Tmc8 (transmembrane channel-like 8) - Rat Genome Database

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Gene: Tmc8 (transmembrane channel-like 8) Rattus norvegicus
Analyze
Symbol: Tmc8
Name: transmembrane channel-like 8
RGD ID: 1591150
Description: Predicted to enable mechanosensitive monoatomic ion channel activity; protein sequestering activity; and tumor necrosis factor binding activity. Predicted to be involved in intracellular zinc ion homeostasis; negative regulation of protein-containing complex assembly; and regulation of extrinsic apoptotic signaling pathway via death domain receptors. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and nuclear membrane. Human ortholog(s) of this gene implicated in epidermodysplasia verruciformis. Orthologous to human TMC8 (transmembrane channel like 8); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC688276; LOC688276; similar to epidermodysplasia verruciformis 2; transmembrane channel-like protein 8; uncharacterized protein LOC688276
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810103,498,505 - 103,509,496 (+)NCBIGRCr8
mRatBN7.210103,000,038 - 103,010,601 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10102,998,402 - 103,010,590 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10108,101,471 - 108,111,735 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010107,564,576 - 107,574,841 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010102,921,135 - 102,931,383 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010106,784,819 - 106,795,307 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10106,785,077 - 106,795,299 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010106,422,924 - 106,433,661 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera10101,561,134 - 101,571,408 (+)NCBICelera
Cytogenetic Map10q32.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12426567   PMID:12477932   PMID:18158319   PMID:20458337   PMID:22664934   PMID:23429285  


Genomics

Comparative Map Data
Tmc8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810103,498,505 - 103,509,496 (+)NCBIGRCr8
mRatBN7.210103,000,038 - 103,010,601 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10102,998,402 - 103,010,590 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10108,101,471 - 108,111,735 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010107,564,576 - 107,574,841 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010102,921,135 - 102,931,383 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010106,784,819 - 106,795,307 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10106,785,077 - 106,795,299 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010106,422,924 - 106,433,661 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera10101,561,134 - 101,571,408 (+)NCBICelera
Cytogenetic Map10q32.2NCBI
TMC8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381778,130,771 - 78,142,968 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1778,130,770 - 78,142,968 (+)EnsemblGRCh38hg38GRCh38
GRCh371776,126,852 - 76,139,049 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361773,638,464 - 73,649,033 (+)NCBINCBI36Build 36hg18NCBI36
Build 341773,638,463 - 73,649,033NCBI
Celera1772,723,257 - 72,735,447 (+)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1771,551,134 - 71,563,324 (+)NCBIHuRef
CHM1_11776,191,412 - 76,203,602 (+)NCBICHM1_1
T2T-CHM13v2.01779,024,550 - 79,036,746 (+)NCBIT2T-CHM13v2.0
Tmc8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911117,672,396 - 117,683,963 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11117,672,902 - 117,683,936 (+)EnsemblGRCm39 Ensembl
GRCm3811117,781,584 - 117,793,137 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11117,782,076 - 117,793,110 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711117,644,364 - 117,654,342 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611117,599,140 - 117,609,118 (+)NCBIMGSCv36mm8
Celera11129,527,125 - 129,537,071 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1182.96NCBI
Tmc8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555064,412,484 - 4,422,520 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555064,412,478 - 4,423,397 (-)NCBIChiLan1.0ChiLan1.0
TMC8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21994,178,291 - 94,194,557 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11799,006,994 - 99,023,240 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01772,204,802 - 72,218,105 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11777,759,805 - 77,771,013 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1777,759,805 - 77,771,013 (+)Ensemblpanpan1.1panPan2
TMC8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.192,989,095 - 2,999,702 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl92,990,419 - 2,999,778 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha93,672,475 - 3,684,201 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.093,666,878 - 3,678,739 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl93,668,216 - 3,677,295 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.193,689,855 - 3,701,233 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.093,814,096 - 3,826,060 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.093,895,552 - 3,907,527 (-)NCBIUU_Cfam_GSD_1.0
Tmc8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056023,643,695 - 3,651,325 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365942,762,019 - 2,768,682 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365942,760,649 - 2,768,438 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMC8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl123,817,049 - 3,837,363 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1123,802,344 - 3,837,413 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TMC8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11643,575,479 - 43,588,888 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1643,573,867 - 43,587,019 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607714,292,076 - 14,306,885 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmc8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248017,658,209 - 7,664,830 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248017,655,989 - 7,666,329 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tmc8
26 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:217
Count of miRNA genes:135
Interacting mature miRNAs:150
Transcripts:ENSRNOT00000075047
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1096703043107057807Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1096703043107057807Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096120911104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096120911104060283Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
631539Oia6Oil induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1097010147104670812Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091228102104060283Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat

Markers in Region
AU047885  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210102,999,096 - 102,999,355 (+)MAPPERmRatBN7.2
Rnor_6.010106,783,833 - 106,784,091NCBIRnor6.0
Rnor_5.010106,421,910 - 106,422,168UniSTSRnor5.0
Celera10101,559,887 - 101,560,145UniSTS
PMC165604P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210103,007,528 - 103,008,366 (+)MAPPERmRatBN7.2
Rnor_6.010106,792,240 - 106,793,076NCBIRnor6.0
Rnor_5.010106,430,594 - 106,431,430UniSTSRnor5.0
Celera10101,568,318 - 101,569,156UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 8 30 22 19 22 4
Low 1 35 27 19 19 2 4 66 35 38 7 2
Below cutoff 6 7 8 3 6

