (IEA)

membrane (IBA)

microtubule cytoskeleton (ISO)

neuron projection (IBA)

nucleus (IEA,ISO)

phagocytic vesicle membrane (IEA)

photoreceptor outer segment (IEA,ISO)

plasma membrane (IEA,ISO)

trans-Golgi network (IEA,ISO)

Molecular Function

GTPase activator activity (IEA,ISO)

inositol phosphate phosphatase activity (IEA,ISO,ISS)

inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity (IEA)

inositol-1,4,5-trisphosphate 5-phosphatase activity (IEA)

phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity (IEA)

phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity (IBA,IEA,ISO)

protein binding (IPI,ISO)

small GTPase binding (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

inositol phosphate metabolic pathway (IEA)

phosphatidylinositol 3-kinase signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Comprehensive gene review and curation	RGD comprehensive gene curation
8.	Interaction of Rab31 and OCRL-1 in oligodendrocytes: its role in transport of mannose 6-phosphate receptors.	Rodriguez-Gabin AG, etal., J Neurosci Res. 2010 Feb 15;88(3):589-604. doi: 10.1002/jnr.22236.
9.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:9593760	PMID:12915445	PMID:16902405	PMID:19211563	PMID:20195868	PMID:21233288	PMID:22228094	PMID:22543976	PMID:23376485	PMID:25869668	PMID:25931508	PMID:29476059

Genomics

Comparative Map Data

Ocrl
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	131,955,775 - 132,018,298 (+)	NCBI		GRCr8
mRatBN7.2	X	127,089,508 - 127,140,362 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	127,089,590 - 127,140,362 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	129,215,952 - 129,266,773 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	132,786,279 - 132,837,107 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	130,313,088 - 130,363,915 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	134,742,226 - 134,793,411 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	134,742,356 - 134,792,618 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	134,814,622 - 134,865,807 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	134,271,916 - 134,322,751 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	126,040,210 - 126,091,039 (+)	NCBI		Celera
Cytogenetic Map	X	q35	NCBI

OCRL
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	129,540,259 - 129,592,556 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	129,539,849 - 129,592,561 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	128,674,236 - 128,726,533 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	128,501,933 - 128,554,214 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	128,399,786 - 128,452,063	NCBI
Celera	X	129,062,951 - 129,113,094 (+)	NCBI		Celera
Cytogenetic Map	X	q26.1	NCBI
HuRef	X	118,081,643 - 118,132,141 (+)	NCBI		HuRef
CHM1_1	X	128,585,639 - 128,637,898 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	127,859,040 - 127,911,341 (+)	NCBI		T2T-CHM13v2.0

Ocrl
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	47,001,289 - 47,055,305 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	47,001,264 - 47,054,745 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	47,912,418 - 47,966,428 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	47,912,387 - 47,965,868 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	45,265,633 - 45,319,045 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	44,157,083 - 44,210,495 (+)	NCBI		MGSCv36	mm8
Celera	X	35,414,246 - 35,467,331 (+)	NCBI		Celera
Cytogenetic Map	X	A4	NCBI
cM Map	X	25.43	NCBI

Ocrl
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955473	5,431,395 - 5,482,385 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955473	5,429,084 - 5,482,377 (-)	NCBI	ChiLan1.0	ChiLan1.0

OCRL
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	128,963,342 - 129,015,706 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	128,966,955 - 129,019,325 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	118,670,612 - 118,721,108 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	128,968,751 - 129,020,444 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	128,968,760 - 129,018,157 (+)	Ensembl	panpan1.1		panPan2

OCRL
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	100,760,302 - 100,817,673 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	100,757,373 - 100,831,500 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	86,935,904 - 86,989,289 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	102,613,937 - 102,667,382 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	102,613,968 - 102,667,382 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	100,031,797 - 100,085,435 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	101,877,493 - 101,930,941 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	101,655,530 - 101,708,953 (+)	NCBI		UU_Cfam_GSD_1.0

