Vps35 (VPS35 retromer complex component) - Rat Genome Database

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Gene: Vps35 (VPS35 retromer complex component) Rattus norvegicus
Analyze
Symbol: Vps35
Name: VPS35 retromer complex component
RGD ID: 1589784
Description: Predicted to enable D1 dopamine receptor binding activity. Involved in retrograde transport, endosome to Golgi. Located in cytosol. Part of retromer complex. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 17. Orthologous to human VPS35 (VPS35 retromer complex component); PARTICIPATES IN altered retromer-mediated pathway; Parkinson's disease pathway; retromer-mediated pathway; INTERACTS WITH 17beta-estradiol; benzo[a]pyrene; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Maternal embryonic message 3; Mem3; vacuolar protein sorting 35; vacuolar protein sorting 35 (mapped); vacuolar protein sorting 35 homolog; vacuolar protein sorting 35 homolog (S. cerevisiae); vacuolar protein sorting-associated protein 35; Vps35_mapped
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81937,938,989 - 37,974,887 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1937,938,720 - 37,974,886 (+)EnsemblGRCr8
mRatBN7.21921,765,771 - 21,801,620 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1921,765,749 - 21,801,618 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1923,455,852 - 23,491,776 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01928,650,370 - 28,686,295 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01931,613,200 - 31,649,098 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01927,464,937 - 27,500,636 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1927,464,937 - 27,500,636 (+)Ensemblrn6Rnor6.0
Rnor_5.01938,430,733 - 38,466,263 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41923,124,790 - 23,161,655 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1921,625,446 - 21,661,413 (+)NCBICelera
Cytogenetic Map19q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
biological_process  (ND)
endocytic recycling  (ISO)
intracellular protein transport  (IBA)
lysosome organization  (IEA,ISO)
mitochondrial fragmentation involved in apoptotic process  (ISO)
mitochondrion to lysosome vesicle-mediated transport  (ISO)
modulation of chemical synaptic transmission  (IEA,ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of late endosome to lysosome transport  (ISO)
negative regulation of lysosomal protein catabolic process  (IEA,ISO)
negative regulation of protein homooligomerization  (IEA,ISO)
negative regulation of protein localization  (IEA,ISO)
neurotransmitter receptor transport, endosome to plasma membrane  (IEA,ISO)
neurotransmitter receptor transport, endosome to postsynaptic membrane  (IEA,ISO)
positive regulation of canonical Wnt signaling pathway  (IEA,ISO)
positive regulation of dopamine biosynthetic process  (IEA,ISO)
positive regulation of dopamine receptor signaling pathway  (ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of locomotion involved in locomotory behavior  (IEA,ISO)
positive regulation of mitochondrial fission  (ISO)
positive regulation of protein catabolic process  (ISO)
positive regulation of protein localization  (IEA)
positive regulation of protein localization to cell periphery  (ISO)
positive regulation of signal transduction  (IEA)
positive regulation of Wnt protein secretion  (IEA,ISO)
protein destabilization  (IEA,ISO)
protein localization to endosome  (ISO)
protein transport  (IEA)
regulation of dendritic spine maintenance  (ISO)
regulation of developmental process  (IEA)
regulation of mitochondrion organization  (ISO)
regulation of postsynapse assembly  (IEA,ISO)
regulation of postsynapse organization  (IEA)
regulation of protein catabolic process  (IEA)
regulation of protein metabolic process  (ISO)
regulation of protein stability  (IEA,ISO)
regulation of synapse maturation  (IEA,ISO)
regulation of terminal button organization  (ISO)
regulation of transport  (IEA)
retrograde transport, endosome to Golgi  (IBA,IEA,IMP,ISO)
transcytosis  (ISO)
vesicle-mediated transport in synapse  (IEA,ISO)
voluntary musculoskeletal movement  (IEA,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Genes associated with Parkinson's disease: regulation of autophagy and beyond. Beilina A and Cookson MR, J Neurochem. 2015 Jul 30. doi: 10.1111/jnc.13266.
2. Retromer and sorting nexins in endosomal sorting. Gallon M and Cullen PJ, Biochem Soc Trans. 2015 Feb;43(1):33-47. doi: 10.1042/BST20140290.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes. Haft CR, etal., Mol Biol Cell. 2000 Dec;11(12):4105-16.
5. Impaired intracellular trafficking defines early Parkinson's disease. Hunn BH, etal., Trends Neurosci. 2015 Mar;38(3):178-88. doi: 10.1016/j.tins.2014.12.009. Epub 2015 Jan 29.
6. RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk. MacLeod DA, etal., Neuron. 2013 Feb 6;77(3):425-39. doi: 10.1016/j.neuron.2012.11.033.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. The endosomal pathway in Parkinson's disease. Perrett RM, etal., Mol Cell Neurosci. 2015 May;66(Pt A):21-8. doi: 10.1016/j.mcn.2015.02.009. Epub 2015 Feb 19.
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Comprehensive gene review and curation RGD comprehensive gene curation
12. Cloning and characterization of human VPS35 and mouse Vps35 and mapping of VPS35 to human chromosome 16q13-q21. Zhang P, etal., Genomics 2000 Dec 1;70(2):253-7.
Additional References at PubMed
PMID:12477932   PMID:15078903   PMID:15247922   PMID:17114649   PMID:17239604   PMID:17897319   PMID:17916227   PMID:18160348   PMID:18193037   PMID:19056867   PMID:20164305   PMID:21040701  
PMID:21602791   PMID:21821005   PMID:23376485   PMID:23563491   PMID:25533483   PMID:26203154   PMID:26521016   PMID:26618722   PMID:26965651   PMID:27385586   PMID:27460146   PMID:27733367  
PMID:28131823   PMID:28384478   PMID:28892079   PMID:29118110   PMID:29445238   PMID:37542299   PMID:37830626  


