Atm (ATM serine/threonine kinase) - Rat Genome Database

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Gene: Atm (ATM serine/threonine kinase) Rattus norvegicus
Analyze
Symbol: Atm
Name: ATM serine/threonine kinase
RGD ID: 1593265
Description: Predicted to enable 1-phosphatidylinositol-3-kinase activity; DNA-dependent protein kinase activity; and identical protein binding activity. Involved in several processes, including positive regulation of DNA catabolic process; positive regulation of neuron apoptotic process; and regulation of microglial cell activation. Located in cytoplasm and nucleus. Used to study ataxia telangiectasia; disease of cellular proliferation; infertility; leukemia; and lymphoma. Biomarker of pre-malignant neoplasm and status epilepticus. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); endometrial cancer; lung carcinoma (multiple); neurodegenerative disease (multiple); and senile cataract. Orthologous to human ATM (ATM serine/threonine kinase); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; homologous recombination pathway of double-strand break repair; nuclear factor kappa B signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-amino-2-deoxy-D-galactopyranose; 7,12-dimethyltetraphene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ataxia telangiectasia gene mutated in human beings; ataxia telangiectasia mutated; ataxia telangiectasia mutated homolog; ataxia telangiectasia mutated homolog (human); ataxia telangiectasia mutated homolog (human) (mapped); Atm_mapped; serine-protein kinase ATM
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Atmm1Kyo   Atmem1Kyo  
Genetic Models: F344-Atmm1Kyo F344-Atmem1Kyo
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2853,828,741 - 53,932,773 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl853,831,093 - 53,932,437 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx859,356,470 - 59,457,803 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0857,635,498 - 57,736,825 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0855,499,734 - 55,601,064 (-)NCBIRnor_WKY
Rnor_6.0858,015,938 - 58,119,973 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl858,015,940 - 58,120,045 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0856,598,503 - 56,703,115 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4856,894,746 - 56,996,565 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera853,321,802 - 53,423,212 (-)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Liver Failure  (IEP,ISO)
adenocarcinoma  (ISO)
adenoid cystic carcinoma  (ISO)
adrenocortical carcinoma  (ISO)
Alzheimer's disease  (ISO)
Arenaviridae infectious disease  (ISO)
arteriosclerosis  (ISO)
ataxia telangiectasia  (IMP,ISO)
Ataxia-Telangiectasia Variant  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
beta-ketothiolase deficiency  (ISO)
bilateral breast cancer  (ISO)
bile duct cancer  (ISO)
brain cancer  (ISO)
Brain Neoplasms  (ISO)
breast cancer  (ISO)
Breast Cancer, Familial  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
cataract  (ISO)
cerebellar ataxia  (ISO)
Chromosome 11, Partial Trisomy 11q  (ISO)
clear cell renal cell carcinoma  (ISO)
colon cancer  (ISO)
colon carcinoma  (ISO)
Colonic Neoplasms  (ISO)
colorectal cancer  (ISO)
dilated cardiomyopathy  (ISO)
disease of cellular proliferation  (IMP,ISO)
endometrial cancer  (ISO)
endometrial carcinoma  (ISO)
endometrial serous adenocarcinoma  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Colitis  (ISO)
Familial Pancreatic Carcinoma  (ISO)
Familial Prostate Cancer  (ISO)
female breast cancer  (ISO)
Fibrosis  (ISO)
Gastro-Enteropancreatic Neuroendocrine Tumor  (ISO)
genetic disease  (ISO)
glioblastoma  (ISO)
Helicobacter Infections  (ISO)
hepatoblastoma  (ISO)
hepatocellular carcinoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
herpes simplex virus keratitis  (ISO)
Herpesviridae Infections  (ISO)
high grade glioma  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Hypercholesterolemia  (ISO)
infertility  (IMP)
influenza A  (ISO)
Insulin Resistance  (IEP,ISO)
intellectual disability  (ISO)
Kidney Reperfusion Injury  (IEP)
leukemia  (IMP)
liver cancer  (ISO)
lung cancer  (ISO)
lung non-small cell carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
lymphoma  (IMP)
Lynch syndrome 1  (ISO)
mantle cell lymphoma  (ISO)
melanoma  (ISO)
Metabolic Syndrome  (ISO)
microcephaly  (ISO)
multiple myeloma  (ISO)
myocardial infarction  (ISO)
nasopharynx carcinoma  (ISO)
oral mucosa leukoplakia  (ISO)
oral squamous cell carcinoma  (ISO)
osteoporosis  (ISO)
Otorhinolaryngologic Neoplasms  (ISO)
ovarian cancer  (ISO)
ovarian carcinoma  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
pancreatic carcinoma  (ISO)
Parkinson's disease  (ISO)
peripheral T-cell lymphoma  (ISO)
Pneumococcal Meningitis  (ISO)
