Ptx3 (pentraxin 3) - Rat Genome Database

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Gene: Ptx3 (pentraxin 3) Rattus norvegicus
Analyze
Symbol: Ptx3
Name: pentraxin 3
RGD ID: 1593476
Description: Predicted to enable several functions, including (1->3)-beta-D-glucan binding activity; complement component C1q complex binding activity; and virion binding activity. Predicted to be involved in several processes, including negative regulation by host of viral process; negative regulation of exo-alpha-sialidase activity; and negative regulation of viral entry into host cell. Predicted to act upstream of or within several processes, including opsonization; ovarian cumulus expansion; and positive regulation of nitric oxide biosynthetic process. Predicted to be located in extracellular matrix. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in cystic fibrosis and invasive aspergillosis. Orthologous to human PTX3 (pentraxin 3); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC689388; pentraxin 3, long; pentraxin related; pentraxin related gene; pentraxin-related protein PTX3; similar to Pentraxin-related protein PTX3 precursor (Pentaxin-related protein PTX3) (Tumor necrosis factor-inducible protein TSG-14)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82152,797,563 - 152,803,372 (+)NCBIGRCr8
mRatBN7.22150,487,513 - 150,493,323 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2150,487,513 - 150,493,323 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2157,593,206 - 157,599,014 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02155,643,731 - 155,649,539 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02150,276,449 - 150,282,257 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02158,097,843 - 158,103,653 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2158,097,843 - 158,103,653 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02177,457,263 - 177,463,073 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42156,089,917 - 156,095,726 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2144,894,946 - 144,900,755 (+)NCBICelera
Cytogenetic Map2q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(E)-thiamethoxam  (ISO)
(S)-nicotine  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-naphthylamine  (ISO)
2-palmitoylglycerol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methylcholanthrene  (ISO)
3-Nitrobenzanthrone  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
belinostat  (ISO)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bortezomib  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chromium(6+)  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
corosolic acid  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
Didecyldimethylammonium  (ISO)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
fenamidone  (ISO)
fentanyl  (EXP)
fluoranthene  (ISO)
fonofos  (ISO)
furan  (EXP)
gentamycin  (EXP)
hexadecanoic acid  (ISO)
hydrogen cyanide  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isoflavones  (ISO)
isoprenaline  (ISO)
ketoconazole  (EXP)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury dibromide  (ISO)
methimazole  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
naphthalene  (ISO)
nickel atom  (ISO)
nicotine  (ISO)
nitrates  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
PD 0325901  (ISO)
pentanal  (ISO)
perfluorononanoic acid  (ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
potassium cyanide  (ISO)
progesterone  (ISO)
propanal  (ISO)
protein kinase inhibitor  (ISO)
raloxifene  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
Tanshinone I  (ISO)
terbufos  (ISO)
thapsigargin  (ISO)
thiamethoxam  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
topotecan  (ISO)
trans-caffeic acid  (ISO)
tricetin  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
valproic acid  (ISO)
vincaleukoblastine  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Source of Circulating Pentraxin 3 in Septic Shock Patients. Albert Vega C, etal., Front Immunol. 2019 Jan 4;9:3048. doi: 10.3389/fimmu.2018.03048. eCollection 2018.
2. Genetic variation in PTX3 and plasma levels associated with hepatocellular carcinoma in patients with HCV. Carmo RF, etal., J Viral Hepat. 2016 Feb;23(2):116-22. doi: 10.1111/jvh.12472. Epub 2015 Sep 24.
3. Significant elevation of plasma pentraxin 3 in patients with pelvic inflammatory disease. Chang CC, etal., Clin Chem Lab Med. 2011 Oct;49(10):1655-60. doi: 10.1515/CCLM.2011.650. Epub 2011 Jun 17.
4. PTX3 genetic variations affect the risk of Pseudomonas aeruginosa airway colonization in cystic fibrosis patients. Chiarini M, etal., Genes Immun. 2010 Dec;11(8):665-70. doi: 10.1038/gene.2010.41. Epub 2010 Oct 7.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Pentraxin-3 as a marker of disease severity and risk of death in patients with necrotizing soft tissue infections: a nationwide, prospective, observational study. Hansen MB, etal., Crit Care. 2016 Feb 15;20:40. doi: 10.1186/s13054-016-1210-z.
7. Pentraxin 3 Gene Polymorphisms and Pulmonary Aspergillosis in Chronic Obstructive Pulmonary Disease Patients. He Q, etal., Clin Infect Dis. 2018 Jan 6;66(2):261-267. doi: 10.1093/cid/cix749.
8. Polymorphisms in Receptors Involved in Opsonic and Nonopsonic Phagocytosis, and Correlation with Risk of Infection in Oncohematology Patients. Herrero-Sánchez MC, etal., Infect Immun. 2018 Nov 20;86(12). pii: IAI.00709-18. doi: 10.1128/IAI.00709-18. Print 2018 Dec.
9. Pentraxin 3 levels in bronchoalveolar lavage fluid of lung transplant recipients with invasive aspergillosis. Kabbani D, etal., J Heart Lung Transplant. 2017 Sep;36(9):973-979. doi: 10.1016/j.healun.2017.04.007. Epub 2017 Apr 19.
10. Pentraxin 3 in bronchoalveolar lavage fluid and plasma in non-neutropenic patients with pulmonary aspergillosis. Li H, etal., Clin Microbiol Infect. 2019 Apr;25(4):504-510. doi: 10.1016/j.cmi.2018.06.015. Epub 2018 Jun 28.
11. Pentraxin-3: A new parameter in predicting the severity of diabetic foot infection? Ozer Balin S, etal., Int Wound J. 2019 Jun;16(3):659-664. doi: 10.1111/iwj.13075. Epub 2019 Feb 15.
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11483299   PMID:14726497   PMID:15060019   PMID:16020751   PMID:16936248   PMID:17675295   PMID:20363749   PMID:22966213   PMID:23544079   PMID:24006456   PMID:25510691   PMID:25786110  
PMID:26806786   PMID:26965847   PMID:29725602   PMID:38724075   PMID:39414396  


Genomics

Comparative Map Data
Ptx3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82152,797,563 - 152,803,372 (+)NCBIGRCr8
mRatBN7.22150,487,513 - 150,493,323 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2150,487,513 - 150,493,323 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2157,593,206 - 157,599,014 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02155,643,731 - 155,649,539 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02150,276,449 - 150,282,257 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02158,097,843 - 158,103,653 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2158,097,843 - 158,103,653 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02177,457,263 - 177,463,073 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42156,089,917 - 156,095,726 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2144,894,946 - 144,900,755 (+)NCBICelera
Cytogenetic Map2q31NCBI
PTX3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383157,436,850 - 157,443,633 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3157,436,850 - 157,443,633 (+)EnsemblGRCh38hg38GRCh38
GRCh373157,154,639 - 157,161,422 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363158,637,301 - 158,644,071 (+)NCBINCBI36Build 36hg18NCBI36
Build 343158,637,308 - 158,644,078NCBI
Celera3155,578,255 - 155,585,092 (+)NCBICelera
Cytogenetic Map3q25.32NCBI
HuRef3154,550,694 - 154,557,531 (+)NCBIHuRef
CHM1_13157,117,566 - 157,124,403 (+)NCBICHM1_1
T2T-CHM13v2.03160,211,418 - 160,218,201 (+)NCBIT2T-CHM13v2.0
Ptx3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39366,127,308 - 66,133,227 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl366,127,331 - 66,133,226 (+)EnsemblGRCm39 Ensembl
GRCm38366,219,887 - 66,225,806 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl366,219,910 - 66,225,805 (+)EnsemblGRCm38mm10GRCm38
MGSCv37366,023,809 - 66,029,728 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36366,307,812 - 66,313,734 (+)NCBIMGSCv36mm8
Celera366,363,920 - 66,369,839 (+)NCBICelera
Cytogenetic Map3E1NCBI
cM Map330.25NCBI
Ptx3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554488,366,925 - 8,372,411 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554488,366,795 - 8,373,010 (+)NCBIChiLan1.0ChiLan1.0
PTX3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22155,347,564 - 155,354,440 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13155,347,508 - 155,359,171 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03154,485,470 - 154,492,293 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13162,537,440 - 162,544,263 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3162,537,577 - 162,543,652 (+)Ensemblpanpan1.1panPan2
PTX3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12350,952,835 - 50,958,607 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2350,952,885 - 50,958,167 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2350,825,322 - 50,831,079 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02351,586,874 - 51,592,673 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2351,586,147 - 51,592,233 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12351,169,291 - 51,175,068 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02351,222,224 - 51,228,028 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02351,507,584 - 51,513,394 (+)NCBIUU_Cfam_GSD_1.0
Ptx3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560285,424,779 - 85,430,719 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365194,303,464 - 4,309,173 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365194,303,549 - 4,309,143 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTX3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1397,273,594 - 97,279,569 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11397,273,594 - 97,279,570 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213105,440,917 - 105,446,892 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTX3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11533,320,592 - 33,327,236 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1533,321,208 - 33,327,268 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660415,897,822 - 5,904,486 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptx3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473035,125,605 - 35,131,367 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473035,125,536 - 35,131,645 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ptx3
18 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:90
Count of miRNA genes:64
Interacting mature miRNAs:82
Transcripts:ENSRNOT00000016541
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1358360Sradr2Stress Responsive Adrenal Weight QTL 210.24adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)2129164097152195315Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2122609194206936711Rat
1549828Bp258Blood pressure QTL 2580.03arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2142323368150650069Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1582257Gluco21Glucose level QTL 213.10.0035blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2118111229157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
738007Anxrr7Anxiety related response QTL 74.4exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2118189491163189491Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
631520Bp73Blood pressure QTL 730.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147686913168355276Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1354594Despr10Despair related QTL 102e-06locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)2114654253159654253Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)228484589169504100Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)228484589169504100Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat

Markers in Region
WI-7070  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22150,492,709 - 150,493,058 (+)MAPPERmRatBN7.2
Rnor_6.02158,103,040 - 158,103,388NCBIRnor6.0
Rnor_5.02177,462,460 - 177,462,808UniSTSRnor5.0
RGSC_v3.42156,095,114 - 156,095,461UniSTSRGSC3.4
Celera2144,900,143 - 144,900,490UniSTS
Cytogenetic Map2q31UniSTS
BF387681  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22150,487,923 - 150,488,105 (+)MAPPERmRatBN7.2
Rnor_6.02158,098,254 - 158,098,435NCBIRnor6.0
Rnor_5.02177,457,674 - 177,457,855UniSTSRnor5.0
RGSC_v3.42156,090,328 - 156,090,509UniSTSRGSC3.4
Celera2144,895,357 - 144,895,538UniSTS
RH 3.4 Map2981.0UniSTS
Cytogenetic Map2q31UniSTS
Ptx3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22150,492,708 - 150,493,251 (+)MAPPERmRatBN7.2
Rnor_6.02158,103,039 - 158,103,581NCBIRnor6.0
Rnor_5.02177,462,459 - 177,463,001UniSTSRnor5.0
RGSC_v3.42156,095,113 - 156,095,654UniSTSRGSC3.4
Celera2144,900,142 - 144,900,683UniSTS
Cytogenetic Map2q31UniSTS
PMC304098P4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22150,492,367 - 150,492,475 (+)MAPPERmRatBN7.2
Rnor_6.02158,102,698 - 158,102,805NCBIRnor6.0
Rnor_5.02177,462,118 - 177,462,225UniSTSRnor5.0
RGSC_v3.42156,094,772 - 156,094,879UniSTSRGSC3.4
Celera2144,899,801 - 144,899,908UniSTS
Cytogenetic Map2q31UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 76 75 48 20 48 6 202 92 93 45 60 27

Sequence


Ensembl Acc Id: ENSRNOT00000016541   ⟹   ENSRNOP00000016541
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2150,487,513 - 150,493,323 (+)Ensembl
Rnor_6.0 Ensembl2158,097,843 - 158,103,653 (+)Ensembl
RefSeq Acc Id: NM_001109536   ⟹   NP_001103006
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82152,797,563 - 152,803,372 (+)NCBI
mRatBN7.22150,487,513 - 150,493,323 (+)NCBI
Rnor_6.02158,097,843 - 158,103,653 (+)NCBI
Rnor_5.02177,457,263 - 177,463,073 (+)NCBI
RGSC_v3.42156,089,917 - 156,095,726 (+)RGD
Celera2144,894,946 - 144,900,755 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001103006 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM00934 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016541.2
RefSeq Acc Id: NP_001103006   ⟸   NM_001109536
- Peptide Label: precursor
- UniProtKB: D3ZT94 (UniProtKB/TrEMBL),   A6J5K6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016541   ⟸   ENSRNOT00000016541
Protein Domains
LamG-like jellyroll fold

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZT94-F1-model_v2 AlphaFold D3ZT94 1-381 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691362
Promoter ID:EPDNEW_R1887
Type:multiple initiation site
Name:Ptx3_1
Description:pentraxin 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02158,097,922 - 158,097,982EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1593476 AgrOrtholog
BioCyc Gene G2FUF-52877 BioCyc
Ensembl Genes ENSRNOG00000012280 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016541.5 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.200 UniProtKB/TrEMBL
InterPro ConA-like_subgrp UniProtKB/TrEMBL
  LamG-like UniProtKB/TrEMBL
  Pentaxin UniProtKB/TrEMBL
  Pentaxin_CS UniProtKB/TrEMBL
  PTX3 UniProtKB/TrEMBL
KEGG Report rno:689388 UniProtKB/TrEMBL
NCBI Gene 689388 ENTREZGENE
PANTHER PENTRAXIN-RELATED PROTEIN PTX3 UniProtKB/TrEMBL
  PTHR46943 UniProtKB/TrEMBL
Pfam Pentaxin UniProtKB/TrEMBL
PhenoGen Ptx3 PhenoGen
PRINTS PENTAXIN UniProtKB/TrEMBL
PROSITE PENTAXIN UniProtKB/TrEMBL
  PTX_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012280 RatGTEx
SMART LamGL UniProtKB/TrEMBL
  PTX UniProtKB/TrEMBL
Superfamily-SCOP ConA_like_lec_gl UniProtKB/TrEMBL
UniProt A6J5K6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZT94 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-30 Ptx3  pentraxin 3  Ptx3  pentraxin 3, long  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-05-13 Ptx3  pentraxin 3, long  Ptx3  pentraxin related gene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-06-15 Ptx3  pentraxin related gene  Ptx3_mapped  pentraxin related gene (mapped)  Data merged from RGD:3456 1643240 APPROVED
2008-03-06 Ptx3  pentraxin related gene  LOC689388  similar to Pentraxin-related protein PTX3 precursor (Pentaxin-related protein PTX3) (Tumor necrosis factor-inducible protein TSG-14)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC689388  similar to Pentraxin-related protein PTX3 precursor (Pentaxin-related protein PTX3) (Tumor necrosis factor-inducible protein TSG-14)  LOC682447  similar to Pentraxin-related protein PTX3 precursor (Pentaxin-related protein PTX3) (Tumor necrosis factor-inducible protein TSG-14)  Data merged from RGD:1583445 1643240 APPROVED
2006-11-20 LOC689388  similar to Pentraxin-related protein PTX3 precursor (Pentaxin-related protein PTX3) (Tumor necrosis factor-inducible protein TSG-14)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC682447  similar to Pentraxin-related protein PTX3 precursor (Pentaxin-related protein PTX3) (Tumor necrosis factor-inducible protein TSG-14)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Ptx3_mapped  pentraxin related gene (mapped)  Ptx3  pentraxin related gene  Symbol and Name updated 1556543 APPROVED
2002-06-10 Ptx3  pentaxin related gene      Symbol and Name status set to approved 70586 APPROVED