Mpo (myeloperoxidase) - Rat Genome Database

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Gene: Mpo (myeloperoxidase) Rattus norvegicus
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Symbol: Mpo
Name: myeloperoxidase
RGD ID: 1592081
Description: Enables peroxidase activity. Involved in several processes, including response to food; response to gold nanoparticle; and response to lipopolysaccharide. Located in extracellular space. Used to study acute kidney failure. Biomarker of chronic obstructive pulmonary disease; cystitis; and renovascular hypertension. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease 1; cystic fibrosis; kidney failure (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human MPO (myeloperoxidase); PARTICIPATES IN etoposide pharmacodynamics pathway; etoposide pharmacokinetics pathway; interleukin-23 signaling pathway; INTERACTS WITH (+)-taxifolin; (20S)-ginsenoside Rg3; (R)-carnitine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Mpo_mapped; myeloperoxidase (mapped)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Mpoem1Mcwi  
Genetic Models: SD-Mpoem1Mcwi
Candidate Gene For: Bp308
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81073,092,124 - 73,102,057 (+)NCBIGRCr8
mRatBN7.21072,594,883 - 72,608,862 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1072,594,661 - 72,604,819 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1077,205,622 - 77,215,277 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01076,710,570 - 76,720,225 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01072,175,076 - 72,184,731 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01075,087,892 - 75,098,260 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1075,087,892 - 75,098,260 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01075,004,128 - 75,014,496 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41076,085,872 - 76,097,012 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1071,507,771 - 71,517,382 (+)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IDA,ISO)
Acute Lung Injury  (ISO)
alcoholic liver cirrhosis  (ISO)
Alzheimer's disease  (ISO)
Alzheimer's disease 1  (ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
bacterial pneumonia  (ISO)
brain disease  (ISO)
Brain Hypoxia-Ischemia  (IEP)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Burns  (IEP,ISO)
cardiovascular system disease  (ISO)
Chronic Bronchitis  (IEP)
chronic obstructive pulmonary disease  (IEP,ISO)
colitis  (ISO)
Contrast-Induced Nephropathy  (IDA)
cystic fibrosis  (ISO)
cystitis  (IEP)
Drug Eruptions  (ISO)
end stage renal disease  (ISO)
Enteritis  (IEP)
Experimental Arthritis  (ISO)
Experimental Colitis  (IEP)
Experimental Diabetes Mellitus  (IEP,ISO)
extrahepatic cholestasis  (ISO)
glomerulonephritis  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hypoxia  (ISO)
Inflammation  (ISO)
intellectual disability  (ISO)
interstitial lung disease  (ISO)
Joubert syndrome 1  (ISO)
keratosis  (ISO)
Kidney Calculi  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (IEP,ISO)
liver cirrhosis  (ISO)
lung cancer  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
lupus nephritis  (ISO)
major depressive disorder  (ISO)
Myeloperoxidase Deficiency  (ISO)
Myocardial Ischemia  (ISO)
Occupational Diseases  (ISO)
pancreatic cancer  (ISO)
pancreatitis  (ISO)
pleurisy  (ISO)
pre-malignant neoplasm  (ISO)
Prostatic Neoplasms  (ISO)
renovascular hypertension  (IEP)
Reperfusion Injury  (IEP,ISO)
rheumatoid arthritis  (ISO)
Sepsis  (ISO)