polycythemia vera  (ISO)
pre-malignant neoplasm  (IEP)
Prenatal Exposure Delayed Effects  (ISO)
primary cutaneous T-cell non-Hodgkin lymphoma  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (ISO)
Prostatic Neoplasms  (ISO)
Radiation Pneumonitis  (ISO)
renal cell carcinoma  (ISO)
Renal Cell Carcinoma 1  (ISO)
Retroviridae Infections  (ISO)
Rhabdoviridae Infections  (ISO)
senile cataract  (ISO)
Sepsis  (ISO)
Spinal Cord Injuries  (IEP)
squamous cell carcinoma  (ISO)
status epilepticus  (IEP)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
Streptococcus pneumonia  (ISO)
T-cell prolymphocytic leukemia  (ISO)
thyroid gland cancer  (ISO)
thyroid gland papillary carcinoma  (ISO)
urinary bladder cancer  (ISO)
uterine corpus cancer  (ISO)
Ventricular Dysfunction, Left  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1S)-bornane-2,3-dione  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-methylcholine  (ISO)
3-aminobenzamide  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-amino-1,8-naphthalimide  (ISO)
4-hydroxynon-2-enal  (ISO)
5-(hydroxymethyl)cytosine  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
Aflatoxin G1  (ISO)
aflatoxin M1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amphetamine  (EXP)
amphibole asbestos  (ISO)
anthocyanin  (ISO)
antimycin A  (ISO)
aphidicolin  (ISO)
aristolochic acids  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
asbestos  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
Brevetoxin B  (ISO)
bromoacetate  (ISO)
busulfan  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbamate ester  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
CCCP  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
clofarabine  (ISO)
cobalt atom  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
curcumin  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
cyproconazole  (EXP)
daunorubicin  (ISO)
Decamethylcyclopentasiloxane  (ISO)
deguelin  (ISO)
desferrioxamine B  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP,ISO)
dibutyl phthalate  (ISO)
dichlorvos  (EXP)
dicoumarol  (ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
diepoxybutane  (ISO)
diethyl maleate  (ISO)
dihydroxyacetone  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
emodin  (ISO)
endosulfan  (ISO)
epoxiconazole  (EXP)
erlotinib hydrochloride  (ISO)
ethanol  (EXP)
Ethyl maltol  (ISO)
etoposide  (ISO)
fenhexamid  (ISO)
fenthion  (ISO)
flavanones  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
furosemide  (EXP)
gadodiamide hydrate  (ISO)
gallic acid  (ISO)
geneticin  (ISO)
genistein  (ISO)
gentamycin  (EXP,ISO)
ginsenoside Rg1  (ISO)
hellebrigenin  (ISO)
hexamethylcyclotrisiloxane  (ISO)
hydrazine  (ISO)
hydrogen peroxide  (ISO)
hydroxyurea  (ISO)
irinotecan  (ISO)
iron atom  (ISO)
iron trichloride  (ISO)
iron(0)  (ISO)
isocyanates  (ISO)
isoflavones  (ISO)
kaempferol  (ISO)
kojic acid  (ISO)
L-ascorbic acid  (ISO)
Lasiocarpine  (ISO)
lead diacetate  (ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
lovastatin  (EXP)
LY294002  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
metformin  (ISO)
methidathion  (ISO)
methotrexate  (ISO)
methoxsalen  (ISO)
methylparaben  (ISO)
mitoxantrone  (EXP,ISO)
monocrotaline  (ISO)
motexafin gadolinium  (ISO)
myristicin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nickel dichloride  (EXP,ISO)
nicotine  (ISO)
nitenpyram  (ISO)
nitrates  (EXP)
nocodazole  (ISO)
O-methyleugenol  (EXP,ISO)
octamethylcyclotetrasiloxane  (ISO)
ouabain  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
paromomycin  (ISO)
PCB138  (ISO)
pentamidine  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenytoin  (ISO)
phosphoramide mustard  (EXP)
pirinixic acid  (ISO)
potassium bromate  (ISO)
potassium chromate  (ISO)
Pranoprofen  (ISO)
prochloraz  (EXP)
promethazine  (EXP)
propiconazole  (ISO)
propylparaben  (ISO)
pyrroloquinoline quinone  (EXP)
quercetin  (ISO)
remdesivir  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rotenone  (ISO)
ruxolitinib  (ISO)
S-nitrosoglutathione  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
silver(1+) nitrate  (ISO)
simvastatin  (ISO)
sodium arsenite  (ISO)
sodium chromate  (ISO)
sodium fluoride  (ISO)
sterigmatocystin  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
trichostatin A  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tungsten  (ISO)
usnic acid  (ISO)
valproic acid  (EXP,ISO)
veliparib  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
wortmannin  (ISO)
yttrium chloride  (EXP)
zearalenone  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEP)
brain development  (ISO)
cellular response to gamma radiation  (ISO)
cellular response to ionizing radiation  (IMP)
cellular response to nitrosative stress  (ISO)
cellular response to reactive oxygen species  (ISO)
cellular response to retinoic acid  (ISO)
cellular response to X-ray  (ISO)
