Tyr (tyrosinase) - Rat Genome Database

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Gene: Tyr (tyrosinase) Rattus norvegicus
Analyze
Symbol: Tyr
Name: tyrosinase
RGD ID: 1589755
Description: Predicted to enable copper ion binding activity; protein homodimerization activity; and tyrosinase activity. Involved in several processes, including response to UV; response to cAMP; and response to vitamin D. Predicted to be located in melanosome and perinuclear region of cytoplasm. Used to study oculocutaneous albinism. Human ortholog(s) of this gene implicated in several diseases, including melanoma (multiple); ocular albinism 1; oculocutaneous albinism (multiple); retinoschisis; and vitiligo. Orthologous to human TYR (tyrosinase); PARTICIPATES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; INTERACTS WITH 6-propyl-2-thiouracil; actinomycin D; atrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: C; Tyr_mapped; tyrosinase (albino coat color) (mapped)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Tyrem1Kyo   TyrsiaKyo  
Genetic Models: KFRS2/Kyo DA-Tyrem1Kyo KFRS2/Kyo-/+
Is Marker For: Strains:   FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi   KFRS2/Kyo   KFRS2/Kyo-/+   DA-Tyrem1Kyo   F344-TyrCKitH/Kyo   F344-AsipATyrCKitH/Kyo   F344-TyrCKitH/Hkv   F344-TyrCKitH.LEA-(Tel-D17Got10)/Hkv  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81150,527,687 - 150,622,857 (-)NCBIGRCr8
mRatBN7.21141,115,036 - 141,210,207 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1141,115,036 - 141,210,207 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1149,090,247 - 149,179,011 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01156,260,901 - 156,349,657 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01149,134,804 - 149,223,566 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01151,012,598 - 151,106,802 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1151,012,598 - 151,106,802 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01157,322,968 - 157,416,594 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41143,641,257 - 143,746,315 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1139,445,261 - 139,532,999 (-)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinic acid  (ISO)
17beta-estradiol  (ISO)
1H-imidazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3-(3,4-dihydroxyphenyl)propanoic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-phenylpropionic acid  (ISO)
4-hydroxynon-2-enal  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
9-cis-retinal  (ISO)
9-cis-retinoic acid  (ISO)
actinomycin D  (EXP,ISO)
afzelin  (ISO)
Alisol B  (ISO)
all-trans-retinoic acid  (ISO)
alpha-melanocyte stimulating hormone  (ISO)
amentoflavone  (ISO)
amikacin  (ISO)
apigenin  (ISO)
atrazine  (EXP)
bathocuproine disulfonic acid  (ISO)
benzo[a]pyrene  (ISO)
beta-ionone  (ISO)
biochanin A  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cannabidiol  (ISO)
carnosic acid  (ISO)
Carnosol  (ISO)
chaetocin  (ISO)
chlorogenic acid  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
chrysin  (ISO)
cis-caffeic acid  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
cordycepin  (ISO)
cyanamide  (ISO)
cycloheximide  (ISO)
daidzein  (ISO)
dibenziodolium  (ISO)
diclofenac  (ISO)
dimercaprol  (ISO)
dopachrome  (ISO)
emodin  (ISO)
epoxiconazole  (ISO)
estriol  (ISO)
ethylenediamine  (ISO)
ethylparaben  (ISO)
fenofibrate  (ISO)
ferulic acid  (ISO)
fulvestrant  (ISO)
galangin  (ISO)
genistein  (ISO)
geranic acid  (ISO)
glabridin  (ISO)
glutathione  (ISO)
glycidol  (EXP)
hydroquinone  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
isorhamnetin  (ISO)
kenpaullone  (ISO)
kojic acid  (ISO)
L-ascorbic acid  (ISO)
lawsone  (ISO)
loliolide  (ISO)
luteolin  (ISO)
LY294002  (ISO)
mefenamic acid  (ISO)
melanins  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-N-nitrosourea  (ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
nicotinamide  (ISO)
nimesulide  (ISO)
nonanedioic acid  (ISO)
omacetaxine mepesuccinate  (ISO)
omeprazole  (ISO)
phenethyl caffeate  (ISO)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phytol  (ISO)
pifithrin-?  (ISO)
prazosin  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (ISO)
resorcinol  (ISO)
resveratrol  (ISO)
rottlerin  (ISO)
sanguinarine  (ISO)
SB 203580  (ISO)
scoparone  (ISO)
stilbenoid  (ISO)
sulforaphane  (ISO)
Sweroside  (ISO)
taurine  (ISO)
testosterone  (ISO)
theophylline  (ISO)
trans-caffeic acid  (ISO)
trans-cinnamic acid  (ISO)
trichloroethene  (EXP)
valproic acid  (EXP,ISO)
vemurafenib  (ISO)
vinclozolin  (EXP)
wortmannin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Tyrosinase as an autoantigen in patients with vitiligo. Baharav E, etal., Clin Exp Immunol. 1996 Jul;105(1):84-8.
2. A Tyrosinase missense mutation causes albinism in the Wistar rat. Blaszczyk WM, etal., Pigment Cell Res. 2005 Apr;18(2):144-5.
3. Pink-eyed dilution protein controls the processing of tyrosinase. Chen K, etal., Mol Biol Cell 2002 Jun;13(6):1953-64.
4. Immunity to melanin and to tyrosinase in melanoma patients, and in people with vitiligo. Dordic M, etal., BMC Complement Altern Med. 2012 Jul 26;12:109.
5. Autosomal recessive ocular albinism associated with a functionally significant tyrosinase gene polymorphism. Fukai K, etal., Nat Genet. 1995 Jan;9(1):92-5.
6. Tyrosinase-like polypeptides in the uterus and in the central nervous system of rats. Garai J, etal., Steroids. 1992 Apr;57(4):183-8.
7. AAV-mediated tyrosinase gene transfer restores melanogenesis and retinal function in a model of oculo-cutaneous albinism type I (OCA1). Gargiulo A, etal., Mol Ther. 2009 Aug;17(8):1347-54. doi: 10.1038/mt.2009.112. Epub 2009 May 12.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. A transgenic mouse model with inducible Tyrosinase gene expression using the tetracycline (Tet-on) system allows regulated rescue of abnormal chiasmatic projections found in albinism. Gimenez E, etal., Pigment Cell Res. 2004 Aug;17(4):363-70.
10. Assessment of tyrosinase variants and skin cancer risk in a large cohort of French subjects. Hu HH, etal., J Dermatol Sci. 2011 Nov;64(2):127-33. doi: 10.1016/j.jdermsci.2011.07.003. Epub 2011 Aug 22.
11. Tyrosinase is the modifier of retinoschisis in mice. Johnson BA, etal., Genetics. 2010 Dec;186(4):1337-44. doi: 10.1534/genetics.110.120840. Epub 2010 Sep 27.
12. Mutation spectrum of the TYR and SLC45A2 genes in patients with oculocutaneous albinism. Ko JM, etal., Mol Med Rep. 2012 Apr;5(4):943-8. doi: 10.3892/mmr.2012.764. Epub 2012 Jan 25.
13. Peripheral blood tyrosinase messenger RNA detection and survival in malignant melanoma. Kunter U, etal., J Natl Cancer Inst. 1996 May 1;88(9):590-4.
14. Molecular basis of mouse Himalayan mutation. Kwon BS, etal., Biochem Biophys Res Commun. 1989 May 30;161(1):252-60.
15. A novel missense mutation of the TYR gene in a pedigree with oculocutaneous albinism type 1 from China. Lin YY, etal., Chin Med J (Engl). 2011 Oct;124(20):3358-61.
16. Tyrosinase gene (TYR) mutations in Chinese patients with oculocutaneous albinism type 1. Liu J, etal., Clin Experiment Ophthalmol. 2010 Jan;38(1):37-42. doi: 10.1111/j.1442-9071.2009.02220.x.
17. Efficient gene targeting by TAL effector nucleases coinjected with exonucleases in zygotes. Mashimo T, etal., Sci Rep. 2013;3:1253. doi: 10.1038/srep01253. Epub 2013 Feb 13.
18. Melanin precursors prevent premature age-related and noise-induced hearing loss in albino mice. Murillo-Cuesta S, etal., Pigment Cell Melanoma Res. 2010 Feb;23(1):72-83. doi: 10.1111/j.1755-148X.2009.00646.x. Epub 2009 Oct 19.
19. Absence of strial melanin coincides with age-associated marginal cell loss and endocochlear potential decline. Ohlemiller KK, etal., Hear Res. 2009 Mar;249(1-2):1-14. doi: 10.1016/j.heares.2008.12.005. Epub 2008 Dec 25.
20. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
21. Mutations of the tyrosinase gene in three Korean patients with type I oculocutaneous albinism. Park KC, etal., Jpn J Hum Genet. 1996 Sep;41(3):299-305.
22. Vitamin D nutrition increases skin tyrosinase response to exposure to ultraviolet radiation. Pavlovitch JH, etal., Mol Cell Endocrinol. 1982 Mar;25(3):295-302.
23. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
24. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Comprehensive gene review and curation RGD comprehensive gene curation
28. Information Derived from GenBank Report RGD, Sept. 2003
29. Loss of tyrosinase activity confers increased skin tumor susceptibility in mice. Saran A, etal., Oncogene. 2004 May 20;23(23):4130-5.
30. Molecular basis of dark-eyed albinism in the mouse. Schmidt A and Beermann F, Proc Natl Acad Sci U S A. 1994 May 24;91(11):4756-60.
31. Melanization in albino mice transformed by introducing cloned mouse tyrosinase gene. Tanaka S, etal., Development. 1990 Feb;108(2):223-7.
32. Tyrosinase gene mutations in type I (tyrosinase-deficient) oculocutaneous albinism define two clusters of missense substitutions. Tripathi RK, etal., Am J Med Genet. 1992 Jul 15;43(5):865-71.
33. Prognosis of metastatic melanoma: no correlation of tyrosinase mRNA in bone marrow and survival time. Waldmann V, etal., Recent Results Cancer Res. 2001;158:118-25.
34. [Study of tyrosinase gene mutation in oculocutaneous albinism type 1 patients]. Zheng H, etal., Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2011 Aug;27(3):329-32.
Additional References at PubMed
PMID:1145200   PMID:7665913   PMID:8126111   PMID:9548375   PMID:9918801   PMID:10890980   PMID:11092760   PMID:13880466   PMID:17247639   PMID:22275436   PMID:26620560  


Genomics

Comparative Map Data
Tyr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81150,527,687 - 150,622,857 (-)NCBIGRCr8
mRatBN7.21141,115,036 - 141,210,207 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1141,115,036 - 141,210,207 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1149,090,247 - 149,179,011 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01156,260,901 - 156,349,657 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01149,134,804 - 149,223,566 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01151,012,598 - 151,106,802 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1151,012,598 - 151,106,802 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01157,322,968 - 157,416,594 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41143,641,257 - 143,746,315 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1139,445,261 - 139,532,999 (-)NCBICelera
Cytogenetic Map1q32NCBI
TYR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381189,177,875 - 89,295,759 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1189,177,875 - 89,295,759 (+)EnsemblGRCh38hg38GRCh38
GRCh371188,911,043 - 89,028,927 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361188,550,688 - 88,668,575 (+)NCBINCBI36Build 36hg18NCBI36
Build 341188,550,687 - 88,668,474NCBI
Celera1185,603,013 - 85,720,910 (-)NCBICelera
Cytogenetic Map11q14.3NCBI
HuRef1185,151,456 - 85,265,865 (+)NCBIHuRef
CHM1_11188,794,044 - 88,911,928 (+)NCBICHM1_1
T2T-CHM13v2.01189,097,534 - 89,215,415 (+)NCBIT2T-CHM13v2.0
Tyr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39787,073,979 - 87,142,637 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl787,073,979 - 87,142,720 (-)EnsemblGRCm39 Ensembl
GRCm38787,424,771 - 87,493,512 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl787,424,771 - 87,493,512 (-)EnsemblGRCm38mm10GRCm38
MGSCv37794,575,915 - 94,641,921 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36787,303,166 - 87,369,172 (-)NCBIMGSCv36mm8
Celera784,786,868 - 84,854,808 (-)NCBICelera
Cytogenetic Map7D3NCBI
cM Map749.01NCBI
Tyr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554144,244,035 - 4,314,001 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554144,244,035 - 4,314,001 (-)NCBIChiLan1.0ChiLan1.0
TYR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2990,055,036 - 90,172,775 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11191,099,017 - 91,216,729 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01184,188,557 - 84,306,686 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11187,769,989 - 87,888,138 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1187,769,606 - 87,888,138 (+)Ensemblpanpan1.1panPan2
TYR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12110,799,940 - 10,894,187 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2110,799,940 - 10,894,191 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2110,649,581 - 10,749,918 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02110,980,195 - 11,074,816 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2110,980,195 - 11,074,820 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12110,768,466 - 10,862,962 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02110,834,102 - 10,934,647 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02110,884,281 - 10,984,898 (-)NCBIUU_Cfam_GSD_1.0
Tyr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494774,823,234 - 74,920,675 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936736421,598 - 519,253 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936736421,623 - 519,085 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TYR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl922,517,047 - 22,604,290 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1922,517,047 - 22,604,290 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2925,164,768 - 25,214,580 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TYR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1180,330,051 - 80,444,646 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604345,283,848 - 45,401,720 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tyr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624845844,293 - 933,098 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624845844,492 - 933,098 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tyr
509 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:529
Count of miRNA genes:257
Interacting mature miRNAs:326
Transcripts:ENSRNOT00000021971
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1103111621148111621Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
631570Bp94Blood pressure QTL 940.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123479780142990467Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)199267916144267916Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1131763437159756369Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1136745990163747690Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1102268556147268556Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1106047847151047847Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
2303591Gluco41Glucose level QTL 412blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1102168504147168504Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)199267916144267916Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1103111621148111621Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1102813953151162766Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat

Markers in Region
RH133723  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21141,116,373 - 141,116,572 (+)MAPPERmRatBN7.2
Rnor_6.01151,013,936 - 151,014,134NCBIRnor6.0
Rnor_5.01157,324,306 - 157,324,504UniSTSRnor5.0
RGSC_v3.41143,642,595 - 143,642,793UniSTSRGSC3.4
Celera1139,446,599 - 139,446,797UniSTS
RH 3.4 Map11113.39UniSTS
Cytogenetic Map1q32UniSTS


Related Rat Strains
The following Strains have been annotated to Tyr


Genetic Models
This gene Tyr is modified in the following models/strains:
KFRS2/Kyo     DA-Tyrem1Kyo     KFRS2/Kyo-/+    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 15 3 15 3 16 4 7 9
Below cutoff 2 10 11 7 3 7 8 10 42 6 4 1 8

Sequence


RefSeq Acc Id: ENSRNOT00000021971   ⟹   ENSRNOP00000021971
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1141,115,036 - 141,210,207 (-)Ensembl
Rnor_6.0 Ensembl1151,012,598 - 151,106,802 (-)Ensembl
RefSeq Acc Id: NM_001107535   ⟹   NP_001101005
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81150,527,687 - 150,622,857 (-)NCBI
mRatBN7.21141,115,036 - 141,210,207 (-)NCBI
Rnor_6.01151,012,598 - 151,106,802 (-)NCBI
Rnor_5.01157,322,968 - 157,416,594 (-)NCBI
RGSC_v3.41143,641,257 - 143,746,315 (-)RGD
Celera1139,445,261 - 139,532,999 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001101005 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM18593 (Get FASTA)   NCBI Sequence Viewer  
  EDM18594 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000021971.4
RefSeq Acc Id: NP_001101005   ⟸   NM_001107535
- Peptide Label: precursor
- UniProtKB: D4A9G4 (UniProtKB/TrEMBL),   A6I5Y6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000021971   ⟸   ENSRNOT00000021971
Protein Domains
Tyrosinase copper-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A9G4-F1-model_v2 AlphaFold D4A9G4 1-530 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1589755 AgrOrtholog
BioCyc Gene G2FUF-58587 BioCyc
BioCyc Pathway PWY-6481 [L-dopa and L-dopachrome biosynthesis] BioCyc
  PWY-7917 [pheomelanin biosynthesis] BioCyc
BioCyc Pathway Image PWY-6481 BioCyc
  PWY-7917 BioCyc
Ensembl Genes ENSRNOG00000016421 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021971.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1280.10 UniProtKB/TrEMBL
InterPro Di-copper_centre UniProtKB/TrEMBL
  Tyrosinase UniProtKB/TrEMBL
KEGG Report rno:308800 UniProtKB/TrEMBL
NCBI Gene 308800 ENTREZGENE
PANTHER TYROSINASE UniProtKB/TrEMBL
  TYROSINASE FAMILY MEMBER UniProtKB/TrEMBL
Pfam Tyrosinase UniProtKB/TrEMBL
PhenoGen Tyr PhenoGen
PRINTS TYROSINASE UniProtKB/TrEMBL
PROSITE TYROSINASE_1 UniProtKB/TrEMBL
  TYROSINASE_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016421 RatGTEx
Superfamily-SCOP Di-copper_centre UniProtKB/TrEMBL
UniProt A6I5Y6 ENTREZGENE, UniProtKB/TrEMBL
  A6I5Y7_RAT UniProtKB/TrEMBL
  D4A9G4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-02-12   tyrosinase  Tyr  tyrosinase (albino coat color) (mapped)  Name updated to reflect Human and Mouse nomenclature 1299863 PROVISIONAL
2007-02-12 Tyr  tyrosinase (albino coat color) (mapped)  Tyr_mapped  tyrosinase (albino coat color) (mapped)  Data merged from RGD:3922 1299863 PROVISIONAL
2006-11-19 Tyr  tyrosinase (albino coat color) (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Tyr_mapped  tyrosinase (albino coat color) (mapped)  Tyr  tyrosinase  Symbol and Name updated 1556543 APPROVED
2002-06-10 Tyr  Tyrosinase (albino coat color)      Symbol and Name status set to approved 70586 APPROVED