Gla (galactosidase, alpha) - Rat Genome Database

Name: Gla
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Gla (galactosidase, alpha) Rattus norvegicus

Analyze

Symbol:

Gla

Name:

galactosidase, alpha

RGD ID:

1589721

Description:

Enables alpha-galactosidase activity and galactoside binding activity. Predicted to be involved in glycosphingolipid catabolic process; negative regulation of nitric oxide biosynthetic process; and oligosaccharide metabolic process. Predicted to act upstream of or within aorta development and glycosylceramide catabolic process. Predicted to be located in Golgi apparatus; extracellular space; and lysosome. Used to study Fabry disease and lysosomal storage disease. Human ortholog(s) of this gene implicated in Fabry disease. Orthologous to human GLA (galactosidase alpha); PARTICIPATES IN Fabry disease pathway; galactose metabolic pathway; galactosemia pathway; INTERACTS WITH 6-propyl-2-thiouracil; amphetamine; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

alpha-galactosidase A; galactosidase, alpha (mapped); Gla_mapped

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GLA (galactosidase alpha)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Gla (galactosidase, alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gla (galactosidase alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GLA (galactosidase alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GLA (galactosidase alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gla (galactosidase alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GLA (galactosidase alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GLA (galactosidase alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gla (galactosidase alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	KRTAP10-8 (keratin associated protein 10-8)	HGNC	OMA
Homo sapiens (human):	KRTAP10-10 (keratin associated protein 10-10)	HGNC	OMA
Homo sapiens (human):	KRTAP10-12 (keratin associated protein 10-12)	HGNC	OMA
Homo sapiens (human):	KRTAP10-11 (keratin associated protein 10-11)	HGNC	OMA
Homo sapiens (human):	KRTAP10-3 (keratin associated protein 10-3)	HGNC	OMA
Homo sapiens (human):	KRTAP10-5 (keratin associated protein 10-5)	HGNC	OMA
Homo sapiens (human):	KRTAP10-2 (keratin associated protein 10-2)	HGNC	OMA
Homo sapiens (human):	KRTAP10-1 (keratin associated protein 10-1)	HGNC	OMA
Homo sapiens (human):	KRTAP10-9 (keratin associated protein 10-9)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Gla (galactosidase, alpha)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	GLA (galactosidase alpha)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	gla (galactosidase, alpha)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gana-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG5731	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	CG7997	Alliance	DIOPT (Hieranoid\|OrthoFinder\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	gla	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Allele / Splice:

Gla^em2Mcwi

Genetic Models:

DA-Gla^em2Mcwi

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	X	97,769,227 - 97,780,646 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	97,768,996 - 97,780,664 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	99,443,442 - 99,454,860 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	102,954,152 - 102,965,578 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	100,456,591 - 100,468,010 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	105,405,915 - 105,417,331 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	105,406,792 - 105,417,323 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	105,295,029 - 105,306,686 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	122,044,703 - 122,056,327 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	98,809,769 - 98,821,187 (-)	NCBI		Celera
Cytogenetic Map	X	q32	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

angiokeratoma (ISO)

autistic disorder (ISO)

cardiomyopathy (ISO)

developmental and epileptic encephalopathy 9 (ISO)

Fabry disease (IMP,ISO,ISS)

Fabry Disease, Cardiac Variant (ISO)

familial hypertrophic cardiomyopathy (ISO)

hypertrophic cardiomyopathy (ISO)

hypertrophic cardiomyopathy 1 (ISO)

isolated growth hormone deficiency type III (ISO)

lysosomal storage disease (IMP)

nephrotic syndrome (ISO)

Pain (IMP)

ROLANDIC EPILEPSY, INTELLECTUAL DISABILITY, AND SPEECH DYSPRAXIA, X-LINKED (ISO)

Stroke (ISO)

Sudden Death (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,3-dimethoxynaphthalene-1,4-dione (ISO)

2-hydroxypropanoic acid (ISO)

4,4'-diaminodiphenylmethane (ISO)

