(+)-artemisinic acid decreases expression ISO RGD:1346000 6480464 artemisic acid results in decreased expression of TYR mRNA CTD PMID:23063590 17beta-estradiol multiple interactions ISO RGD:11466 6480464 Estradiol inhibits the reaction [imidazole results in increased expression of TYR protein] CTD PMID:3127403 1H-imidazole multiple interactions ISO RGD:11466 6480464 Estradiol inhibits the reaction [imidazole results in increased expression of TYR protein], Estriol inhibits the reaction [imidazole results in increased expression of TYR protein] CTD PMID:3127403 1H-imidazole increases expression ISO RGD:11466 6480464 imidazole results in increased expression of TYR protein CTD PMID:3127403 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:11466 6480464 Tetrachlorodibenzodioxin affects the expression of TYR mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine increases activity ISO RGD:1346000 6480464 Tetrachlorodibenzodioxin results in increased activity of TYR protein CTD PMID:20973933 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1346000 6480464 Tetrachlorodibenzodioxin results in increased expression of TYR mRNA CTD PMID:20973933 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1346000 6480464 [Tetrachlorodibenzodioxin results in increased activity of TYR protein] which results in increased abundance of Melanins more ... CTD PMID:20973933 2-hydroxypropanoic acid affects expression ISO RGD:1346000 6480464 Lactic Acid affects the expression of TYR mRNA CTD PMID:30851411 3-(3,4-dihydroxyphenyl)propanoic acid multiple interactions ISO RGD:1346000 6480464 [TYR protein results in increased oxidation of 3, 4-dihydroxyphenylpropionic acid] which results in decreased abundance of Glutathione CTD PMID:20685355 3-(3,4-dihydroxyphenyl)propanoic acid increases oxidation ISO RGD:1346000 6480464 TYR protein results in increased oxidation of 3, 4-dihydroxyphenylpropionic acid CTD PMID:20685355 3-isobutyl-1-methyl-7H-xanthine increases expression ISO RGD:11466 6480464 1-Methyl-3-isobutylxanthine results in increased expression of TYR mRNA CTD PMID:26748310 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:11466 6480464 1-Methyl-3-isobutylxanthine results in increased expression of and results in increased activity of TYR protein more ... CTD PMID:26748310 3-phenylpropionic acid increases oxidation ISO RGD:1346000 6480464 TYR protein results in increased oxidation of 3-phenylpropionic acid CTD PMID:20685355 3-phenylpropionic acid multiple interactions ISO RGD:1346000 6480464 [TYR protein results in increased oxidation of 3-phenylpropionic acid] which results in decreased abundance of Glutathione CTD PMID:20685355 4-hydroxynon-2-enal decreases expression ISO RGD:1346000 6480464 4-hydroxy-2-nonenal results in decreased expression of TYR mRNA CTD PMID:23489423 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole multiple interactions ISO RGD:1346000 6480464 Omeprazole affects the N-linked glycosylation of and results in increased degradation of TYR protein, Omeprazole inhibits the reaction [ATP7A protein results in increased activity of TYR protein] CTD PMID:25337692 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole decreases expression ISO RGD:11466 6480464 Omeprazole results in decreased expression of TYR protein CTD PMID:25337692 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of TYR mRNA CTD PMID:25825206 7,12-dimethyltetraphene multiple interactions ISO RGD:11466 6480464 [9 more ... CTD PMID:20691676 9-cis-retinal multiple interactions ISO RGD:1346000 6480464 ALDH1A1 mutant form inhibits the reaction [9-cis-retinal results in increased expression of TYR mRNA] CTD PMID:23489423 9-cis-retinal increases expression ISO RGD:1346000 6480464 9-cis-retinal results in increased expression of TYR mRNA CTD PMID:23489423 9-cis-retinoic acid increases expression ISO RGD:1346000 6480464 Alitretinoin results in increased expression of TYR mRNA, Alitretinoin results