Esco2 (establishment of sister chromatid cohesion N-acetyltransferase 2) - Rat Genome Database

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Gene: Esco2 (establishment of sister chromatid cohesion N-acetyltransferase 2) Rattus norvegicus
Analyze
Symbol: Esco2
Name: establishment of sister chromatid cohesion N-acetyltransferase 2
RGD ID: 1593313
Description: Predicted to enable lysine N-acetyltransferase activity, acting on acetyl phosphate as donor and peptide-lysine-N-acetyltransferase activity. Predicted to be involved in mitotic sister chromatid cohesion; post-translational protein acetylation; and regulation of DNA replication. Predicted to act upstream of or within several processes, including double-strand break repair; hematopoietic progenitor cell differentiation; and protein localization to chromatin. Predicted to be located in several cellular components, including Golgi apparatus; chromocenter; and chromosome. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Roberts syndrome and lung adenocarcinoma. Orthologous to human ESCO2 (establishment of sister chromatid cohesion N-acetyltransferase 2); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: establishment of cohesion 1 homolog 2; establishment of cohesion 1 homolog 2 (S. cerevisiae); LOC691979; N-acetyltransferase ESCO2; similar to N-acetyltransferase ESCO2 (Establishment of cohesion 1 homolog 2) (ECO1 homolog 2)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Esco2-ps1   Esco2-ps2  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81544,210,124 - 44,230,785 (-)NCBIGRCr8
mRatBN7.21540,034,566 - 40,052,295 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1540,034,568 - 40,055,306 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01542,500,929 - 42,519,019 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1542,500,929 - 42,518,855 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01549,072,219 - 49,091,726 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41545,239,871 - 45,254,898 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1539,706,954 - 39,724,684 (-)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,1-dichloroethene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-butoxyethanol  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-methylcholanthrene  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
arsenite(3-)  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
coumarin  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyanocob(III)alamin  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dichloroacetic acid  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP)
geldanamycin  (ISO)
glycine betaine  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
itraconazole  (ISO)
ketoconazole  (ISO)
L-methionine  (ISO)
lidocaine  (EXP)
lucanthone  (ISO)
MeIQx  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
propanal  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
senecionine  (EXP)
Senkirkine  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
zaragozic acid A  (EXP,ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Upregulation of KAT2B and ESCO2 gene expression level in patients with rheumatoid arthritis. Ghasemi A, etal., Clin Rheumatol. 2022 Sep 15. doi: 10.1007/s10067-022-06351-4.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
7. Prenatal diagnosis of Roberts syndrome and detection of an ESCO2 frameshift mutation in a Pakistani family. Schulz S, etal., Prenat Diagn. 2008 Jan;28(1):42-5. doi: 10.1002/pd.1904.
8. Roberts syndrome is caused by mutations in ESCO2, a human homolog of yeast ECO1 that is essential for the establishment of sister chromatid cohesion. Vega H, etal., Nat Genet. 2005 May;37(5):468-70. Epub 2005 Apr 10.
9. ESCO2 promotes lung adenocarcinoma progression by regulating hnRNPA1 acetylation. Zhu HE, etal., J Exp Clin Cancer Res. 2021 Feb 11;40(1):64. doi: 10.1186/s13046-021-01858-1.
Additional References at PubMed
PMID:15958495   PMID:19907496   PMID:21111234   PMID:22101327   PMID:22614755   PMID:22699483   PMID:24029230  