4-hydroxyphenyl retinamide (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

all-trans-retinoic acid (ISO)

amphetamine (EXP)

antimony(0) (ISO)

antirheumatic drug (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

beta-naphthoflavone (ISO)

bisphenol A (EXP,ISO)

bortezomib (ISO)

calcitriol (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

cobalt dichloride (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) chloride (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

cyfluthrin (ISO)

D-glucose (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (EXP)

dicrotophos (ISO)

dioxygen (ISO)

dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

elesclomol (ISO)

flutamide (ISO)

folic acid (ISO)

formaldehyde (ISO)

furan (EXP)

gentamycin (EXP)

glucose (ISO)

hydralazine (ISO)

ivermectin (ISO)

mercury atom (ISO)

mercury(0) (ISO)

methyl methacrylate (ISO)

migalastat (ISO)

N-nitrosodimethylamine (ISO)

nickel dichloride (ISO)

O-methyleugenol (ISO)

ozone (ISO)

paracetamol (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (ISO)

phenylephrine (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

piroxicam (ISO)

propiconazole (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

rotenone (ISO)

SB 431542 (ISO)

serotonin (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

Soman (EXP)

sulforaphane (ISO)

sunitinib (ISO)

tert-butyl hydroperoxide (ISO)

testosterone (ISO)

tetrachloromethane (ISO)

thapsigargin (ISO)

tremolite asbestos (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vinclozolin (EXP)

zalcitabine (EXP)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

aorta development (ISO)

biological_process (ND)

bone mineralization (ISO)

glycoside catabolic process (IBA)

glycosphingolipid catabolic process (ISO)

glycosylceramide catabolic process (ISO)

negative regulation of nitric oxide biosynthetic process (ISO)

oligosaccharide metabolic process (IBA,ISO)

Cellular Component

cytoplasm (IBA,ISO)

extracellular region (ISO)

extracellular space (ISO)

Golgi apparatus (ISO)

lysosome (ISO)

Molecular Function

alpha-galactosidase activity (IBA,IDA,IMP,ISO)

catalytic activity (ISO)

galactoside binding (IDA)

hydrolase activity (ISO)

protein binding (ISO)

protein homodimerization activity (ISO)

signaling receptor binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Fabry disease pathway (ISO)

galactose metabolic pathway (IEA,ISO)

galactosemia pathway (ISO)

Gaucher's disease pathway (ISO)

globoside metabolic pathway (IEA)

glycerolipid metabolic pathway (IEA)

Krabbe disease pathway (ISO)

metachromatic leukodystrophy pathway (ISO)

sphingolipid metabolic pathway (IEA,ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal glycosphingolipid level (IMP)

abnormal sensory neuron morphology (IMP)

allodynia (IMP)

decreased mechanical nociceptive threshold (IMP)

hyperresponsive to tactile stimuli (IMP)

nervous system inclusion bodies (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Fabry disease: six gene rearrangements and an exonic point mutation in the alpha-galactosidase gene.	Bernstein HS, etal., J Clin Invest. 1989 Apr;83(4):1390-9.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Neuropathic pain in a Fabry disease rat model.	Miller JJ, etal., JCI Insight. 2018 Mar 22;3(6). pii: 99171. doi: 10.1172/jci.insight.99171.
4.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	SMPDB Annotation Import Pipeline	Pipeline to import SMPDB annotations from SMPDB into RGD
7.	Alterations in certain lysosomal glycohydrolases and cathepsins in rats on dexamethasone administration.	Rajashree S and Puvanakrishnan R, Mol Cell Biochem. 1996 Jan 26;154(2):165-70.
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Comprehensive gene review and curation	RGD comprehensive gene curation
11.	Rat brain contains high levels of mannose-6-phosphorylated glycoproteins including lysosomal enzymes and palmitoyl-protein thioesterase, an enzyme implicated in infantile neuronal lipofuscinosis.	Sleat DE, etal., J Biol Chem. 1996 Aug 9;271(32):19191-8.