Spinal Cord Injuries  (IEP)
status asthmaticus  (ISO)
Systemic Candidiasis  (ISO)
traumatic brain injury  (ISO)
trichuriasis  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
urticaria  (ISO)
vasculitis  (ISO)
Viral Bronchiolitis  (ISO)
Wounds and Injuries  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-isoborneol  (ISO)
(+)-taxifolin  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-ginsenoside Rg3  (EXP)
(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid  (ISO)
(R)-camphor  (ISO)
(R)-carnitine  (EXP)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-colchicine  (EXP)
(S)-nicotine  (EXP)
(Z)-ligustilide  (ISO)
1,2-dimethylhydrazine  (ISO)
1,2-phenylenediamine  (ISO)
1,4-benzoquinone  (ISO)
1,7-dimethylxanthine  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (EXP,ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
12-methyltetradecanoic acid  (ISO)
16,16-dimethylprostaglandin E2  (EXP)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (EXP)
2''-galloylhyperin  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-dichloroaniline  (ISO)
2,4-dimethylaniline  (ISO)
2,6-dihydroxybenzoic acid  (ISO)
2,6-dimethylaniline  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-arachidonoylglycerol  (ISO)
2-bromohexadecanoic acid  (ISO)
2-naphthylamine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-dichloroaniline  (ISO)
3,4-dihydroxybenzoic acid  (EXP,ISO)
3,4-dimethylaniline  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-acetyldeoxynivalenol  (ISO)
3-Amino-1-methyl-5H-pyrido[4,3-b]indole  (ISO)
3-aminobenzamide  (ISO)
3-Chloroaniline  (ISO)
3-methyladenine  (EXP)
3-phenylprop-2-enal  (EXP,ISO)
4'-epidoxorubicin  (EXP)
4'-hydroxydiclofenac  (ISO)
4,4'-methylene-bis-(2-chloroaniline)  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP,ISO)
4-amino-TEMPO  (ISO)
4-aminobenzhydrazide  (ISO)
4-carboxy-TEMPO  (ISO)
4-chloroaniline  (ISO)
4-fluoroaniline  (ISO)
4-hydroxy-TEMPO  (ISO)
4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester  (ISO)
4-nitroaniline  (ISO)
4-phenylbutyric acid  (ISO)
5,5-dimethyl-1-pyrroline N-oxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (EXP)
5-hydroxydiclofenac  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP,ISO)
6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (EXP,ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
abacavir  (ISO)
acetaldehyde  (ISO)
acetic acid  (EXP,ISO)
acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester  (ISO)
acetohydrazide  (ISO)
acetylsalicylic acid  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
albuterol  (ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (EXP,ISO)
Alkannin  (ISO)
all-trans-retinoic acid  (ISO)
allicin  (EXP)
allopurinol  (EXP)
alloxan  (EXP)
alpha-amanitin  (ISO)
Alpinetin  (ISO)
aluminium atom  (ISO)
aluminium oxide  (ISO)
aluminium(0)  (ISO)
ambroxol  (EXP)
amifostine  (ISO)
aminoglutethimide  (ISO)
aminoguanidine  (EXP)
amiodarone  (EXP)
ammonia  (ISO)
ammonium chloride  (EXP)
amodiaquine  (ISO)
amphetamine  (EXP)
ampicillin  (EXP)
andrographolide  (EXP)
aniline  (ISO)
anthocyanin  (EXP)
apocynin  (EXP,ISO)
arachidonic acid  (ISO)
arachidonyl-2'-chloroethylamide  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
artesunate  (EXP)
asbestos  (ISO)
asperuloside  (ISO)
astragaloside IV  (EXP)
atorvastatin calcium  (EXP)
baicalein  (ISO)
balsalazide  (ISO)
benzene  (ISO)
benzidine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzohydrazide  (ISO)
benzoic acid  (ISO)
Benzoyl peroxide  (ISO)
