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Gene: Ncf4 (neutrophil cytosolic factor 4) Rattus norvegicus

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Symbol:

Ncf4

Name:

neutrophil cytosolic factor 4

RGD ID:

1593157

Description:

Predicted to enable phosphatidylinositol-3-phosphate binding activity and superoxide-generating NADPH oxidase activator activity. Predicted to be involved in superoxide anion generation. Predicted to be located in cytosol and endosome membrane. Predicted to be part of NADPH oxidase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive chronic granulomatous disease 3 and rheumatoid arthritis. Orthologous to human NCF4 (neutrophil cytosolic factor 4); PARTICIPATES IN Leishmaniasis pathway; phagocytosis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 17beta-estradiol 3-benzoate.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC366956; LOC500904; neutrophil cytosol factor 4; similar to neutrophil cytosolic factor 4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NCF4 (neutrophil cytosolic factor 4)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Ncf4 (neutrophil cytosolic factor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ncf4 (neutrophil cytosolic factor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NCF4 (neutrophil cytosolic factor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NCF4 (neutrophil cytosolic factor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ncf4 (neutrophil cytosolic factor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NCF4 (neutrophil cytosolic factor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NCF4 (neutrophil cytosolic factor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ncf4 (neutrophil cytosolic factor 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	NCF4 (neutrophil cytosolic factor 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ncf4 (neutrophil cytosolic factor 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ncf4 (neutrophil cytosolic factor 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	BEM1	Alliance	DIOPT (Ensembl Compara\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	ncf4	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	111,705,926 - 111,723,893 (+)	NCBI		GRCr8
GRCr8 Ensembl	7	111,706,520 - 111,723,898 (+)	Ensembl		GRCr8 Ensembl
mRatBN7.2	7	109,825,420 - 109,843,389 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	109,826,020 - 109,843,389 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	111,575,804 - 111,592,610 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	113,799,365 - 113,816,171 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	113,768,035 - 113,784,810 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	119,481,711 - 119,499,426 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	119,482,272 - 119,499,425 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	119,473,732 - 119,490,872 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	116,167,621 - 116,190,630 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	7	106,165,444 - 106,181,739 (+)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adenylosuccinase lyase deficiency (ISO)

autosomal recessive chronic granulomatous disease 3 (ISO)

chronic granulomatous disease (ISO)

Crohn's disease (ISO)

Emery-Dreifuss muscular dystrophy (ISO)

heart disease (ISO)

myoclonic dystonia 26 (ISO)

neurodegeneration with brain iron accumulation 2A (ISO)

rheumatoid arthritis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (ISO)

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (EXP)

17beta-estradiol 3-benzoate (EXP)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-diaminotoluene (ISO)

3,3',4,4',5-pentachlorobiphenyl (ISO)

4,4'-diaminodiphenylmethane (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

AICA ribonucleotide (EXP)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

amphetamine (EXP)

antirheumatic drug (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

Benzo[k]fluoranthene (ISO)

bisphenol A (EXP,ISO)

bortezomib (ISO)

buta-1,3-diene (ISO)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

cadmium sulfate (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chloroprene (ISO)

chlorpyrifos (ISO)

choline (ISO)

chromium(6+) (ISO)

cocaine (ISO)

copper atom (EXP)

copper(0) (EXP)

crocidolite asbestos (ISO)

Cuprizon (EXP)

D-glucose (ISO)

DDE (ISO)

Dibutyl phosphate (ISO)

diclofenac (ISO)

dioxygen (EXP)

diuron (ISO)

ethyl methanesulfonate (ISO)

folic acid (ISO)

fructose (ISO)

fulvestrant (ISO)

glucose (ISO)

indometacin (EXP)

L-methionine (ISO)

manganese(II) chloride (EXP)

methapyrilene (ISO)

methimazole (EXP)

methotrexate (ISO)

microcystin-LR (ISO)

N-acetyl-L-cysteine (EXP)

N-formyl-L-methionyl-L-leucyl-L-phenylalanine (EXP)

nickel atom (ISO)

nitrates (ISO)

ozone (ISO)

paracetamol (ISO)

paraquat (ISO)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (EXP)

quercetin (ISO)

senecionine (ISO)

silicon dioxide (EXP,ISO)

sirolimus (EXP)

sodium dichromate (ISO)

