Garem1 (GRB2 associated regulator of MAPK1 subtype 1) - Rat Genome Database

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Gene: Garem1 (GRB2 associated regulator of MAPK1 subtype 1) Rattus norvegicus
Analyze
Symbol: Garem1
Name: GRB2 associated regulator of MAPK1 subtype 1
RGD ID: 1591842
Description: Predicted to enable proline-rich region binding activity. Predicted to be involved in several processes, including cellular response to epidermal growth factor stimulus; epidermal growth factor receptor signaling pathway; and positive regulation of ERK1 and ERK2 cascade. Orthologous to human GAREM1 (GRB2 associated regulator of MAPK1 subtype 1); INTERACTS WITH amphetamine; bisphenol A; tetrachloromethane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Garem; GRB2 associated regulator of MAPK1, member 1; GRB2 associated, regulator of MAPK1; GRB2-associated and regulator of MAPK protein 1; GRB2-associated and regulator of MAPK protein-like; LOC498827; LOC679154; RGD1562080; similar to DNA-directed RNA polymerase II largest subunit (RPB1); similar to Hypothetical protein CBG10141
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81812,695,082 - 12,860,219 (-)NCBIGRCr8
mRatBN7.21812,420,169 - 12,585,323 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1812,423,882 - 12,585,345 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01814,982,604 - 15,007,245 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1812,224,514 - 12,284,188 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1812,224,514 - 12,284,188 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01814,769,102 - 14,791,523 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41812,944,256 - 12,946,270 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1812,415,517 - 12,519,188 (-)NCBICelera
Cytogenetic Map18p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:19509291   PMID:24003223  


Genomics

Comparative Map Data
Garem1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81812,695,082 - 12,860,219 (-)NCBIGRCr8
mRatBN7.21812,420,169 - 12,585,323 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1812,423,882 - 12,585,345 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01814,982,604 - 15,007,245 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1812,224,514 - 12,284,188 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1812,224,514 - 12,284,188 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01814,769,102 - 14,791,523 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41812,944,256 - 12,946,270 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1812,415,517 - 12,519,188 (-)NCBICelera
Cytogenetic Map18p12NCBI
GAREM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381832,263,522 - 32,470,882 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1832,124,877 - 32,470,882 (-)EnsemblGRCh38hg38GRCh38
GRCh371829,843,485 - 30,050,845 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361828,101,461 - 28,304,445 (-)NCBINCBI36Build 36hg18NCBI36
Build 341828,101,474 - 28,304,445NCBI
Celera1826,654,417 - 26,857,408 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
HuRef1826,700,077 - 26,907,135 (-)NCBIHuRef
CHM1_11829,770,990 - 29,977,911 (-)NCBICHM1_1
T2T-CHM13v2.01832,453,815 - 32,661,186 (-)NCBIT2T-CHM13v2.0
Garem1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391821,257,916 - 21,433,196 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1821,260,258 - 21,433,195 (-)EnsemblGRCm39 Ensembl
GRCm381821,127,342 - 21,300,139 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1821,127,201 - 21,300,138 (-)EnsemblGRCm38mm10GRCm38
MGSCv371821,285,843 - 21,458,640 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361821,270,211 - 21,443,148 (-)NCBIMGSCv36mm8
Celera1821,623,035 - 21,796,413 (-)NCBICelera
Cytogenetic Map18A2NCBI
cM Map1811.87NCBI
Garem1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540219,469,649 - 19,663,654 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540219,469,652 - 19,663,654 (-)NCBIChiLan1.0ChiLan1.0
GAREM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21749,639,460 - 49,847,521 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11835,332,057 - 35,540,119 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01825,470,702 - 25,678,146 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11829,065,053 - 29,272,225 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1829,065,053 - 29,272,231 (-)Ensemblpanpan1.1panPan2
GAREM1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1757,158,005 - 57,423,643 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl757,295,070 - 57,419,252 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha756,654,442 - 56,856,713 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0757,196,399 - 57,404,576 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl757,195,979 - 57,400,589 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1756,881,075 - 57,082,118 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0756,898,894 - 57,100,606 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0757,195,790 - 57,397,330 (+)NCBIUU_Cfam_GSD_1.0
Garem1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494452,926,545 - 53,066,880 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936682947,487 - 1,068,482 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936682947,420 - 1,068,468 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GAREM1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6116,100,372 - 116,325,133 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16116,100,371 - 116,324,853 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26108,838,673 - 109,028,414 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GAREM1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11848,287,589 - 48,483,135 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1848,287,579 - 48,483,552 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605022,837,054 - 23,033,716 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Garem1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624770500,641 - 728,014 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624770501,113 - 727,736 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Garem1
1050 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301410Bp317Blood pressure QTL 3170.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194427326548295Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194179131393320Rat
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18125758124Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
1331781Scl28Serum cholesterol level QTL 283.995blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)181194429924797117Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
2312568Glom21Glomerulus QTL 2120.005kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)18518585840503530Rat
1331766Bp236Blood pressure QTL 2363.022arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194429931359530Rat
70178EaezExperimental allergic encephalomyelitis QTL z2.4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)181235778612874620Rat
631264Scl22Serum cholesterol level QTL 226.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)181194179131393320Rat
12904680Bw189Body weight QTL 1890.019body mass (VT:0001259)body weight (CMO:0000012)181194427326548295Rat
2293708Bss46Bone structure and strength QTL 468.80.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)181179151863636873Rat
1641910Colcr3Colorectal carcinoma resistance QTL 35.020.000007intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)18224947722066430Rat
12904693Am20Aortic mass QTL 200.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)181194427326548295Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat
1578667Bss21Bone structure and strength QTL 213.5femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)181179151883218561Rat
12904695Kidm73Kidney mass QTL 730.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)181194427326548295Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18130558703Rat
12904689Cm128Cardiac mass QTL 1280.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)181194427326548295Rat
12904690Cm129Cardiac mass QTL 1290.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)181194427326548295Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat
12904691Cm130Cardiac mass QTL 1300.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)181194427326548295Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18125758124Rat
2299160Iddm35Insulin dependent diabetes mellitus QTL 352.79blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)18420794160377792Rat
1578661Bss20Bone structure and strength QTL 203.7femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)181179151883218561Rat
1331753Bp231Blood pressure QTL 2313.643arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194429952293055Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134291613Rat
61375Bp41Blood pressure QTL 412.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)181194429941122201Rat