beraprost  (ISO)
berberine  (ISO)
Bergenin  (EXP)
beta-carotene  (EXP)
beta-D-glucosamine  (EXP)
biochanin A  (ISO)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP)
Bisphenol A diglycidyl ether  (EXP,ISO)
bisphenol F  (EXP)
bivalirudin  (ISO)
bleomycin A2  (EXP,ISO)
Boldine  (ISO)
budesonide  (EXP)
buta-1,3-diene  (ISO)
cadaverine  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
Calcimycin  (EXP,ISO)
calciol  (ISO)
camphor  (ISO)
candesartan  (EXP)
cannabidiol  (ISO)
capsaicin  (EXP)
capsazepine  (EXP,ISO)
carbendazim  (EXP)
CARBENOXOLONE  (ISO)
carbon nanotube  (EXP,ISO)
carboplatin  (EXP)
Cardamonin  (ISO)
carnosic acid  (ISO)
carnosine  (ISO)
carrageenan  (EXP)
carvacrol  (ISO)
carvedilol  (EXP,ISO)
celastrol  (EXP,ISO)
celecoxib  (EXP)
ceric oxide  (EXP,ISO)
cerium trichloride  (ISO)
ceruletide  (ISO)
CGP 52608  (ISO)
chalcones  (EXP)
chelerythrine  (ISO)
Chloralose  (ISO)
chlorogenic acid  (ISO)
chlorphenamine  (EXP)
chlorpyrifos  (EXP,ISO)
chondroitin sulfate  (EXP)
chrysin  (EXP)
ciprofloxacin  (EXP)
cirsilineol  (ISO)
cis-caffeic acid  (EXP,ISO)
cisplatin  (EXP,ISO)
clopidogrel  (ISO)
clozapine  (ISO)
cocaine  (EXP)
coenzyme Q10  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
cordycepin  (EXP)
corynoline  (ISO)
coumarins  (ISO)
crocidolite asbestos  (EXP,ISO)
crocin-1  (EXP)
cumene hydroperoxide  (ISO)
curcumin  (EXP,ISO)
cyanides  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
cysteamine  (EXP)
D-glucose  (EXP,ISO)
D-penicillamine  (ISO)
dapagliflozin  (EXP)
deoxynivalenol  (ISO)
desmethylnaproxen  (ISO)
dexamethasone  (EXP,ISO)
dextran  (ISO)
dextran sulfate  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
dibenziodolium  (ISO)
Dibromoacetonitrile  (ISO)
dichlorine  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (EXP,ISO)
Dihydrotanshinone I  (ISO)
dimethyl sulfoxide  (ISO)
Diosbulbin B  (ISO)
diosmin  (EXP)
dioxygen  (EXP)
diquat  (EXP)
disodium selenite  (EXP)
docebenone  (ISO)
domperidone  (ISO)
donepezil hydrochloride  (EXP,ISO)
doxorubicin  (EXP)
edaravone  (EXP)
efavirenz  (EXP)
emodin  (EXP)
enalapril  (EXP)
erdosteine  (EXP)
eriodictyol  (ISO)
ethambutol  (EXP)
ethanol  (EXP,ISO)
ethylenediamine  (ISO)
etoposide  (ISO)
eugenol  (EXP)
EUK-134  (EXP)
famotidine  (EXP,ISO)
Fargesin  (ISO)
fasudil  (ISO)
fenoterol  (ISO)
ferroheme b  (EXP)
ferulic acid  (ISO)
fisetin  (EXP)
flucloxacillin  (ISO)
fluconazole  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
Fraxinellone  (ISO)
fucoidan  (EXP,ISO)
fulvestrant  (EXP)
furan  (EXP)
gadolinium trichloride  (EXP)
galanthamine  (EXP)
gallic acid  (EXP,ISO)
gallocatechin  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gemcitabine  (ISO)
genistein  (EXP)
gentamycin  (EXP)
geraniol  (EXP,ISO)
gingerol  (EXP,ISO)
Ginkgolide C  (EXP)
ginsenoside Re  (ISO)
gliclazide  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
glutathione disulfide  (ISO)
glyburide  (EXP)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glycyrrhizinic acid  (ISO)
gossypin  (EXP)
GR 113808  (ISO)
granisetron  (ISO)
halothane  (EXP)
heme b  (EXP)
hemin  (EXP)
heparin  (ISO)
hesperetin  (EXP,ISO)
hesperidin  (EXP)
hexane-1,6-diamine  (ISO)
hispidulin  (ISO)
hyaluronic acid  (EXP)
hydrazine  (ISO)
hydrogen chloride  (EXP,ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxamic acid  (EXP)
hydroxysafflor yellow A  (ISO)
hypochlorous acid  (ISO)
ibuprofen  (EXP)
imidacloprid  (EXP)
imiquimod  (ISO)
IMP  (EXP)
indole-3-butyric acid  (EXP)
indometacin  (EXP,ISO)
irinotecan  (ISO)