Ocrl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	98,975,434 - 99,033,762 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936479	1,953,488 - 2,012,018 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936479	1,955,362 - 2,011,608 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

OCRL
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	106,135,431 - 106,190,110 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	106,124,991 - 106,188,066 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	121,904,287 - 121,959,049 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

OCRL
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	104,784,900 - 104,834,718 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	104,785,526 - 104,837,243 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666065	42,269,909 - 42,321,337 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ocrl
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624797	8,730,713 - 8,792,727 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624797	8,731,130 - 8,792,300 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ocrl
84 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	1255
Count of miRNA genes:	346
Interacting mature miRNAs:	495
Transcripts:	ENSRNOT00000005267
Prediction methods:	Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1598872	Memor14	Memory QTL 14	4.5		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	X	93956491	138956491	Rat
1598856	Memor1	Memory QTL 1	1.9		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	X	103312877	148312877	Rat
1598809	Memor15	Memory QTL 15	4.4		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	X	103312877	148312877	Rat
738025	Stresp3	Stress response QTL 3	4.61	0.0066	stress-related behavior trait (VT:0010451)	defensive burying - approach	X	100567703	150256146	Rat
634346	Insul4	Insulin level QTL 4	0		blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	X	126975089	152453651	Rat
738029	Stresp2	Stress response QTL 2	3.4	0.0004	stress-related behavior trait (VT:0010451)	defensive burying - approach	X	112934952	138400867	Rat
10059603	Bw174	Body weight QTL 174	3.4	0.025	body mass (VT:0001259)	body weight (CMO:0000012)	X	113937816	152453651	Rat
1598837	Memor13	Memory QTL 13	3.2		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	X	41052407	146860749	Rat

Markers in Region

DXWox29

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	127,143,992 - 127,144,286 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	134,797,042 - 134,797,335	NCBI	Rnor6.0
Rnor_5.0	X	134,869,438 - 134,869,731	UniSTS	Rnor5.0
RGSC_v3.4	X	134,326,391 - 134,326,684	UniSTS	RGSC3.4
Celera	X	126,094,670 - 126,094,963	UniSTS
Cytogenetic Map	X	q35	UniSTS

AI010734

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	127,140,118 - 127,140,272 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	134,793,168 - 134,793,321	NCBI	Rnor6.0
Rnor_5.0	X	134,865,564 - 134,865,717	UniSTS	Rnor5.0
RGSC_v3.4	X	134,322,517 - 134,322,670	UniSTS	RGSC3.4
Celera	X	126,090,796 - 126,090,949	UniSTS
RH 3.4 Map	X	907.9	UniSTS
Cytogenetic Map	X	q35	UniSTS

BF394020

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	127,135,238 - 127,135,461 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	134,788,288 - 134,788,510	NCBI	Rnor6.0
Rnor_5.0	X	134,860,684 - 134,860,906	UniSTS	Rnor5.0
RGSC_v3.4	X	134,317,637 - 134,317,859	UniSTS	RGSC3.4
Celera	X	126,085,916 - 126,086,138	UniSTS
RH 3.4 Map	X	907.7	UniSTS
Cytogenetic Map	X	q35	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108256	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006257528	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006257529	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039099845	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039099847	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280089	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280090	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473991	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000005267 ⟹ ENSRNOP00000005267

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	127,089,590 - 127,140,362 (+)	Ensembl
Rnor_6.0 Ensembl	X	134,742,356 - 134,792,618 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000082363 ⟹ ENSRNOP00000072408

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	127,089,590 - 127,140,362 (+)	Ensembl
Rnor_6.0 Ensembl	X	134,742,429 - 134,791,157 (+)	Ensembl

RefSeq Acc Id:

NM_001108256 ⟹ NP_001101726

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	131,967,471 - 132,018,298 (+)	NCBI
mRatBN7.2	X	127,089,536 - 127,140,362 (+)	NCBI
Rnor_6.0	X	134,742,226 - 134,793,411 (+)	NCBI
Rnor_5.0	X	134,814,622 - 134,865,807 (+)	NCBI
RGSC_v3.4	X	134,271,916 - 134,322,751 (+)	RGD
Celera	X	126,040,210 - 126,091,039 (+)	NCBI

Sequence:

show sequence

GACTCTCTCCTCCCGGCTCCCCAGCTCCCCGGCTGGCTCCCAGGCTCCCGGGCTCCCGGGCTCC
CAGGCTCCCCGCGCCCAGCGGCGCCGGAGCTCTTCCTCTCCGCCTAGGCAAGGCGGGCGGGCGG
GCGGCAGGCCGCAGGAGGCGGTGTCGTGGAATCCGCTGGCAGTCCGCAGCCCCGCAGAGCCTGG
AGGCCGCCCTGATGGAGCCGCGGCTCCCGATCGGAGCTCAGCCCCTGGCAATGGTGGCGGGTTT
GGAGATGAAGGGTCCTCTCCGGGAGCCCTGCGTCCTGACCCTAGCCCGGAGGAACGGGCAATAT
GAGTTAATAATCCAGTTGCATGGGAAGGAACAGCATGTTCAAGATATCATTCCTATAAATAGCC
ACTTCAGATGTGTTCAAGAAGCAGAAGAAACTCTTTTGATTGATATTGCTTCAAACAGTGGCTG
CAAAATTCGGGTACAGGGAGACTGGACCAGAGAGCGCCACTTTGAAATTCCTGATGAAGAACGC
TGTTTGAAGTTCCTCTCAGAGGTCCTTGCTGCTCAGGAAGCTCAGTCACAGCTTCTTGTTCCAG
AACAAAAAGACTCATCTAACTGGTACCAGAAATTAGACACTAAGGATAAACCTGCTTATTCAGG
ACTGCTTGGATTTGAAGATAATTTTTCATCTATGAATTTAGATAAAAAAATGAATACACAAAAT
CCCCCCACAGGGATTCATCGGGAACCACCCCCTCCACCTTCTTCAAATAGAATGCTTCCACGTG
AAAAGGAAGCTTTAAACAAAGAACAGCCCAAAGTGACCAATACCATGCGGAAGCTGTTCGCACC
AAACAGCCAATCTGGCCAGCGAGAGGGTCTCATCAAACACATCCTTGCAAAGCGAGAGAAAGAG
TATGTCAACATCCAGTCTTTCAGATTTTTTGTTGGAACTTGGAATGTGAATGGCCAGTCTCCAG
ACAGCAGCTTAGAACCTTGGCTGAACTGTGATCCAAATCCTCCTGATATTTACTGCATTGGATT
CCAAGAGCTGGACTTGAGCACAGAAGCCTTTTTCTACTTTGAGTCTGTAAAAGAGCAAGAATGG
GCCATGGCTGTGGAAAGGGGTCTGCCTTCGAAGGCCAAGTATAAAAAGGTTCAACTGGTCCGCC
TTGTGGGGATGATGCTTCTCGTATTTGCCAAAAAAGATCAGTGTCAATATATCCGAGATATTGC
TACAGAAACAGTCGGAACAGGAATCATGGGGAAAATGGGAAACAAAGGTGGAGTAGCTATGAGA
TTTGTGTTCCACAACACCACTTTCTGCATTGTCAATTCCCACCTGGCTGCCCACGTGGAAGAGT
TTGAACGAAGGAACCAGGATTATAAAGACATCTGTGCGAGAATGAGCTTTTCAGTCCCCAATCA
GACTCTCCCACAAGTGAACATCATGAAGCATGATGTTGTCATTTGGTTGGGAGACTTGAACTAC
