Prodh1 (proline dehydrogenase 1) - Rat Genome Database

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Gene: Prodh1 (proline dehydrogenase 1) Rattus norvegicus
Analyze
Symbol: Prodh1 (Ensembl: Prodh)
Name: proline dehydrogenase 1 (Ensembl:proline dehydrogenase)
RGD ID: 1590932
Description: Enables amino acid binding activity and proline dehydrogenase activity. Predicted to be involved in L-proline catabolic process to L-glutamate and regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in amino acid metabolic disorder; hyperprolinemia type 1; and schizophrenia 4. Orthologous to human PRODH (proline dehydrogenase 1); PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; guanidinoacetate methyltransferase deficiency pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC680409; Prodh; Prodh_mapped; proline dehydrogenase; proline dehydrogenase (mapped); proline dehydrogenase (oxidase) 1; proline dehydrogenase (proline oxidase); proline dehydrogenase 1, mitochondrial; proline dehydrogenase, mitochondrial; similar to Proline oxidase, mitochondrial precursor (Proline dehydrogenase)
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81196,414,275 - 96,431,604 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1196,414,224 - 96,433,418 (+)EnsemblGRCr8
mRatBN7.21182,910,043 - 82,927,305 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,910,137 - 82,927,305 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1191,638,491 - 91,655,681 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01184,299,609 - 84,316,799 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01183,353,230 - 83,370,416 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01187,058,478 - 87,075,785 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1187,058,616 - 87,075,785 (+)Ensemblrn6Rnor6.0
Rnor_5.01190,150,469 - 90,167,638 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41184,905,060 - 84,922,229 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1181,685,816 - 81,702,985 (+)NCBICelera
Cytogenetic Map11q23NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
aripiprazole  (EXP)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
Bisphenol A diglycidyl ether  (ISO)
cadmium dichloride  (EXP)
calcitriol  (ISO)
camptothecin  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
dibutyl phthalate  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
dizocilpine maleate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (ISO)
finasteride  (EXP)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
glafenine  (EXP)
indometacin  (EXP)
isoprenaline  (ISO)
methamphetamine  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
mifepristone  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nimesulide  (EXP)
Nutlin-3  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
p-menthan-3-ol  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
progesterone  (ISO)
prostaglandin E2  (ISO)
reactive oxygen species  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sotorasib  (ISO)
sulfadimethoxine  (EXP)
sulindac  (EXP)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
triadimefon  (EXP)
triclosan  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, etal., Genome Res 1996 Sep;6(9):791-806.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. PRODH mutations and hyperprolinemia in a subset of schizophrenic patients. Jacquet H, etal., Hum Mol Genet. 2002 Sep 15;11(19):2243-9.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Mechanism-based inhibition of proline dehydrogenase by proline analogues. Tritsch D, etal., Biochim Biophys Acta. 1993 Sep 3;1202(1):77-81.
Additional References at PubMed
PMID:1300406   PMID:12477932   PMID:12525555   PMID:12865426   PMID:15662599   PMID:18614015   PMID:18775783   PMID:23743200  


Genomics

Comparative Map Data
Prodh1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81196,414,275 - 96,431,604 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1196,414,224 - 96,433,418 (+)EnsemblGRCr8
mRatBN7.21182,910,043 - 82,927,305 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,910,137 - 82,927,305 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1191,638,491 - 91,655,681 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01184,299,609 - 84,316,799 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01183,353,230 - 83,370,416 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01187,058,478 - 87,075,785 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1187,058,616 - 87,075,785 (+)Ensemblrn6Rnor6.0
Rnor_5.01190,150,469 - 90,167,638 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41184,905,060 - 84,922,229 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1181,685,816 - 81,702,985 (+)NCBICelera
Cytogenetic Map11q23NCBI
PRODH
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382218,912,781 - 18,936,553 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2218,912,774 - 18,936,553 (-)Ensemblhg38GRCh38
GRCh372218,900,294 - 18,924,066 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362217,280,295 - 17,304,066 (-)NCBIBuild 36Build 36hg18NCBI36
Build 342217,274,848 - 17,298,620NCBI
Celera222,752,487 - 2,775,952 (-)NCBICelera
Cytogenetic Map22q11.21NCBI
HuRef222,522,549 - 2,546,463 (-)NCBIHuRef
CHM1_12218,900,046 - 18,923,816 (-)NCBICHM1_1
T2T-CHM13v2.02219,288,173 - 19,311,947 (-)NCBIT2T-CHM13v2.0
Prodh
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391617,889,593 - 17,907,147 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1617,878,221 - 17,908,067 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381618,071,726 - 18,089,283 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1618,060,357 - 18,090,203 (-)Ensemblmm10GRCm38
MGSCv371618,071,819 - 18,089,283 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361617,985,289 - 18,002,710 (-)NCBIMGSCv36mm8
Celera1618,644,311 - 18,661,775 (-)NCBICelera
Cytogenetic Map16A3NCBI
cM Map1611.19NCBI
PRODH
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22328,539,527 - 28,563,800 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12231,087,140 - 31,111,607 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0221,654,019 - 1,678,389 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12217,351,283 - 17,376,108 (-)NCBIPanPan1.1PanPan1.1panPan2
LOC477562
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12629,039,007 - 29,059,722 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2628,998,409 - 29,019,789 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02630,442,109 - 30,463,491 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.12628,490,997 - 28,512,379 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02628,116,817 - 28,138,201 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02629,201,167 - 29,222,548 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC110256626
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11451,624,919 - 51,644,467 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PRODH
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1195,425,243 - 5,431,466 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666100938,968 - 963,361 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prodh
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v143,328,494 - 3,345,633 (-)NCBIRrattus_CSIRO_v1

