Znf750 (zinc finger protein 750) - Rat Genome Database

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Gene: Znf750 (zinc finger protein 750) Rattus norvegicus
Analyze
Symbol: Znf750
Name: zinc finger protein 750
RGD ID: 1590044
Description: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and promoter-specific chromatin binding activity. Predicted to be involved in epidermis development; negative regulation of epithelial to mesenchymal transition; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within establishment of skin barrier; membrane biogenesis; and positive regulation of biosynthetic process. Predicted to be active in nucleus. Orthologous to human ZNF750 (zinc finger protein 750); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC688328; LOC688328
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810107,270,926 - 107,279,904 (-)NCBIGRCr8
mRatBN7.210106,772,162 - 106,781,186 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10106,772,669 - 106,781,200 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.010110,698,581 - 110,701,222 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10110,698,891 - 110,701,137 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010110,283,100 - 110,286,758 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera10105,308,542 - 105,311,184 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleus  (IBA,IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:22364861   PMID:27907090  


Genomics

Comparative Map Data
Znf750
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810107,270,926 - 107,279,904 (-)NCBIGRCr8
mRatBN7.210106,772,162 - 106,781,186 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10106,772,669 - 106,781,200 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.010110,698,581 - 110,701,222 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10110,698,891 - 110,701,137 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010110,283,100 - 110,286,758 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera10105,308,542 - 105,311,184 (-)NCBICelera
Cytogenetic Map10q32.3NCBI
ZNF750
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381782,829,434 - 82,840,022 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1782,829,434 - 82,840,022 (-)EnsemblGRCh38hg38GRCh38
GRCh371780,787,310 - 80,797,898 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361778,380,599 - 78,391,220 (-)NCBINCBI36Build 36hg18NCBI36
Celera1777,382,410 - 77,393,031 (-)NCBICelera
Cytogenetic Map17q25.3NCBI
HuRef1776,188,827 - 76,199,624 (-)NCBIHuRef
CHM1_11780,873,594 - 80,884,216 (-)NCBICHM1_1
T2T-CHM13v2.01783,704,197 - 83,714,778 (-)NCBIT2T-CHM13v2.0
Zfp750
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911121,401,802 - 121,410,168 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11121,401,804 - 121,410,159 (-)EnsemblGRCm39 Ensembl
GRCm3811121,510,976 - 121,519,342 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11121,510,978 - 121,519,333 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711121,372,290 - 121,380,656 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611121,327,068 - 121,335,392 (-)NCBIMGSCv36mm8
Celera11133,246,969 - 133,255,334 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1185.49NCBI
Znf750
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955506352,552 - 363,003 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955506352,616 - 360,802 (+)NCBIChiLan1.0ChiLan1.0
ZNF750
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21999,372,233 - 99,389,529 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan117104,275,815 - 104,282,018 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01777,246,953 - 77,260,598 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11783,043,886 - 83,054,446 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1783,043,886 - 83,054,446 (-)Ensemblpanpan1.1panPan2
ZNF750
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha9276,880 - 289,093 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.09268,566 - 280,803 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl9277,747 - 280,045 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.19262,771 - 274,975 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.09424,031 - 436,203 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.09499,233 - 511,457 (+)NCBIUU_Cfam_GSD_1.0
Znf750
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602262,603 - 270,355 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936923299,719 - 307,488 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936923299,725 - 302,741 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZNF750
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl12398,559 - 405,632 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.112398,498 - 407,812 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.212329,870 - 339,270 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ZNF750
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11674,720,080 - 74,731,951 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1674,720,763 - 74,723,075 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607746,375,040 - 46,386,964 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Znf750
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480111,520,636 - 11,522,890 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480111,519,383 - 11,528,264 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Znf750
23 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:135
Count of miRNA genes:110
Interacting mature miRNAs:116
Transcripts:ENSRNOT00000074193
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1064890616107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1096703043107057807Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1096703043107057807Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 23 100 78 77 46 24 46 6 177 69 80 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000074193   ⟹   ENSRNOP00000063957
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10106,772,669 - 106,781,200 (-)Ensembl
Rnor_6.0 Ensembl10110,698,891 - 110,701,137 (-)Ensembl
RefSeq Acc Id: XM_039087573   ⟹   XP_038943501
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810107,270,926 - 107,279,904 (-)NCBI
mRatBN7.210106,772,162 - 106,781,186 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001417206 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943501 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000063957
  ENSRNOP00000063957.2
Ensembl Acc Id: ENSRNOP00000063957   ⟸   ENSRNOT00000074193
RefSeq Acc Id: XP_038943501   ⟸   XM_039087573
Protein Domains
Zinc finger protein 750-like zinc finger

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R3N9-F1-model_v2 AlphaFold M0R3N9 1-710 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1590044 AgrOrtholog
BioCyc Gene G2FUF-22352 BioCyc
Ensembl Genes ENSRNOG00000046482 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000074193 ENTREZGENE
  ENSRNOT00000074193.3 UniProtKB/TrEMBL
InterPro ZNF750 UniProtKB/TrEMBL
  ZNF750_zf UniProtKB/TrEMBL
NCBI Gene 688328 ENTREZGENE
PANTHER PTHR14678 UniProtKB/TrEMBL
  ZINC FINGER PROTEIN 750 UniProtKB/TrEMBL
Pfam zf-C2H2_7 UniProtKB/TrEMBL
PhenoGen Znf750 PhenoGen
RatGTEx ENSRNOG00000046482 RatGTEx
UniProt M0R3N9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-09-16 Znf750  zinc finger protein 750  LOC688328  hypothetical protein LOC688328  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC688328  hypothetical protein LOC688328      Symbol and Name status set to provisional 70820 PROVISIONAL