Markers in Region
AU047296  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81812,729,126 - 12,729,324 (+)Marker Load Pipeline
mRatBN7.21812,454,210 - 12,454,409 (-)MAPPERmRatBN7.2
Rnor_6.01814,992,080 - 14,992,278NCBIRnor6.0
Rnor_5.01814,776,706 - 14,776,904UniSTSRnor5.0
Celera1812,445,611 - 12,445,809UniSTS
WI-14403  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21812,423,905 - 12,424,053 (-)MAPPERmRatBN7.2
Rnor_6.01815,032,610 - 15,032,757NCBIRnor6.0
Rnor_5.01814,816,887 - 14,817,034UniSTSRnor5.0
Celera1812,415,280 - 12,415,427UniSTS
AU049676  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21812,442,334 - 12,442,576 (-)MAPPERmRatBN7.2
Rnor_6.01815,007,872 - 15,008,113NCBIRnor6.0
Rnor_6.01815,014,688 - 15,014,929NCBIRnor6.0
Rnor_5.01814,799,314 - 14,799,555UniSTSRnor5.0
Rnor_5.01814,792,498 - 14,792,739UniSTSRnor5.0
Celera1812,433,735 - 12,433,976UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000083236
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1812,224,514 - 12,284,188 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095044   ⟹   ENSRNOP00000089678
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1812,423,882 - 12,549,791 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100631   ⟹   ENSRNOP00000087833
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1812,423,882 - 12,585,345 (-)Ensembl
RefSeq Acc Id: NM_001427249   ⟹   NP_001414178
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81812,695,082 - 12,860,219 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001414178 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000087833.1
  ENSRNOP00000089678.1
Ensembl Acc Id: ENSRNOP00000087833   ⟸   ENSRNOT00000100631
Ensembl Acc Id: ENSRNOP00000089678   ⟸   ENSRNOT00000095044
RefSeq Acc Id: NP_001414178   ⟸   NM_001427249
- UniProtKB: A0A8I6AHF4 (UniProtKB/TrEMBL)
Protein Domains
CABIT

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1591842 AgrOrtholog
BioCyc Gene G2FUF-8203 BioCyc
Ensembl Genes ENSRNOG00000060341 Ensembl
  ENSRNOG00000062552 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000095044.1 UniProtKB/TrEMBL
  ENSRNOT00000100631.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/TrEMBL
InterPro CABIT_dom UniProtKB/TrEMBL
  GAREM UniProtKB/TrEMBL
  SAM/pointed_sf UniProtKB/TrEMBL
NCBI Gene 679154 ENTREZGENE
PANTHER GRB2-ASSOCIATED AND REGULATOR OF MAPK PROTEIN 1 UniProtKB/TrEMBL
  GRB2-ASSOCIATED AND REGULATOR OF MAPK PROTEIN FAMILY MEMBER UniProtKB/TrEMBL
Pfam CABIT UniProtKB/TrEMBL
PhenoGen Garem1 PhenoGen
RatGTEx ENSRNOG00000060341 RatGTEx
  ENSRNOG00000062552 RatGTEx
Superfamily-SCOP SSF47769 UniProtKB/TrEMBL
UniProt A0A8I6AC94_RAT UniProtKB/TrEMBL
  A0A8I6AHF4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Garem1  GRB2 associated regulator of MAPK1 subtype 1  Garem1  GRB2 associated regulator of MAPK1 subtype 1  Data merged from RGD:149736220 737654 PROVISIONAL
2021-08-09 Garem1  GRB2 associated regulator of MAPK1 subtype 1      Symbol and Name status set to provisional 45752 PROVISIONAL
2021-03-09 Garem1  GRB2 associated regulator of MAPK1 subtype 1  RGD1562080  similar to Hypothetical protein CBG10141  Data merged from RGD:1562080 737654 PROVISIONAL
2016-11-14 Garem1  GRB2 associated regulator of MAPK1 subtype 1  Garem1  GRB2 associated regulator of MAPK1, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-11-12 Garem1  GRB2 associated regulator of MAPK1, member 1  Garem  GRB2 associated, regulator of MAPK1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-09 Garem  GRB2 associated, regulator of MAPK1  LOC679154  similar to DNA-directed RNA polymerase II largest subunit (RPB1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1562080  similar to Hypothetical protein CBG10141   RGD1562080_predicted  similar to Hypothetical protein CBG10141 (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-20 LOC679154  similar to DNA-directed RNA polymerase II largest subunit (RPB1)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-07 RGD1562080_predicted  similar to Hypothetical protein CBG10141 (predicted)  LOC498827  similar to Hypothetical protein CBG10141  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498827  similar to Hypothetical protein CBG10141      Symbol and Name status set to provisional 70820 PROVISIONAL