chromosome organization involved in meiotic cell cycle  (ISO)
determination of adult lifespan  (ISO)
DNA damage checkpoint signaling  (IBA,ISO)
DNA damage response  (IDA,IMP,ISO)
DNA repair  (ISO)
double-strand break repair via homologous recombination  (ISO)
establishment of protein-containing complex localization to telomere  (ISO)
establishment of RNA localization to telomere  (ISO)
female gamete generation  (ISO)
female gonad development  (ISO)
female meiotic nuclear division  (ISO)
heart development  (ISO)
histone mRNA catabolic process  (ISO)
immune system process  (ISO)
intrinsic apoptotic signaling pathway in response to DNA damage  (IBA,ISO)
lipoprotein catabolic process  (ISO)
male meiotic nuclear division  (ISO)
meiotic telomere clustering  (ISO)
mitotic G2 DNA damage checkpoint signaling  (ISO)
mitotic spindle assembly checkpoint signaling  (ISO)
multicellular organism growth  (ISO)
negative regulation of B cell proliferation  (ISO)
negative regulation of telomere capping  (ISO)
negative regulation of TORC1 signaling  (IBA,ISO)
neuron apoptotic process  (ISO)
oocyte development  (ISO)
ovarian follicle development  (ISO)
peptidyl-serine autophosphorylation  (ISO)
peptidyl-serine phosphorylation  (ISO)
pexophagy  (ISO)
phosphatidylinositol-3-phosphate biosynthetic process  (IEA)
positive regulation of apoptotic process  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of DNA catabolic process  (IMP)
positive regulation of DNA damage response, signal transduction by p53 class mediator  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of neuron apoptotic process  (IMP,ISO)
positive regulation of neuron death  (IMP)
positive regulation of telomerase catalytic core complex assembly  (ISO)
positive regulation of telomere maintenance via telomerase  (ISO)
positive regulation of telomere maintenance via telomere lengthening  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
post-embryonic development  (ISO)
pre-B cell allelic exclusion  (ISO)
protein autophosphorylation  (ISO)
protein phosphorylation  (IBA,ISO)
regulation of autophagy  (ISO)
regulation of cell cycle  (IMP)
regulation of cell cycle  (ISO)
regulation of microglial cell activation  (IMP)
regulation of telomerase activity  (ISO)
regulation of telomere maintenance via telomerase  (ISO)
replicative senescence  (ISO)
response to hypoxia  (IDA)
response to ionizing radiation  (ISO)
signal transduction in response to DNA damage  (ISO)
somitogenesis  (ISO)
telomere maintenance  (IBA)
thymus development  (ISO)
V(D)J recombination  (ISO)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Inhibition of ataxia telangiectasia mutated (ATM) kinase suppresses herpes simplex virus type 1 (HSV-1) keratitis. Alekseev O, etal., Invest Ophthalmol Vis Sci. 2014 Feb 3;55(2):706-15. doi: 10.1167/iovs.13-13461.
2. ATM protein overexpression in prostate tumors: possible role in telomere maintenance. Angele S, etal., Am J Clin Pathol. 2004 Feb;121(2):231-6.
3. Histopathological features of breast cancer in carriers of ATM gene variants. Balleine RL, etal., Histopathology. 2006 Nov;49(5):523-32.
4. Perturbations in ataxia telangiectasia mutant signaling pathways after drug-induced acute liver failure and their reversal during rescue of animals by cell therapy. Bandi S, etal., Am J Pathol. 2011 Jan;178(1):161-74. doi: 10.1016/j.ajpath.2010.11.001. Epub 2010 Dec 23.
5. ATM protein kinase: the linchpin of cellular defenses to stress. Bhatti S, etal., Cell Mol Life Sci. 2011 Sep;68(18):2977-3006. doi: 10.1007/s00018-011-0683-9. Epub 2011 May 2.
6. The ATM tumour suppressor gene is down-regulated in EBV-associated nasopharyngeal carcinoma. Bose S, etal., J Pathol. 2009 Feb;217(3):345-52. doi: 10.1002/path.2487.
7. Activation of ataxia telangiectasia muted under experimental models and human Parkinson's disease. Camins A, etal., Cell Mol Life Sci. 2010 Nov;67(22):3865-82. doi: 10.1007/s00018-010-0408-5. Epub 2010 May 26.
8. Aberrant CD8+ T-cell responses and memory differentiation upon viral infection of an ataxia-telangiectasia mouse model driven by hyper-activated Akt and mTORC1 signaling. D'Souza AD, etal., Am J Pathol. 2011 Jun;178(6):2740-51. doi: 10.1016/j.ajpath.2011.02.022.
9. B Cell-Specific Expression of Ataxia-Telangiectasia Mutated Protein Kinase Promotes Chronic Gammaherpesvirus Infection. Darrah EJ, etal., J Virol. 2017 Sep 12;91(19). pii: JVI.01103-17. doi: 10.1128/JVI.01103-17. Print 2017 Oct 1.
10. Effect of ATM, CHEK2 and ERBB2 TAGSNPs and haplotypes on endometrial cancer risk. Einarsdottir K, etal., Hum Mol Genet. 2007 Jan 15;16(2):154-64. Epub 2006 Dec 12.
11. Loss of the DNA Damage Repair Kinase ATM Impairs Inflammasome-Dependent Anti-Bacterial Innate Immunity. Erttmann SF, etal., Immunity. 2016 Jul 19;45(1):106-18. doi: 10.1016/j.immuni.2016.06.018. Epub 2016 Jul 12.