Genomics

Comparative Map Data
Vps35
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81937,938,989 - 37,974,887 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1937,938,720 - 37,974,886 (+)EnsemblGRCr8
mRatBN7.21921,765,771 - 21,801,620 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1921,765,749 - 21,801,618 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1923,455,852 - 23,491,776 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01928,650,370 - 28,686,295 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01931,613,200 - 31,649,098 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01927,464,937 - 27,500,636 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1927,464,937 - 27,500,636 (+)Ensemblrn6Rnor6.0
Rnor_5.01938,430,733 - 38,466,263 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41923,124,790 - 23,161,655 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1921,625,446 - 21,661,413 (+)NCBICelera
Cytogenetic Map19q11NCBI
VPS35
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381646,656,132 - 46,689,178 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1646,656,132 - 46,689,518 (-)Ensemblhg38GRCh38
GRCh371646,690,044 - 46,723,090 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361645,251,090 - 45,280,645 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341645,251,091 - 45,280,593NCBI
Celera1631,201,751 - 31,231,306 (-)NCBICelera
Cytogenetic Map16q11.2NCBI
HuRef1632,582,305 - 32,611,908 (-)NCBIHuRef
CHM1_11648,100,524 - 48,130,101 (-)NCBICHM1_1
T2T-CHM13v2.01652,452,996 - 52,486,052 (-)NCBIT2T-CHM13v2.0
Vps35
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39885,987,014 - 86,026,146 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl885,987,021 - 86,026,431 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38885,260,385 - 85,299,517 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl885,260,392 - 85,299,802 (-)Ensemblmm10GRCm38
MGSCv37887,784,291 - 87,823,396 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36888,150,497 - 88,189,603 (-)NCBIMGSCv36mm8
Celera889,541,447 - 89,580,450 (-)NCBICelera
Cytogenetic Map8C3NCBI
cM Map841.61NCBI
Vps35
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955448204,991 - 240,160 (-)Ensembl
ChiLan1.0NW_004955448207,582 - 240,264 (-)NCBIChiLan1.0ChiLan1.0
VPS35
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21856,118,897 - 56,148,460 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11662,024,010 - 62,053,586 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01626,924,901 - 26,954,443 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11645,815,716 - 45,846,672 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1645,817,371 - 45,846,531 (-)EnsemblpanPan2panpan1.1
VPS35
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1158,428,073 - 8,454,601 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl158,428,172 - 8,454,049 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha158,581,899 - 8,608,418 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0158,544,407 - 8,570,955 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl158,544,515 - 8,571,199 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1158,373,461 - 8,399,977 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0158,454,130 - 8,480,928 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0158,469,932 - 8,496,696 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Vps35
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934959,511,247 - 59,538,597 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647550,321 - 78,097 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647550,476 - 77,797 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VPS35
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl637,944,127 - 37,986,171 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1637,944,099 - 37,977,091 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
VPS35
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1532,509,037 - 32,539,371 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl532,508,580 - 32,539,343 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604744,064,261 - 44,095,348 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Vps35
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624914160,483 - 188,490 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624914160,483 - 188,534 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Vps35
142 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:76
Count of miRNA genes:69
Interacting mature miRNAs:74
Transcripts:ENSRNOT00000024020
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19799775052997750Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)191922068964220689Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19799775052997750Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)19574806450748064Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)193236531174246245Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)192409397369093973Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
2303628Vencon9Ventilatory control QTL 90.005respiration trait (VT:0001943)minute ventilation (CMO:0000132)192318858668188586Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)193253961574246245Rat
1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)193128753251431640Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19799775052997750Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19799775052997750Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)193177788874246245Rat
1554318Bmd5Bone mineral density QTL 512.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)192318858668188586Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)192010930665109306Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat
61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)193009938347207961Rat