in increased expression of TYR protein CTD PMID:23489423 actinomycin D multiple interactions ISO RGD:1346000 6480464 Dactinomycin inhibits the reaction [Quercetin results in increased activity of TYR protein] CTD PMID:14717847 actinomycin D multiple interactions EXP 6480464 Dactinomycin inhibits the reaction [Phenylephrine results in increased activity of TYR protein] CTD PMID:15278367 afzelin multiple interactions ISO RGD:1346000 6480464 afzelin results in increased expression of and results in increased activity of TYR protein CTD PMID:27287415 afzelin increases expression ISO RGD:1346000 6480464 afzelin results in increased expression of TYR mRNA CTD PMID:27287415 all-trans-retinoic acid increases expression ISO RGD:11466 6480464 Tretinoin results in increased expression of TYR mRNA CTD PMID:11851873 alpha-melanocyte stimulating hormone multiple interactions ISO RGD:11466 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytol inhibits the reaction [alpha-MSH results in increased expression of TYR protein]] more ... CTD PMID:29486182 alpha-melanocyte stimulating hormone increases expression ISO RGD:11466 6480464 alpha-MSH results in increased expression of TYR protein CTD PMID:29486182 amentoflavone decreases activity ISO RGD:1346000 6480464 amentoflavone analog results in decreased activity of TYR protein CTD PMID:17473463 amikacin decreases activity ISO RGD:1346000 6480464 Amikacin results in decreased activity of TYR protein CTD PMID:23416261 apigenin increases expression ISO RGD:11466 6480464 Apigenin results in increased expression of TYR mRNA CTD PMID:21071833 atrazine affects methylation EXP 6480464 Atrazine affects the methylation of TYR gene CTD PMID:28931070 bathocuproine disulfonic acid multiple interactions ISO RGD:1346000 6480464 bathocuproine sulfonate inhibits the reaction [ATP7A protein results in increased activity of TYR protein], cupric chloride inhibits the reaction [bathocuproine sulfonate inhibits the reaction [ATP7A protein results in increased activity of TYR protein]] CTD PMID:11092760 benzo[a]pyrene increases activity ISO RGD:11466 6480464 Benzo(a)pyrene results in increased activity of TYR protein CTD PMID:34856342 benzo[a]pyrene multiple interactions ISO RGD:11466 6480464 [Acetylcysteine co-treated with Benzo(a)pyrene] results in increased activity of TYR protein more ... CTD PMID:34856342 benzo[a]pyrene increases expression ISO RGD:11466 6480464 Benzo(a)pyrene results in increased expression of TYR mRNA CTD PMID:34856342 beta-ionone increases expression ISO RGD:1346000 6480464 beta-ionone results in increased expression of TYR mRNA, beta-ionone results in increased expression of TYR protein CTD PMID:27226631 biochanin A increases expression ISO RGD:11466 6480464 biochanin A results in increased expression of TYR mRNA CTD PMID:21071833 bis(2-chloroethyl) sulfide decreases expression ISO RGD:1346000 6480464 Mustard Gas results in decreased expression of TYR protein CTD PMID:31785464 bis(2-chloroethyl) sulfide affects expression ISO RGD:1346000 6480464 Mustard Gas affects the expression of TYR mRNA CTD PMID:31785464 bisphenol A increases expression ISO RGD:11466 6480464 bisphenol A results in increased expression of TYR mRNA CTD PMID:30951980 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of TYR mRNA CTD PMID:34947998 bisphenol F multiple interactions ISO RGD:1346000 6480464 [bisphenol F co-treated with Fulvestrant] results in decreased methylation of TYR gene CTD PMID:31601247 cannabidiol multiple interactions ISO RGD:1346000 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Cannabidiol results in increased activity of TYR protein] more ... CTD PMID:28601556 cannabidiol increases expression ISO RGD:1346000 6480464 Cannabidiol results in increased expression of TYR mRNA CTD PMID:28601556 carnosic acid decreases expression ISO RGD:11466 6480464 salvin results in decreased expression of TYR mRNA CTD PMID:21071833 Carnosol decreases expression