Soman (EXP)

sulfadimethoxine (EXP)

tamoxifen (ISO)

tert-butyl hydroperoxide (ISO)

testosterone (EXP)

Theaflavin 3,3'-digallate (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

phagocytosis (IEA)

respiratory burst (IEA)

superoxide anion generation (IBA,ISO)

Cellular Component

cytoplasm (IBA,IEA,ISO)

cytosol (IEA,ISO)

endosome (IEA)

endosome membrane (IEA,ISO)

membrane (IEA,ISO)

NADPH oxidase complex (IBA,IEA,ISO)

Molecular Function

lipid binding (IEA)

phosphatidylinositol binding (IEA)

phosphatidylinositol-3-phosphate binding (ISO)

protein binding (ISO)

superoxide-generating NADPH oxidase activator activity (IBA,IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Leishmaniasis pathway (IEA)

phagocytosis pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	A case-control study of rheumatoid arthritis identifies an associated single nucleotide polymorphism in the NCF4 gene, supporting a role for the NADPH-oxidase complex in autoimmunity.	Olsson LM, etal., Arthritis Res Ther. 2007;9(5):R98. doi: 10.1186/ar2299.
3.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8280052	PMID:11684018	PMID:12477932	PMID:15850784	PMID:25224032

Genomics

Comparative Map Data

Ncf4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	111,705,926 - 111,723,893 (+)	NCBI		GRCr8
GRCr8 Ensembl	7	111,706,520 - 111,723,898 (+)	Ensembl		GRCr8 Ensembl
mRatBN7.2	7	109,825,420 - 109,843,389 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	109,826,020 - 109,843,389 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	111,575,804 - 111,592,610 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	113,799,365 - 113,816,171 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	113,768,035 - 113,784,810 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	119,481,711 - 119,499,426 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	119,482,272 - 119,499,425 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	119,473,732 - 119,490,872 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	116,167,621 - 116,190,630 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	7	106,165,444 - 106,181,739 (+)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

NCF4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	36,861,006 - 36,878,015 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	36,860,988 - 36,878,017 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	37,257,048 - 37,274,057 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	35,586,991 - 35,604,005 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	35,581,544 - 35,598,558	NCBI
Celera	22	21,054,984 - 21,075,404 (+)	NCBI		Celera
Cytogenetic Map	22	q12.3	NCBI
HuRef	22	20,219,193 - 20,235,709 (+)	NCBI		HuRef
CHM1_1	22	37,215,777 - 37,232,815 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	22	37,316,866 - 37,336,974 (+)	NCBI		T2T-CHM13v2.0

Ncf4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	78,128,324 - 78,146,782 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	78,129,001 - 78,146,780 (+)	Ensembl		GRCm39 Ensembl
GRCm38	15	78,244,164 - 78,262,582 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	78,244,801 - 78,262,580 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	78,075,241 - 78,093,010 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	78,072,089 - 78,089,829 (+)	NCBI		MGSCv36	mm8
Celera	15	79,705,722 - 79,723,507 (+)	NCBI		Celera
Cytogenetic Map	15	E1	NCBI
cM Map	15	37.1	NCBI

Ncf4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	23,388,018 - 23,408,090 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	23,388,456 - 23,405,121 (+)	NCBI	ChiLan1.0	ChiLan1.0

NCF4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	46,715,341 - 46,735,474 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	49,406,644 - 49,426,776 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	17,775,590 - 17,795,725 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	35,611,589 - 35,631,400 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	35,611,589 - 35,631,400 (+)	Ensembl	panpan1.1		panPan2

NCF4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	27,597,296 - 27,672,199 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	27,597,486 - 27,615,261 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	27,551,611 - 27,626,188 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	28,389,229 - 28,463,826 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	28,389,225 - 28,407,201 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	28,110,753 - 28,185,319 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	28,419,256 - 28,493,843 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	28,598,068 - 28,672,687 (-)	NCBI		UU_Cfam_GSD_1.0