Markers in Region
AI647796  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21921,801,279 - 21,801,413 (+)MAPPERmRatBN7.2
Rnor_6.01927,500,296 - 27,500,429NCBIRnor6.0
Rnor_5.01938,465,923 - 38,466,056UniSTSRnor5.0
RGSC_v3.41923,161,315 - 23,161,448UniSTSRGSC3.4
Celera1921,661,073 - 21,661,206UniSTS
Cytogenetic Map19q11UniSTS
Mem3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21921,801,316 - 21,801,481 (+)MAPPERmRatBN7.2
Rnor_6.01927,500,333 - 27,500,497NCBIRnor6.0
Rnor_5.01938,465,960 - 38,466,124UniSTSRnor5.0
RGSC_v3.41923,161,352 - 23,161,516UniSTSRGSC3.4
Celera1921,661,110 - 21,661,274UniSTS
Cytogenetic Map19q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000024020   ⟹   ENSRNOP00000024020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1937,938,988 - 37,974,880 (+)Ensembl
mRatBN7.2 Ensembl1921,765,749 - 21,801,618 (+)Ensembl
Rnor_6.0 Ensembl1927,464,937 - 27,500,636 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111690   ⟹   ENSRNOP00000094666
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1937,938,720 - 37,974,886 (+)Ensembl
mRatBN7.2 Ensembl1921,765,798 - 21,801,459 (+)Ensembl
RefSeq Acc Id: NM_001105718   ⟹   NP_001099188
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81937,938,989 - 37,974,887 (+)NCBI
mRatBN7.21921,765,771 - 21,801,620 (+)NCBI
Rnor_6.01927,464,937 - 27,500,636 (+)NCBI
Rnor_5.01938,430,733 - 38,466,263 (+)NCBI
RGSC_v3.41923,124,790 - 23,161,655 (+)RGD
Celera1921,625,446 - 21,661,413 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001099188 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI69004 (Get FASTA)   NCBI Sequence Viewer  
  EDL87475 (Get FASTA)   NCBI Sequence Viewer  
  EDL87476 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000024020.4
  ENSRNOP00000094666
  ENSRNOP00000094666.1
RefSeq Acc Id: NP_001099188   ⟸   NM_001105718
- UniProtKB: G3V8A5 (UniProtKB/TrEMBL),   A6KDF0 (UniProtKB/TrEMBL),   A0A8I6AI89 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024020   ⟸   ENSRNOT00000024020
Ensembl Acc Id: ENSRNOP00000094666   ⟸   ENSRNOT00000111690

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V8A5-F1-model_v2 AlphaFold G3V8A5 1-796 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701046
Promoter ID:EPDNEW_R11569
Type:initiation region
Name:Vps35_1
Description:VPS35 retromer complex component
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01927,464,936 - 27,464,996EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1589784 AgrOrtholog
BioCyc Gene G2FUF-6200 BioCyc
Ensembl Genes ENSRNOG00000017612 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024020.6 UniProtKB/TrEMBL
  ENSRNOT00000111690 ENTREZGENE
  ENSRNOT00000111690.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.660 UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  VPS35 UniProtKB/TrEMBL
  Vps35_C UniProtKB/TrEMBL
KEGG Report rno:25479 UniProtKB/TrEMBL
NCBI Gene 25479 ENTREZGENE
PANTHER VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 35 UniProtKB/TrEMBL
  Vps35 UniProtKB/TrEMBL
Pfam Vps35 UniProtKB/TrEMBL
PhenoGen Vps35 PhenoGen
PIRSF Retromer_Vps35 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017612 RatGTEx
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
UniProt A0A8I6AI89 ENTREZGENE, UniProtKB/TrEMBL
  A6KDF0 ENTREZGENE, UniProtKB/TrEMBL
  A6KDF1_RAT UniProtKB/TrEMBL
  B5DFC1_RAT UniProtKB/TrEMBL
  G3V8A5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-01 Vps35  VPS35 retromer complex component  Vps35  vacuolar protein sorting 35 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Vps35  vacuolar protein sorting 35 homolog (S. cerevisiae)  Vps35  vacuolar protein sorting 35  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-13   vacuolar protein sorting 35  Vps35  vacuolar protein sorting 35 (mapped)  Name updated 737654 APPROVED
2007-04-11 Vps35  vacuolar protein sorting 35 (mapped)  Vps35_mapped  vacuolar protein sorting 35 (mapped)  Data merged from RGD:3077 737654 APPROVED
2006-11-20 Vps35  vacuolar protein sorting 35 (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Vps35_mapped  vacuolar protein sorting 35 (mapped)  Vps35  vacuolar protein sorting 35  Symbol and Name updated 1556543 APPROVED
2002-11-06 Vps35  vacuolar protein sorting 35  Mem3  Maternal embryonic message 3  Symbol and Name updated 625702 APPROVED
2002-06-10 Mem3  Maternal embryonic message 3      Symbol and Name status set to approved 70586 APPROVED