Hist1h3b (histone cluster 1, H3b) - Rat Genome Database

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Gene: Hist1h3b (histone cluster 1, H3b) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Hist1h3b (Ensembl: H3c1)
Name: histone cluster 1, H3b (Ensembl:H3 clustered histone 1)
RGD ID: 1591702
Description: Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be a structural constituent of chromatin. Predicted to be located in nucleus. Predicted to be part of nucleosome. Orthologous to several human genes including H3C12 (H3 clustered histone 12); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; gentamycin; paracetamol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: histone H3; histone H3.1; LOC680498; similar to CG31613-PA; uncharacterized protein LOC680498
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81747,419,196 - 47,419,668 (+)NCBIGRCr8
mRatBN7.21742,723,453 - 42,723,925 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1742,723,450 - 42,723,911 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01744,760,023 - 44,764,058 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1744,839,721 - 44,840,131 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1743,616,247 - 43,616,657 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1744,763,598 - 44,764,008 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1743,814,773 - 43,815,183 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01758,702,404 - 58,707,449 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41750,354,359 - 50,354,769 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1753,737,495 - 53,737,984 (-)NCBICelera
Cytogenetic Map17p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleoplasm  (TAS)
nucleosome  (IEA)
nucleus  (ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14718166   PMID:16267050   PMID:20498094   PMID:21636898   PMID:22720776   PMID:24699735   PMID:25615412   PMID:37897558  


Genomics

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:22
Count of miRNA genes:22
Interacting mature miRNAs:22
Transcripts:ENSRNOT00000075332
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)171864018263640182Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318457246843Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172702794956836890Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173136839162109574Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173199078450909196Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173455084373951021Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173583708569599340Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174054004180387013Rat
1358295Aocep1Aortic cell protein QTL 16.10.00000071thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
631497Bp98Blood pressure QTL 983.66arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)174135465160463643Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)174207316069599340Rat
1354635Bp245Blood pressure QTL 2456arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)174207316069599340Rat


Expression


Sequence


RefSeq Acc Id: ENSRNOT00000072019   ⟹   ENSRNOP00000064431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1743,616,247 - 43,616,657 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000073188   ⟹   ENSRNOP00000067217
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1743,814,773 - 43,815,183 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079880   ⟹   ENSRNOP00000074909
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1744,763,598 - 44,764,008 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000083417   ⟹   ENSRNOP00000069899
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1744,839,721 - 44,840,131 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000117255   ⟹   ENSRNOP00000095460
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1742,723,450 - 42,723,911 (+)Ensembl
RefSeq Acc Id: NM_001408765   ⟹   NP_001395694
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81747,419,196 - 47,419,668 (+)NCBI
mRatBN7.21742,723,453 - 42,723,925 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001395694 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000095460
RefSeq Acc Id: ENSRNOP00000074909   ⟸   ENSRNOT00000079880
RefSeq Acc Id: ENSRNOP00000067217   ⟸   ENSRNOT00000073188
RefSeq Acc Id: ENSRNOP00000069899   ⟸   ENSRNOT00000083417
RefSeq Acc Id: ENSRNOP00000064431   ⟸   ENSRNOT00000072019
RefSeq Acc Id: ENSRNOP00000095460   ⟸   ENSRNOT00000117255
RefSeq Acc Id: NP_001395694   ⟸   NM_001408765
- UniProtKB: Q6LED0 (UniProtKB/Swiss-Prot),   A6KLL9 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6LED0-F1-model_v2 AlphaFold Q6LED0 1-136 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1591702 AgrOrtholog
BioCyc Gene G2FUF-9248 BioCyc
Ensembl Genes ENSRNOG00000046144 Ensembl
  ENSRNOG00000046434 Ensembl
  ENSRNOG00000054539 Ensembl
  ENSRNOG00000056281 Ensembl
  ENSRNOG00000063167 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000117255 ENTREZGENE
NCBI Gene 680498 ENTREZGENE
PhenoGen Hist1h3b PhenoGen
RatGTEx ENSRNOG00000046144 RatGTEx
  ENSRNOG00000046434 RatGTEx
  ENSRNOG00000054539 RatGTEx
  ENSRNOG00000056281 RatGTEx
  ENSRNOG00000063167 RatGTEx
UniProt A6KLL9 ENTREZGENE
  Q6LED0 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-01 Hist1h3b  histone cluster 1, H3b  Hist1h3b  histone cluster 1, H3b  Data merged from RGD:149736167 737654 PROVISIONAL
2021-08-09 Hist1h3b  histone cluster 1, H3b      Symbol and Name status set to provisional 45752 PROVISIONAL
2010-04-21 Hist1h3b  histone cluster 1, H3b  LOC680498  similar to CG31613-PA  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC680498  similar to CG31613-PA      Symbol and Name status set to provisional 70820 PROVISIONAL