12. ATM activation is accompanied with earlier stages of prostate tumorigenesis. Fan C, etal., Biochim Biophys Acta. 2006 Oct;1763(10):1090-7. Epub 2006 Aug 24.
13. Anthracyclines induce DNA damage response-mediated protection against severe sepsis. Figueiredo N, etal., Immunity. 2013 Nov 14;39(5):874-84. doi: 10.1016/j.immuni.2013.08.039. Epub 2013 Oct 31.
14. Deficiency of ataxia telangiectasia mutated kinase modulates cardiac remodeling following myocardial infarction: involvement in fibrosis and apoptosis. Foster CR, etal., PLoS One. 2013 Dec 16;8(12):e83513. doi: 10.1371/journal.pone.0083513. eCollection 2013.
15. Glycine propionyl l-carnitine attenuates d-Galactosamine induced fulminant hepatic failure in wistar rats. Ganai AA, etal., Chem Biol Interact. 2014 May 5;214:33-40. doi: 10.1016/j.cbi.2014.02.006. Epub 2014 Feb 22.
16. Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation. Gatei M, etal., J Biol Chem 2003 Apr 25;278(17):14806-11. Epub 2003 Feb 14.
17. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
18. Familial breast cancer and DNA repair genes: Insights into known and novel susceptibility genes from the GENESIS study, and implications for multigene panel testing. Girard E, etal., Int J Cancer. 2019 Apr 15;144(8):1962-1974. doi: 10.1002/ijc.31921. Epub 2018 Nov 13.
19. DNA damage induced by polyglutamine-expanded proteins. Giuliano P, etal., Hum Mol Genet. 2003 Sep 15;12(18):2301-9. Epub 2003 Jul 22.
20. Expression of DNA double-strand break repair proteins ATM and BRCA1 predicts survival in colorectal cancer. Grabsch H, etal., Clin Cancer Res. 2006 Mar 1;12(5):1494-500. doi: 10.1158/1078-0432.CCR-05-2105.
21. ATM protein kinase mediates full activation of Akt and regulates glucose transporter 4 translocation by insulin in muscle cells. Halaby MJ, etal., Cell Signal. 2008 Aug;20(8):1555-63. doi: 10.1016/j.cellsig.2008.04.011. Epub 2008 Apr 26.
22. ATM in oral carcinogenesis: association with clinicopathological features. He Y, etal., J Cancer Res Clin Oncol. 2008 Sep;134(9):1013-20. doi: 10.1007/s00432-008-0365-7. Epub 2008 Feb 21.
23. Caspases and mitochondria in c-Myc-induced apoptosis: identification of ATM as a new target of caspases. Hotti A, etal., Oncogene. 2000 May 4;19(19):2354-62.
24. DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity. Härtlova A, etal., Immunity. 2015 Feb 17;42(2):332-343. doi: 10.1016/j.immuni.2015.01.012.
25. Ataxia-telangiectasia mutated expression is associated with tobacco smoke exposure in esophageal cancer tissues and benzo[a]pyrene diol epoxide in cell lines. Jiang Y, etal., Int J Cancer. 2007 Jan 1;120(1):91-5. doi: 10.1002/ijc.22121.
26. Metformin: a cheap and well-tolerated drug that provides benefits for viral infections. Joven J, etal., HIV Med. 2013 Apr;14(4):233-40. doi: 10.1111/hiv.12000. Epub 2012 Nov 21.
27. ATM protein synthesis patterns in sporadic breast cancer. Kairouz R, etal., Mol Pathol. 1999 Oct;52(5):252-6.
28. Expression status of ataxia-telangiectasia-mutated gene correlated with prognosis in advanced gastric cancer. Kang B, etal., Mutat Res. 2008 Feb 1;638(1-2):17-25. doi: 10.1016/j.mrfmmm.2007.08.013. Epub 2007 Sep 1.
29. Cell cycle checkpoint abnormalities during dementia: A plausible association with the loss of protection against oxidative stress in Alzheimer's disease . Katsel P, etal., PLoS One. 2013 Jul 5;8(7):e68361. doi: 10.1371/journal.pone.0068361. Print 2013.
30. Loss of heterozygosity in bilateral breast cancer. Kollias J, etal., Breast Cancer Res Treat. 2000 Dec;64(3):241-51.
31. p53- and Bax-mediated apoptosis in injured rat spinal cord. Kotipatruni RR, etal., Neurochem Res. 2011 Nov;36(11):2063-74. doi: 10.1007/s11064-011-0530-2. Epub 2011 Jul 7.
32. Modes of p53 regulation. Kruse JP and Gu W, Cell. 2009 May 15;137(4):609-22. doi: 10.1016/j.cell.2009.04.050.
33. Ataxia telangiectasia mutated kinase controls chronic gammaherpesvirus infection. Kulinski JM, etal., J Virol. 2012 Dec;86(23):12826-37. doi: 10.1128/JVI.00917-12. Epub 2012 Sep 19.
34. The complexity of p53 stabilization and activation. Lavin MF and Gueven N, Cell Death Differ. 2006 Jun;13(6):941-50.
35. Metastasis of neuroendocrine tumors are characterized by increased cell proliferation and reduced expression of the ATM gene. Lee J, etal., PLoS One. 2012;7(4):e34456. doi: 10.1371/journal.pone.0034456. Epub 2012 Apr 2.