AGACTTTGCATGCCTGATGCCAATGAGGTGAAAAGTCTTATTAATAAAAATGAGCTTCAGAAGC
TGTTGAAATTCGACCAGTTAAACATTCAGCGCACACAGAAAAAAGCTTTTGTGGATTTCAATGA
AGGGGAAATCAAGTTTATTCCCACTTACAAGTATGATTCTAAAACTGACAGATGGGATTCCAGT
GGGAAATGCCGAGTCCCAGCCTGGTGTGACCGAATTCTTTGGAGAGGAATAAATGTTAATCAAC
TTCATTACCGGAGTCACATGGAACTCAAAACTAGTGACCACAAACCTGTTAGCGCCCTGTTCCA
TATTGGGGTGAAGGTTGTAGATGAACGGCGGTATCGGAAGGTCTTTGAAGATATTGTACGCATT
ATGGACAGAATGGAAAATGACTTCCTTCCTTCATTAGACCTTAGCAGGAGAGAGTTTATGTTTG
AGAATGTGAAGTTTCGGCAGCTGCAAAAGGAGAAGTTCCAGATCAGCAACAATGGACAGGTTCC
CTGCCATTTTTCTTTCATCCCTAAGCTTAATGACACCCAATACTGCAAGCCATGGCTTCGAGCT
GAACCTTTTGAGGGCTACTTGGAGCCAAACGAGACAATAGACATTTCCCTTGATGTATACGTCA
GCAAAGACTCTGTAACCATCCTGAACTCTGGTGAAGATAAGATTGAAGATATTCTTGTCCTCCA
TTTGGATCGAGGAAAAGATTACTTCTTGACCATCAGTGGGAATTACCTTCCAAGTTGCTTTGGA
ACCTCATTGGAGGCTTTGTGCCGAATGAAAAGACCAATCCGAGAAGTTCCTGTCACCAAACTCA
TAGACTTGGAAGAAGACAGCTTCCTAGAAAAGGAGAAATCCCTTCTGCAGATGGTCCCCTTGGA
TGAAGGTACCAGTGAGCGACCCCTTCAAGTCCCCAAAGAGATCTGGCTTCTAGTAGATCACTTG
TTCAAATATGCATGTCACCAGGAGGACTTGTTCCAAACCCCTGGAATGCAGGAGGAGTTACAGC
AGATCATTGATTGTCTGGATACCAGCATTCCTGAGACAATCCCTGGTAGTAACCATTCTGTGGC
TGAAGCACTGCTCATTTTCCTGGAAGCCCTGCCAGAGCCAGTCATCTGTTATGAGCTGTATCAG
CGATGTCTCGACTCTGCTCATGATCCTCGGATCTGCAAACAGGTCATTTCCCAGCTTCCAAGGT
GCCATAGAAATGTTTTCCGCTACTTGATGGCATTCCTTCGAGAACTCTTAAAATTCTCTGATTA
CAACAATGTCAGCACCAACATGATCGCTACTCTGTTCACTAGCCTTCTCCTAAGGCCTCCACCA
AACCTCATGGCAAGACAGACTCCAAGTGACCGCCAGCGCGCCATCCAGTTTCTTCTAGTCTTCC
TGCTTGGGAGCGAGGAAGACTAAATCTTTTCCTATCTGAGATTCTAGAGGAGGAAGATCTTGGG
CTCCGAGTAGTTCAGAATGATTTGAAAAGTCATGACACAAAAAGGGTCTATTGTAGGATCTTAC
ATTCTGTTAATAATACAAAGGGAAGAGTTTCCTAATCCTTCCATACCATATCCTACACAGCAAA
ATCCTTTTAGACATATATTGCCAAGCCAAAGTTACCATATTTCGGTGTTTTTGTGTTTACTCTT
TGTAAAGCAAAGAGGTCTGTATTTACACACCTTTTCTGGAGGTTTTCTGCCCTGCTTCCTAGTC
CTCATGATTTAATACCCTAGGCCTGGATTGAGAGGCATTCCCATTCTAAGCCTACAAGCACTAC
TTGCTATATAGCCCAGACTTGTCTGCAGTCCTTTGTACACAATGCACTTTGGATCCACCCTCTC
