Chmp1b (charged multivesicular body protein 1B) - Rat Genome Database

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Gene: Chmp1b (charged multivesicular body protein 1B) Rattus norvegicus
Analyze
Symbol: Chmp1b
Name: charged multivesicular body protein 1B
RGD ID: 1593500
Description: Predicted to enable MIT domain binding activity and identical protein binding activity. Predicted to be involved in several processes, including midbody abscission; plasma membrane repair; and regulation of cell cycle process. Predicted to be located in several cellular components, including bounding membrane of organelle; kinetochore microtubule; and midbody. Predicted to be part of ESCRT III complex; membrane coat; and nuclear pore. Orthologous to human CHMP1B (charged multivesicular body protein 1B); PARTICIPATES IN endocytosis pathway; INTERACTS WITH bisphenol A; dibutyl phthalate; gentamycin.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: chromatin modifying protein 1B; LOC689364; similar to chromatin modifying protein 1B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81863,010,270 - 63,012,800 (+)NCBIGRCr8
mRatBN7.21860,740,349 - 60,742,879 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1862,813,159 - 62,815,686 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01863,511,902 - 63,514,429 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01861,360,955 - 61,363,485 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01862,923,620 - 62,926,150 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01862,110,410 - 62,112,940 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41863,715,066 - 63,717,596 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1858,848,127 - 58,850,657 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:16730941   PMID:17928862   PMID:19056867   PMID:19129479   PMID:19525971   PMID:20458337   PMID:20616062   PMID:23015756   PMID:23376485   PMID:23533145   PMID:24878737  
PMID:25556234  


