Prxl2c (peroxiredoxin like 2C) - Rat Genome Database

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Gene: Prxl2c (peroxiredoxin like 2C) Rattus norvegicus
Analyze
Symbol: Prxl2c
Name: peroxiredoxin like 2C
RGD ID: 1589650
Description: Predicted to be involved in positive regulation of ERK1 and ERK2 cascade and positive regulation of glycolytic process. Orthologous to human PRXL2C (peroxiredoxin like 2C); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Aaed1; AhpC/TSA antioxidant enzyme domain containing 1; hypothetical protein LOC498685; LOC498685; peroxiredoxin-like 2C; similar to UPF0308 protein C9orf21; thioredoxin-like protein AAED1; uncharacterized protein LOC498685
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr817817,932 - 849,965 (+)NCBIGRCr8
mRatBN7.217812,199 - 839,536 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl17812,213 - 844,075 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx17830,906 - 848,128 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0172,373,483 - 2,390,705 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.017828,334 - 845,556 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0171,798,224 - 1,830,011 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl171,798,388 - 1,830,001 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0171,787,497 - 1,819,908 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4176,336,052 - 6,370,548 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera171,672,532 - 1,704,457 (-)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:29901208  


Genomics

Comparative Map Data
Prxl2c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr817817,932 - 849,965 (+)NCBIGRCr8
mRatBN7.217812,199 - 839,536 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl17812,213 - 844,075 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx17830,906 - 848,128 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0172,373,483 - 2,390,705 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.017828,334 - 845,556 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0171,798,224 - 1,830,011 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl171,798,388 - 1,830,001 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0171,787,497 - 1,819,908 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4176,336,052 - 6,370,548 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera171,672,532 - 1,704,457 (-)NCBICelera
Cytogenetic Map17p14NCBI
PRXL2C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38996,639,577 - 96,655,317 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl996,639,577 - 96,655,317 (-)EnsemblGRCh38hg38GRCh38
GRCh37999,401,859 - 99,417,599 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36998,443,354 - 98,457,420 (-)NCBINCBI36Build 36hg18NCBI36
Celera969,845,106 - 69,859,172 (-)NCBICelera
Cytogenetic Map9q22.33NCBI
HuRef969,014,734 - 69,028,253 (-)NCBIHuRef
CHM1_1999,550,355 - 99,564,421 (-)NCBICHM1_1
T2T-CHM13v2.09108,811,352 - 108,827,123 (-)NCBIT2T-CHM13v2.0
Prxl2c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391364,437,612 - 64,460,524 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1364,423,094 - 64,460,524 (-)EnsemblGRCm39 Ensembl
GRCm381364,289,798 - 64,312,710 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1364,275,280 - 64,312,710 (-)EnsemblGRCm38mm10GRCm38
MGSCv371364,393,144 - 64,414,018 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361364,301,606 - 64,326,737 (-)NCBIMGSCv36mm8
Celera1365,956,327 - 65,976,100 (-)NCBICelera
Cytogenetic Map13B3NCBI
cM Map1333.26NCBI
PRXL2C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21142,796,286 - 42,810,351 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1942,798,683 - 42,812,729 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0967,737,639 - 67,751,691 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1995,857,770 - 95,889,532 (-)NCBIpanpan1.1PanPan1.1panPan2
PRXL2C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1170,199,278 - 70,209,026 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl170,199,357 - 70,208,534 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha170,962,502 - 70,972,184 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0170,487,981 - 70,508,109 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl170,498,486 - 70,509,863 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1170,312,093 - 70,321,759 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0170,074,911 - 70,084,654 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0170,786,250 - 70,795,855 (+)NCBIUU_Cfam_GSD_1.0
PRXL2C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1025,428,164 - 25,446,185 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11025,428,129 - 25,444,609 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21076,570,687 - 76,584,991 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRXL2C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112106,486,772 - 106,500,124 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl12106,486,811 - 106,499,618 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603894,883,326 - 94,897,531 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prxl2c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475317,901,544 - 17,918,042 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475317,901,281 - 17,922,146 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prxl2c
56 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:36
Count of miRNA genes:33
Interacting mature miRNAs:34
Transcripts:ENSRNOT00000066230
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat

Markers in Region
D17Got225  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr817847,257 - 847,401 (+)Marker Load Pipeline
mRatBN7.217841,528 - 841,672 (-)MAPPERmRatBN7.2
Rnor_6.0171,800,756 - 1,800,899NCBIRnor6.0
Rnor_5.0171,790,274 - 1,790,417UniSTSRnor5.0
RGSC_v3.4176,367,505 - 6,367,648UniSTSRGSC3.4
Celera171,675,076 - 1,675,219UniSTS
Cytogenetic Map17p14UniSTS
BE102255  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.217828,433 - 828,584 (-)MAPPERmRatBN7.2
Rnor_6.0171,813,844 - 1,813,994NCBIRnor6.0
Rnor_5.0171,803,362 - 1,803,512UniSTSRnor5.0
RGSC_v3.4176,354,410 - 6,354,560UniSTSRGSC3.4
Celera171,688,164 - 1,688,314UniSTS
RH 3.4 Map1716.0UniSTS
Cytogenetic Map17p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000066230   ⟹   ENSRNOP00000062637
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl17812,215 - 844,075 (+)Ensembl
Rnor_6.0 Ensembl171,798,388 - 1,830,001 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104207   ⟹   ENSRNOP00000086014
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl17812,213 - 828,650 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109028   ⟹   ENSRNOP00000079468
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl17812,213 - 829,448 (+)Ensembl
RefSeq Acc Id: NM_001399210   ⟹   NP_001386139
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr817817,969 - 835,191 (+)NCBI
mRatBN7.217812,239 - 829,462 (+)NCBI
RefSeq Acc Id: NM_001399211   ⟹   NP_001386140
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr817817,969 - 835,191 (+)NCBI
mRatBN7.217812,239 - 829,462 (+)NCBI
RefSeq Acc Id: XM_039095987   ⟹   XP_038951915
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr817817,935 - 840,954 (+)NCBI
mRatBN7.217812,203 - 835,682 (+)NCBI
RefSeq Acc Id: XM_039095988   ⟹   XP_038951916
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr817817,932 - 840,954 (+)NCBI
mRatBN7.217812,199 - 839,536 (+)NCBI
RefSeq Acc Id: XM_063276679   ⟹   XP_063132749
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr817817,935 - 849,965 (+)NCBI
RefSeq Acc Id: XR_010058909
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr817817,936 - 829,024 (+)NCBI
Ensembl Acc Id: ENSRNOP00000062637   ⟸   ENSRNOT00000066230
RefSeq Acc Id: XP_038951916   ⟸   XM_039095988
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038951915   ⟸   XM_039095987
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000086014   ⟸   ENSRNOT00000104207
Ensembl Acc Id: ENSRNOP00000079468   ⟸   ENSRNOT00000109028
RefSeq Acc Id: NP_001386139   ⟸   NM_001399210
- Peptide Label: isoform 1
- UniProtKB: A0A8I6G5D2 (UniProtKB/TrEMBL),   A6KQE1 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001386140   ⟸   NM_001399211
- Peptide Label: isoform 2
- UniProtKB: A0A8I6A506 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063132749   ⟸   XM_063276679
- Peptide Label: isoform X3
- UniProtKB: A6KQD9 (UniProtKB/TrEMBL),   D3ZAK1 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZAK1-F1-model_v2 AlphaFold D3ZAK1 1-147 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700263
Promoter ID:EPDNEW_R10787
Type:initiation region
Name:Aaed1_1
Description:AhpC/TSA antioxidant enzyme domain containing 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0171,829,954 - 1,830,014EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1589650 AgrOrtholog
BioCyc Gene G2FUF-10544 BioCyc
Ensembl Genes ENSRNOG00000018886 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066230 ENTREZGENE
  ENSRNOT00000066230.2 UniProtKB/TrEMBL
  ENSRNOT00000104207 ENTREZGENE
  ENSRNOT00000104207.1 UniProtKB/TrEMBL
  ENSRNOT00000109028 ENTREZGENE
  ENSRNOT00000109028.1 UniProtKB/TrEMBL
Gene3D-CATH Glutaredoxin UniProtKB/TrEMBL
InterPro FAM213/AAED1 UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/TrEMBL
NCBI Gene 498685 ENTREZGENE
PANTHER PEROXIREDOXIN-LIKE 2C UniProtKB/TrEMBL
  PTHR28630 UniProtKB/TrEMBL
Pfam AhpC-TSA_2 UniProtKB/TrEMBL
PhenoGen Prxl2c PhenoGen
RatGTEx ENSRNOG00000018886 RatGTEx
Superfamily-SCOP Thiordxn-like_fd UniProtKB/TrEMBL
UniProt A0A8I6A506 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G5D2 ENTREZGENE, UniProtKB/TrEMBL
  A6KQD9 ENTREZGENE, UniProtKB/TrEMBL
  A6KQE1 ENTREZGENE, UniProtKB/TrEMBL
  D3ZAK1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-07-26 Prxl2c  peroxiredoxin like 2C  Aaed1  AhpC/TSA antioxidant enzyme domain containing 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-09 Aaed1  AhpC/TSA antioxidant enzyme domain containing 1  LOC498685  similar to UPF0308 protein C9orf21  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC498685  similar to UPF0308 protein C9orf21      Symbol and Name status set to provisional 70820 PROVISIONAL