Ncf4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	10,991,297 - 11,005,134 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936492	4,001,898 - 4,010,456 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936492	4,001,711 - 4,015,253 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NCF4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	10,874,953 - 10,994,014 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	10,876,147 - 10,994,002 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	8,477,878 - 8,593,943 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NCF4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	19,560,047 - 19,579,342 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	19,566,562 - 19,579,352 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	106,283,752 - 106,303,762 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ncf4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624752	10,901,934 - 10,918,106 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624752	10,902,035 - 10,918,183 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ncf4
115 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	35
Count of miRNA genes:	30
Interacting mature miRNAs:	34
Transcripts:	ENSRNOT00000009544
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	43747012	135012528	Rat
1331728	Bp214	Blood pressure QTL 214	2.825		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	80221299	124373579	Rat
1331731	Bp216	Blood pressure QTL 216	2.851		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	102297359	133492884	Rat
2298475	Eau6	Experimental allergic uveoretinitis QTL 6		0.0029	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	7	84257275	129257275	Rat
71114	Niddm14	Non-insulin dependent diabetes mellitus QTL 14	4.5		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	7	84257275	129257275	Rat
1357336	Gluco6	Glucose level QTL 6	3.4		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	7	94811326	116294265	Rat
1357338	Stl17	Serum triglyceride level QTL 17	3.23		blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	69736356	112729554	Rat
631687	Hcas1	Hepatocarcinoma susceptibility QTL 1	3.9	0.001	liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	7	91412594	129807172	Rat
70159	Bp61	Blood pressure QTL 61		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	103146217	116738842	Rat
634331	Pia17	Pristane induced arthritis QTL 17	4.7		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	7	73829340	130221005	Rat
1358914	Bp266	Blood pressure QTL 266			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	44421311	118198041	Rat
634322	Bw12	Body weight QTL 12	0		body mass (VT:0001259)	body weight (CMO:0000012)	7	83153392	128153392	Rat
70173	Niddm19	Non-insulin dependent diabetes mellitus QTL 19	4.33	0.00005	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	64002457	135012528	Rat
1549899	Stresp8	Stress response QTL 8	4.37	0.0008	stress-related behavior trait (VT:0010451)	defensive burying duration (CMO:0001961)	7	90482196	135012528	Rat
2317052	Aia17	Adjuvant induced arthritis QTL 17	2.13		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	7	81737938	126737938	Rat
731176	Glom5	Glomerulus QTL 5	2.5	0.0035	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	7	96670164	135012528	Rat
7411607	Foco15	Food consumption QTL 15		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	75918751	120918751	Rat
2306821	Bp335	Blood pressure QTL 335		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	106571501	135012528	Rat
1558655	Swd4	Spike wave discharge measurement QTL 4	3.68	0.0002	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge severity grade (CMO:0001988)	7	86983365	131983365	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	924703	115097879	Rat
1331768	Kidm10	Kidney mass QTL 10	4.62096		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	80221299	125221299	Rat
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	41333674	119109060	Rat
2313102	Bmd79	Bone mineral density QTL 79	2.3	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	7	94811085	116738842	Rat
731174	Uae23	Urinary albumin excretion QTL 23	2.4	0.0042	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	7	104603555	135012528	Rat
2316947	Rf58	Renal function QTL 58	7.8		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	7	68938720	113886318	Rat
1331746	Kidm9	Kidney mass QTL 9	3.934		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	7	80221299	112308525	Rat
7411654	Foco25	Food consumption QTL 25	9.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	75918751	120918751	Rat
2316955	Stl24	Serum triglyceride level QTL 24	7.1		blood triglyceride amount (VT:0002644)	plasma triglyceride level (CMO:0000548)	7	68938720	113886318	Rat
2299163	Iddm34	Insulin dependent diabetes mellitus QTL 34	2.71		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	7	91281130	135012528	Rat
2316952	Pur22	Proteinuria QTL 22	5.2		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	7	68938720	113886318	Rat
631540	Bw9	Body weight QTL 9	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	7	69736226	117455174	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat

Markers in Region

RH144260

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	109,842,949 - 109,843,178 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	119,498,986 - 119,499,214	NCBI	Rnor6.0
Rnor_5.0	7	119,490,432 - 119,490,660	UniSTS	Rnor5.0
RGSC_v3.4	7	116,190,191 - 116,190,419	UniSTS	RGSC3.4
Celera	7	106,181,300 - 106,181,528	UniSTS
RH 3.4 Map	7	813.5	UniSTS
Cytogenetic Map	7	q34	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
9	11	47	113	91	90	59	25	59	6	216	95	11	93	45	59	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001127304	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006241939	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC167076	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000009544 ⟹ ENSRNOP00000009544

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	111,706,521 - 111,723,898 (+)	Ensembl
mRatBN7.2 Ensembl	7	109,826,020 - 109,843,389 (+)	Ensembl
Rnor_6.0 Ensembl	7	119,482,272 - 119,499,425 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000101098 ⟹ ENSRNOP00000079654

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	111,710,810 - 111,723,898 (+)	Ensembl
mRatBN7.2 Ensembl	7	109,830,304 - 109,843,389 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000142103 ⟹ ENSRNOP00000110351

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	7	111,706,520 - 111,723,834 (+)	Ensembl

RefSeq Acc Id:

NM_001127304 ⟹ NP_001120776

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	111,706,526 - 111,723,893 (+)	NCBI
mRatBN7.2	7	109,826,020 - 109,843,389 (+)	NCBI
Rnor_6.0	7	119,482,272 - 119,499,425 (+)	NCBI
Rnor_5.0	7	119,473,732 - 119,490,872 (+)	NCBI
RGSC_v3.4	7	116,167,621 - 116,190,630 (+)	RGD
Celera	7	106,165,444 - 106,181,739 (+)	RGD

Sequence:

show sequence

GGGAAGTGGGTGAGAAGAAGTGTGGAGCCAGGCAGCTCAGAGTCTCAAGGAGGTACTTCAAGGA
GGGTCCAGAGAAGCTGGGGAGGGAGGGACCTCCTCAAAGGGTGCTCCCGAGGACACCCCGAGCT
TTCAGGAAGCTCCCAGATGCACATAGGAGGAAGTGAGAGGTGAACTCAGCCTCAGCCTGGCTGG
GCAAGGCCTTCATCTATCTGCTTTCCTGACTACTGACAGCCATGGCCCTGGCCCAGCAGCTGCG
ATCAGAGAGCGATTTTGAGCAGCTTCCAGATGATGTGGCCATCTCAGCCAACATCGCTGACATC
GAGGAGAAGAGGGGCTTCACCAGCCACTTTGTGTTTGTCATCGAGGTAAAGACAAAAGGAGGAT
CCAAGTATCTCATCTACCGCCGATATCGCCAGTTCTACGCCCTGCAGAGCAAGCTGGAGGAGCG
GTTTGGACCAGAGAGCAAGAACAGCCCATTCACCTGCAGCCTGCCCACACTGCCAGCCAAAGTC
TACATGGGTGTCAAACAAGAGATTGCTGAGACTCGGATCCCGGCCCTCAATGCCTACATGAAGA
ACCTCCTGAGCCTGCCGGTCTGCGTGCTGATGGACCCCGACGTCAGAATATTCTTCTATCAGTC
TGCTTACGACGCAGAGCAGGTGCCTCAGGCACTTCGTAGGCTCCGACCGCGCACGCGCAAAATC
AAGGGCGTGACTCCACAAGGGCCCAGCATGGACCGCATGGAAGCTCCAAGAGCAGAGGCCTTGT
TTGACTTCACTGGGAACAGCAAACTGGAGCTAAGTTTCAAAGCTGGAGATGTGATCTTCCTTCT
CAGTAAGATCAACAAAGACTGGTTGGAGGGCACAACCCAGGGAGCCACAGGCATCTTCCCAGGG
TCTTTCGTGAAGATCCTCAAGGACTTCCCCGAAGACGAGGACACTACCAACTGGCTGCGATGCT
ACTTCTACGAAGACACAGGCAAAACCATCAAGGACATTGCAGTGGAGGAGGACCTCAGCAGCAC
CCCCCTGTTCAAAGACCTGCTAGCACTCATGAGGCGTGAATTCCAGAGAGAGGACATTGCCCTT
AATTACCAAGATGCTGAGGGGGACCTGGTTCGGCTGCTGTCAGATGAGGATGTGGGACTCATGG
TGAAGCAGGCCCAAGGCCTCCCCTCCCAGAAGCGCCTCTTCCCCTGGAAGCTGCACGTCACCCA
GAAGGACAATTACGGTGTCTACAACACCGTACCCTGAGTCACAGGGACCCAGTGGCAAGGATGG
GTACTCAGCAAAGGACCTTACCTTCCAAGAACATGAAGACCCTCCAGGAGGCTGGCACAAGATG
CAAACCTCCTGGGCCAGAGTGCCCACTGGACAGGATTCTACTTAATTTTTGACACTTTACCTTT
GGATTAAATAAACCATTCTGTGTCAAAGGGCCAGTGTTGGGAAATGAGATTTTGTGGAGGAACG
GGGAGTAAAATGTAATTGATTAAG