Additional References at PubMed

PMID:39940	PMID:198184	PMID:205481	PMID:895843	PMID:1008807	PMID:1300216	PMID:1332979	PMID:2890215	PMID:2906327	PMID:3029062	PMID:6251472	PMID:6256390
PMID:6852525	PMID:9122231	PMID:10840053	PMID:10841515	PMID:11115376	PMID:11752062	PMID:12938095	PMID:15629890	PMID:15668341	PMID:16372133	PMID:16697974	PMID:19710420
PMID:23376485	PMID:23533145	PMID:27211852	PMID:29979634

Genomics

Comparative Map Data

Gla
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	X	97,769,227 - 97,780,646 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	97,768,996 - 97,780,664 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	99,443,442 - 99,454,860 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	102,954,152 - 102,965,578 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	100,456,591 - 100,468,010 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	105,405,915 - 105,417,331 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	105,406,792 - 105,417,323 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	105,295,029 - 105,306,686 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	122,044,703 - 122,056,327 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	98,809,769 - 98,821,187 (-)	NCBI		Celera
Cytogenetic Map	X	q32	NCBI

GLA
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	101,397,803 - 101,407,925 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	101,393,273 - 101,408,012 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	100,652,791 - 100,662,913 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	100,539,435 - 100,549,657 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	100,458,941 - 100,469,096	NCBI
Celera	X	101,172,239 - 101,182,459 (-)	NCBI		Celera
Cytogenetic Map	X	q22.1	NCBI
HuRef	X	90,459,075 - 90,468,889 (-)	NCBI		HuRef
CHM1_1	X	100,546,260 - 100,556,479 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	X	99,841,918 - 99,852,040 (-)	NCBI		T2T-CHM13v2.0

Gla
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	133,488,912 - 133,501,707 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	133,488,898 - 133,501,874 (-)	Ensembl		GRCm39 Ensembl
GRCm38	X	134,588,169 - 134,601,005 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	134,588,149 - 134,601,125 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	131,122,708 - 131,135,544 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	129,934,706 - 129,947,305 (-)	NCBI		MGSCv36	mm8
Celera	X	117,467,753 - 117,480,561 (-)	NCBI		Celera
Cytogenetic Map	X	E3	NCBI
cM Map	X	56.2	NCBI

Gla
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955503	7,521,930 - 7,535,817 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955503	7,526,077 - 7,535,817 (-)	NCBI	ChiLan1.0	ChiLan1.0

GLA
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	X	101,000,787 - 101,010,979 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	90,600,412 - 90,610,594 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	100,732,311 - 100,742,280 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	X	100,732,311 - 100,742,280 (-)	Ensembl	panpan1.1		panPan2

GLA
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	75,311,536 - 75,320,391 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	75,311,536 - 75,320,249 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
ROS_Cfam_1.0	X	76,731,752 - 76,740,708 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	76,731,752 - 76,740,486 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	74,296,077 - 74,305,030 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	75,956,280 - 75,965,243 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	75,718,710 - 75,727,662 (-)	NCBI		UU_Cfam_GSD_1.0

Gla
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	62,990,371 - 63,000,657 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936813	474,949 - 484,760 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936813	474,938 - 484,753 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GLA
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	83,023,903 - 83,032,570 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	83,024,582 - 83,032,273 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

GLA
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	89,738,097 - 89,749,740 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	89,737,966 - 89,750,539 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666065	14,657,735 - 14,667,684 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gla
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624902	1,163,611 - 1,173,177 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624902	1,163,360 - 1,173,087 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Gla
20 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	399
Count of miRNA genes:	220
Interacting mature miRNAs:	275
Transcripts:	ENSRNOT00000015494
Prediction methods:	Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61430	Cia18	Collagen induced arthritis QTL 18	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	X	14843113	120568734	Rat
1598837	Memor13	Memory QTL 13	3.2		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	X	41052407	146860749	Rat
738035	Stresp1	Stress response QTL 1	4.96	0.000011	stress-related behavior trait (VT:0010451)	defensive burying - coping	X	41304447	112935181	Rat
61431	Cia19	Collagen induced arthritis QTL 19	4.4		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	X	65612192	120568734	Rat
724551	Glom1	Glomerulus QTL 1	2.8	0.0004	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	X	75294106	120294106	Rat
1598872	Memor14	Memory QTL 14	4.5		exploratory behavior trait (VT:0010471)	difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)	X	93956491	138956491	Rat