CTCATGTCACTACTTTGCACACTTCCTCCGTTAATGCTATCGCTTTGAAGGAAGCCTGGATGAG
GTTAGTGACTCCGTGGGTATCCTGAACAGTGAAGTTCACTGTCTACATGTGATTGTTACATGCG
TTCGTGCATTTCTACTACAATAATGTCTATGTGTCACTGTAATATTGGCCTTCTTGTGGAGCCA
CACTTGGTGGAACCATATTCCCTTGTCTCAGACCATGTTTAGTTATGTAATTTTATGGACTATT
AGAGATGGCATCCCACTGATGTGAAAAACATCACAACAGCGAGGAAAGCACTGTGACTATGTCA
GAGTGAAAATGTCCCTGCTTCCCATCCTCTTTCCCTGGTAATATCCACACTAGACATGAGGAGC
AATCCTGCATGTCATGGTACCCATCTTCCCCACTAGAAACCCACTTCCAGAATAATGTTTGCAT
CACACTCAAAAGAGGAGTTTGTGCACCTCAAGTAAGGCCCAATGGAGCTTTCCTCACTCTCCAA
AACAAGTATTGAGGGTAACCCTCAGAAGCCAGTCTCCTATCTTCAGAAGTATTGAGGGAACACA
TTGACCTCCTCAACAGGGCTGACTCTAAGCTCCACATCTGCCTCCTTCAAGCAAAGACTTCAAA
GACTGCCCTTGGCTTGAGACACTATATCCAGTGCTGTGTATGAGAGACTGGTCCATGGGACCAG
CCACACACATTACCTCTTCCACTTGAAACGACTCTAAGGTTTTCATTTTATTCAAGCGGTATGG
GACAGACAAACTTTTTAAAAATCAACTTGTTGACTGACAAACCAGCTGCCAGCTTCTGGCTGCA
AAAACTGCCTGGTGAAATTGACTTGCTCGGTTTCATTCACCAAACCAACCCAAGTCGTCTCGTT
CTTGCCTATGTACAATCTTGGGTACTGATTCCATCAGTAGCATCTTATACCATCCAAGGAGAGG
GCCAGGGAAACAGCCACCATCAAATGGTTTTCCAGCTTCCCCGTCTCTTCAAAAATTGAGTTCT
TGGGAGAACAAAAGGTATGTATCCTGCAATAGACCTGATAAGCCCTCAAATAAGTGGGAGTTGG
GAAATCAGAGTCAAAGTATTGGTGCCAGCTCACTGAGGATCTGATTGGGTCAACAGTTGATTAA
CGGAAGACTGAGAGGAAAAGAAAGTTGTCATATCTATTAGGCCAGAAAGTAATCACTGAAGAAG
CAGATGATGTGGAACAAGGTGGTCCACAGGGAAATGCCTCTCCTGGGCCCACTTTACAATACCT
TGCCAAGCTTGGGTCTTCAGATGAGCAAGGATATGGTGAGTGGGGCCTCTGTGGAGCATGCACG
TAGTGCCCTGTCTTCATCAGGCCAAAGCACCAAGTTGCTTCACTGCCTCAGCCTTTTGTCCAGC
TTGGCCTGGGATTTATATAGAGCTGAGGGTTTTAGACAATCTCCAGGTAGGGGATACAAAACAG
ATCAGATGGAAGAAACCTGCTTCCCTATCCTGCCTATCCTGCACCTCAGCCTCTTAATTCCTAA
TTCCTCCAAGGTACTATTTCATAGTTGCTCTGAATTAAGGATTTCACATCCAACTGGTACGGAA
AGACTCCGCACCTAGCATCTTTGGGAAGAAATGATTCCAATCTAATGGGTGATACTGCATTAGT
TTCCCTTTCTGATTCTTAATCTGTAGGTCTTTGTTATACTTCACAAAAAGGAAAAATGTCTCGG
TCACTACGCAAAGCTGCTAGTGGAATTCTGTATTTTGTGTCATCTTTTTTATTATAATTTATTG
CAATTTTATGAATAAATATATGTTGTGTGAAAACTCA