iron atom  (EXP)
iron dextran  (EXP)
iron(0)  (EXP)
isatin  (EXP)
isoflurane  (EXP)
isoniazide  (ISO)
isoorientin  (EXP)
isoprenaline  (EXP)
isovitexin  (ISO)
ketoprofen  (EXP)
ketorolac  (EXP)
Kukoamine B  (ISO)
kynurenic acid  (ISO)
L-arginine  (EXP)
L-ascorbic acid  (EXP,ISO)
L-cysteine  (ISO)
L-leucine  (ISO)
L-threonine  (ISO)
Lafutidine  (EXP)
lamivudine  (EXP)
lansoprazole  (EXP)
lanthanum trichloride  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (ISO)
liquiritigenin  (EXP)
liquiritin  (EXP)
lisinopril dihydrate  (ISO)
lovastatin  (EXP)
loxoprofen  (EXP)
lupeol  (EXP,ISO)
luteolin  (EXP)
malathion  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP,ISO)
mangiferin  (ISO)
mechlorethamine  (ISO)
melatonin  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
mesalamine  (EXP,ISO)
Mesna  (ISO)
metacetamol  (ISO)
metformin  (ISO)
methimazole  (EXP)
methotrexate  (EXP)
methylene blue  (EXP)
metoclopramide  (ISO)
mirabegron  (EXP)
mirtazapine  (EXP)
MK 571  (ISO)
ML-7  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (EXP,ISO)
monotropein  (ISO)
montelukast  (EXP)
Morphiceptin  (ISO)
N'-acetylisoniazid  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N,N-dimethylformamide  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-[3-(aminomethyl)benzyl]acetamidine  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-ethyl-N-nitrosourea  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
n-propyl gallate  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naproxen  (ISO)
naringin  (EXP)
nickel atom  (EXP)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
nicorandil  (EXP)
nicotine  (EXP)
nimesulide  (EXP,ISO)
nitric oxide  (EXP,ISO)
nitroflurbiprofen  (EXP)
nitrogen dioxide  (ISO)
nitroglycerin  (EXP)
nitrososulfamethoxazole  (ISO)
notoginsenoside R1  (EXP,ISO)
NSC 23766  (ISO)
o-anisidine  (ISO)
o-toluidine  (ISO)
obeticholic acid  (ISO)
octadecanoic acid  (ISO)
olaparib  (ISO)
olmesartan  (EXP)
Olmesartan medoxomil  (EXP)
omeprazole  (EXP,ISO)
omethoate  (EXP)
Ono-AE1-329  (EXP)
oxaliplatin  (ISO)
p-toluidine  (ISO)
paclitaxel  (EXP)
pantoprazole  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentetrazol  (EXP)
pentobarbital  (EXP)
Pentoxifylline  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenethyl caffeate  (EXP)
phenethyl isothiocyanate  (ISO)
phenol  (ISO)
phenol red  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (EXP)
platycodin D  (EXP)
PNU-282987  (ISO)
polymyxin B2  (ISO)
Potassium 2,6-dihydroxytriazinecarboxylate  (EXP)
potassium chloride  (ISO)
potassium cyanide  (ISO)
prednisolone  (EXP,ISO)
probenecid  (ISO)
procainamide  (ISO)
procyanidin B2  (EXP)
progesterone  (ISO)
prostaglandin E2  (EXP)
putrescine  (ISO)
pyridaben  (ISO)
Pyridostigmine bromide  (EXP)
pyrrolidine dithiocarbamate  (ISO)
pyrvinium  (EXP)
quercetin  (EXP,ISO)
quetiapine fumarate  (ISO)
raloxifene  (EXP)
ranitidine  (EXP)
Rebamipide  (EXP,ISO)
resolvin D1  (ISO)
resolvin D2  (ISO)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
riboflavin  (EXP)
rifampicin  (EXP)
rifaximin  (ISO)
rolipram  (EXP,ISO)
rosmarinic acid  (EXP)
rotenone  (EXP,ISO)
ruthenium red  (ISO)
rutin  (EXP)
ruxolitinib  (ISO)
S-allylcysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
salicylic acid  (ISO)
saxagliptin  (EXP)
SB 203580  (EXP,ISO)
scalaradial  (ISO)
senecionine  (ISO)
serotonin  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (EXP)
sildenafil citrate  (EXP)
silibinin  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sinapic acid  (EXP)