hide sequence

RefSeq Acc Id:

XM_006241939 ⟹ XP_006242001

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	111,705,926 - 111,723,834 (+)	NCBI
mRatBN7.2	7	109,825,420 - 109,843,332 (+)	NCBI
Rnor_6.0	7	119,481,711 - 119,499,426 (+)	NCBI
Rnor_5.0	7	119,473,732 - 119,490,872 (+)	NCBI

Sequence:

show sequence

CAGGTCTCTTTCTCAAAGGGCAGCTTCCCAGCTGAGGCCTACAGGAGATAGGAAAGCAGTGTTG
GAAGTGAGGAGGCAGTGAGGGAAGACAGAGCTAGGAGAGCAGGCAGCCTACAGGACCTTGAGGA
TTAGAATAAGGCCAGCCGCAGGTGCATGGAGCTCTTCTGAGAGCCGAGTAGGGAGGAGGAGGAG
GCAGATTTTAAGGAGAGCCCCTGTGTGGCTGGAAGCTCTGGGGGGGCTGAACATGGAATCTCAG
AGCCCAGAGCACCAGGGTGAGGACAAGATAGGGCACAAGCCAATGACATCCTAGCATAATAGAG
GGAGGGAAACCAGGACAGTTTCCTGCAAGAAACAATATCCCCACCAGTCCTTAAGGATGCAGGT
TTTGGAAGCATGGGGAAGGGGTTCAGGAAGAAGCATGGATGGACTATCCAGGGCTACAACTGCT
CAGTGATGGGTGGAGCTTAGCACTAGAGACAGGCACTGAGGAAGTCCCCAAAGCCAGTGGCCTC
ACGTAAGCCCAGCACCCAAGCGTGACACTTCCTCAACTGCTGTGCAGCTGGGAAGTGGGTGAGA
AGAAGTGTGGAGCCAGGCAGCTCAGAGTCTCAAGGAGGTACTTCAAGGAGGGTCCAGAGAAGCT
GGGGAGGGAGGGACCTCCTCAAAGGGTGCTCCCGAGGACACCCCGAGCTTTCAGGAAGCTCCCA
GATGCACATAGGAGGAAGTGAGAGGTGAACTCAGCCTCAGCCTGGCTGGGCAAGGCCTTCATCT
ATCTGCTTTCCTGACTACTGACAGCCATGGCCCTGGCCCAGCAGCTGCGATCAGAGAGCGATTT
TGAGCAGCTTCCAGATGATGTGGCCATCTCAGCCAACATCGCTGACATCGAGGAGAAGAGGGGC
TTCACCAGCCACTTTGGTGGTTGCTGACACATGCTGGATAGAATGTAGGGCGCTCCTGAACACA
TCCAAAAGCATGGGACACCCCGGTGAAGGCTTACCCTACTCAGCGTGCACCGTGTTTGTCATCG
AGGTAAAGACAAAAGGAGGATCCAAGTATCTCATCTACCGCCGATATCGCCAGTTCTACGCCCT
GCAGAGCAAGCTGGAGGAGCGGTTTGGACCAGAGAGCAAGAACAGCCCATTCACCTGCAGCCTG
CCCACACTGCCAGCCAAAGTCTACATGGGTGTCAAACAAGAGATTGCTGAGACTCGGATCCCGG
CCCTCAATGCCTACATGAAGAACCTCCTGAGCCTGCCGGTCTGCGTGCTGATGGACCCCGACGT
CAGAATATTCTTCTATCAGTCTGCTTACGACGCAGAGCAGGTGCCTCAGGCACTTCGTAGGCTC
CGACCGCGCACGCGCAAAATCAAGGGCGTGACTCCACAAGGGCCCAGCATGGACCGCATGGAAG
CTCCAAGAGCAGAGGCCTTGTTTGACTTCACTGGGAACAGCAAACTGGAGCTAAGTTTCAAAGC
TGGAGATGTGATCTTCCTTCTCAGTAAGATCAACAAAGACTGGTTGGAGGGCACAACCCAGGGA
GCCACAGGCATCTTCCCAGGGTCTTTCGTGAAGATCCTCAAGGACTTCCCCGAAGACGAGGACA
CTACCAACTGGCTGCGATGCTACTTCTACGAAGACACAGGCAAAACCATCAAGGACATTGCAGT
GGAGGAGGACCTCAGCAGCACCCCCCTGTTCAAAGACCTGCTAGCACTCATGAGGCGTGAATTC
CAGAGAGAGGACATTGCCCTTAATTACCAAGATGCTGAGGGGGACCTGGTTCGGCTGCTGTCAG
ATGAGGATGTGGGACTCATGGTGAAGCAGGCCCAAGGCCTCCCCTCCCAGAAGCGCCTCTTCCC
CTGGAAGCTGCACGTCACCCAGAAGGACAATTACGGTGTCTACAACACCGTACCCTGAGTCACA
GGGACCCAGTGGCAAGGATGGGTACTCAGCAAAGGACCTTACCTTCCAAGAACATGAAGACCCT
CCAGGAGGCTGGCACAAGATGCAAACCTCCTGGGCCAGAGTGCCCACTGGACAGGATTCTACTT
AATTTTTGACACTTTACCTTTGGATTAAATAAACCATTCTGTGTCAAAGGGCCAGTGTTGGGAA
ATGAGATTTTGTGGAGGAACGGGGAGTAAAATGTAATTGATTAAGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001120776	(Get FASTA)	NCBI Sequence Viewer
	XP_006242001	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI67076	(Get FASTA)	NCBI Sequence Viewer
	EDM15882	(Get FASTA)	NCBI Sequence Viewer
	EDM15883	(Get FASTA)	NCBI Sequence Viewer
	EDM15884	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000009544
	ENSRNOP00000009544.6
	ENSRNOP00000079654.1
	ENSRNOP00000110351