Sequence


RefSeq Acc Id: ENSRNOT00000075047   ⟹   ENSRNOP00000067877
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10103,000,344 - 103,010,590 (+)Ensembl
Rnor_6.0 Ensembl10106,785,077 - 106,795,299 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111973   ⟹   ENSRNOP00000089622
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10102,998,402 - 103,010,590 (+)Ensembl
RefSeq Acc Id: NM_001126301   ⟹   NP_001119773
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810103,499,042 - 103,509,290 (+)NCBI
mRatBN7.210103,000,344 - 103,010,593 (+)NCBI
Rnor_6.010106,785,077 - 106,795,299 (+)NCBI
Rnor_5.010106,422,924 - 106,433,661 (+)NCBI
Celera10101,561,134 - 101,571,408 (+)RGD
Sequence:
RefSeq Acc Id: XM_006247818   ⟹   XP_006247880
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810103,498,918 - 103,509,496 (+)NCBI
mRatBN7.210103,000,215 - 103,010,601 (+)NCBI
Rnor_6.010106,785,023 - 106,795,307 (+)NCBI
Rnor_5.010106,422,924 - 106,433,661 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006247819   ⟹   XP_006247881
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810103,498,917 - 103,509,496 (+)NCBI
mRatBN7.210103,000,215 - 103,010,601 (+)NCBI
Rnor_6.010106,785,023 - 106,795,307 (+)NCBI
Rnor_5.010106,422,924 - 106,433,661 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006247821   ⟹   XP_006247883
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810103,498,505 - 103,509,496 (+)NCBI
mRatBN7.210103,000,055 - 103,010,601 (+)NCBI
Rnor_6.010106,784,819 - 106,795,307 (+)NCBI
Rnor_5.010106,422,924 - 106,433,661 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008768392   ⟹   XP_008766614
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810103,498,505 - 103,509,496 (+)NCBI
mRatBN7.210103,000,038 - 103,010,601 (+)NCBI
Rnor_6.010106,784,819 - 106,795,307 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039086846   ⟹   XP_038942774
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810103,498,918 - 103,509,496 (+)NCBI
mRatBN7.210103,000,215 - 103,010,601 (+)NCBI
RefSeq Acc Id: XM_039086847   ⟹   XP_038942775
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810103,498,918 - 103,509,496 (+)NCBI
mRatBN7.210103,000,215 - 103,010,601 (+)NCBI
RefSeq Acc Id: XM_039086848   ⟹   XP_038942776
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810103,498,914 - 103,506,278 (+)NCBI
mRatBN7.210103,000,212 - 103,007,621 (+)NCBI
RefSeq Acc Id: XM_039086849   ⟹   XP_038942777
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810103,498,915 - 103,506,093 (+)NCBI
mRatBN7.210103,000,213 - 103,007,395 (+)NCBI
RefSeq Acc Id: XR_005489944
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810103,498,914 - 103,507,006 (+)NCBI
mRatBN7.210103,000,212 - 103,008,317 (+)NCBI
RefSeq Acc Id: NP_001119773   ⟸   NM_001126301
- UniProtKB: B1H258 (UniProtKB/TrEMBL),   M0RE13 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247883   ⟸   XM_006247821
- Peptide Label: isoform X3
- UniProtKB: M0RE13 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247880   ⟸   XM_006247818
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ACB7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247881   ⟸   XM_006247819
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ACB7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008766614   ⟸   XM_008768392
- Peptide Label: isoform X3
- UniProtKB: M0RE13 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000067877   ⟸   ENSRNOT00000075047
RefSeq Acc Id: XP_038942776   ⟸   XM_039086848
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038942777   ⟸   XM_039086849
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038942774   ⟸   XM_039086846
- Peptide Label: isoform X3
- UniProtKB: M0RE13 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038942775   ⟸   XM_039086847
- Peptide Label: isoform X3
- UniProtKB: M0RE13 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000089622   ⟸   ENSRNOT00000111973
Protein Domains
TMC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RE13-F1-model_v2 AlphaFold M0RE13 1-723 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697930
Promoter ID:EPDNEW_R8455
Type:single initiation site
Name:Tmc8_1
Description:transmembrane channel-like 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.010106,785,065 - 106,785,125EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1591150 AgrOrtholog
BioCyc Gene G2FUF-22543 BioCyc
Ensembl Genes ENSRNOG00000046086 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000075047.2 UniProtKB/TrEMBL
  ENSRNOT00000111973.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7366375 IMAGE-MGC_LOAD
InterPro TMC UniProtKB/TrEMBL
  TMC UniProtKB/TrEMBL
KEGG Report rno:688276 UniProtKB/TrEMBL
MGC_CLONE MGC:188240 IMAGE-MGC_LOAD
NCBI Gene 688276 ENTREZGENE
PANTHER PTHR23302 UniProtKB/TrEMBL
  TRANSMEMBRANE CHANNEL-LIKE PROTEIN 8 UniProtKB/TrEMBL
Pfam TMC UniProtKB/TrEMBL
PhenoGen Tmc8 PhenoGen
RatGTEx ENSRNOG00000046086 RatGTEx
UniProt A0A8I6ACB7 ENTREZGENE, UniProtKB/TrEMBL
  B1H258 ENTREZGENE, UniProtKB/TrEMBL
  M0RE13 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-16 Tmc8  transmembrane channel-like 8  LOC688276  similar to epidermodysplasia verruciformis 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC688276  similar to epidermodysplasia verruciformis 2      Symbol and Name status set to provisional 70820 PROVISIONAL