ISO RGD:11466 6480464 carnosol results in decreased expression of TYR mRNA, carnosol results in decreased expression of TYR protein CTD PMID:21071833 chaetocin multiple interactions ISO RGD:11466 6480464 chaetocin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased activity of TYR protein] more ... CTD PMID:26748310 chlorogenic acid increases oxidation ISO RGD:1346000 6480464 TYR protein results in increased oxidation of Chlorogenic Acid CTD PMID:20685355 chlorogenic acid multiple interactions ISO RGD:1346000 6480464 [TYR protein results in increased oxidation of Chlorogenic Acid] which results in decreased abundance of Glutathione CTD PMID:20685355 chlorpromazine increases expression ISO RGD:1346000 6480464 Chlorpromazine results in increased expression of TYR protein CTD PMID:25449126 chlorpyrifos decreases expression ISO RGD:11466 6480464 Chlorpyrifos results in decreased expression of TYR mRNA CTD PMID:32715474 chrysin increases expression ISO RGD:11466 6480464 chrysin results in increased expression of TYR mRNA CTD PMID:21071833 cis-caffeic acid increases oxidation ISO RGD:1346000 6480464 TYR protein results in increased oxidation of caffeic acid CTD PMID:20685355 cis-caffeic acid multiple interactions ISO RGD:1346000 6480464 [TYR protein results in increased oxidation of caffeic acid] which results in decreased abundance of Glutathione CTD PMID:20685355 colforsin daropate hydrochloride multiple interactions ISO RGD:11466 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Colforsin results in increased expression of TYR protein] more ... CTD PMID:28849034 colforsin daropate hydrochloride increases expression ISO RGD:1346000 6480464 Colforsin results in increased expression of TYR mRNA CTD PMID:23700242 , PMID:28601556 colforsin daropate hydrochloride increases activity ISO RGD:1346000 6480464 Colforsin results in increased activity of TYR protein CTD PMID:17460731 colforsin daropate hydrochloride multiple interactions ISO RGD:1346000 6480464 [resveratrol co-treated with Colforsin] results in decreased activity of TYR protein more ... CTD PMID:17460731 more ... colforsin daropate hydrochloride decreases expression ISO RGD:1346000 6480464 Colforsin results in decreased expression of TYR protein CTD PMID:28849034 colforsin daropate hydrochloride increases expression ISO RGD:11466 6480464 Colforsin results in increased expression of TYR protein CTD PMID:28849034 copper atom multiple interactions ISO RGD:11466 6480464 [SLC31A1 gene mutant form affects the abundance of Copper] which results in decreased activity of TYR protein, Copper inhibits the reaction [[SLC31A1 gene mutant form affects the abundance of Copper] which results in decreased activity of TYR protein] CTD PMID:12177073 copper atom multiple interactions ISO RGD:1346000 6480464 [CLDN3 protein results in increased abundance of Copper] promotes the reaction [[TYR protein results in increased oxidation of Levodopa] which results in increased chemical synthesis of Melanins] more ... CTD PMID:23053666 , PMID:23700242 copper atom affects binding ISO RGD:11466 6480464 TYR protein binds to Copper CTD PMID:11781109 copper(0) multiple interactions ISO RGD:11466 6480464 [SLC31A1 gene mutant form affects the abundance of Copper] which results in decreased activity of TYR protein, Copper inhibits the reaction [[SLC31A1 gene mutant form affects the abundance of Copper] which results in decreased activity of TYR protein] CTD PMID:12177073 copper(0) multiple interactions ISO RGD:1346000 6480464 [CLDN3 protein results in increased abundance of Copper] promotes the reaction [[TYR protein results in increased oxidation of Levodopa] which results in increased chemical synthesis of Melanins] more ... CTD PMID:23053666 , PMID:23700242 copper(0) affects binding ISO RGD:11466 6480464 TYR protein binds to Copper CTD PMID:11781109 copper(II) chloride multiple interactions ISO RGD:1346000 6480464 cupric chloride inhibits the reaction [bathocuproine sulfonate inhibits the reaction [ATP7A protein results in increased activity of TYR protein]] CTD PMID:11092760 cyanamide decreases expression ISO RGD:1346000 6480464 Cyanamide results in decreased expression of TYR mRNA CTD PMID:23489423 cycloheximide multiple interactions ISO RGD:1346000 6480464 Cycloheximide inhibits the reaction [Quercetin results in increased activity of TYR protein] CTD PMID:14717847 cycloheximide multiple interactions ISO RGD:11466 6480464 [resorcinol co-treated with Cycloheximide] results in increased expression of TYR protein, SB 203580 inhibits the reaction [[resorcinol co-treated with Cycloheximide] results in increased expression of TYR protein] CTD PMID:29621941 daidzein increases expression ISO RGD:11466 6480464 daidzein results in increased expression of TYR mRNA CTD PMID:21071833 dibenziodolium multiple interactions ISO RGD:11466 6480464 [diphenyleneiodonium co-treated with Benzo(a)pyrene] results in increased activity of TYR protein more ... CTD PMID:34856342 diclofenac decreases expression ISO RGD:11466 6480464 Diclofenac results in decreased expression of TYR protein CTD PMID:21079976 dimercaprol decreases activity ISO RGD:1346000 6480464 Dimercaprol results in decreased activity of TYR protein CTD PMID:16928136 dopachrome multiple interactions ISO RGD:11466 6480464 [POMC protein modified form results in increased activity of TYR protein] which results in increased chemical synthesis of dopachrome, Quercetin analog inhibits the reaction [[POMC protein modified form results in increased activity of TYR protein] which results in increased chemical synthesis of dopachrome] CTD PMID:26586997 emodin decreases activity ISO RGD:1346000 6480464 Emodin results in decreased activity of TYR protein CTD PMID:26972667 epoxiconazole increases expression ISO RGD:11466 6480464 epoxiconazole results in increased expression of TYR mRNA CTD PMID:35436446 estriol multiple interactions ISO RGD:11466 6480464 Estriol inhibits the reaction [imidazole results in increased expression of TYR protein] CTD PMID:3127403 ethylenediamine multiple interactions ISO RGD:1346000 6480464 ethylenediamine inhibits the reaction [[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of Ascorbic Acid] more ... CTD PMID:20685355 ethylparaben affects response to substance ISO RGD:1346000 6480464 TYR protein affects the susceptibility to ethyl-p-hydroxybenzoate CTD PMID:19944085 fenofibrate decreases expression ISO RGD:11466 6480464 Fenofibrate results in decreased expression of TYR mRNA CTD PMID:23872139 fenofibrate multiple interactions ISO RGD:11466 6480464 [Fenofibrate results in decreased chemical synthesis of Melanins] which results in decreased expression of TYR more ... CTD PMID:23872139 ferulic acid increases oxidation ISO RGD:1346000 6480464 TYR protein results in increased oxidation of ferulic acid CTD PMID:20685355 ferulic acid multiple interactions ISO RGD:1346000 6480464 [TYR protein results in increased oxidation of ferulic acid] which results in decreased abundance of Glutathione CTD PMID:20685355 fulvestrant multiple interactions ISO RGD:1346000 6480464 [bisphenol F co-treated with Fulvestrant] results in decreased methylation of TYR gene CTD PMID:31601247 fulvestrant decreases methylation ISO RGD:1346000 6480464 Fulvestrant results in decreased methylation of TYR gene CTD PMID:31601247 galangin increases expression ISO RGD:11466 6480464 galangin results in increased expression of TYR mRNA CTD PMID:21071833 genistein increases expression ISO RGD:11466 6480464 Genistein results in increased expression of TYR mRNA CTD PMID:21071833 geranic acid decreases expression ISO RGD:11466 6480464 decaprenoic acid results in decreased expression of TYR protein CTD PMID:23286867 glutathione multiple interactions ISO RGD:1346000 6480464 [TYR protein affects the susceptibility to caffeic acid phenethyl ester] which affects the abundance of Glutathione more ... CTD PMID:20685355 glycidol decreases expression EXP 6480464 glycidol results in decreased expression of TYR mRNA CTD PMID:24395379 hydroquinone increases expression ISO RGD:1346000 6480464 hydroquinone results in increased expression of TYR mRNA, hydroquinone results in increased expression of TYR protein CTD PMID:23738040 hydroquinone O-beta-D-glucopyranoside decreases expression ISO RGD:11466 6480464 Arbutin results in decreased expression of TYR mRNA CTD PMID:21071833 hydroquinone O-beta-D-glucopyranoside decreases activity ISO RGD:11466 6480464 Arbutin results in decreased activity of TYR protein CTD PMID:22705713 isorhamnetin increases expression ISO RGD:11466 6480464 3-methylquercetin results in increased expression of TYR protein CTD PMID:24853321 kenpaullone increases expression ISO RGD:11466 6480464 kenpaullone results in increased expression of TYR mRNA CTD PMID:21071833 kojic acid decreases activity ISO RGD:11466 6480464 kojic acid results in decreased activity of TYR protein CTD PMID:27586645 kojic acid increases expression ISO RGD:1346000 6480464 kojic acid results in increased expression of TYR mRNA, kojic acid results in increased expression of TYR protein CTD PMID:23738040 L-ascorbic acid multiple interactions ISO RGD:1346000 6480464 ethylenediamine inhibits the reaction [[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of Ascorbic Acid], Glutathione inhibits the reaction [[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of Ascorbic Acid] CTD PMID:20685355 L-ascorbic acid increases oxidation ISO RGD:1346000 6480464 [TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of Ascorbic Acid CTD PMID:20685355 lawsone multiple interactions ISO RGD:11466 6480464 lawsone results in decreased expression of and results in decreased activity of TYR protein CTD PMID:25584612 luteolin increases expression ISO RGD:11466 6480464 Luteolin results in increased expression of TYR mRNA CTD PMID:21071833 LY294002 multiple interactions ISO RGD:11466 6480464 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Drugs more ... CTD PMID:21816215 , PMID:28849034 LY294002 multiple interactions ISO RGD:1346000 6480464 [Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased expression of TYR protein CTD PMID:28849034 mefenamic acid decreases expression ISO RGD:11466 6480464 Mefenamic Acid results in decreased expression of TYR mRNA, Mefenamic Acid results in decreased expression of TYR protein CTD PMID:21079976 melanins multiple interactions ISO RGD:1346000 6480464 [CLDN3 protein results in increased abundance of Copper] promotes the reaction [[TYR protein results in increased oxidation of Levodopa] which results in increased chemical synthesis of Melanins] more ... CTD PMID:11092760 more ... melanins multiple interactions ISO RGD:11466 6480464 [Fenofibrate results in decreased chemical synthesis of Melanins] which results in decreased expression of TYR CTD PMID:23872139 N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide multiple interactions ISO RGD:11466 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [scoparone results in increased expression of TYR protein] CTD PMID:17049123 N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide decreases activity ISO RGD:1346000 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased activity of TYR protein CTD PMID:30849679 N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide decreases activity ISO RGD:11466 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased activity of TYR protein CTD PMID:30849679 N-acetyl-L-cysteine multiple interactions ISO RGD:11466 6480464 [Acetylcysteine co-treated with 6-formylindolo(3 more ... CTD PMID:34856342 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions ISO RGD:11466 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Fenofibrate results in decreased expression of TYR protein] CTD PMID:23872139 N-ethyl-N-nitrosourea increases mutagenesis ISO RGD:11466 6480464 Ethylnitrosourea results in increased mutagenesis of TYR gene CTD PMID:16180137 more ... N-methyl-N-nitrosourea increases mutagenesis ISO RGD:11466 6480464 Methylnitrosourea results in increased mutagenesis of TYR gene CTD PMID:17174358 NAD zwitterion multiple interactions ISO RGD:1346000 6480464 ethylenediamine inhibits the reaction [[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of NAD], Glutathione inhibits the reaction [[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of NAD] CTD PMID:20685355 NAD zwitterion increases oxidation ISO RGD:1346000 6480464 [TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of NAD CTD PMID:20685355 NAD(+) multiple interactions ISO RGD:1346000 6480464 ethylenediamine inhibits the reaction [[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of NAD], Glutathione inhibits the reaction [[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of NAD] CTD PMID:20685355 NAD(+) increases oxidation ISO RGD:1346000 6480464 [TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of NAD CTD PMID:20685355 nicotinamide increases expression ISO RGD:1346000 6480464 Niacinamide results in increased expression of TYR mRNA, Niacinamide results in increased expression of TYR protein CTD PMID:23738040 nimesulide decreases expression ISO RGD:11466 6480464 nimesulide results in decreased expression of TYR mRNA, nimesulide results in decreased expression of TYR protein CTD PMID:21079976 nonanedioic acid decreases expression ISO RGD:11466 6480464 azelaic acid results in decreased expression of TYR protein CTD PMID:20804622 nonanedioic acid multiple interactions ISO RGD:11466 6480464 [Taurine co-treated with azelaic acid] results in decreased activity of TYR protein, [Taurine co-treated with azelaic acid] results in decreased expression of TYR protein CTD PMID:20804622 omacetaxine mepesuccinate increases expression ISO RGD:11466 6480464 Homoharringtonine results in increased expression of TYR mRNA CTD PMID:21071833 omeprazole decreases expression ISO RGD:11466 6480464 Omeprazole results in decreased expression of TYR protein CTD PMID:25337692 omeprazole multiple interactions ISO RGD:1346000 6480464 Omeprazole affects the N-linked glycosylation of and results in increased degradation of TYR protein, Omeprazole inhibits the reaction [ATP7A protein results in increased activity of TYR protein] CTD PMID:25337692 phenethyl caffeate multiple interactions ISO RGD:1346000 6480464 [TYR protein affects the susceptibility to caffeic acid phenethyl ester] which affects the abundance of Glutathione more ... CTD PMID:20685355 , PMID:21458432 phenethyl caffeate increases oxidation ISO RGD:1346000 6480464 [TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of Ascorbic Acid more ... CTD PMID:20685355 phenethyl caffeate affects response to substance ISO RGD:1346000 6480464 TYR protein affects the susceptibility to caffeic acid phenethyl ester CTD PMID:20685355 phenylephrine multiple interactions EXP 6480464 Dactinomycin inhibits the reaction [Phenylephrine results in increased activity of TYR protein], Prazosin inhibits the reaction [Phenylephrine results in increased activity of TYR protein] CTD PMID:15278367 phenylephrine increases activity EXP 6480464 Phenylephrine results in increased activity of TYR protein CTD PMID:15278367 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:11466 6480464 [9 more ... CTD PMID:20691676 phytol multiple interactions ISO RGD:11466 6480464 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytol inhibits the reaction [alpha-MSH results in increased expression of TYR protein]], Phytol inhibits the reaction [alpha-MSH results in increased expression of TYR protein] CTD PMID:29486182 prazosin multiple interactions EXP 6480464 Prazosin inhibits the reaction [Phenylephrine results in increased activity of TYR protein] CTD PMID:15278367 quercetin multiple interactions ISO RGD:1346000 6480464 Cycloheximide inhibits the reaction [Quercetin results in increased activity of TYR protein], Dactinomycin inhibits the reaction [Quercetin results in increased activity of TYR protein] CTD PMID:14717847 quercetin increases expression ISO RGD:11466 6480464 Quercetin results in increased expression of TYR protein CTD PMID:24318284 quercetin affects activity ISO RGD:1346000 6480464 Quercetin affects the activity of TYR protein CTD PMID:21290442 quercetin affects expression ISO RGD:11466 6480464 Quercetin affects the expression of TYR protein, Quercetin affects the expression of TYR protein modified form CTD PMID:21290442 quercetin affects activity ISO RGD:11466 6480464 Quercetin affects the activity of TYR protein CTD PMID:21290442 quercetin affects expression ISO RGD:1346000 6480464 Quercetin affects the expression of TYR protein, Quercetin affects the expression of TYR protein modified form CTD PMID:21290442 quercetin multiple interactions ISO RGD:11466 6480464 Quercetin analog inhibits the reaction [[POMC protein modified form results in increased activity of TYR protein] which results in increased chemical synthesis of dopachrome] more ... CTD PMID:21290442 , PMID:26586997 quercetin increases response to substance ISO RGD:1346000 6480464 TYR protein results in increased susceptibility to Quercetin CTD PMID:18001220 quercetin increases metabolic processing ISO RGD:1346000 6480464 TYR protein results in increased metabolism of Quercetin CTD PMID:18001220 quercetin increases activity ISO RGD:1346000 6480464 Quercetin results in increased activity of TYR protein CTD PMID:14717847 rac-lactic acid affects expression ISO RGD:1346000 6480464 Lactic Acid affects the expression of TYR mRNA CTD PMID:30851411 reactive oxygen species multiple interactions ISO RGD:1346000 6480464 [TYR protein affects the susceptibility to caffeic acid phenethyl ester] which affects the abundance of Reactive Oxygen Species CTD PMID:20685355 resorcinol decreases activity ISO RGD:1346000 6480464 resorcinol results in decreased activity of TYR protein CTD PMID:29621941 resorcinol decreases expression ISO RGD:11466 6480464 resorcinol results in decreased expression of TYR mRNA, resorcinol results in decreased expression of TYR protein CTD PMID:29621941 resorcinol decreases activity ISO RGD:11466 6480464 resorcinol results in decreased activity of TYR protein CTD PMID:29621941 , PMID:30849679 resorcinol multiple interactions ISO RGD:11466 6480464 [resorcinol co-treated with Cycloheximide] results in increased expression of TYR protein more ... CTD PMID:25584612 , PMID:29621941 resveratrol affects localization ISO RGD:1346000 6480464 resveratrol affects the localization of TYR protein modified form CTD PMID:17460731 resveratrol multiple interactions ISO RGD:11466 6480464 resveratrol inhibits the reaction [alpha-MSH results in increased expression of TYR protein] CTD PMID:29486182 resveratrol increases expression ISO RGD:11466 6480464 resveratrol results in increased expression of TYR mRNA CTD PMID:21071833 resveratrol decreases expression ISO RGD:1346000 6480464 resveratrol results in decreased expression of TYR protein CTD PMID:17460731 resveratrol decreases activity ISO RGD:1346000 6480464 resveratrol results in decreased activity of TYR protein CTD PMID:17460731 resveratrol multiple interactions ISO RGD:1346000 6480464 [Plant Extracts co-treated with Resveratrol] results in decreased expression of TYR mRNA, [Resveratrol co-treated with Colforsin] results in decreased activity of TYR protein CTD PMID:17460731 , PMID:23557933 rottlerin decreases expression ISO RGD:11466 6480464 rottlerin results in decreased expression of TYR mRNA, rottlerin results in decreased expression of TYR protein CTD PMID:21071833 sanguinarine multiple interactions ISO RGD:11466 6480464 [9 more ... CTD PMID:20691676 SB 203580 multiple interactions ISO RGD:1346000 6480464 SB 203580 inhibits the reaction [Cannabidiol results in increased activity of TYR protein], SB 203580 inhibits the reaction [Cannabidiol results in increased expression of TYR mRNA] CTD PMID:28601556 SB 203580 multiple interactions ISO RGD:11466 6480464 SB 203580 inhibits the reaction [[resorcinol co-treated with Cycloheximide] results in increased expression of TYR protein], SB 203580 inhibits the reaction [resorcinol results in decreased activity of TYR protein] CTD PMID:29621941 scoparone multiple interactions ISO RGD:11466 6480464 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [scoparone results in increased expression of TYR protein], scoparone results in increased expression of and results in increased activity of TYR protein CTD PMID:17049123 scoparone increases expression ISO RGD:11466 6480464 scoparone results in increased expression of TYR mRNA CTD PMID:17049123 stilbenoid decreases expression ISO RGD:11466 6480464 Stilbenes analog results in decreased expression of TYR mRNA CTD PMID:29042215 sulforaphane decreases expression ISO RGD:11466 6480464 sulforaphane results in decreased expression of TYR mRNA CTD PMID:21071833 Sweroside decreases expression ISO RGD:11466 6480464 sweroside results in decreased expression of TYR protein CTD PMID:26051519 taurine multiple interactions ISO RGD:11466 6480464 [Taurine co-treated with azelaic acid] results in decreased activity of TYR protein, [Taurine co-treated with azelaic acid] results in decreased expression of TYR protein CTD PMID:20804622 taurine decreases expression ISO RGD:11466 6480464 Taurine results in decreased expression of TYR protein CTD PMID:20804622 testosterone decreases expression ISO RGD:11466 6480464 Testosterone results in decreased expression of TYR protein CTD PMID:18336327 theophylline increases expression ISO RGD:11466 6480464 Theophylline results in increased expression of TYR mRNA, Theophylline results in increased expression of TYR protein CTD PMID:21071833 , PMID:32001318 trans-caffeic acid increases oxidation ISO RGD:1346000 6480464 TYR protein results in increased oxidation of caffeic acid CTD PMID:20685355 trans-caffeic acid multiple interactions ISO RGD:1346000 6480464 [TYR protein results in increased oxidation of caffeic acid] which results in decreased abundance of Glutathione CTD PMID:20685355 trans-cinnamic acid increases oxidation ISO RGD:1346000 6480464 TYR protein results in increased oxidation of cinnamic acid CTD PMID:20685355 trans-cinnamic acid multiple interactions ISO RGD:1346000 6480464 [TYR protein results in increased oxidation of cinnamic acid] which results in decreased abundance of Glutathione CTD PMID:20685355 trichloroethene decreases expression EXP 6480464 Trichloroethylene results in decreased expression of TYR mRNA CTD PMID:33387578 valproic acid increases expression ISO RGD:1346000 6480464 Valproic Acid results in increased expression of TYR mRNA CTD PMID:27188386 valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of TYR mRNA CTD PMID:35594946 vemurafenib increases expression ISO RGD:1346000 6480464 Vemurafenib results in increased expression of TYR mRNA, Vemurafenib results in increased expression of TYR protein CTD PMID:26640592 vinclozolin increases methylation EXP 6480464 vinclozolin results in increased methylation of TYR gene CTD PMID:31079544 wortmannin multiple interactions ISO RGD:1346000 6480464 [Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased expression of TYR protein CTD PMID:28849034 wortmannin multiple interactions ISO RGD:11466 6480464 [Colforsin co-treated with Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased expression of TYR protein more ... CTD PMID:28849034 zinc atom multiple interactions ISO RGD:1346000 6480464 [Zinc analog co-treated with Copper analog] inhibits the reaction [Colforsin results in increased expression of TYR mRNA] CTD PMID:23700242 zinc(0) multiple interactions ISO RGD:1346000 6480464 [Zinc analog co-treated with Copper analog] inhibits the reaction [Colforsin results in increased expression of TYR mRNA] CTD PMID:23700242