Genomics

Comparative Map Data
Chmp1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81863,010,270 - 63,012,800 (+)NCBIGRCr8
mRatBN7.21860,740,349 - 60,742,879 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1862,813,159 - 62,815,686 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01863,511,902 - 63,514,429 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01861,360,955 - 61,363,485 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01862,923,620 - 62,926,150 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01862,110,410 - 62,112,940 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41863,715,066 - 63,717,596 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1858,848,127 - 58,850,657 (+)NCBICelera
Cytogenetic Map18q12.1NCBI
CHMP1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381811,851,413 - 11,854,444 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1811,851,413 - 11,854,444 (+)EnsemblGRCh38hg38GRCh38
GRCh371811,851,412 - 11,854,443 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361811,841,426 - 11,842,697 (+)NCBINCBI36Build 36hg18NCBI36
Celera1811,729,892 - 11,732,949 (+)NCBICelera
Cytogenetic Map18p11.21NCBI
HuRef1811,805,683 - 11,808,740 (+)NCBIHuRef
CHM1_11811,850,434 - 11,853,491 (+)NCBICHM1_1
T2T-CHM13v2.01812,013,673 - 12,016,702 (+)NCBIT2T-CHM13v2.0
Chmp1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391867,338,430 - 67,340,958 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1867,338,437 - 67,340,960 (+)EnsemblGRCm39 Ensembl
GRCm381867,205,359 - 67,207,887 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1867,205,366 - 67,207,889 (+)EnsemblGRCm38mm10GRCm38
MGSCv371867,365,013 - 67,367,541 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361867,330,792 - 67,332,370 (+)NCBIMGSCv36mm8
MGSCv361867,543,513 - 67,545,091 (+)NCBIMGSCv36mm8
Cytogenetic Map18E1NCBI
cM Map1839.89NCBI
Chmp1b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554021,196,912 - 1,199,480 (-)NCBIChiLan1.0ChiLan1.0
CHMP1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21726,170,602 - 26,175,519 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11811,863,198 - 11,868,123 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0182,452,393 - 2,455,509 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1184,716,131 - 4,719,173 (-)NCBIpanpan1.1PanPan1.1panPan2
CHMP1B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1777,500,378 - 77,503,092 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha776,902,033 - 76,904,738 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0777,558,134 - 77,560,841 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1777,255,319 - 77,258,026 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0777,301,902 - 77,304,609 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0777,589,038 - 77,591,744 (+)NCBIUU_Cfam_GSD_1.0
Chmp1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049441,163,626 - 1,166,513 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936626391,942 - 394,440 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CHMP1B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1697,356,924 - 97,359,613 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2690,689,845 - 90,692,131 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CHMP1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11869,534,547 - 69,539,377 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605044,533,784 - 44,536,828 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Chmp1b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477019,487,040 - 19,489,740 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Chmp1b
13 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331733Bp233Blood pressure QTL 2333.97196arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182479697779788953Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
1298072Cia26Collagen induced arthritis QTL 263.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)185470976983828827Rat
1300125Rf26Renal function QTL 263.2urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)185253986365844950Rat
631834Sach3Saccharin preference QTL 33.90.01consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)185880568763636873Rat
6893683Bw110Body weight QTL 1102.70.002body mass (VT:0001259)body weight (CMO:0000012)184334502283828827Rat
1331727Bp237Blood pressure QTL 2373.053arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183135940861698465Rat
9589041Epfw12Epididymal fat weight QTL 1217.080.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)184664067583828827Rat
8694432Bw165Body weight QTL 1653.810.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)184664067583828827Rat
70185BpQTLcluster15Blood pressure QTL cluster 154.61arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)185971241776477814Rat
9589816Gluco68Glucose level QTL 687.250.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)182979296574792965Rat
1331770Bp234Blood pressure QTL 2343.807arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647871893566Rat
2300177Bmd65Bone mineral density QTL 6519.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
2301969Bp324Blood pressure QTL 3244.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185971241776477814Rat
2303120Mamtr8Mammary tumor resistance QTL 80.001mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)183135940883218561Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
12880368Bw187Body weight QTL 1870.045body mass (VT:0001259)body weight (CMO:0000012)185253976376104388Rat
724542Kidm2Kidney mass QTL 22.6kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)185917211583828827Rat
61367Iddm4Insulin dependent diabetes mellitus QTL 42.330.0074blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)183819245583192455Rat
2293658Bmd23Bone mineral density QTL 237.30.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)185146473363636873Rat
1359020Ppulsi2Prepulse inhibition QTL 22.71prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)185229287573997283Rat
2312600Bp341Blood pressure QTL 3410.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185933040970263868Rat
1331752Bw27Body weight QTL 272.963body mass (VT:0001259)body weight (CMO:0000012)185229287565845095Rat
9590318Scort22Serum corticosterone level QTL 227.640.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)182979296574792965Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1331754Bp230Blood pressure QTL 2304.61609arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182979296574792965Rat
12904069Cm123Cardiac mass QTL 1230.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)185253976376104388Rat
12904070Cm124Cardiac mass QTL 1240.01heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)185253976376104388Rat
2303584Gluco55Glucose level QTL 552blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)184852004483828827Rat
12904071Am18Aortic mass QTL 180.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)185253976376104388Rat
12904067Cm122Cardiac mass QTL 1220.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)185253976376104388Rat
61384Bp48Blood pressure QTL 4819.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)186062231177209844Rat
2301417Bp319Blood pressure QTL 3190.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185253976376104388Rat
12904073Kidm71Kidney mass QTL 710.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)185253976376104388Rat
6903353Bp353Blood pressure QTL 3532.8arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)185979647883828827Rat
738008Hcar14Hepatocarcinoma resistance QTL 144.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion number (CMO:0001462)185146473383218561Rat
6903356Bp354Blood pressure QTL 3544.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)185979647883828827Rat
631518Bw11Body weight QTL 112.8body mass (VT:0001259)body weight (CMO:0000012)183587072380870723Rat
8694366Abfw8Abdominal fat weight QTL 86.380.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)184664067583828827Rat
631509Sald2Serum aldosterone level QTL 22.9blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)185253976369140759Rat
738005Anxrr11Anxiety related response QTL 113.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)183003981375039813Rat
2300157Bmd66Bone mineral density QTL 6613.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)182896485373964853Rat
631274Sprol1Serum protein level QTL 15.3blood total protein amount (VT:0005567)serum total protein level (CMO:0000661)183139332077209694Rat
1358193Emca2Estrogen-induced mammary cancer QTL 21.6mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)181800759963571040Rat
2293704Bss35Bone structure and strength QTL 354.590.0002femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)182896485373964853Rat
2325839Bp348Blood pressure QTL 3480.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)182557098570570985Rat
1600373Mamtr6Mammary tumor resistance QTL 6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)181927890183218561Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
8694378Bw157Body weight QTL 1573.590.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)182979296574792965Rat
1600375Mcs22Mammary carcinoma susceptibility QTL 223.3mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)185253976363933058Rat
2303571Bw92Body weight QTL 923body mass (VT:0001259)body weight (CMO:0000012)184852004483828827Rat
631675Iddm15Insulin dependent diabetes mellitus QTL 15urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)186062231177209844Rat
1598826Anxrr20Anxiety related response QTL 203.04body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)184143297183828827Rat
61429Cia17Collagen induced arthritis QTL 174.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)183135940870263868Rat
7411719Strs5Sensitivity to stroke QTL 59.4cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)184999995865845095Rat

Markers in Region
RH129239  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21860,741,670 - 60,741,886 (+)MAPPERmRatBN7.2
Rnor_6.01862,924,942 - 62,925,157NCBIRnor6.0
Rnor_5.01862,111,732 - 62,111,947UniSTSRnor5.0
RGSC_v3.41863,716,388 - 63,716,603UniSTSRGSC3.4
Celera1858,849,449 - 58,849,664UniSTS
RH 3.4 Map18615.3UniSTS
Cytogenetic Map18q12.1UniSTS
Cytogenetic Map18q12.1-q12.2UniSTS
RH129499  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21860,741,670 - 60,741,878 (+)MAPPERmRatBN7.2
Rnor_6.01862,924,942 - 62,925,149NCBIRnor6.0
Rnor_5.01862,111,732 - 62,111,939UniSTSRnor5.0
RGSC_v3.41863,716,388 - 63,716,595UniSTSRGSC3.4
Celera1858,849,449 - 58,849,656UniSTS
RH 3.4 Map18616.3UniSTS
Cytogenetic Map18q12.1UniSTS
Cytogenetic Map18q12.1-q12.2UniSTS
UniSTS:237833  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21860,740,919 - 60,741,119 (+)MAPPERmRatBN7.2
Rnor_6.01862,924,191 - 62,924,390NCBIRnor6.0
Rnor_5.01862,110,981 - 62,111,180UniSTSRnor5.0
RGSC_v3.41863,715,637 - 63,715,836UniSTSRGSC3.4
Celera1858,848,698 - 58,848,897UniSTS
Cytogenetic Map18q12.1UniSTS
Cytogenetic Map18q12.1-q12.2UniSTS


Expression


Sequence


RefSeq Acc Id: NM_001109533   ⟹   NP_001103003
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81863,010,270 - 63,012,800 (+)NCBI
mRatBN7.21860,740,349 - 60,742,879 (+)NCBI
Rnor_6.01862,923,620 - 62,926,150 (+)NCBI
Rnor_5.01862,110,410 - 62,112,940 (+)NCBI
RGSC_v3.41863,715,066 - 63,717,596 (+)RGD
Celera1858,848,127 - 58,850,657 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001103003 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI68175 (Get FASTA)   NCBI Sequence Viewer  
  EDM14717 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001103003   ⟸   NM_001109533
- UniProtKB: A6IXT6 (UniProtKB/TrEMBL),   B4F787 (UniProtKB/TrEMBL)
- Sequence:


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1593500 AgrOrtholog
BioCyc Gene G2FUF-7151 BioCyc
Gene3D-CATH 6.10.140.1230 UniProtKB/TrEMBL
InterPro Snf7_fam UniProtKB/TrEMBL
KEGG Report rno:689364 UniProtKB/TrEMBL
NCBI Gene 689364 ENTREZGENE
PANTHER CHARGED MULTIVESICULAR BODY PROTEIN 1B UniProtKB/TrEMBL
  PTHR10476 UniProtKB/TrEMBL
Pfam Snf7 UniProtKB/TrEMBL
PhenoGen Chmp1b PhenoGen
UniProt A6IXT6 ENTREZGENE, UniProtKB/TrEMBL
  B4F787 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-09-29 Chmp1b  charged multivesicular body protein 1B  Chmp1b  chromatin modifying protein 1B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-07-08 Chmp1b  chromatin modifying protein 1B  LOC682926  similar to chromatin modifying protein 1B  Data merged from RGD:1592818 1643240 APPROVED
2008-03-06 Chmp1b  chromatin modifying protein 1B  LOC689364  similar to chromatin modifying protein 1B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC689364  similar to chromatin modifying protein 1B      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC682926  similar to chromatin modifying protein 1B      Symbol and Name status set to provisional 70820 PROVISIONAL