Sinomenine  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium azide  (EXP,ISO)
sodium chloride  (ISO)
sodium cyanide  (ISO)
sodium fluoride  (EXP)
sodium hypochlorite  (ISO)
sodium nitrate  (EXP)
sodium thiosulfate pentahydrate  (EXP)
spermine  (ISO)
spironolactone  (EXP)
stattic  (ISO)
streptozocin  (EXP,ISO)
sulfamethoxazole  (ISO)
sulfasalazine  (EXP,ISO)
sulfur dioxide  (EXP)
superoxide  (ISO)
synephrine  (ISO)
syringic acid  (ISO)
syringin  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (EXP)
taurine  (EXP,ISO)
taurocholic acid  (EXP)
telmisartan  (EXP,ISO)
TEMPO  (ISO)
tenofovir disoproxil fumarate  (EXP)
terbufos  (ISO)
terbutaline  (ISO)
tetrachloromethane  (EXP,ISO)
tetracyclines  (ISO)
tetramethylpyrazine  (ISO)
thalidomide  (ISO)
theophylline  (EXP,ISO)
thiabendazole  (ISO)
thiazolidines  (EXP)
thioacetamide  (EXP,ISO)
thiophenes  (ISO)
thymoquinone  (EXP)
tianeptine  (EXP)
tiquizium bromide  (EXP)
titanium dioxide  (ISO)
trans-caffeic acid  (EXP,ISO)
tributylstannane  (EXP)
trichloroacetic acid  (ISO)
trichostatin A  (ISO)
trimethylenediamine  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
tropisetron  (EXP,ISO)
tungsten  (ISO)
umbelliferone  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
usnic acid  (EXP)
valproic acid  (EXP,ISO)
verapamil  (EXP)
vinclozolin  (EXP)
Vinpocetine  (ISO)
vitamin E  (EXP)
warfarin  (EXP)
WIN 55212-2  (ISO)
withaferin A  (EXP)
wortmannin  (EXP,ISO)
zafirlukast  (EXP)
zearalenone  (EXP,ISO)
zileuton  (EXP,ISO)
zinc atom  (EXP)
zinc oxide  (ISO)
zinc protoporphyrin  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Levels of IL-8 and myeloperoxidase in the lungs of pneumonia patients. Abul H, etal., Mol Cell Biochem. 2001 Jan;217(1-2):107-12.
2. Susceptibility to arsenic-induced hyperkeratosis and oxidative stress genes myeloperoxidase and catalase. Ahsan H, etal., Cancer Lett. 2003 Nov 10;201(1):57-65.
3. Bronchoalveolar matrix metalloproteinase 9 relates to restrictive lung function impairment in systemic sclerosis. Andersen GN, etal., Respir Med. 2007 Oct;101(10):2199-206. Epub 2007 Jul 20.
4. Critical role of myeloperoxidase and nicotinamide adenine dinucleotide phosphate-oxidase in high-burden systemic infection of mice with Candida albicans. Aratani Y, etal., J Infect Dis. 2002 Jun 15;185(12):1833-7. doi: 10.1086/340635. Epub 2002 May 16.
5. Effect of sodium bicarbonate in an experimental model of radiocontrast nephropathy. Barlak A, etal., Ren Fail. 2010;32(8):992-9.
6. Association of the G-463A myeloperoxidase gene polymorphism with renal disease in African Americans with systemic lupus erythematosus. Bouali H, etal., J Rheumatol. 2007 Oct;34(10):2028-34. Epub 2007 Sep 15.
7. Augmented inducible nitric oxide synthase expression and increased NO production reduce sepsis-induced lung injury and mortality in myeloperoxidase-null mice. Brovkovych V, etal., Am J Physiol Lung Cell Mol Physiol. 2008 Jul;295(1):L96-103. Epub 2008 Apr 18.
8. Lycopene inhibits caspase-3 activity and reduces oxidative organ damage in a rat model of thermal injury. Cevik O, etal., Burns. 2012 Sep;38(6):861-71. doi: 10.1016/j.burns.2012.01.006. Epub 2012 Feb 20.
9. THE ROLE OF CALCITONIN RECEPTOR-LIKE RECEPTOR IN COLONIC MOTILITY AND INFLAMMATION. Clifton MS, etal., Am J Physiol Gastrointest Liver Physiol. 2007 Mar 15;.
10. Inhibition of myeloperoxidase release from rat polymorphonuclear leukocytes by a series of azachalcone derivatives. Edwards ML, etal., J Med Chem. 1994 Dec 9;37(25):4357-62.