hide sequence

RefSeq Acc Id:

XM_039099845 ⟹ XP_038955773

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	131,967,444 - 132,018,294 (+)	NCBI
mRatBN7.2	X	127,089,508 - 127,140,362 (+)	NCBI

RefSeq Acc Id:

XM_039099847 ⟹ XP_038955775

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	131,967,444 - 132,010,286 (+)	NCBI
mRatBN7.2	X	127,089,509 - 127,132,350 (+)	NCBI

RefSeq Acc Id:

XM_063280089 ⟹ XP_063136159

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	131,955,775 - 132,018,294 (+)	NCBI

RefSeq Acc Id:

XM_063280090 ⟹ XP_063136160

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	131,955,775 - 132,018,294 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001101726	(Get FASTA)	NCBI Sequence Viewer
	XP_038955773	(Get FASTA)	NCBI Sequence Viewer
	XP_038955775	(Get FASTA)	NCBI Sequence Viewer
	XP_063136159	(Get FASTA)	NCBI Sequence Viewer
	XP_063136160	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	D3ZGS3	(Get FASTA)	NCBI Sequence Viewer
	EDM10902	(Get FASTA)	NCBI Sequence Viewer
	EDM10903	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000005267.7
	ENSRNOP00000072408.2

RefSeq Acc Id:

NP_001101726 ⟸ NM_001108256

- UniProtKB:

D3ZGS3 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MEPRLPIGAQPLAMVAGLEMKGPLREPCVLTLARRNGQYELIIQLHGKEQHVQDIIPINSHFRC
VQEAEETLLIDIASNSGCKIRVQGDWTRERHFEIPDEERCLKFLSEVLAAQEAQSQLLVPEQKD
SSNWYQKLDTKDKPAYSGLLGFEDNFSSMNLDKKMNTQNPPTGIHREPPPPPSSNRMLPREKEA
LNKEQPKVTNTMRKLFAPNSQSGQREGLIKHILAKREKEYVNIQSFRFFVGTWNVNGQSPDSSL
EPWLNCDPNPPDIYCIGFQELDLSTEAFFYFESVKEQEWAMAVERGLPSKAKYKKVQLVRLVGM
MLLVFAKKDQCQYIRDIATETVGTGIMGKMGNKGGVAMRFVFHNTTFCIVNSHLAAHVEEFERR
NQDYKDICARMSFSVPNQTLPQVNIMKHDVVIWLGDLNYRLCMPDANEVKSLINKNELQKLLKF
DQLNIQRTQKKAFVDFNEGEIKFIPTYKYDSKTDRWDSSGKCRVPAWCDRILWRGINVNQLHYR
SHMELKTSDHKPVSALFHIGVKVVDERRYRKVFEDIVRIMDRMENDFLPSLDLSRREFMFENVK
FRQLQKEKFQISNNGQVPCHFSFIPKLNDTQYCKPWLRAEPFEGYLEPNETIDISLDVYVSKDS
VTILNSGEDKIEDILVLHLDRGKDYFLTISGNYLPSCFGTSLEALCRMKRPIREVPVTKLIDLE
EDSFLEKEKSLLQMVPLDEGTSERPLQVPKEIWLLVDHLFKYACHQEDLFQTPGMQEELQQIID
CLDTSIPETIPGSNHSVAEALLIFLEALPEPVICYELYQRCLDSAHDPRICKQVISQLPRCHRN
VFRYLMAFLRELLKFSDYNNVSTNMIATLFTSLLLRPPPNLMARQTPSDRQRAIQFLLVFLLGS
EED

hide sequence

Ensembl Acc Id:

ENSRNOP00000072408 ⟸ ENSRNOT00000082363

Ensembl Acc Id:

ENSRNOP00000005267 ⟸ ENSRNOT00000005267

RefSeq Acc Id:	XP_038955773 ⟸ XM_039099845
- Peptide Label:	isoform X1
- UniProtKB:	D3ZGS3 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_038955775 ⟸ XM_039099847
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_063136160 ⟸ XM_063280090
- Peptide Label:	isoform X4
- UniProtKB:	R9PXS2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063136159 ⟸ XM_063280089
- Peptide Label:	isoform X2
- UniProtKB:	A6JMP0 (UniProtKB/TrEMBL), A0A8L2R5U9 (UniProtKB/TrEMBL)

Protein Domains

Inositol polyphosphate-related phosphatase PH Rho-GAP

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZGS3-F1-model_v2	AlphaFold	D3ZGS3	1-902	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1594526	AgrOrtholog
BioCyc Gene	G2FUF-1145	BioCyc
Ensembl Genes	ENSRNOG00000003875	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000005267.8	UniProtKB/TrEMBL
	ENSRNOT00000082363.2	UniProtKB/TrEMBL
Gene3D-CATH	1.10.555.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2.30.29.110	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2.60.40.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	3.60.10.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	Endo/exonu/phosph_ase_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IP5	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IPPc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	OCRL-1_2_ASH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	OCRL1/INPP5B_INPP5c	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	OCRL1_PH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	OCRL_clath-bd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Rho_GTPase_activation_prot	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RhoGAP_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RhoGAP_OCRL1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	317576	ENTREZGENE
PANTHER	INOSITOL 5-PHOSPHATASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	INOSITOL POLYPHOSPHATE 5-PHOSPHATASE OCRL	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Exo_endo_phos2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	OCRL-like_ASH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	OCRL_clath_bd	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RhoGAP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Ocrl	PhenoGen
PROSITE	RHOGAP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000003875	RatGTEx
SMART	IPPc	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RhoGAP	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF48350	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF56219	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8L2R5U9	ENTREZGENE, UniProtKB/TrEMBL
	A6JMP0	ENTREZGENE, UniProtKB/TrEMBL
	A6JMP1_RAT	UniProtKB/TrEMBL
	D3ZGS3	ENTREZGENE, UniProtKB/Swiss-Prot
	R9PXS2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-06-02	Ocrl	OCRL, inositol polyphosphate-5-phosphatase	Ocrl	oculocerebrorenal syndrome of Lowe	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2007-04-13		oculocerebrorenal syndrome of Lowe	Ocrl	oculocerebrorenal syndrome of Lowe (mapped)	Name updated	737654	APPROVED
2007-04-11	Ocrl	oculocerebrorenal syndrome of Lowe (mapped)	Ocrl_mapped	oculocerebrorenal syndrome of Lowe (mapped)	Data merged from RGD:3223	737654	APPROVED
2006-11-20	Ocrl	oculocerebrorenal syndrome of Lowe (mapped)			Symbol and Name status set to provisional	70820	PROVISIONAL
2005-11-17	Ocrl_mapped	oculocerebrorenal syndrome of Lowe (mapped)	Ocrl	oculocerebrorenal syndrome of Lowe	Symbol and Name updated	1556543	APPROVED
2002-06-10	Ocrl	Oculocerebrorenal syndrome of Lowe			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_homology	mutation in human OCRL causes Lowe syndrome, also known as oculocerebrorenal syndrome	1302257
gene_homology	human homolog OCRL possesses phosphoinositide 5-phosphatase activity	1302257
gene_homology	human homolog OCRL is involved in lipid metabolism	1302257
gene_homology	mouse homolog RIKEN cDNA 9530014D17 possesses an inositol polyphosphate phosphatase domain	737633

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)