RefSeq Acc Id:

NP_001120776 ⟸ NM_001127304

- UniProtKB:

B2RZ98 (UniProtKB/TrEMBL), D3ZS40 (UniProtKB/TrEMBL), A0A9K3Y7E3 (UniProtKB/TrEMBL), A0A8I5ZNF3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MALAQQLRSESDFEQLPDDVAISANIADIEEKRGFTSHFVFVIEVKTKGGSKYLIYRRYRQFYA
LQSKLEERFGPESKNSPFTCSLPTLPAKVYMGVKQEIAETRIPALNAYMKNLLSLPVCVLMDPD
VRIFFYQSAYDAEQVPQALRRLRPRTRKIKGVTPQGPSMDRMEAPRAEALFDFTGNSKLELSFK
AGDVIFLLSKINKDWLEGTTQGATGIFPGSFVKILKDFPEDEDTTNWLRCYFYEDTGKTIKDIA
VEEDLSSTPLFKDLLALMRREFQREDIALNYQDAEGDLVRLLSDEDVGLMVKQAQGLPSQKRLF
PWKLHVTQKDNYGVYNTVP

hide sequence

RefSeq Acc Id:	XP_006242001 ⟸ XM_006241939
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5ZNF3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MMWPSQPTSLTSRRRGASPATLVVADTCWIECRALLNTSKSMGHPGEGLPYSACTVFVIEVKTK GGSKYLIYRRYRQFYALQSKLEERFGPESKNSPFTCSLPTLPAKVYMGVKQEIAETRIPALNAY MKNLLSLPVCVLMDPDVRIFFYQSAYDAEQVPQALRRLRPRTRKIKGVTPQGPSMDRMEAPRAE ALFDFTGNSKLELSFKAGDVIFLLSKINKDWLEGTTQGATGIFPGSFVKILKDFPEDEDTTNWL RCYFYEDTGKTIKDIAVEEDLSSTPLFKDLLALMRREFQREDIALNYQDAEGDLVRLLSDEDVG LMVKQAQGLPSQKRLFPWKLHVTQKDNYGVYNTVP hide sequence