11. 15-epi-lipoxin A4 inhibits myeloperoxidase signaling and enhances resolution of acute lung injury. El Kebir D, etal., Am J Respir Crit Care Med. 2009 Aug 15;180(4):311-9. Epub 2009 May 29.
12. Melatonin improves cardiovascular function and ameliorates renal, cardiac and cerebral damage in rats with renovascular hypertension. Ersahin M, etal., J Pineal Res. 2009 Aug;47(1):97-106. Epub 2009 Jun 22.
13. Montelukast inhibits caspase-3 activity and ameliorates oxidative damage in the spinal cord and urinary bladder of rats with spinal cord injury. Ersahin M, etal., Prostaglandins Other Lipid Mediat. 2012 Sep 15. pii: S1098-8823(12)00119-0. doi: 10.1016/j.prostaglandins.2012.09.002.
14. Serum ECP and MPO are increased during exacerbations of chronic bronchitis with airway obstruction. Fiorini G, etal., Biomed Pharmacother. 2000 Jun;54(5):274-8.
15. Myeloperoxidase and adenosine-deaminase levels in the pleural fluid leakage induced by carrageenan in the mouse model of pleurisy. Frode TS and Medeiros YS, Mediators Inflamm. 2001 Aug;10(4):223-7.
16. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
17. Dexmedetomidine attenuates remote lung injury induced by renal ischemia-reperfusion in mice. Gu J, etal., Acta Anaesthesiol Scand. 2011 Nov;55(10):1272-8. doi: 10.1111/j.1399-6576.2011.02526.x. Epub 2011 Sep 26.
18. The oxidation induced by anti-MPO antibodies triggers fibrosis in microscopic polyangiitis. Guilpain P, etal., Eur Respir J. 2010 Nov 11.
19. Serum levels of eosinophilic cationic protein (ECP), myeloperoxidase (MPO), lipid peroxidation products, interleukin (IL)-5 and interferon (IFN)-gamma in children with bronchial asthma at acute asthma attack and remission. Kalayci O, etal., Turk J Pediatr. 2000 Jan-Mar;42(1):9-16.
20. Association of a myeloperoxidase promoter polymorphism with multiple sclerosis. Kantarci OH, etal., J Neuroimmunol 2000 Jun 26;105(2):189-94.
21. Halofuginone has a beneficial effect on gentamicin-induced acute nephrotoxicity in rats. Karakoyun B, etal., Drug Chem Toxicol. 2009;32(4):312-8.
22. [MPO-positive cells and extracellular MPO in the glomeruli of MPO-ANCA-associated glomerulonephritis]. Kawashima S, etal., Nihon Jinzo Gakkai Shi. 2009;51(1):56-67.
23. [Changes in nitric oxide, prostaglandins and myeloperoxidase activity in acrolein-induced cystitis in rats]. Linares-Fernandez B and Alfieri AB, Invest Clin. 2009 Mar;50(1):23-33.
24. [A study on tumor necrosis factor alpha, macrophage inflammatory protein-2 and myeloperoxidase in blood, broncho-alveolar fluid and lung tissues of rat chronic bronchitis model]. Ma N, etal., Zhonghua Nei Ke Za Zhi. 1999 Aug;38(8):523-6.
25. Myeloperoxidase is critically involved in the induction of organ damage after renal ischemia reperfusion. Matthijsen RA, etal., Am J Pathol. 2007 Dec;171(6):1743-52. Epub 2007 Nov 30.
26. Diazoxide attenuates indomethacin-induced small intestinal damage in the rat. Menozzi A, etal., Eur J Pharmacol. 2011 Jan 10;650(1):378-83. Epub 2010 Oct 13.
27. Analysis of differential gene expression in rat tibia after an osteogenic stimulus in vivo: mechanical loading regulates osteopontin and myeloperoxidase. Miles RR, etal., J Cell Biochem. 1998 Mar 1;68(3):355-65.
28. Novel dry powder formulation of ovalbumin for development of COPD-like animal model: Physicochemical characterization and biomarker profiling in rats. Misaka S, etal., Eur J Pharm Sci. 2009 Jun 28;37(3-4):469-76. Epub 2009 Apr 10.