Markers in Region

RH140281

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	97,768,844 - 97,768,996 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	105,405,533 - 105,405,684	NCBI	Rnor6.0
Rnor_5.0	X	105,294,887 - 105,295,038	UniSTS	Rnor5.0
RGSC_v3.4	X	122,044,513 - 122,044,664	UniSTS	RGSC3.4
Celera	X	98,809,387 - 98,809,538	UniSTS
Cytogenetic Map	X	q34	UniSTS

RH130891

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	97,769,026 - 97,769,213 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	105,405,715 - 105,405,901	NCBI	Rnor6.0
Rnor_5.0	X	105,295,069 - 105,295,255	UniSTS	Rnor5.0
RGSC_v3.4	X	122,044,695 - 122,044,881	UniSTS	RGSC3.4
Celera	X	98,809,569 - 98,809,755	UniSTS
RH 3.4 Map	1	942.6	UniSTS
Cytogenetic Map	X	q34	UniSTS

BE118467

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	97,770,604 - 97,770,788 (+)	MAPPER	mRatBN7.2
Rnor_6.0	X	105,407,293 - 105,407,476	NCBI	Rnor6.0
Rnor_5.0	X	105,296,647 - 105,296,830	UniSTS	Rnor5.0
RGSC_v3.4	X	122,046,273 - 122,046,456	UniSTS	RGSC3.4
Celera	X	98,811,147 - 98,811,330	UniSTS
RH 3.4 Map	1	943.1	UniSTS
Cytogenetic Map	X	q34	UniSTS

Genetic Models

This gene Gla is modified in the following models/strains:

DA-Gla^em2Mcwi

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	16	39	23	19	23			74	35	34	11
Low		27	18	18		18	8	11			7		8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108820	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473969	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CR468644	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM042657	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM104174	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM128994	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM134560	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM135509	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM137073	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000445	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000015494 ⟹ ENSRNOP00000015494

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	X	97,768,996 - 97,780,664 (-)	Ensembl
Rnor_6.0 Ensembl	X	105,406,792 - 105,417,323 (-)	Ensembl

RefSeq Acc Id:

NM_001108820 ⟹ NP_001102290

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	X	97,769,227 - 97,780,646 (-)	NCBI
Rnor_6.0	X	105,405,915 - 105,417,331 (-)	NCBI
Rnor_5.0	X	105,295,029 - 105,306,686 (-)	NCBI
RGSC_v3.4	X	122,044,703 - 122,056,327 (-)	RGD
Celera	X	98,809,769 - 98,821,187 (-)	NCBI

Sequence:

show sequence

GGATTTCTATGGCCATGAAGCTTTTGAGCGGAGATACACCGCTGGTCTGTGAGCTTGCGCTTCG
CCCCCTGGCTTTAGTTTTCTGGAGCATTCTTGGGGCCAGAGCATTGGACAATGGCTTGGCGCGG
ACACCTACTATGGGCTGGCTGCACTGGGAACGTTTCATGTGCAACCTTGACTGCCAAGAAGAGC
CTGATGCCTGCATAAGTGAGCAACTGTTCATGCAGATGGCAGAGCTCATGGTCTCTGATGGCTG
GAGGGACGCGGGTTATGAATACCTCTGCATAGATGACTGCTGGATGGCTCCCGAGAGGGATTCA
AAGGGCCGGCTTCAGGCAGATCCCAAGCGCTTTCCTAGTGGGATCAAACACCTCGCTAATTACG
TCCACAGCAAAGGCTTAAAGCTAGGGATTTATGCAGATGTTGGCAAGAAAACCTGTGCAGGTTT
CCCTGGGAGCTTTGGATCCTATGACATTGATGCCCAGACATTTGCTGACTGGGGTATAGATCTG
CTAAAATTTGATGGTTGTCACTGTGACAGTGTGGTATCCTTGGCGAATGGTTACAAGTACATGT
CCTTGGCCTTGAACAGGACTGGCAGAAGTATTGTGTACTCCTGTGAGTGGCCTCTTTATTTGAG
ACCCTTTCATAAGCCTAATTATACAGATATCCAATATTACTGCAATCACTGGAGAAATTTTGAT
GATGTTTATGATTCCTGGGAAAGCATAAAGTCTATCTTGGCCTGGACAGTAACTCACCAGAAGG
ACATTGTTGAAGTCGCCGGACCAGGGGGCTGGAATGACCCAGACATGTTAGTGATTGGCAACTT
TGGCCTCAGTTGGGACCAGCAGGTAACACAGATGGCCCTCTGGGCTATCATGGCAGCTCCTCTA
CTCATGTCCAATGATCTCCGACAAATCAGCTCTCAAGCCAAGGCTCTACTTCAGAATGAGGATG
TAATTGCCATCAACCAAGACCCCTTGGGCAAGCAGGGGTACTGTTTTAGAAAGGAAAACGAAAT
TGAGGTTTGGGAACGGCCACTCTCAAACCTAGCCTGGGCCGTGGCTGTGAGAAACCTGCAGGAG
ATTGGTGGACCTCGTTTTTACACCATCCAGATTTCTTCCCTGGGTCGAGGACTAGCCTGCAATC
CTGGCTGCATCATCACTCAGATTCTCCCTGAGAAAGTACATCTAGGCTTCTATGAATGGCCTTT
AACCTTAAAAACTCGAATAAATCCCTCAGGTACTGTTTTGCTTCGGTTAGAAAGATAAACTATA
CTATGTTGGAAGGCAGAGATCTGCATAAGTGCCCAGTTTTCCTAAAGACCAAACTATTCCCTGC
CCTTCCCTGTTTCACCTTAGGCTTTTGAAATTAAGTGGGTACTCCTGTGCCAGGCACTGTAACA
GATGCTTCCTGTCTACCGGTTGATTTTAATCATCACAACCCCAAAGCAGGTGTTTATCCACTAT
AATCTGTACAGCTAGATCAGATTAAAAAAACTTGATTGTTTTTTTTTTAAATGTGGTTCAAGTG
TTTTGCTTTTATGTATGAGTTCCACATGCATACCTGGTGCCCAGGAAGTCAGAAGCCGGCACGA
AATCCTCTGGAACTGAACCTGAGACCTCTGTAAAGAACAAGTGCTCTTAATCGCTGAGCCAGCT
CTCTAGCACCTATAACCAGGATTCAGAGCTAAGCCAACTAGACACAAATCAGTAGGGGTACTTG
GCATGGACTGCTTATAGTCTAATAAAAAGGAAAAAAAATGAAAATCTGTTTCCTCAGTTAAAAA
CTCATGTACCTAAGTTACTCTAAGATTAGAGTAAGCCAGCAGTATATTTTAGAAATTTACAAGC
AGTTTCATTTCAGAAAGCTGAAGCAGAATTGCCAATGTGGAAACCAGTCCAGGATATGTAACAG
AATCACAAGCAAAATGATGTACCTCTGATATTCTGAATGTGCAAAAACACCTGAGATATTGAAG
GGGTTGGATGAAACCCAGTCACGGGTGAGAGTCGAGCATGTAAGCAGTATGGCTGCTCTCTGTG
AGGACTCATTCCCAGTACTCACATGGAGGCAGAGGACTGCTAACATTAGTCCCAGGGGATCTGA
CCACCCTTTTGAGTCATTTGTAGACTAGTTTTACTGCTG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001102290	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM07018	(Get FASTA)	NCBI Sequence Viewer
	EDM07019	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000015494
	ENSRNOP00000015494.6

RefSeq Acc Id:

NP_001102290 ⟸ NM_001108820

- UniProtKB:

D3ZJF9 (UniProtKB/TrEMBL), A6IVG1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAMKLLSGDTPLVCELALRPLALVFWSILGARALDNGLARTPTMGWLHWERFMCNLDCQEEPDA
CISEQLFMQMAELMVSDGWRDAGYEYLCIDDCWMAPERDSKGRLQADPKRFPSGIKHLANYVHS
KGLKLGIYADVGKKTCAGFPGSFGSYDIDAQTFADWGIDLLKFDGCHCDSVVSLANGYKYMSLA
LNRTGRSIVYSCEWPLYLRPFHKPNYTDIQYYCNHWRNFDDVYDSWESIKSILAWTVTHQKDIV
EVAGPGGWNDPDMLVIGNFGLSWDQQVTQMALWAIMAAPLLMSNDLRQISSQAKALLQNEDVIA
INQDPLGKQGYCFRKENEIEVWERPLSNLAWAVAVRNLQEIGGPRFYTIQISSLGRGLACNPGC
IITQILPEKVHLGFYEWPLTLKTRINPSGTVLLRLER

hide sequence

RefSeq Acc Id:

ENSRNOP00000015494 ⟸ ENSRNOT00000015494

Protein Domains

Alpha galactosidase A C-terminal beta-sandwich

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZJF9-F1-model_v2	AlphaFold	D3ZJF9	1-420	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701935

Promoter ID:

EPDNEW_R12459

Type:

multiple initiation site

Name:

Gla_1

Description:

galactosidase, alpha

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	X	105,417,343 - 105,417,403	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1589721	AgrOrtholog
BioCyc Gene	G2FUF-1680	BioCyc
BioCyc Pathway	PWY0-1301 [melibiose degradation]	BioCyc
Ensembl Genes	ENSRNOG00000011513	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000015494	ENTREZGENE
	ENSRNOT00000015494.8	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.1180	UniProtKB/TrEMBL
	3.20.20.70	UniProtKB/TrEMBL
InterPro	Aldolase_TIM	UniProtKB/TrEMBL
	Glyco_hydro_27	UniProtKB/TrEMBL
	Glyco_hydro_b	UniProtKB/TrEMBL
	Glyco_hydro_catalytic_core	UniProtKB/TrEMBL
	Glyco_hydro_GHD	UniProtKB/TrEMBL
	Melibiase/NAGA_C	UniProtKB/TrEMBL
KEGG Report	rno:363494	UniProtKB/TrEMBL
NCBI Gene	363494	ENTREZGENE
PANTHER	ALPHA-GALACTOSIDASE A	UniProtKB/TrEMBL
	PTHR11452	UniProtKB/TrEMBL
Pfam	Melibiase_2	UniProtKB/TrEMBL
	Melibiase_2_C	UniProtKB/TrEMBL
PhenoGen	Gla	PhenoGen
PRINTS	GLHYDRLASE27	UniProtKB/TrEMBL
PROSITE	ALPHA_GALACTOSIDASE	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000011513	RatGTEx
Superfamily-SCOP	Glyco_hydro_cat	UniProtKB/TrEMBL
	Glycosyl hydrolase domain	UniProtKB/TrEMBL
UniProt	A6IVG1	ENTREZGENE, UniProtKB/TrEMBL
	A6IVG2_RAT	UniProtKB/TrEMBL
	D3ZJF9	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2007-04-13		galactosidase, alpha	Gla	galactosidase, alpha (mapped)	Name updated	737654	APPROVED
2007-04-11	Gla	galactosidase, alpha (mapped)	Gla_mapped	galactosidase, alpha (mapped)	Data merged from RGD:2698	737654	APPROVED
2006-11-19	Gla	galactosidase, alpha (mapped)			Symbol and Name status set to provisional	70820	PROVISIONAL
2005-11-17	Gla_mapped	galactosidase, alpha (mapped)	Gla	galactosidase, alpha	Symbol and Name updated	1556543	APPROVED
2002-06-10	Gla	Galactosidase, alpha			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_disease	mutation of the human homolog causes Fabry disease, a disorder of glycosphingolipid catabolism	1300216

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

Mammalian Phenotype

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

Mammalian Phenotype