Ensembl Acc Id:

ENSRNOP00000009544 ⟸ ENSRNOT00000009544

Ensembl Acc Id:

ENSRNOP00000079654 ⟸ ENSRNOT00000101098

Ensembl Acc Id:

ENSRNOP00000110351 ⟸ ENSRNOT00000142103

Protein Domains

PB1 PX SH3

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B2RZ98-F1-model_v2	AlphaFold	B2RZ98	1-339	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695458

Promoter ID:

EPDNEW_R5983

Type:

initiation region

Name:

Ncf4_1

Description:

neutrophil cytosolic factor 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	119,482,248 - 119,482,308	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1593157	AgrOrtholog
BioCyc Gene	G2FUF-32836	BioCyc
Ensembl Genes	ENSRNOG00000006940	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000009544	ENTREZGENE
	ENSRNOT00000009544.7	UniProtKB/TrEMBL
	ENSRNOT00000101098.1	UniProtKB/TrEMBL
	ENSRNOT00000142103	ENTREZGENE
Gene3D-CATH	3.30.1520.10	UniProtKB/TrEMBL
	Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1	UniProtKB/TrEMBL
	SH3 Domains	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7129758	IMAGE-MGC_LOAD
InterPro	IPR001683	UniProtKB/TrEMBL
	NADPH_Oxidase/PX-Domain	UniProtKB/TrEMBL
	NCF_P40	UniProtKB/TrEMBL
	OPR_PB1	UniProtKB/TrEMBL
	p40phox_SH3	UniProtKB/TrEMBL
	PB1-like	UniProtKB/TrEMBL
	PB1_P40	UniProtKB/TrEMBL
	PX_dom_sf	UniProtKB/TrEMBL
	PX_p40phox	UniProtKB/TrEMBL
	SH3-like_dom	UniProtKB/TrEMBL
	SH3_domain	UniProtKB/TrEMBL
KEGG Report	rno:500904	UniProtKB/TrEMBL
MGC_CLONE	MGC:189418	IMAGE-MGC_LOAD
NCBI Gene	500904	ENTREZGENE
PANTHER	PTHR15706:SF20	UniProtKB/TrEMBL
	SH3 MULTIPLE DOMAIN	UniProtKB/TrEMBL
Pfam	PB1	UniProtKB/TrEMBL
	PF00787	UniProtKB/TrEMBL
	SH3_1	UniProtKB/TrEMBL
PhenoGen	Ncf4	PhenoGen
PRINTS	P40PHOX	UniProtKB/TrEMBL
	SH3DOMAIN	UniProtKB/TrEMBL
PROSITE	PB1	UniProtKB/TrEMBL
	PS50195	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000006940	RatGTEx
SMART	PB1	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
	SM00312	UniProtKB/TrEMBL
Superfamily-SCOP	64268	UniProtKB/TrEMBL
	CAD & PB1 domains	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
UniProt	A0A8I5ZNF3	ENTREZGENE, UniProtKB/TrEMBL
	A0A9K3Y7E3	ENTREZGENE, UniProtKB/TrEMBL
	B2RZ98	ENTREZGENE, UniProtKB/TrEMBL
	D3ZS40	ENTREZGENE
UniProt Secondary	D3ZS40	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2009-06-15	Ncf4	neutrophil cytosolic factor 4	Ncf4_predicted	neutrophil cytosolic factor 4 (predicted)	Data merged from RGD:1305943	1643240	APPROVED
2008-03-05	Ncf4	neutrophil cytosolic factor 4	LOC500904	similar to neutrophil cytosolic factor 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-20	LOC500904	similar to neutrophil cytosolic factor 4			Symbol and Name status set to provisional	70820	PROVISIONAL
2005-01-12	Ncf4_predicted	neutrophil cytosolic factor 4 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)