Tpt1l2 (tumor protein, translationally-controlled 1 like 2) - Rat Genome Database

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Gene: Tpt1l2 (tumor protein, translationally-controlled 1 like 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Tpt1l2 (Ensembl: AABR07024742.1)
Name: tumor protein, translationally-controlled 1 like 2
RGD ID: 1590250
Description: Predicted to enable calcium ion binding activity. Predicted to be active in cytoplasm. Orthologous to several human genes including TPT1 (tumor protein, translationally-controlled 1).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC685718; similar to tumor protein, translationally-controlled 1; Tpt1l1; translationally-controlled tumor protein-like; tumor protein, translationally-controlled 1 like 1
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81612,496,929 - 12,497,533 (+)NCBIGRCr8
GRCr8 Ensembl1612,496,948 - 12,497,482 (+)EnsemblGRCr8 Ensembl
mRatBN7.21612,476,660 - 12,477,351 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1612,476,735 - 12,477,253 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01613,950,401 - 13,950,949 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01613,841,678 - 13,842,196 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41612,907,137 - 12,912,718 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1612,734,189 - 12,734,737 (+)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Tpt1l2
16 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760916039848Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16422773017696785Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)16285170915884239Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
sensory system
visual system
7 1 23 46 61 47 1 31 7 2 2

Sequence


Ensembl Acc Id: ENSRNOT00000048912   ⟹   ENSRNOP00000094066
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1612,496,948 - 12,497,482 (+)Ensembl
mRatBN7.2 Ensembl1612,476,735 - 12,477,253 (+)Ensembl
Rnor_6.0 Ensembl1613,950,416 - 13,950,934 (+)Ensembl
RefSeq Acc Id: XM_039094897   ⟹   XP_038950825
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81612,496,929 - 12,497,533 (+)NCBI
mRatBN7.21612,476,660 - 12,477,351 (+)NCBI
Protein Sequences
Protein RefSeqs XP_038950825 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000082883.1
  ENSRNOP00000094066
  ENSRNOP00000094066.1
RefSeq Acc Id: XP_038950825   ⟸   XM_039094897
- UniProtKB: A0A8I6AN27 (UniProtKB/TrEMBL),   A0A8I5ZVT0 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000094066   ⟸   ENSRNOT00000048912
Protein Domains
TCTP

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1590250 AgrOrtholog
BioCyc Gene G2FUF-12003 BioCyc
Ensembl Genes ENSRNOG00000001049 UniProtKB/TrEMBL
  ENSRNOG00000030299 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000048912 ENTREZGENE
  ENSRNOT00000048912.6 UniProtKB/TrEMBL
  ENSRNOT00000106386.1 UniProtKB/TrEMBL
Gene3D-CATH Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A UniProtKB/TrEMBL
InterPro Mss4-like_sf UniProtKB/TrEMBL
  Mss4/transl-control_tumour UniProtKB/TrEMBL
  TCTP UniProtKB/TrEMBL
  Translation_control_tumour_CS UniProtKB/TrEMBL
  Translational_control_tumour_p UniProtKB/TrEMBL
NCBI Gene 685718 ENTREZGENE
PANTHER PTHR11991 UniProtKB/TrEMBL
  TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN UniProtKB/TrEMBL
Pfam TCTP UniProtKB/TrEMBL
PhenoGen Tpt1l2 PhenoGen
PRINTS TCTPROTEIN UniProtKB/TrEMBL
PROSITE TCTP_1 UniProtKB/TrEMBL
  TCTP_2 UniProtKB/TrEMBL
  TCTP_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001049 RatGTEx
  ENSRNOG00000030299 RatGTEx
Superfamily-SCOP SSF51316 UniProtKB/TrEMBL
UniProt A0A8I5ZVT0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AN27 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-10-17 Tpt1l2  tumor protein, translationally-controlled 1 like 2  Tpt1l1  tumor protein, translationally-controlled 1 like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2023-09-19 Tpt1l1  tumor protein, translationally-controlled 1 like 1  LOC685718  similar to tumor protein, translationally-controlled 1  Symbol and Name Changed 1299863 APPROVED
2006-11-20 LOC685718  similar to tumor protein, translationally-controlled 1      Symbol and Name status set to provisional 70820 PROVISIONAL