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:70
Count of miRNA genes:53
Interacting mature miRNAs:61
Transcripts:ENSRNOT00000002576
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10450831Scl80Serum cholesterol level QTL 804.70.01blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)119046178196556255Rat
10058954Gmadr7Adrenal mass QTL 72.490.0049adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)117385089499753367Rat
4889859Pur28Proteinuria QTL 2819.50.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)115892833699753367Rat
724561Plsm4Polydactyly-luxate syndrome (PLS) morphotypes QTL 40.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)116796218499753367Rat
4889521Gluco62Glucose level QTL 622.820.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)116859932196497754Rat
7411658Foco27Food consumption QTL 2716.20.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)116985594399753367Rat
631506Bp104Blood pressure QTL 1042.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)117330831599753367Rat
1549848Bvd6Brain ventricular dilatation QTL 63.10.0001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)117961851999753367Rat

Markers in Region
Prodh  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81196,430,935 - 96,431,158 (+)Marker Load Pipeline
mRatBN7.21182,926,636 - 82,926,859 (+)MAPPERmRatBN7.2
Rnor_6.01187,075,117 - 87,075,339NCBIRnor6.0
Rnor_5.01190,166,970 - 90,167,192UniSTSRnor5.0
RGSC_v3.41184,921,561 - 84,921,783UniSTSRGSC3.4
Celera1181,702,317 - 81,702,539UniSTS
Cytogenetic Map11q23UniSTS
RH124940  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21182,920,400 - 82,921,801 (+)MAPPERmRatBN7.2
Rnor_6.01187,068,878 - 87,070,278NCBIRnor6.0
Rnor_5.01190,160,731 - 90,162,131UniSTSRnor5.0
RGSC_v3.41184,915,322 - 84,916,722UniSTSRGSC3.4
Celera1181,696,080 - 81,697,480UniSTS
Cytogenetic Map11q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 91 59 6 355 191 11 140 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000002576   ⟹   ENSRNOP00000002576
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1196,414,224 - 96,431,603 (+)Ensembl
mRatBN7.2 Ensembl1182,910,137 - 82,927,305 (+)Ensembl
Rnor_6.0 Ensembl1187,058,616 - 87,075,785 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000082855   ⟹   ENSRNOP00000072350
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1196,414,433 - 96,431,603 (+)Ensembl
mRatBN7.2 Ensembl1182,910,172 - 82,927,305 (+)Ensembl
Rnor_6.0 Ensembl1187,058,640 - 87,075,625 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000126432   ⟹   ENSRNOP00000100179
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1196,414,446 - 96,433,418 (+)Ensembl
RefSeq Acc Id: NM_001135778   ⟹   NP_001129250
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81196,414,438 - 96,431,604 (+)NCBI
mRatBN7.21182,910,137 - 82,927,305 (+)NCBI
Rnor_6.01187,058,616 - 87,075,785 (+)NCBI
Rnor_5.01190,150,469 - 90,167,638 (+)NCBI
RGSC_v3.41184,905,060 - 84,922,229 (+)RGD
Celera1181,685,816 - 81,702,985 (+)RGD
Sequence:
RefSeq Acc Id: XM_006248642   ⟹   XP_006248704
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81196,414,283 - 96,431,598 (+)NCBI
mRatBN7.21182,910,136 - 82,927,305 (+)NCBI
Rnor_6.01187,058,610 - 87,075,785 (+)NCBI
Rnor_5.01190,150,469 - 90,167,638 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006248643   ⟹   XP_006248705
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81196,414,591 - 96,431,598 (+)NCBI
mRatBN7.21182,910,292 - 82,927,305 (+)NCBI
Rnor_6.01187,058,823 - 87,075,785 (+)NCBI
Rnor_5.01190,150,469 - 90,167,638 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008768903   ⟹   XP_008767125
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81196,414,275 - 96,431,598 (+)NCBI
mRatBN7.21182,910,043 - 82,927,305 (+)NCBI
Rnor_6.01187,058,478 - 87,075,785 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063270762   ⟹   XP_063126832
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81196,414,441 - 96,430,048 (+)NCBI
RefSeq Acc Id: XR_005491055
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81196,414,441 - 96,430,048 (+)NCBI
