Aida (axin interactor, dorsalization associated) - Rat Genome Database

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Gene: Aida (axin interactor, dorsalization associated) Rattus norvegicus
Analyze
Symbol: Aida
Name: axin interactor, dorsalization associated
RGD ID: 1592746
Description: Predicted to enable phosphatidylinositol binding activity and protein domain specific binding activity. Predicted to be involved in determination of ventral identity; negative regulation of JNK cascade; and negative regulation of protein-containing complex assembly. Predicted to act upstream of or within negative regulation of JUN kinase activity and regulation of protein-containing complex assembly. Predicted to be located in cytoplasm. Predicted to be active in membrane. Orthologous to human AIDA (axin interactor, dorsalization associated); INTERACTS WITH 1-naphthyl isothiocyanate; 4,4'-diaminodiphenylmethane; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: axin interactor, dorsalization-associated protein; hypothetical protein LOC682999; LOC682999; MGC187619; uncharacterized protein LOC682999
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81397,471,931 - 97,499,531 (+)NCBIGRCr8
GRCr8 Ensembl1397,471,604 - 97,499,535 (+)EnsemblGRCr8 Ensembl
mRatBN7.21394,940,311 - 94,967,920 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1394,939,741 - 94,967,920 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1397,445,676 - 97,473,280 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01398,845,486 - 98,873,089 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01396,027,632 - 96,055,235 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013101,698,096 - 101,724,928 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13101,698,096 - 101,724,923 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013100,906,568 - 100,933,404 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41399,339,703 - 99,357,665 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1394,467,274 - 94,494,504 (+)NCBICelera
Cytogenetic Map13q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
membrane  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:17681137  


Genomics

Comparative Map Data
Aida
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81397,471,931 - 97,499,531 (+)NCBIGRCr8
GRCr8 Ensembl1397,471,604 - 97,499,535 (+)EnsemblGRCr8 Ensembl
mRatBN7.21394,940,311 - 94,967,920 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1394,939,741 - 94,967,920 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1397,445,676 - 97,473,280 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01398,845,486 - 98,873,089 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01396,027,632 - 96,055,235 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013101,698,096 - 101,724,928 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13101,698,096 - 101,724,923 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013100,906,568 - 100,933,404 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41399,339,703 - 99,357,665 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1394,467,274 - 94,494,504 (+)NCBICelera
Cytogenetic Map13q26NCBI
AIDA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381222,668,013 - 222,712,491 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1222,668,013 - 222,713,210 (-)EnsemblGRCh38hg38GRCh38
GRCh371222,841,355 - 222,885,833 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361220,907,978 - 220,952,487 (-)NCBINCBI36Build 36hg18NCBI36
Celera1196,060,430 - 196,105,032 (-)NCBICelera
Cytogenetic Map1q41NCBI
HuRef1193,515,353 - 193,560,247 (-)NCBIHuRef
CHM1_11224,113,870 - 224,158,930 (-)NCBICHM1_1
T2T-CHM13v2.01221,901,757 - 221,946,247 (-)NCBIT2T-CHM13v2.0
Aida
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391183,078,604 - 183,105,356 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1183,078,134 - 183,106,331 (+)EnsemblGRCm39 Ensembl
GRCm381183,297,060 - 183,324,501 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1183,296,590 - 183,325,476 (+)EnsemblGRCm38mm10GRCm38
MGSCv3684,087,219 - 4,089,901 (+)NCBIMGSCv36mm8
Celera1190,298,074 - 190,324,759 (+)NCBICelera
Cytogenetic Map1H5NCBI
Aida
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555201,819,706 - 1,851,273 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555201,819,617 - 1,851,273 (+)NCBIChiLan1.0ChiLan1.0
AIDA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2126,608,479 - 26,652,939 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1126,562,347 - 26,606,494 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01198,341,375 - 198,385,682 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11203,354,925 - 203,399,193 (-)NCBIpanpan1.1PanPan1.1panPan2
AIDA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13816,938,279 - 16,971,200 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3816,939,556 - 16,971,200 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3816,994,631 - 17,027,543 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03816,984,669 - 17,017,699 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3816,983,891 - 17,017,672 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13816,990,054 - 17,022,930 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03817,338,903 - 17,371,799 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03817,634,148 - 17,667,198 (-)NCBIUU_Cfam_GSD_1.0
AIDA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1011,428,399 - 11,466,643 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11011,430,758 - 11,466,849 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21013,585,250 - 13,621,298 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AIDA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1256,858,138 - 6,900,064 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl256,858,152 - 6,898,175 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660557,096,822 - 7,138,698 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aida
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248355,207,011 - 5,240,269 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248355,206,365 - 5,240,534 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aida
189 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:442
Count of miRNA genes:238
Interacting mature miRNAs:283
Transcripts:ENSRNOT00000004961
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1383286150109350286Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat

Markers in Region
RH143707  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21394,967,432 - 94,967,702 (+)MAPPERmRatBN7.2
Rnor_6.013101,724,446 - 101,724,715NCBIRnor6.0
Rnor_5.013100,932,922 - 100,933,191UniSTSRnor5.0
Celera1394,494,022 - 94,494,291UniSTS
RH 3.4 Map13651.3UniSTS
BI278943  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21394,944,250 - 94,944,491 (+)MAPPERmRatBN7.2
Rnor_6.013101,702,138 - 101,702,378NCBIRnor6.0
Rnor_5.013100,910,610 - 100,910,850UniSTSRnor5.0
RGSC_v3.41399,343,644 - 99,343,884UniSTSRGSC3.4
Celera1394,471,213 - 94,471,453UniSTS
RH 3.4 Map13654.2UniSTS
RH134995  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21394,957,048 - 94,957,231 (+)MAPPERmRatBN7.2
Rnor_6.013101,714,238 - 101,714,420NCBIRnor6.0
Rnor_5.013100,922,710 - 100,922,892UniSTSRnor5.0
RGSC_v3.41399,356,441 - 99,356,623UniSTSRGSC3.4
Celera1394,484,007 - 94,484,189UniSTS
RH 3.4 Map13640.5UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 49 113 91 90 59 25 59 6 218 97 11 93 45 60 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000089309   ⟹   ENSRNOP00000072748
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1397,472,149 - 97,499,535 (+)Ensembl
mRatBN7.2 Ensembl1394,940,267 - 94,967,904 (+)Ensembl
Rnor_6.0 Ensembl13101,698,096 - 101,724,923 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000105873   ⟹   ENSRNOP00000082859
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1394,940,443 - 94,967,910 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106985   ⟹   ENSRNOP00000094213
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1397,471,604 - 97,499,526 (+)Ensembl
mRatBN7.2 Ensembl1394,939,741 - 94,967,910 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110785   ⟹   ENSRNOP00000081586
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1397,471,604 - 97,499,526 (+)Ensembl
mRatBN7.2 Ensembl1394,940,311 - 94,967,917 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111581   ⟹   ENSRNOP00000083220
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1394,940,303 - 94,967,920 (+)Ensembl
RefSeq Acc Id: NM_001127600   ⟹   NP_001121072
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81397,471,931 - 97,499,531 (+)NCBI
mRatBN7.21394,940,311 - 94,967,915 (+)NCBI
Rnor_6.013101,698,096 - 101,724,928 (+)NCBI
Rnor_5.013100,906,568 - 100,933,404 (+)NCBI
RGSC_v3.41399,339,703 - 99,357,665 (+)RGD
Celera1394,467,274 - 94,494,504 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001121072 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI61899 (Get FASTA)   NCBI Sequence Viewer  
  EDL94890 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072748.2
  ENSRNOP00000081586.1
  ENSRNOP00000082859.1
  ENSRNOP00000083220.1
  ENSRNOP00000094213
  ENSRNOP00000094213.1
RefSeq Acc Id: NP_001121072   ⟸   NM_001127600
- UniProtKB: B1WBV1 (UniProtKB/TrEMBL),   F1LQI0 (UniProtKB/TrEMBL),   A0A8I6G8N1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072748   ⟸   ENSRNOT00000089309
Ensembl Acc Id: ENSRNOP00000083220   ⟸   ENSRNOT00000111581
Ensembl Acc Id: ENSRNOP00000094213   ⟸   ENSRNOT00000106985
Ensembl Acc Id: ENSRNOP00000081586   ⟸   ENSRNOT00000110785
Ensembl Acc Id: ENSRNOP00000082859   ⟸   ENSRNOT00000105873
Protein Domains
C2 Aida-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B1WBV1-F1-model_v2 AlphaFold B1WBV1 1-305 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699085
Promoter ID:EPDNEW_R9609
Type:initiation region
Name:Aida_1
Description:axin interactor, dorsalization associated
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.013101,698,088 - 101,698,148EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1592746 AgrOrtholog
BioCyc Gene G2FUF-17042 BioCyc
Ensembl Genes ENSRNOG00000058805 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000089309.2 UniProtKB/TrEMBL
  ENSRNOT00000105873.1 UniProtKB/TrEMBL
  ENSRNOT00000106985 ENTREZGENE
  ENSRNOT00000106985.1 UniProtKB/TrEMBL
  ENSRNOT00000110785.1 UniProtKB/TrEMBL
  ENSRNOT00000111581.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.120.360 UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8367117 IMAGE-MGC_LOAD
InterPro Aida_C UniProtKB/TrEMBL
  AIDA_N UniProtKB/TrEMBL
  AIDA_N_sf UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
KEGG Report rno:682999 UniProtKB/TrEMBL
MGC_CLONE MGC:187619 IMAGE-MGC_LOAD
NCBI Gene 682999 ENTREZGENE
PANTHER AXIN INTERACTOR, DORSALIZATION-ASSOCIATED PROTEIN UniProtKB/TrEMBL
  AXIN INTERACTOR, DORSALIZATION-ASSOCIATED PROTEIN UniProtKB/TrEMBL
Pfam Aida_C2 UniProtKB/TrEMBL
  DUF1855 UniProtKB/TrEMBL
PhenoGen Aida PhenoGen
PROSITE C2_AIDA UniProtKB/TrEMBL
RatGTEx ENSRNOG00000058805 RatGTEx
Superfamily-SCOP SSF109779 UniProtKB/TrEMBL
UniProt A0A0G2K3R8_RAT UniProtKB/TrEMBL
  A0A8I5ZRZ6_RAT UniProtKB/TrEMBL
  A0A8I5ZUW1_RAT UniProtKB/TrEMBL
  A0A8I6G8N1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GL24_RAT UniProtKB/TrEMBL
  B1WBV1 ENTREZGENE, UniProtKB/TrEMBL
  F1LQI0 ENTREZGENE
UniProt Secondary F1LQI0 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-09-26 Aida  axin interactor, dorsalization associated  LOC682999  hypothetical protein LOC682999  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC682999  hypothetical protein LOC682999      Symbol and Name status set to provisional 70820 PROVISIONAL