29. Myeloperoxidase and superoxide dismutase 2 polymorphisms comodulate the risk of hepatocellular carcinoma and death in alcoholic cirrhosis. Nahon P, etal., Hepatology. 2009 Nov;50(5):1484-93. doi: 10.1002/hep.23187.
30. A variant in myeloperoxidase promoter hastens the emergence of hepatocellular carcinoma in patients with HCV-related cirrhosis. Nahon P, etal., J Hepatol. 2012 Feb;56(2):426-32. doi: 10.1016/j.jhep.2011.08.010. Epub 2011 Sep 8.
31. Protein nitration in rat lungs during hyperoxia exposure: a possible role of myeloperoxidase. Narasaraju TA, etal., Am J Physiol Lung Cell Mol Physiol 2003 Nov;285(5):L1037-45. Epub 2003 Aug 15.
32. Endogenous myeloperoxidase promotes neutrophil-mediated renal injury, but attenuates T cell immunity inducing crescentic glomerulonephritis. Odobasic D, etal., J Am Soc Nephrol. 2007 Mar;18(3):760-70. Epub 2007 Jan 31.
33. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
34. A functional variant of the myeloperoxidase gene is associated with cardiovascular disease in end-stage renal disease patients. Pecoits-Filho R, etal., Kidney Int Suppl. 2003 May;(84):S172-6.
35. Effects of gold nanoparticles on endotoxin-induced uveitis in rats. Pereira DV, etal., Invest Ophthalmol Vis Sci. 2012 Dec 7;53(13):8036-41. doi: 10.1167/iovs.12-10743.
36. Polymorphisms in the myeloperoxidase gene locus are associated with acute kidney injury-related outcomes. Perianayagam MC, etal., Kidney Int. 2012 Oct;82(8):909-19. doi: 10.1038/ki.2012.235. Epub 2012 Jun 27.
37. Neuroinflammation after neonatal hypoxia-ischemia is associated with alterations in the purinergic system: adenosine deaminase 1 isoenzyme is the most predominant after insult. Pimentel VC, etal., Mol Cell Biochem. 2015 May;403(1-2):169-77. doi: 10.1007/s11010-015-2347-9. Epub 2015 Feb 27.
38. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
39. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
40. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
41. Genetic variation of myeloperoxidase gene contributes to atopic asthma susceptibility: a preliminary association study in Russian population. Polonikov AV, etal., J Asthma. 2009 Jun;46(5):523-8.
42. Myeloperoxidase promoter polymorphism -463G is associated with more severe clinical expression of cystic fibrosis pulmonary disease. Reynolds WF, etal., Mediators Inflamm. 2006;2006(2):36735.
43. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
44. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
45. Diagnostic efficacy of myeloperoxidase for the detection of acute coronary syndromes. Sawicki M, etal., Eur J Clin Invest. 2011 Jan 12. doi: 10.1111/j.1365-2362.2010.02457.x.
46. Opposing effects of emphysema, hay fever, and select genetic variants on lung cancer risk. Schabath MB, etal., Am J Epidemiol. 2005 Mar 1;161(5):412-22.
47. Eosinophil cationic protein in nasal secretion and in serum and myeloperoxidase in serum in respiratory syncytial virus bronchiolitis: relation to asthma and atopy. Sigurs N, etal., Acta Paediatr. 1994 Nov;83(11):1151-5.
48. Ischemia-reperfusion injury-induced pulmonary mitochondrial damage. Sommer SP, etal., J Heart Lung Transplant. 2011 Apr 4.
49. Aging effect on myeloperoxidase in rat kidney and its modulation by calorie restriction. Son TG, etal., Free Radic Res. 2005 Mar;39(3):283-9.
50. Protective effect of infliximab on ischemia/reperfusion-induced damage in rat kidney. Tasdemir C, etal., Ren Fail. 2012;34(9):1144-9. doi: 10.3109/0886022X.2012.717490. Epub 2012 Sep 6.
51. Multiple risk markers for atherogenesis associated with chronic inflammation are detectable in patients with renal stones. Tsao KC, etal., J Clin Lab Anal. 2007;21(6):426-31.
52. The effect of experimental diabetes on the circadian pattern of adenosine deaminase and myeloperoxidase activities in rat liver. Uluoglu C, etal., Gen Physiol Biophys. 2008 Mar;27(1):25-31.