Genomics

Comparative Map Data
Esco2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81544,210,124 - 44,230,785 (-)NCBIGRCr8
mRatBN7.21540,034,566 - 40,052,295 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1540,034,568 - 40,055,306 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01542,500,929 - 42,519,019 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1542,500,929 - 42,518,855 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01549,072,219 - 49,091,726 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41545,239,871 - 45,254,898 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1539,706,954 - 39,724,684 (-)NCBICelera
Cytogenetic Map15p12NCBI
ESCO2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38827,771,974 - 27,819,660 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl827,771,949 - 27,812,640 (+)EnsemblGRCh38hg38GRCh38
GRCh37827,632,071 - 27,662,833 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36827,687,977 - 27,718,344 (+)NCBINCBI36Build 36hg18NCBI36
Celera826,591,951 - 26,622,299 (+)NCBICelera
Cytogenetic Map8p21.1NCBI
HuRef826,176,933 - 26,207,305 (+)NCBIHuRef
CHM1_1827,833,977 - 27,864,365 (+)NCBICHM1_1
T2T-CHM13v2.0828,046,848 - 28,097,943 (+)NCBIT2T-CHM13v2.0
Esco2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391466,056,476 - 66,071,418 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1466,056,487 - 66,071,443 (-)EnsemblGRCm39 Ensembl
GRCm381465,819,027 - 65,833,969 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1465,819,038 - 65,833,994 (-)EnsemblGRCm38mm10GRCm38
MGSCv371466,437,864 - 66,452,806 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361464,773,148 - 64,787,994 (-)NCBIMGSCv36mm8
Celera1463,572,076 - 63,587,018 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1434.36NCBI
Esco2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540350,307,681 - 50,372,822 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540350,306,726 - 50,328,015 (+)NCBIChiLan1.0ChiLan1.0
ESCO2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2746,308,606 - 46,351,625 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1822,022,865 - 22,065,888 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0827,049,858 - 27,080,396 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1824,250,435 - 24,281,007 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl824,251,557 - 24,284,001 (+)Ensemblpanpan1.1panPan2
ESCO2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12529,785,641 - 29,812,536 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2529,787,132 - 29,811,112 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2530,439,599 - 30,464,378 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02529,978,376 - 30,003,256 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2529,978,379 - 30,003,186 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12529,908,235 - 29,932,879 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02529,789,703 - 29,814,487 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02529,956,082 - 29,981,766 (-)NCBIUU_Cfam_GSD_1.0
Esco2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049437,885,816 - 7,916,735 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936675670,915 - 697,668 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936675670,915 - 697,696 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ESCO2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11411,495,297 - 11,532,898 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21412,674,855 - 12,710,818 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ESCO2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1825,885,823 - 25,919,863 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl825,887,309 - 25,916,630 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605216,220,597 - 16,252,214 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Esco2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475822,578,528 - 22,600,804 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475822,578,565 - 22,600,731 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Esco2
73 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:76
Count of miRNA genes:66
Interacting mature miRNAs:71
Transcripts:ENSRNOT00000021320
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)152788577486257085Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat

Markers in Region
D15Mco7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21540,053,576 - 40,053,755 (+)MAPPERmRatBN7.2
Rnor_6.01542,520,317 - 42,520,495NCBIRnor6.0
Rnor_5.01549,072,160 - 49,072,338UniSTSRnor5.0
RGSC_v3.41545,257,662 - 45,257,840UniSTSRGSC3.4
RGSC_v3.41545,257,661 - 45,257,840RGDRGSC3.4
RGSC_v3.11545,273,361 - 45,273,540RGD
Celera1539,725,981 - 39,726,159UniSTS
Cytogenetic Map15p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 49 113 91 90 59 25 59 6 217 96 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000021320   ⟹   ENSRNOP00000021320
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1542,502,447 - 42,517,556 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076451   ⟹   ENSRNOP00000068247
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1540,034,568 - 40,055,306 (-)Ensembl
Rnor_6.0 Ensembl1542,500,929 - 42,518,855 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000081500   ⟹   ENSRNOP00000072962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1542,502,447 - 42,517,553 (-)Ensembl
RefSeq Acc Id: XM_003751495   ⟹   XP_003751543
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81544,210,124 - 44,229,150 (-)NCBI
mRatBN7.21540,034,566 - 40,052,293 (-)NCBI
Rnor_6.01542,500,929 - 42,519,019 (-)NCBI
Rnor_5.01549,072,219 - 49,091,726 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063274882   ⟹   XP_063130952
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81544,210,124 - 44,230,785 (-)NCBI
RefSeq Acc Id: XM_063274883   ⟹   XP_063130953
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81544,210,124 - 44,230,257 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001420032 (Get FASTA)   NCBI Sequence Viewer  
  NP_001420036 (Get FASTA)   NCBI Sequence Viewer  
  XP_003751543 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130952 (Get FASTA)   NCBI Sequence Viewer  
  XP_063130953 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL85365 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000068247.1
RefSeq Acc Id: XP_003751543   ⟸   XM_003751495
- Sequence:
Ensembl Acc Id: ENSRNOP00000021320   ⟸   ENSRNOT00000021320
Ensembl Acc Id: ENSRNOP00000072962   ⟸   ENSRNOT00000081500
Ensembl Acc Id: ENSRNOP00000068247   ⟸   ENSRNOT00000076451
RefSeq Acc Id: XP_063130952   ⟸   XM_063274882
RefSeq Acc Id: XP_063130953   ⟸   XM_063274883
- UniProtKB: A0A096MJS9 (UniProtKB/TrEMBL),   A6K6K6 (UniProtKB/TrEMBL)
Protein Domains
N-acetyltransferase ESCO acetyl-transferase   N-acetyltransferase ESCO zinc-finger

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A096MJS9-F1-model_v2 AlphaFold A0A096MJS9 1-595 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699751
Promoter ID:EPDNEW_R10272
Type:initiation region
Name:Esco2_1
Description:establishment of sister chromatid cohesion N-acetyltransferase2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01542,518,854 - 42,518,914EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1593313 AgrOrtholog
BioCyc Gene G2FUF-13344 BioCyc
Ensembl Genes ENSRNOG00000015921 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000076451.3 UniProtKB/TrEMBL
InterPro AcTrfase_ESCO_Znf_dom UniProtKB/TrEMBL
  ESCO_Acetyltransf_dom UniProtKB/TrEMBL
KEGG Report rno:691979 UniProtKB/TrEMBL
NCBI Gene 691979 ENTREZGENE
PANTHER N-ACETYLTRANSFERASE ECO UniProtKB/TrEMBL
  N-ACETYLTRANSFERASE ESCO2 UniProtKB/TrEMBL
Pfam Acetyltransf_13 UniProtKB/TrEMBL
  zf-C2H2_3 UniProtKB/TrEMBL
PhenoGen Esco2 PhenoGen
RatGTEx ENSRNOG00000015921 RatGTEx
UniProt A0A096MJS9 ENTREZGENE, UniProtKB/TrEMBL
  A6K6K6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-22 Esco2  establishment of sister chromatid cohesion N-acetyltransferase 2  Esco2  establishment of cohesion 1 homolog 2 (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-01-23 Esco2   establishment of cohesion 1 homolog 2 (S. cerevisiae)   LOC691979  similar to N-acetyltransferase ESCO2 (Establishment of cohesion 1 homolog 2) (ECO1 homolog 2)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-01-09 LOC691979  similar to N-acetyltransferase ESCO2 (Establishment of cohesion 1 homolog 2) (ECO1 homolog 2)  LOC683635  similar to N-acetyltransferase ESCO2 (Establishment of cohesion 1 homolog 2) (ECO1 homolog 2)  Data merged from RGD:1584516 1643240 APPROVED
2006-11-20 LOC691979  similar to N-acetyltransferase ESCO2 (Establishment of cohesion 1 homolog 2) (ECO1 homolog 2)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC683635  similar to N-acetyltransferase ESCO2 (Establishment of cohesion 1 homolog 2) (ECO1 homolog 2)      Symbol and Name status set to provisional 70820 PROVISIONAL