Rrm1 (ribonucleotide reductase catalytic subunit M1) - Rat Genome Database

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Gene: Rrm1 (ribonucleotide reductase catalytic subunit M1) Rattus norvegicus
Analyze
Symbol: Rrm1
Name: ribonucleotide reductase catalytic subunit M1
RGD ID: 1592569
Description: Predicted to enable several functions, including ATP binding activity; disordered domain specific binding activity; and identical protein binding activity. Involved in several processes, including cell proliferation in forebrain; male gonad development; and response to ionizing radiation. Located in cell projection; neuronal cell body; and nuclear envelope. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in chronic progressive external ophthalmoplegia. Orthologous to human RRM1 (ribonucleotide reductase catalytic subunit M1); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC685579; MGC94742; ribonucleoside-diphosphate reductase large subunit; ribonucleotide reductase M1; similar to ribonucleotide reductase M1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Rrm1-ps1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Note: NCBI's current annotation of the functional gene (chromosome 1) and a pseudogene (chromosome 14) are not consistent on all assemblies. The functional gene on the Celera assembly is currently annotated with the GeneID of the pseudogene on chromosome 14. [17 Jun 2014]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81166,235,904 - 166,260,206 (+)NCBIGRCr8
mRatBN7.21156,823,960 - 156,848,262 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1156,823,960 - 156,848,261 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1164,801,707 - 164,826,040 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01171,981,799 - 172,006,127 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01164,859,508 - 164,883,799 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01167,538,387 - 167,562,688 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1167,538,263 - 167,562,688 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01173,726,994 - 173,751,295 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41159,930,994 - 159,937,860 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1154,890,871 - 154,915,173 (+)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (ISO)
2-bromohexadecanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-methylcholanthrene  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
beta-carotene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
corosolic acid  (ISO)
corticosterone  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gamma-tocopherol  (ISO)
gefitinib  (ISO)
gemcitabine  (ISO)
graphite  (ISO)
hydrogen peroxide  (ISO)
indometacin  (EXP)
ivermectin  (ISO)
lead(0)  (ISO)
lidocaine  (EXP)
menadione  (ISO)
methimazole  (EXP)
methylseleninic acid  (ISO)
Mitotane  (ISO)
N-nitrosodiethylamine  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
palbociclib  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
quercetin  (ISO)
quinoline  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
senecionine  (EXP)
sodium arsenite  (ISO)
sodium dichromate  (EXP,ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tocopherol  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
tributylstannane  (EXP)
Tributyltin oxide  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vorinostat  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Tumor BRCA1, RRM1 and RRM2 mRNA expression levels and clinical response to first-line gemcitabine plus docetaxel in non-small-cell lung cancer patients. Boukovinas I, etal., PLoS One. 2008;3(11):e3695. doi: 10.1371/journal.pone.0003695. Epub 2008 Nov 11.
2. Gene expression profiling of alpha-radiation-induced rat osteosarcomas: identification of dysregulated genes involved in radiation-induced tumorigenesis of bone. Daino K, etal., Int J Cancer. 2009 Aug 1;125(3):612-20.
3. Alterations in specific gene expression and focal neoplastic growth during spontaneous hepatocarcinogenesis in albumin-SV40 T antigen transgenic rats. Dragan YP, etal., Mol Carcinog. 2004 Jul;40(3):150-9.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Insulin-like growth factor I in the developing and mature rat testis: immunohistochemical aspects. Hansson HA, etal., Biol Reprod. 1989 Jun;40(6):1321-8.
6. Changes in the distribution of insulin-like growth factor I, thioredoxin, thioredoxin reductase and ribonucleotide reductase during the development of the retina. Hansson HA, etal., Exp Eye Res. 1989 Mar;48(3):411-20.
7. The regulation of ribonucleoside diphosphate reductase by the tumor promoter orotic acid in normal rat liver in vivo. Manjeshwar S, etal., Mol Carcinog. 1999 Mar;24(3):188-96.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Evidence that mammalian ribonucleotide reductase is a nuclear membrane associated glycoprotein. Sikorska M, etal., Biochem Cell Biol. 1990 May;68(5):880-8.
14. Changes in the cytoplasmic and nuclear activities of the ribonucleotide reductase holoenzyme and its subunits in regenerating liver cells in normal and thyroparathyroidectomized rats. Youdale T, etal., Can J Biochem Cell Biol. 1984 Sep;62(9):914-9.
15. Visualization of proliferating cells in the adult mammalian brain with the aid of ribonucleotide reductase. Zhu H, etal., Brain Res. 2003 Jul 11;977(2):180-9.
16. Characterization of cell proliferation in the adult dentate under normal conditions and after kainate induced seizures using ribonucleotide reductase and BrdU. Zhu H, etal., Brain Res. 2005 Mar 2;1036(1-2):7-17.
Additional References at PubMed
PMID:8130196   PMID:12477932   PMID:15632090   PMID:16861739   PMID:17726094   PMID:19176520   PMID:21336276   PMID:21925507   PMID:23376485   PMID:25416956  


Genomics

Comparative Map Data
Rrm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81166,235,904 - 166,260,206 (+)NCBIGRCr8
mRatBN7.21156,823,960 - 156,848,262 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1156,823,960 - 156,848,261 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1164,801,707 - 164,826,040 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01171,981,799 - 172,006,127 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01164,859,508 - 164,883,799 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01167,538,387 - 167,562,688 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1167,538,263 - 167,562,688 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01173,726,994 - 173,751,295 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41159,930,994 - 159,937,860 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1154,890,871 - 154,915,173 (+)NCBICelera
Cytogenetic Map1q32NCBI
RRM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38114,094,685 - 4,138,932 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl114,094,707 - 4,138,932 (+)EnsemblGRCh38hg38GRCh38
GRCh37114,115,915 - 4,160,162 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36114,072,500 - 4,116,682 (+)NCBINCBI36Build 36hg18NCBI36
Build 34114,072,586 - 4,116,681NCBI
Celera114,120,880 - 4,164,701 (+)NCBICelera
Cytogenetic Map11p15.4NCBI
HuRef113,849,345 - 3,893,165 (+)NCBIHuRef
CHM1_1114,115,391 - 4,159,561 (+)NCBICHM1_1
T2T-CHM13v2.0114,159,950 - 4,204,024 (+)NCBIT2T-CHM13v2.0
Rrm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397102,090,902 - 102,118,978 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7102,090,902 - 102,118,978 (+)EnsemblGRCm39 Ensembl
GRCm387102,441,695 - 102,469,771 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7102,441,695 - 102,469,771 (+)EnsemblGRCm38mm10GRCm38
MGSCv377109,590,209 - 109,618,285 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367102,315,688 - 102,342,747 (+)NCBIMGSCv36mm8
Celera7102,809,638 - 102,837,567 (+)NCBICelera
Cytogenetic Map7E3NCBI
cM Map754.72NCBI
Rrm1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541419,850,530 - 19,905,266 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541419,850,523 - 19,904,879 (+)NCBIChiLan1.0ChiLan1.0
RRM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v296,348,683 - 6,392,806 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1115,588,407 - 5,632,547 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0113,956,528 - 3,999,205 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1114,068,119 - 4,110,474 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl114,068,119 - 4,110,474 (+)Ensemblpanpan1.1panPan2
RRM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12126,595,838 - 26,631,476 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2126,595,914 - 26,631,135 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2126,365,162 - 26,400,602 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02126,805,233 - 26,840,936 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2126,805,323 - 26,840,930 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12126,595,614 - 26,630,876 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02126,811,885 - 26,847,337 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02126,714,390 - 26,749,830 (+)NCBIUU_Cfam_GSD_1.0
Rrm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494759,215,865 - 59,249,179 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936498815,399 - 848,793 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936498815,401 - 848,749 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RRM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl96,025,073 - 6,065,143 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.196,026,151 - 6,065,211 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.296,818,979 - 6,880,069 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RRM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1162,606,112 - 62,649,979 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl162,604,486 - 62,650,200 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604363,252,138 - 63,296,602 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rrm1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248175,523,665 - 5,568,994 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248175,523,648 - 5,568,997 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rrm1
47 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:290
Count of miRNA genes:188
Interacting mature miRNAs:208
Transcripts:ENSRNOT00000074058
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1131763437159756369Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1136745990163747690Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1144267916172949660Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144267916174133260Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
1582204Livw1Liver weight QTL 13.60.0003liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)1155422851172949803Rat
4889419Cstrr2Cold stress response QTL 20.05urine catecholamine amount (VT:0010502)absolute change in urine norepinephrine level (CMO:0001634)1155866514158592016Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1156677124176484451Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat

Markers in Region
BI279462  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21156,847,740 - 156,847,913 (+)MAPPERmRatBN7.2
mRatBN7.21472,179,804 - 72,179,977 (+)MAPPERmRatBN7.2
Rnor_6.01476,911,798 - 76,911,970NCBIRnor6.0
Rnor_6.01167,562,167 - 167,562,339NCBIRnor6.0
Rnor_5.01476,896,190 - 76,896,362UniSTSRnor5.0
Rnor_5.01173,750,774 - 173,750,946UniSTSRnor5.0
RGSC_v3.41477,411,056 - 77,411,228UniSTSRGSC3.4
Celera1471,132,095 - 71,132,267UniSTS
Celera1154,914,652 - 154,914,824UniSTS
RH 3.4 Map11275.7UniSTS
Cytogenetic Map1q32UniSTS
Cytogenetic Map14q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 47 31 19 31 8 11 74 35 41 11 8
Low 10 10 10
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000074058   ⟹   ENSRNOP00000064166
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1156,823,960 - 156,848,261 (+)Ensembl
Rnor_6.0 Ensembl1167,538,263 - 167,562,688 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093070   ⟹   ENSRNOP00000075981
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1156,824,317 - 156,825,141 (+)Ensembl
Rnor_6.0 Ensembl1167,538,744 - 167,539,568 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093112   ⟹   ENSRNOP00000076052
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1167,539,036 - 167,546,917 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000113303   ⟹   ENSRNOP00000076633
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1156,823,960 - 156,848,261 (+)Ensembl
RefSeq Acc Id: NM_001013236   ⟹   NP_001013254
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81166,235,904 - 166,260,206 (+)NCBI
mRatBN7.21156,823,960 - 156,848,262 (+)NCBI
Rnor_6.01167,538,387 - 167,562,688 (+)NCBI
Rnor_5.01173,726,994 - 173,751,295 (+)NCBI
Celera1154,890,871 - 154,915,173 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001013254 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH85906 (Get FASTA)   NCBI Sequence Viewer  
  EDM18189 (Get FASTA)   NCBI Sequence Viewer  
  EDM18190 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064166
  ENSRNOP00000064166.1
  ENSRNOP00000075981.1
  ENSRNOP00000076633.1
RefSeq Acc Id: NP_001013254   ⟸   NM_001013236
- UniProtKB: Q5U2Q5 (UniProtKB/TrEMBL),   M0R486 (UniProtKB/TrEMBL),   A0A8I5Y915 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000076052   ⟸   ENSRNOT00000093112
RefSeq Acc Id: ENSRNOP00000075981   ⟸   ENSRNOT00000093070
RefSeq Acc Id: ENSRNOP00000064166   ⟸   ENSRNOT00000074058
RefSeq Acc Id: ENSRNOP00000076633   ⟸   ENSRNOT00000113303
Protein Domains
ATP-cone

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U2Q5-F1-model_v2 AlphaFold Q5U2Q5 1-792 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690271
Promoter ID:EPDNEW_R795
Type:initiation region
Name:Rrm1_1
Description:ribonucleotide reductase catalytic subunit M1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01167,538,413 - 167,538,473EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1592569 AgrOrtholog
BioCyc Gene G2FUF-58247 BioCyc
BioCyc Pathway PWY-7184 [pyrimidine deoxyribonucleotides de novo biosynthesis I] BioCyc
  PWY-7210 [pyrimidine deoxyribonucleotides biosynthesis from CTP] BioCyc
  PWY-7226 [guanosine deoxyribonucleotides de novo biosynthesis I] BioCyc
  PWY-7227 [adenosine deoxyribonucleotides de novo biosynthesis I] BioCyc
BioCyc Pathway Image PWY-7184 BioCyc
  PWY-7210 BioCyc
  PWY-7226 BioCyc
  PWY-7227 BioCyc
Ensembl Genes ENSRNOG00000045752 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000074058 ENTREZGENE
  ENSRNOT00000074058.3 UniProtKB/TrEMBL
  ENSRNOT00000093070.2 UniProtKB/TrEMBL
  ENSRNOT00000113303.1 UniProtKB/TrEMBL
Gene3D-CATH 3.20.70.20 UniProtKB/TrEMBL
InterPro ATP-cone UniProtKB/TrEMBL
  NrdE_NrdA UniProtKB/TrEMBL
  Ribncl_Rdtase_lsu_N UniProtKB/TrEMBL
  Ribncl_red_lg_C UniProtKB/TrEMBL
  Ribnucl_Rdtase_R1-su_N UniProtKB/TrEMBL
  Rrm1 UniProtKB/TrEMBL
KEGG Report rno:685579 UniProtKB/TrEMBL
NCBI Gene 685579 ENTREZGENE
PANTHER PTHR11573 UniProtKB/TrEMBL
  RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT UniProtKB/TrEMBL
Pfam ATP-cone UniProtKB/TrEMBL
  Ribonuc_red_lgC UniProtKB/TrEMBL
  Ribonuc_red_lgN UniProtKB/TrEMBL
PhenoGen Rrm1 PhenoGen
PRINTS RIBORDTASEM1 UniProtKB/TrEMBL
PROSITE ATP_CONE UniProtKB/TrEMBL
  RIBORED_LARGE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000045752 RatGTEx
Superfamily-SCOP PFL-like glycyl radical enzymes UniProtKB/TrEMBL
  Ribonucleo_red_N UniProtKB/TrEMBL
UniProt A0A1B0GWQ3_RAT UniProtKB/TrEMBL
  A0A8I5Y915 ENTREZGENE, UniProtKB/TrEMBL
  M0R486 ENTREZGENE, UniProtKB/TrEMBL
  Q5U2Q5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-21 Rrm1  ribonucleotide reductase catalytic subunit M1  Rrm1  ribonucleotide reductase M1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 Rrm1  ribonucleotide reductase M1  LOC100361270  ribonucleotide reductase M1  Data merged from RGD:2320493 1643240 APPROVED
2010-05-05 LOC100361270  ribonucleotide reductase M1      Symbol and Name status set to provisional 70820 PROVISIONAL
2009-01-26 Rrm1  ribonucleotide reductase M1  LOC685579  similar to ribonucleotide reductase M1  Symbol and Name updated 1299863 APPROVED
2006-11-20 LOC685579  similar to ribonucleotide reductase M1      Symbol and Name status set to provisional 70820 PROVISIONAL