53. Evaluation of thiol-based antioxidant therapeutics in cystic fibrosis sputum: Focus on myeloperoxidase. Vasu VT, etal., Free Radic Res. 2011 Feb;45(2):165-76. Epub 2010 Oct 18.
54. Prognostic value of plasma myeloperoxidase in ESRD patients. Wang AY, etal., Am J Kidney Dis. 2010 Nov;56(5):937-46. Epub 2010 Jul 16.
55. Galantamine anti-colitic effect: Role of alpha-7 nicotinic acetylcholine receptor in modulating Jak/STAT3, NF-κB/HMGB1/RAGE and p-AKT/Bcl-2 pathways. Wazea SA, etal., Sci Rep. 2018 Mar 23;8(1):5110. doi: 10.1038/s41598-018-23359-6.
56. Myeloperoxidase and superoxide dismutase polymorphisms are associated with an increased risk of developing pancreatic adenocarcinoma. Wheatley-Price P, etal., Cancer. 2008 Mar 1;112(5):1037-42.
57. Clinical features of patients with anti-neutrophil cytoplasmic autoantibodies targeting native myeloperoxidase antigen. Yamanishi Y, etal., Mod Rheumatol. 2012 Oct 21.
Additional References at PubMed
PMID:2981589   PMID:10085024   PMID:10772654   PMID:11792727   PMID:11907569   PMID:11980719   PMID:12089442   PMID:14613914   PMID:14651853   PMID:15159534   PMID:15878909   PMID:16502470  
PMID:17072967   PMID:17950080   PMID:18283562   PMID:18617697   PMID:19056867   PMID:19301098   PMID:19330621   PMID:20228064   PMID:21327394   PMID:21630459   PMID:21704008   PMID:23376485  
PMID:23533145   PMID:23691142   PMID:24035742   PMID:25404055   PMID:25645918   PMID:26474698   PMID:28131839   PMID:28466093   PMID:29270751   PMID:32762560   PMID:37981258  


Genomics

Comparative Map Data
Mpo
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81073,092,124 - 73,102,057 (+)NCBIGRCr8
mRatBN7.21072,594,883 - 72,608,862 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1072,594,661 - 72,604,819 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1077,205,622 - 77,215,277 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01076,710,570 - 76,720,225 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01072,175,076 - 72,184,731 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01075,087,892 - 75,098,260 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1075,087,892 - 75,098,260 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01075,004,128 - 75,014,496 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41076,085,872 - 76,097,012 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1071,507,771 - 71,517,382 (+)NCBICelera
Cytogenetic Map10q26NCBI
MPO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381758,269,855 - 58,280,935 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1758,269,855 - 58,280,935 (-)EnsemblGRCh38hg38GRCh38
GRCh371756,347,216 - 56,358,296 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361753,702,216 - 53,713,295 (-)NCBINCBI36Build 36hg18NCBI36
Build 341753,702,215 - 53,713,295NCBI
Celera1752,808,995 - 52,820,066 (-)NCBICelera
Cytogenetic Map17q22NCBI
HuRef1751,708,013 - 51,718,966 (-)NCBIHuRef
CHM1_11756,412,238 - 56,423,315 (-)NCBICHM1_1
T2T-CHM13v2.01759,137,736 - 59,148,814 (-)NCBIT2T-CHM13v2.0
Mpo
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391187,684,610 - 87,695,238 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1187,684,407 - 87,695,239 (+)EnsemblGRCm39 Ensembl
GRCm381187,793,784 - 87,804,412 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1187,793,581 - 87,804,413 (+)EnsemblGRCm38mm10GRCm38
MGSCv371187,607,286 - 87,617,914 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361187,609,776 - 87,620,592 (+)NCBIMGSCv36mm8
Celera1197,389,547 - 97,400,150 (+)NCBICelera
Cytogenetic Map11CNCBI
cM Map1152.22NCBI
Mpo
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554514,743,744 - 4,753,358 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554514,743,744 - 4,753,358 (+)NCBIChiLan1.0ChiLan1.0
MPO
(Pan paniscus - bonobo/pygmy chimpanzee)		 <
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowse