Advanced Search (OLGA)

Gene: Tktl1 (transketolase-like 1) Rattus norvegicus

Analyze

Symbol:

Tktl1

Name:

transketolase-like 1

RGD ID:

1593490

Description:

Predicted to enable thiamine pyrophosphate binding activity and transketolase activity. Predicted to be located in cytosol. Orthologous to human TKTL1 (transketolase like 1); PARTICIPATES IN pentose phosphate pathway; INTERACTS WITH acrylamide; bisphenol A; copper atom.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC103689980; LOC689374; similar to transketolase-like 1; transketolase-like protein 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TKTL1 (transketolase like 1)	HGNC	Ensembl, HomoloGene, NCBI, Panther
Mus musculus (house mouse):	Tktl1 (transketolase-like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tktl1 (transketolase like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TKTL1 (transketolase like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TKTL1 (transketolase like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tktl1 (transketolase like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TKTL1 (transketolase like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TKTL1 (transketolase like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tktl1 (transketolase like 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	TKTL2 (transketolase like 2)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	TKTL1 (transketolase like 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|OrthoFinder\|PANTHER\|PhylomeDB)
Mus musculus (house mouse):	Tktl1 (transketolase-like 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tktb (transketolase b)	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	CG5103	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	TKL1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	TKL2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	tkt-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG8036	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	157,105,455 - 157,138,510 (+)	NCBI		GRCr8
mRatBN7.2	X	151,954,261 - 151,987,208 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	151,954,175 - 151,987,208 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	154,095,403 - 154,128,342 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	157,658,639 - 157,691,577 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	155,330,437 - 155,363,375 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	156,507,797 - 156,540,733 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	156,507,797 - 156,540,733 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	151,506,633 - 151,523,468 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	1	152,248,857 - 152,281,793 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	160,144,916 - 160,177,852 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	135,909,517 - 135,940,852 (-)	NCBI		Celera
Cytogenetic Map	X	q37	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adrenoleukodystrophy (ISO)

autistic disorder (ISO)

autosomal hemophilia A (ISO)

Barth syndrome (ISO)

cerebral creatine deficiency syndrome 1 (ISO)

Chromosome Xq28 Duplication Syndrome (ISO)

dyskeratosis congenita (ISO)

Emery-Dreifuss muscular dystrophy (ISO)

factor VIII deficiency (ISO)

favism (ISO)

frontometaphyseal dysplasia (ISO)

immunodeficiency 33 (ISO)

Juberg Hayward Syndrome (ISO)

Melnick-Needles syndrome (ISO)

methylmalonic acidemia and homocysteinemia cblX type (ISO)

otopalatodigital syndrome type 2 (ISO)

paraplegia (ISO)

periventricular nodular heterotopia (ISO)

Periventricular Nodular Heterotopia 4 (ISO)

severe congenital encephalopathy due to MECP2 mutation (ISO)

Splenomegaly (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

acrylamide (EXP,ISO)

amiodarone (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

carbamazepine (ISO)

CGP 52608 (ISO)

copper atom (EXP)

copper(0) (EXP)

dioxygen (ISO)

dorsomorphin (ISO)

epoxiconazole (ISO)

folic acid (ISO)

lead diacetate (EXP)

methotrexate (ISO)

nitrofen (EXP)

panobinostat (ISO)

paracetamol (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

trichostatin A (ISO)

triptonide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

cytosol (IEA,ISO)

Molecular Function

thiamine pyrophosphate binding (IBA)

transketolase activity (IBA)

Molecular Pathway Annotations Click to see Annotation Detail View

pentose phosphate pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data

Tktl1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	157,105,455 - 157,138,510 (+)	NCBI		GRCr8
mRatBN7.2	X	151,954,261 - 151,987,208 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	151,954,175 - 151,987,208 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	154,095,403 - 154,128,342 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	157,658,639 - 157,691,577 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	155,330,437 - 155,363,375 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	156,507,797 - 156,540,733 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	156,507,797 - 156,540,733 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	151,506,633 - 151,523,468 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	1	152,248,857 - 152,281,793 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	160,144,916 - 160,177,852 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	135,909,517 - 135,940,852 (-)	NCBI		Celera
Cytogenetic Map	X	q37	NCBI

TKTL1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	154,295,795 - 154,330,350 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	154,295,795 - 154,330,350 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	153,524,148 - 153,558,700 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	153,177,345 - 153,211,894 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	153,044,997 - 153,079,545	NCBI
Celera	X	153,685,095 - 153,719,771 (+)	NCBI		Celera
Cytogenetic Map	X	q28	NCBI
HuRef	X	142,101,239 - 142,134,950 (+)	NCBI		HuRef
CHM1_1	X	153,435,658 - 153,470,347 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	152,532,310 - 152,566,865 (+)	NCBI		T2T-CHM13v2.0

Tktl1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	73,220,865 - 73,252,104 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	73,220,865 - 73,252,106 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	74,177,259 - 74,208,498 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	74,177,259 - 74,208,500 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	71,422,598 - 71,453,837 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	70,430,004 - 70,461,211 (+)	NCBI		MGSCv36	mm8
Celera	X	65,429,659 - 65,462,614 (+)	NCBI		Celera
Cytogenetic Map	X	A7.3	NCBI
cM Map	X	37.83	NCBI

Tktl1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955580	829,594 - 851,470 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955580	829,653 - 851,422 (+)	NCBI	ChiLan1.0	ChiLan1.0

TKTL1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	154,263,474 - 154,304,907 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	154,267,079 - 154,308,512 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	143,736,589 - 143,772,277 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

TKTL1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	122,007,270 - 122,034,500 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	122,007,282 - 122,034,255 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	107,336,003 - 107,363,191 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	125,148,940 - 125,176,143 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	125,148,958 - 125,176,646 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	120,918,050 - 120,945,228 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	123,433,366 - 123,460,383 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	123,194,859 - 123,221,957 (+)	NCBI		UU_Cfam_GSD_1.0

Tktl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	119,310,855 - 119,346,858 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936809	1,048,672 - 1,083,994 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936809	1,048,672 - 1,084,125 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TKTL1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	124,839,995 - 124,867,614 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	124,840,072 - 124,867,313 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

TKTL1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	128,607,766 - 128,642,074 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	128,607,901 - 128,642,063 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666065	66,535,359 - 66,559,996 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tktl1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624946	760,078 - 775,073 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Tktl1
43 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	486
Count of miRNA genes:	237
Interacting mature miRNAs:	283
Transcripts:	ENSRNOT00000056323
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
634346	Insul4	Insulin level QTL 4	0		blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	X	126975089	152453651	Rat
10059603	Bw174	Body weight QTL 174	3.4	0.025	body mass (VT:0001259)	body weight (CMO:0000012)	X	113937816	152453651	Rat

Markers in Region

Nfatc2

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	151,960,823 - 151,962,481 (-)	MAPPER	mRatBN7.2
Rnor_6.0	X	156,532,524 - 156,534,181	NCBI	Rnor6.0
Rnor_6.0	X	155,795,871 - 155,797,528	NCBI	Rnor6.0
Rnor_5.0	1	151,515,195 - 151,516,852	UniSTS	Rnor5.0
Rnor_5.0	1	152,273,584 - 152,275,241	UniSTS	Rnor5.0
RGSC_v3.4	3	159,751,583 - 159,751,874	UniSTS	RGSC3.4
Celera	1	135,932,603 - 135,934,260	UniSTS
Cytogenetic Map	X	q37	UniSTS
Cytogenetic Map	3	q42	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
4	20	27	41	44	27	12	27	5	77	37	18	9	58	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001109534	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039100080	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063280308	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC106169	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474099	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000091029 ⟹ ENSRNOP00000071464

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	151,954,175 - 151,987,208 (+)	Ensembl

RefSeq Acc Id:

NM_001109534 ⟹ NP_001103004

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	157,105,569 - 157,138,505 (+)	NCBI
mRatBN7.2	X	151,954,272 - 151,987,208 (+)	NCBI
Rnor_6.0	X	156,507,797 - 156,540,733 (-)	NCBI
Rnor_5.0	1	152,248,857 - 152,281,793 (-)	NCBI
RGSC_v3.4	X	160,144,916 - 160,177,852 (+)	RGD
Celera	1	135,909,517 - 135,940,852 (-)	NCBI

Sequence:

show sequence

ATGTCAGAAGCTGAGGCAAGCGTTGGGATGGCCCACGATGCTGGGCCTGATGAAAAGACATTGC
AGGTGTTGCGGGACATGGCCAACCGCCTGCGAATCCGTTTTATCAGGACCACAAGTTCCTCGAC
CACTAGCTATCTCACACCATGCAGCAGTGCTGCTGAGATCATGTCTGTGCTATTTTTCTATACA
ATGAGATATAAACAGGAAGACCCTGAAAACCCAGACAATGACCGATGCATCCTTTCAAAGGGAA
TACCGTTTGTTAAAGTAGCAACAGGATGGCCTGGGCAAGGACTAGGAGCTGCCCGTGGGATGGC
ATATACTGGCAAGTACTTTGACCAAGCCAGCTACCGGGTGTTCTGTCTTCTGGGGGATGAAGAG
TCCACAGAAGGCTCTGTTTGGGAGGCATTTGCCTTTGCATCCTACTACAATCTGGACAATCTTA
TGGCAATCTTTGATGTGAACCGCATTGGACACAGTAGCTCCATGTCTGTTGAGCACTGCGTTGG
CATCTACCAGAAGCGTTGTGAAGCCTTTGGGTGGAATACTTACGTGGTGGATGGCCGTAATGTG
GAGACCCTATGCCGTGTATTCTCACAGGCAGCTCAAGTAAGAGGCAAGCCCACTGCTGTGGTTG
CCAAAACCTTCAAGGCCCGAGGCATGCCAAATGTTGAGGATGCAGAAAGTTGGCATGGAAGGCC
AATGCCAAAAGAAAGAGCAGATGCAATTATCAAATTAATTGAGAGCCAGATACAGTCCAACAAA
ATTCTTGTACCTTCACCCCCTATTGAGAACTCACCTCAAATTAACATCATGGATATACATATGG
CCTCGCCCCCTGCTTATGTAGCTGATGACATGGTGTCTACTCAAAGAGCATGTGGTTTGGCTCT
GGCTAAACTGGGCCATGAAAATGACAGAGTTATTGTGCTGGATAGTGACACCGAGAACTGCAAC
TTTTCTGACATATTCAAGAAAGAACACCCAGAGAGGTTCATCCAGTGTTATATTGCTGAACAAA
ACATGGTGAATGTGGCTCTAGGATGTGCCACCCGTGACCGGATCATTGCTTTTGCTTGCACCTT
TGCTGCCTTTTTCACCCGAGCATTTGATCAGATTCGAGTGGGAGCCATCTCTCAAATCAACATC
AACCTTATTGGTTGTCACTGTGGGGTATCTACTGGTGATGACAACCCCTACCATATGGCATTGG
AAGACCTGGCAATGTTCCGAGCAATTCCTAATTGCATTGTTTTCTATCCAAGTGATGCTGTCTC
CACAGAGCATGCTATTTACTTAGCAGCCAATACTAAGGAAATGTGCTTCATTCATACCAGCCAA
GCAGAAACAGCAATTATTTACACCACTCAAGAAACTTTTGAGATTGGACAGGCCAAGGTTGTCC
GCCATAGTAACGATGACAAGGTCATAGTTATTGGAGCAGGAGTCACTCTGCATGAAGCCCTAGT
AGCTGCTGATGAGCTCTCTAAAGAAGATATTTCTATCCGTGTCATTGATTTGTTTACCATTAAA
CCTCTGGACAGTGCCACCATCATTTCCAATGCAAAAGCCACAGGTGGCCGAATTGTCACCGTGG
AGGATCACTATCTAGAAGGTGGCATTGGAGGAGCTGTCTGTGCAGCAGTCTCCATGGAGCCTAA
CATTGTGGTTCATCGGCTCGCAGTGATGGATGTGCCTCGGAGTGGAAGATGCAATGAAGCACTA
GATTTTTCTGGAATCAGTTCCAGACACATCATTGTGGCTGTGAAATGCATCTTAATGAACTAAA
TTAGCTGTTGGCTTTGGTCTTAGAATATTAGCCTCTTCTCTGTATGTTTATGCTTATGCCAAAA
CCATAAGTTAGAAATGATTGTGCTTTGTTTTCCTTAAAGGCAAAACCAGTTAACAACTTTGTTC
CACATTCAGAAATTCTAATTTCCGTTTAATCTGTAACTACATATACAAATATTACTGTTTTAAC
CATCAAAATGGGTCATAAAATTTATAATGGCAGAATAGCTAACAAGACAATCACCTGACACTGA
ACTTTCTCATTAGACTGAATATAAATGGATTAAGGAACACTGTAGAAGTGTCAGTTTAAAAGTA
TTTCCTTCATAAGTAAAGCAAATGTGTGTGGAATTGTAGTCCTCAGACCACCTGTCACAGAACT
AGACCCCTGAGATACATAGTGCTGTTCAACTAAAGTTAACATGTATACTGCCTTCCTACCTGCA
GCTTCCTGAGTTATGTGTAACTTCAGATGCTCTTGACTTTTCTCTGCTATTTCCCTTTATATCC
CCTCTACAGTTCACAGGTCGATGAACAAAATAAAAGCAGTTAGGATGACTTCTGCTGTTCTGGT
GACTGTTCTGTGAAGACATAAGGATACTTCATCTCCACACTATCCTGTTTGATGTTAATAAAGC
ATTTAA

hide sequence

RefSeq Acc Id:

XM_039100080 ⟹ XP_038956008

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	157,109,484 - 157,138,510 (+)	NCBI
mRatBN7.2	X	151,958,183 - 151,987,170 (+)	NCBI

RefSeq Acc Id:

XM_063280308 ⟹ XP_063136378

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	X	157,105,455 - 157,116,676 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001103004	(Get FASTA)	NCBI Sequence Viewer
	XP_038956008	(Get FASTA)	NCBI Sequence Viewer
	XP_063136378	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL84992	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000071464.1

RefSeq Acc Id:

NP_001103004 ⟸ NM_001109534

- UniProtKB:

D3ZPV2 (UniProtKB/TrEMBL), A6KRS6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSEAEASVGMAHDAGPDEKTLQVLRDMANRLRIRFIRTTSSSTTSYLTPCSSAAEIMSVLFFYT
MRYKQEDPENPDNDRCILSKGIPFVKVATGWPGQGLGAARGMAYTGKYFDQASYRVFCLLGDEE
STEGSVWEAFAFASYYNLDNLMAIFDVNRIGHSSSMSVEHCVGIYQKRCEAFGWNTYVVDGRNV
ETLCRVFSQAAQVRGKPTAVVAKTFKARGMPNVEDAESWHGRPMPKERADAIIKLIESQIQSNK
ILVPSPPIENSPQINIMDIHMASPPAYVADDMVSTQRACGLALAKLGHENDRVIVLDSDTENCN
FSDIFKKEHPERFIQCYIAEQNMVNVALGCATRDRIIAFACTFAAFFTRAFDQIRVGAISQINI
NLIGCHCGVSTGDDNPYHMALEDLAMFRAIPNCIVFYPSDAVSTEHAIYLAANTKEMCFIHTSQ
AETAIIYTTQETFEIGQAKVVRHSNDDKVIVIGAGVTLHEALVAADELSKEDISIRVIDLFTIK
PLDSATIISNAKATGGRIVTVEDHYLEGGIGGAVCAAVSMEPNIVVHRLAVMDVPRSGRCNEAL
DFSGISSRHIIVAVKCILMN

hide sequence

RefSeq Acc Id:	XP_038956008 ⟸ XM_039100080
- Peptide Label:	isoform X1

Ensembl Acc Id:

ENSRNOP00000071464 ⟸ ENSRNOT00000091029

RefSeq Acc Id:	XP_063136378 ⟸ XM_063280308
- Peptide Label:	isoform X2

Protein Domains

Transketolase-like pyrimidine-binding

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZPV2-F1-model_v2	AlphaFold	D3ZPV2	1-596	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1593490	AgrOrtholog
BioCyc Gene	G2FUF-639	BioCyc
Ensembl Genes	ENSRNOG00000055557	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000091029.2	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.920	UniProtKB/TrEMBL
	3.40.50.970	UniProtKB/TrEMBL
InterPro	THDP-binding	UniProtKB/TrEMBL
	Transketo_C/Pyr-ferredox_oxred	UniProtKB/TrEMBL
	Transketolase-like	UniProtKB/TrEMBL
	Transketolase-like_Pyr-bd	UniProtKB/TrEMBL
	Transketolase_C	UniProtKB/TrEMBL
	Transketolase_N	UniProtKB/TrEMBL
KEGG Report	rno:689374	UniProtKB/TrEMBL
NCBI Gene	689374	ENTREZGENE
PANTHER	TRANSKETOLASE	UniProtKB/TrEMBL
	TRANSKETOLASE-LIKE PROTEIN 1	UniProtKB/TrEMBL
Pfam	Transket_pyr	UniProtKB/TrEMBL
	Transketolase_C	UniProtKB/TrEMBL
	Transketolase_N	UniProtKB/TrEMBL
PhenoGen	Tktl1	PhenoGen
RatGTEx	ENSRNOG00000055557	RatGTEx
SMART	Transket_pyr	UniProtKB/TrEMBL
Superfamily-SCOP	SSF52518	UniProtKB/TrEMBL
	Transketo_C_like	UniProtKB/TrEMBL
UniProt	A6KRS6	ENTREZGENE, UniProtKB/TrEMBL
	D3ZPV2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Tktl1	transketolase-like 1	LOC103689980	transketolase-like protein 1	Data merged from RGD:9428685	737654	PROVISIONAL
2014-08-25	LOC103689980	transketolase-like protein 1			Symbol and Name status set to provisional	70820	PROVISIONAL
2008-03-06	Tktl1	transketolase-like 1	LOC689374	similar to transketolase-like 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-20	LOC689374	similar to transketolase-like 1			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

Send us a Message

Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)