36. Lower ataxia telangiectasia mutated (ATM) mRNA expression is correlated with poor outcome of laryngeal and pharyngeal cancer patients. Lee KW, etal., Ann Oncol. 2011 May;22(5):1088-1093. doi: 10.1093/annonc/mdq569. Epub 2010 Dec 1.
37. DNA repair gene polymorphisms and risk of pancreatic cancer. Li D, etal., Clin Cancer Res. 2009 Jan 15;15(2):740-6.
38. Single nucleotide polymorphisms of RecQ1, RAD54L, and ATM genes are associated with reduced survival of pancreatic cancer. Li D, etal., J Clin Oncol. 2006 Apr 10;24(11):1720-8. Epub 2006 Mar 6.
39. EBV-encoded miRNAs target ATM-mediated response in nasopharyngeal carcinoma. Lung RW, etal., J Pathol. 2018 Apr;244(4):394-407. doi: 10.1002/path.5018. Epub 2018 Feb 16.
40. Dual phases of apoptosis in pneumococcal meningitis. Mitchell L, etal., J Infect Dis. 2004 Dec 1;190(11):2039-46. doi: 10.1086/425520. Epub 2004 Nov 3.
41. SUMOylation attenuates sensitivity toward hypoxia- or desferroxamine-induced injury by modulating adaptive responses in salivary epithelial cells. Nguyen HV, etal., Am J Pathol. 2006 May;168(5):1452-63.
42. Single-nucleotide polymorphisms of DNA damage response genes are associated with overall survival in patients with pancreatic cancer. Okazaki T, etal., Clin Cancer Res. 2008 Apr 1;14(7):2042-8.
43. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
44. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
45. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
46. Oxidative stress-induced DNA damage and cell cycle regulation in B65 dopaminergic cell line. Pizarro JG, etal., Free Radic Res. 2009 Oct;43(10):985-94. Epub 2009 Aug 5.
47. A rat model of ataxia-telangiectasia: evidence for a neurodegenerative phenotype. Quek H, etal., Hum Mol Genet. 2017 Jan 1;26(1):109-123. doi: 10.1093/hmg/ddw371.
48. Rats with a missense mutation in Atm display neuroinflammation and neurodegeneration subsequent to accumulation of cytosolic DNA following unrepaired DNA damage. Quek H, etal., J Leukoc Biol. 2017 Apr;101(4):927-947. doi: 10.1189/jlb.4VMA0716-316R. Epub 2016 Nov 28.
49. Prognostic impact of ATM mutations in patients with metastatic colorectal cancer. Randon G, etal., Sci Rep. 2019 Feb 27;9(1):2858. doi: 10.1038/s41598-019-39525-3.
50. Atm-deficient mice: an osteoporosis model with defective osteoblast differentiation and increased osteoclastogenesis. Rasheed N, etal., Hum Mol Genet. 2006 Jun 15;15(12):1938-48. Epub 2006 Apr 27.
51. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
52. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
53. Comprehensive gene review and curation RGD comprehensive gene curation
54. MiR-2964a-5p binding site SNP regulates ATM expression contributing to age-related cataract risk. Rong H, etal., Oncotarget. 2017 May 3;8(49):84945-84957. doi: 10.18632/oncotarget.17600. eCollection 2017 Oct 17.
55. Epigenetic Mechanisms of ATM Activation after Helicobacter pylori Infection. Santos JC, etal., Am J Pathol. 2018 Feb;188(2):329-335. doi: 10.1016/j.ajpath.2017.10.005. Epub 2017 Nov 9.
56. ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome. Schneider JG, etal., Cell Metab. 2006 Nov;4(5):377-89.
57. Growth hormone supplementation increased latency to tumourigenesis in Atm-deficient mice. Schubert R, etal., Growth Factors. 2009 Oct;27(5):265-73. doi: 10.1080/08977190903112663.
58. Reduced ATM kinase activity and an attenuated p53 response to DNA damage in carcinogen-induced preneoplastic hepatic lesions in the rat. Silins I, etal., Carcinogenesis. 2001 Dec;22(12):2023-31.
59. Ataxia telangiectasia mutated activation by transcription- and topoisomerase I-induced DNA double-strand breaks. Sordet O, etal., EMBO Rep. 2009 Aug;10(8):887-93. Epub 2009 Jun 26.
60. Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK. Storozhuk Y, etal., Br J Cancer. 2013 May 28;108(10):2021-32. doi: 10.1038/bjc.2013.187. Epub 2013 Apr 30.
61. The ATM signaling network in development and disease. Stracker TH, etal., Front Genet. 2013 Mar 25;4:37. doi: 10.3389/fgene.2013.00037. eCollection 2013.
62. Immunohistochemical study of p53-associated proteins in rat brain following lithium-pilocarpine status epilepticus. Tan Z, etal., Brain Res. 2002 Mar 1;929(1):129-38.
63. Induction of p53 renders ATM-deficient mice refractory to hepatocarcinogenesis. Teoh N, etal., Gastroenterology. 2010 Mar;138(3):1155-65.e1-2. doi: 10.1053/j.gastro.2009.11.008. Epub 2009 Nov 14.
64. Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death. Tian B, etal., Nat Cell Biol. 2009 Feb;11(2):211-8. doi: 10.1038/ncb1829. Epub 2009 Jan 18.
65. NFAT5 is activated by hypoxia: role in ischemia and reperfusion in the rat kidney. Villanueva S, etal., PLoS One. 2012;7(7):e39665. doi: 10.1371/journal.pone.0039665. Epub 2012 Jul 2.
66. In Vivo and In Vitro Effects of ATM/ATR Signaling Pathway on Proliferation, Apoptosis, and Radiosensitivity of Nasopharyngeal Carcinoma Cells. Wang M, etal., Cancer Biother Radiopharm. 2017 Aug;32(6):193-203. doi: 10.1089/cbr.2017.2212.
67. Ataxia-telangiectasia mutated is required for the development of protective immune memory after influenza A virus infection. Warren R, etal., Am J Physiol Lung Cell Mol Physiol. 2019 Nov 1;317(5):L591-L601. doi: 10.1152/ajplung.00031.2019. Epub 2019 Sep 11.
68. Atm-deficient mice exhibit increased sensitivity to dextran sulfate sodium-induced colitis characterized by elevated DNA damage and persistent immune activation. Westbrook AM and Schiestl RH, Cancer Res. 2010 Mar 1;70(5):1875-84. doi: 10.1158/0008-5472.CAN-09-2584. Epub 2010 Feb 23.
69. MicroRNA-18a attenuates DNA damage repair through suppressing the expression of ataxia telangiectasia mutated in colorectal cancer. Wu CW, etal., PLoS One. 2013;8(2):e57036. doi: 10.1371/journal.pone.0057036. Epub 2013 Feb 21.
70. Heterozygous mutation of ataxia-telangiectasia mutated gene aggravates hypercholesterolemia in apoE-deficient mice. Wu D, etal., J Lipid Res. 2005 Jul;46(7):1380-7. Epub 2005 May 1.
71. DNA damage: a trigger of innate immunity but a requirement for adaptive immune homeostasis. Xu Y Nat Rev Immunol. 2006 Apr;6(4):261-70.
72. DNA-dependent protein kinase enhances DNA damage-induced apoptosis in association with Friend gp70. Yamaguchi S, etal., Leuk Res. 2005 Mar;29(3):307-16. doi: 10.1016/j.leukres.2004.07.003.
73. ATM sequence variants associate with susceptibility to non-small cell lung cancer. Yang H, etal., Int J Cancer. 2007 Nov 15;121(10):2254-9. doi: 10.1002/ijc.22918.
74. ATM polymorphisms are associated with risk of radiation-induced pneumonitis. Zhang L, etal., Int J Radiat Oncol Biol Phys. 2010 Aug 1;77(5):1360-8. doi: 10.1016/j.ijrobp.2009.07.1675. Epub 2010 Feb 18.
75. ATM Deficiency Accelerates DNA Damage, Telomere Erosion, and Premature T Cell Aging in HIV-Infected Individuals on Antiretroviral Therapy. Zhao J, etal., Front Immunol. 2019 Nov 5;10:2531. doi: 10.3389/fimmu.2019.02531. eCollection 2019.
76. Expression of DNA doublestrand repair proteins in oral leukoplakia and the risk of malignant transformation. Zhu M, etal., Oncol Lett. 2018 Jun;15(6):9827-9835. doi: 10.3892/ol.2018.8574. Epub 2018 Apr 25.
Additional References at PubMed
PMID:8843194   PMID:9733515   PMID:9925639   PMID:10639175   PMID:10710310   PMID:11040211   PMID:11248063   PMID:11375976   PMID:11536012   PMID:11679583   PMID:11943150   PMID:12937170  
PMID:15149599   PMID:15364958   PMID:15509711   PMID:15542845   PMID:15640358   PMID:15790808   PMID:15916964   PMID:16086026   PMID:16213212   PMID:16687486   PMID:16777961   PMID:17010969  
PMID:17476307   PMID:17694070   PMID:17875758   PMID:18162465   PMID:18571408   PMID:19061978   PMID:19208651   PMID:19448632   PMID:20096447   PMID:20111719   PMID:20213763   PMID:20876357  
PMID:21186350   PMID:22505033   PMID:23836881   PMID:23878245   PMID:24217620   PMID:24550317   PMID:24610783   PMID:26323318   PMID:26586427   PMID:26586433   PMID:27664052   PMID:27829214  
PMID:28220272   PMID:28344092   PMID:28894083   PMID:29203878   PMID:30612738   PMID:30886180   PMID:31315051   PMID:31401888   PMID:32810137  


Genomics

Comparative Map Data
Atm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2853,828,741 - 53,932,773 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl853,831,093 - 53,932,437 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx859,356,470 - 59,457,803 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0857,635,498 - 57,736,825 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0855,499,734 - 55,601,064 (-)NCBIRnor_WKY
Rnor_6.0858,015,938 - 58,119,973 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl858,015,940 - 58,120,045 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0856,598,503 - 56,703,115 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4856,894,746 - 56,996,565 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera853,321,802 - 53,423,212 (-)NCBICelera
Cytogenetic Map8q24NCBI
ATM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811108,223,067 - 108,369,102 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl11108,223,044 - 108,369,102 (+)EnsemblGRCh38hg38GRCh38
GRCh3711108,093,794 - 108,239,829 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611107,598,769 - 107,745,036 (+)NCBINCBI36Build 36hg18NCBI36
Celera11105,248,510 - 105,394,764 (+)NCBICelera
Cytogenetic Map11q22.3NCBI
HuRef11104,019,183 - 104,165,444 (+)NCBIHuRef
CHM1_111107,976,660 - 108,122,959 (+)NCBICHM1_1
T2T-CHM13v2.011108,230,609 - 108,376,596 (+)NCBIT2T-CHM13v2.0
Atm
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39953,348,422 - 53,448,125 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl953,350,449 - 53,448,040 (-)EnsemblGRCm39 Ensembl
