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Gene: Spen (spen family transcriptional repressor) Rattus norvegicus
Symbol: Spen
Name: spen family transcriptional repressor
Description: Predicted to have several functions, including DNA-binding transcription factor activity; RNA polymerase II transcription factor binding activity; and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; positive regulation of neurogenesis; and positive regulation of transcription, DNA-templated. Predicted to localize to nucleoplasm and transcription repressor complex. Orthologous to human SPEN (spen family transcriptional repressor); PARTICIPATES IN Notch signaling pathway; INTERACTS WITH bisphenol A; 1,2-dimethylhydrazine (ortholog); 2,3,7,8-tetrachlorodibenzodioxine (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: LOC298604; LOC690911; rCG30673-like; RGD1564662; similar to Msx-2 interacting nuclear target protein; similar to Msx2-interacting protein (SPEN homolog) (SMART/HDAC1-associated repressor protein); SPEN homolog, transcriptional regulator; spen homolog, transcriptional regulator (Drosophila); uncharacterized protein LOC690911
Homo sapiens (human) : SPEN (spen family transcriptional repressor)  HGNC  Alliance
Mus musculus (house mouse) : Spen (spen family transcription repressor)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Spen (spen family transcriptional repressor)
Pan paniscus (bonobo/pygmy chimpanzee) : SPEN (spen family transcriptional repressor)
Canis lupus familiaris (dog) : SPEN (spen family transcriptional repressor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Spen (spen family transcriptional repressor)
Sus scrofa (pig) : SPEN (spen family transcriptional repressor)
Chlorocebus sabaeus (African green monkey) : SPEN (spen family transcriptional repressor)
Heterocephalus glaber (naked mole-rat) : Spen (spen family transcriptional repressor)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.05160,015,573 - 160,070,915 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5160,015,454 - 160,070,965 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05163,735,389 - 163,790,132 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45160,359,738 - 160,414,311 (-)NCBIRGSC3.4rn4RGSC3.4
Celera5152,134,833 - 152,205,318 (-)NCBICelera
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Spen
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1589867
Created: 2006-11-20
Species: Rattus norvegicus
Last Modified: 2020-09-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.