mRatBN7.21182,910,135 - 82,927,305 (+)NCBI
RefSeq Acc Id: XR_005491056
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81196,414,441 - 96,428,011 (+)NCBI
mRatBN7.21182,910,135 - 82,927,305 (+)NCBI
RefSeq Acc Id: NP_001129250   ⟸   NM_001135778
- Sequence:
RefSeq Acc Id: XP_006248704   ⟸   XM_006248642
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006248705   ⟸   XM_006248643
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008767125   ⟸   XM_008768903
- Peptide Label: isoform X4
- Sequence:
Ensembl Acc Id: ENSRNOP00000072350   ⟸   ENSRNOT00000082855
Ensembl Acc Id: ENSRNOP00000002576   ⟸   ENSRNOT00000002576
RefSeq Acc Id: XP_063126832   ⟸   XM_063270762
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000100179   ⟸   ENSRNOT00000126432
Protein Domains
Proline dehydrogenase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1MAR6-F1-model_v2 AlphaFold F1MAR6 1-599 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698310
Promoter ID:EPDNEW_R8835
Type:single initiation site
Name:Prodh1_1
Description:proline dehydrogenase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01187,058,635 - 87,058,695EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1590932 AgrOrtholog
BioCyc Gene G2FUF-20634 BioCyc
BioCyc Pathway CITRULBIO-PWY [L-citrulline biosynthesis] BioCyc
  PROUT-PWY [L-proline degradation I] BioCyc
BioCyc Pathway Image CITRULBIO-PWY BioCyc
  PROUT-PWY BioCyc
Ensembl Genes ENSRNOG00000000281 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002576 ENTREZGENE
  ENSRNOT00000002576.9 UniProtKB/TrEMBL
  ENSRNOT00000082855 ENTREZGENE
  ENSRNOT00000082855.3 UniProtKB/TrEMBL
  ENSRNOT00000126432 ENTREZGENE
  ENSRNOT00000126432.1 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.220 UniProtKB/TrEMBL
InterPro FAD-linked_oxidoreductase-like UniProtKB/TrEMBL
  Proline_DH UniProtKB/TrEMBL
  Proline_oxidase UniProtKB/TrEMBL
NCBI Gene Prodh ENTREZGENE
PANTHER PROLINE DEHYDROGENASE 1, MITOCHONDRIAL UniProtKB/TrEMBL
  Proline_oxidase UniProtKB/TrEMBL
Pfam Pro_dh UniProtKB/TrEMBL
PhenoGen Prodh1 PhenoGen
RatGTEx ENSRNOG00000000281 RatGTEx
Superfamily-SCOP SSF51730 UniProtKB/TrEMBL
UniProt A0A0G2K2S1 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LAQ3_RAT UniProtKB/TrEMBL
  A6JSI7 ENTREZGENE, UniProtKB/TrEMBL
  F1MAR6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2025-10-23 Prodh1  proline dehydrogenase 1  Prodh  proline dehydrogenase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2022-09-30 Prodh  proline dehydrogenase  Prodh1  proline dehydrogenase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-05-04 Prodh1  proline dehydrogenase 1  Prodh  proline dehydrogenase (oxidase) 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 Prodh  proline dehydrogenase (oxidase) 1  LOC682565  similar to Proline oxidase, mitochondrial precursor (Proline dehydrogenase)  Data merged from RGD:1597911 1643240 APPROVED
2012-02-02 Prodh  proline dehydrogenase (oxidase) 1  Prodh  proline dehydrogenase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-21 Prodh  proline dehydrogenase  LOC680409  similar to Proline oxidase, mitochondrial precursor (Proline dehydrogenase)  Data merged from RGD:1591791 737654 APPROVED
2007-04-12 Prodh  proline dehydrogenase  Prodh_mapped  proline dehydrogenase (mapped)  Data merged from RGD:3412 737654 APPROVED
2006-11-20 LOC680409  similar to Proline oxidase, mitochondrial precursor (Proline dehydrogenase)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 Prodh_mapped  proline dehydrogenase(mapped)  Prodh  proline dehydrogenase  Symbol set to symbol_mapped, name set to name (mapped) 1582166 APPROVED
2006-11-20 Prodh  proline dehydrogenase      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-20 LOC682565  similar to Proline oxidase, mitochondrial precursor (Proline dehydrogenase)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Prodh  proline dehydrogenase    proline dehydrogenase (oxidase) 1  Name updated 1299863 APPROVED
2004-09-10 Prodh  proline dehydrogenase (oxidase) 1    proline dehydrogenase  Name updated 1299863 APPROVED
2002-06-10 Prodh  proline dehydrogenase      Name updated 70584 APPROVED