GRCm38953,437,122 - 53,536,828 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl953,439,149 - 53,536,740 (-)EnsemblGRCm38mm10GRCm38
MGSCv37953,245,227 - 53,344,776 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36953,201,763 - 53,298,968 (-)NCBIMGSCv36mm8
Celera950,696,862 - 50,796,451 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map929.12NCBI
Atm
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541210,426,135 - 10,530,545 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541210,422,753 - 10,531,406 (+)NCBIChiLan1.0ChiLan1.0
ATM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111106,584,228 - 106,728,457 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11106,584,228 - 106,727,041 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v011103,109,979 - 103,256,405 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
ATM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1524,180,129 - 24,297,207 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl524,182,135 - 24,297,207 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha524,107,778 - 24,222,696 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0524,211,375 - 24,326,057 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl524,211,375 - 24,326,057 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1524,258,890 - 24,373,424 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0524,160,300 - 24,274,920 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0524,218,488 - 24,333,125 (-)NCBIUU_Cfam_GSD_1.0
Atm
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494791,001,856 - 91,178,286 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936551359,362 - 532,211 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936551359,134 - 534,672 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl936,620,658 - 36,759,552 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1936,620,656 - 36,759,555 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2940,746,630 - 40,837,766 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.2940,926,043 - 40,945,434 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ATM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1199,653,208 - 99,786,889 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl199,653,139 - 99,791,520 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604326,170,879 - 26,305,849 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atm
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247842,937,499 - 3,078,216 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247842,933,172 - 3,080,131 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Atm
691 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:42
Count of miRNA genes:41
Interacting mature miRNAs:42
Transcripts:ENSRNOT00000050555
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82720571554998217Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)82824291253961020Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088624Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat
2303570Gluco48Glucose level QTL 482blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)84980583194805831Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85009524982460899Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85009524982460899Rat
1358912Bw51Body weight QTL 512.95body mass (VT:0001259)body weight (CMO:0000012)851351728107062046Rat

Markers in Region
RH143065  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2853,921,312 - 53,921,471 (+)MAPPERmRatBN7.2
Rnor_6.0858,108,501 - 58,108,659NCBIRnor6.0
Rnor_5.0856,691,121 - 56,691,279UniSTSRnor5.0
RGSC_v3.4856,985,443 - 56,985,601UniSTSRGSC3.4
Celera853,412,090 - 53,412,248UniSTS
RH 3.4 Map8583.1UniSTS
Cytogenetic Map8q24UniSTS
RH135390  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2853,920,992 - 53,921,186 (+)MAPPERmRatBN7.2
Rnor_6.0858,108,181 - 58,108,374NCBIRnor6.0
Rnor_5.0856,690,801 - 56,690,994UniSTSRnor5.0
RGSC_v3.4856,985,123 - 56,985,316UniSTSRGSC3.4
Celera853,411,770 - 53,411,963UniSTS
RH 3.4 Map8582.5UniSTS
Cytogenetic Map8q24UniSTS
RH141713  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2853,829,570 - 53,829,754 (+)MAPPERmRatBN7.2
Rnor_6.0858,016,768 - 58,016,951NCBIRnor6.0
Rnor_5.0856,599,333 - 56,599,516UniSTSRnor5.0
RGSC_v3.4856,893,224 - 56,893,407UniSTSRGSC3.4
Celera853,320,280 - 53,320,463UniSTS
RH 3.4 Map8584.7UniSTS
Cytogenetic Map8q24UniSTS


Genetic Models
This gene Atm is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 9 30 14 19 14 1 1 59 28 37 9 1
Low 1 34 27 27 27 7 10 15 7 4 2 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000050555   ⟹   ENSRNOP00000045529
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl853,831,093 - 53,932,437 (-)Ensembl
Rnor_6.0 Ensembl858,018,290 - 58,119,623 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000086812   ⟹   ENSRNOP00000072646
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl858,015,940 - 58,120,045 (-)Ensembl
RefSeq Acc Id: NM_001106821   ⟹   NP_001100291
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2853,831,093 - 53,932,437 (-)NCBI
Rnor_6.0858,018,290 - 58,119,623 (-)NCBI
Rnor_5.0856,598,503 - 56,703,115 (-)NCBI
RGSC_v3.4856,894,746 - 56,996,565 (-)RGD
Celera853,321,802 - 53,423,212 (-)RGD
Sequence:
RefSeq Acc Id: XM_008766222   ⟹   XP_008764444
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2853,828,741 - 53,932,770 (-)NCBI
Rnor_6.0858,015,938 - 58,119,957 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039081068   ⟹   XP_038936996
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2853,828,741 - 53,932,770 (-)NCBI
RefSeq Acc Id: XM_039081069   ⟹   XP_038936997
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2853,828,741 - 53,932,760 (-)NCBI
RefSeq Acc Id: XM_039081070   ⟹   XP_038936998
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2853,828,741 - 53,932,753 (-)NCBI
RefSeq Acc Id: XM_039081071   ⟹   XP_038936999
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2853,848,954 - 53,932,772 (-)NCBI
RefSeq Acc Id: XM_039081072   ⟹   XP_038937000
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2853,828,741 - 53,911,306 (-)NCBI
RefSeq Acc Id: XM_039081073   ⟹   XP_038937001
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2853,852,033 - 53,932,772 (-)NCBI
RefSeq Acc Id: XM_039081074   ⟹   XP_038937002
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2853,855,277 - 53,932,773 (-)NCBI
RefSeq Acc Id: XR_005487761
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2853,859,324 - 53,932,773 (-)NCBI
RefSeq Acc Id: XR_005487762
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2853,859,130 - 53,932,773 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001100291   ⟸   NM_001106821
- UniProtKB: D4ACL8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008764444   ⟸   XM_008766222
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K3I0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000045529   ⟸   ENSRNOT00000050555
RefSeq Acc Id: ENSRNOP00000072646   ⟸   ENSRNOT00000086812
RefSeq Acc Id: XP_038936996   ⟸   XM_039081068
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038936997   ⟸   XM_039081069
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038936998   ⟸   XM_039081070
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038937000   ⟸   XM_039081072
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038936999   ⟸   XM_039081071
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038937001   ⟸   XM_039081073
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038937002   ⟸   XM_039081074
- Peptide Label: isoform X6
Protein Domains
FAT   FATC   PI3K/PI4K catalytic

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1593265 AgrOrtholog
BioCyc Gene G2FUF-30436 BioCyc
Ensembl Genes ENSRNOG00000029773 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000045529 ENTREZGENE
  ENSRNOP00000045529.3 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000050555 ENTREZGENE
  ENSRNOT00000050555.4 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1070.11 UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  ATM_plant UniProtKB/TrEMBL
  FATC UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  PI3/4_kinase_cat UniProtKB/TrEMBL
  PI3/4_kinase_cat_sf UniProtKB/TrEMBL
  PI3/4_kinase_CS UniProtKB/TrEMBL
  PIK-rel_kinase_FAT UniProtKB/TrEMBL
  PIK_FAT UniProtKB/TrEMBL
  PIKKc_ATM UniProtKB/TrEMBL
  TAN UniProtKB/TrEMBL
KEGG Report rno:300711 UniProtKB/TrEMBL
NCBI Gene 300711 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE ATM UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN KINASE ATM UniProtKB/TrEMBL
Pfam FAT UniProtKB/TrEMBL
  FATC UniProtKB/TrEMBL
  PI3_PI4_kinase UniProtKB/TrEMBL
  TAN UniProtKB/TrEMBL
PhenoGen Atm PhenoGen
PROSITE FAT UniProtKB/TrEMBL
  FATC UniProtKB/TrEMBL
  PI3_4_KINASE_1 UniProtKB/TrEMBL
  PI3_4_KINASE_2 UniProtKB/TrEMBL
  PI3_4_KINASE_3 UniProtKB/TrEMBL
SMART FATC UniProtKB/TrEMBL
  PI3Kc UniProtKB/TrEMBL
  TAN UniProtKB/TrEMBL
Superfamily-SCOP ARM-type_fold UniProtKB/TrEMBL
  Kinase_like UniProtKB/TrEMBL
UniProt A0A0G2K3I0 ENTREZGENE
  D4ACL8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-06-25 Atm  ATM serine/threonine kinase  Atm  ataxia telangiectasia mutated  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-01-14 Atm  ataxia telangiectasia mutated  Atm  ataxia telangiectasia mutated homolog (human)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-12   ataxia telangiectasia mutated homolog (human)  Atm  ataxia telangiectasia mutated homolog (human) (mapped)  Name updated 737654 APPROVED
2007-04-10 Atm  ataxia telangiectasia mutated homolog (human) (mapped)  Atm_mapped  ataxia telangiectasia mutated homolog (human) (mapped)  Data Merged 737654 APPROVED
2006-11-20 Atm  ataxia telangiectasia mutated homolog (human) (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Atm_mapped  ataxia telangiectasia mutated homolog (human) (mapped)  Atm  ataxia telangiectasia mutated homolog (human)  Symbol and Name updated 1556543 APPROVED
2002-11-06 Atm  ataxia telangiectasia mutated homolog (human)    Ataxia telangiectasia gene mutated in human beings  Name updated 625702 APPROVED
2002-06-10 Atm  Ataxia telangiectasia gene mutated in human beings      Symbol and Name status set to approved 70586 APPROVED