Mllt1 (MLLT1, super elongation complex subunit) - Rat Genome Database

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Gene: Mllt1 (MLLT1, super elongation complex subunit) Rattus norvegicus
Analyze
Symbol: Mllt1
Name: MLLT1, super elongation complex subunit
RGD ID: 1588581
Description: Predicted to enable chromatin binding activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to act upstream of or within negative regulation of protein kinase activity. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Predicted to be part of transcription elongation factor complex. Orthologous to human MLLT1 (MLLT1 super elongation complex subunit); PARTICIPATES IN RNA polymerase II transcription elongation pathway; INTERACTS WITH bisphenol A; 1,2-dimethylhydrazine (ortholog); 17beta-estradiol (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC301119; myeloid/lymphoid or mixed lineage leukemia translocation to 1 homolog; myeloid/lymphoid or mixed lineage leukemia translocation to 1 homolog (Drosophila); myeloid/lymphoid or mixed lineage-leukemia translocation to 1 homolog; myeloid/lymphoid or mixed-lineage leukemia; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); protein ENL; similar to myeloid/lymphoid or mixed lineage-leukemia translocation to 1 homolog; translocated to, 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,818,204 - 1,863,091 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl91,818,204 - 1,863,089 (-)EnsemblGRCr8
mRatBN7.291,731,077 - 1,775,985 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,731,080 - 1,775,970 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx92,164,990 - 2,209,816 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,514,684 - 7,559,510 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,470,184 - 6,515,010 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0910,110,389 - 10,155,305 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,110,389 - 10,155,302 (+)Ensemblrn6Rnor6.0
Rnor_5.099,110,342 - 9,154,498 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera96,741,249 - 6,786,040 (+)NCBICelera
Cytogenetic Map9q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA,ISO)
fibrillar center  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO)
transcription elongation factor complex  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. The super elongation complex (SEC) family in transcriptional control. Luo Z, etal., Nat Rev Mol Cell Biol. 2012 Sep;13(9):543-7. doi: 10.1038/nrm3417. Epub 2012 Aug 16.
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:11007757   PMID:22195968  


Genomics

Comparative Map Data
Mllt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,818,204 - 1,863,091 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl91,818,204 - 1,863,089 (-)EnsemblGRCr8
mRatBN7.291,731,077 - 1,775,985 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,731,080 - 1,775,970 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx92,164,990 - 2,209,816 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,514,684 - 7,559,510 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,470,184 - 6,515,010 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0910,110,389 - 10,155,305 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,110,389 - 10,155,302 (+)Ensemblrn6Rnor6.0
Rnor_5.099,110,342 - 9,154,498 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera96,741,249 - 6,786,040 (+)NCBICelera
Cytogenetic Map9q11NCBI
MLLT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38196,210,381 - 6,279,975 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl196,210,381 - 6,279,975 (-)Ensemblhg38GRCh38
GRCh37196,210,392 - 6,279,986 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36196,161,392 - 6,230,959 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34196,163,965 - 6,230,959NCBI
Celera196,149,173 - 6,218,734 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef195,969,364 - 6,038,974 (-)NCBIHuRef
CHM1_1196,209,972 - 6,279,567 (-)NCBICHM1_1
T2T-CHM13v2.0196,198,560 - 6,268,171 (-)NCBIT2T-CHM13v2.0
Mllt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391757,199,611 - 57,242,497 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1757,198,385 - 57,242,415 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381756,892,608 - 56,935,509 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1756,892,611 - 56,935,415 (-)Ensemblmm10GRCm38
MGSCv371757,032,034 - 57,074,811 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361756,577,735 - 56,620,512 (-)NCBIMGSCv36mm8
Celera1761,237,292 - 61,280,070 (-)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.56NCBI
Mllt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554953,289,641 - 3,336,509 (+)Ensembl
ChiLan1.0NW_0049554953,289,644 - 3,336,455 (+)NCBIChiLan1.0ChiLan1.0
MLLT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22010,611,270 - 10,680,997 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1199,837,231 - 9,906,921 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0195,231,481 - 5,301,160 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1196,156,365 - 6,224,043 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl196,156,365 - 6,216,779 (-)EnsemblpanPan2panpan1.1
MLLT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12053,844,972 - 53,913,753 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2053,779,802 - 53,913,651 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2053,592,802 - 53,659,964 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02054,500,058 - 54,567,226 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2054,500,058 - 54,570,642 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12053,566,637 - 53,633,779 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02054,015,551 - 54,082,695 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02054,245,032 - 54,312,120 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mllt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118214,156,251 - 214,213,547 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365883,619,493 - 3,669,854 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365883,619,480 - 3,678,532 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MLLT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl272,781,121 - 72,847,685 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1272,780,950 - 72,847,694 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2273,345,660 - 73,409,227 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MLLT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.165,835,483 - 5,913,096 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl65,834,660 - 5,913,119 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660812,116,213 - 2,194,227 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mllt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248284,093,502 - 4,110,350 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248284,055,244 - 4,110,246 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Mllt1
187 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:329
Count of miRNA genes:183
Interacting mature miRNAs:225
Transcripts:ENSRNOT00000071211
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631533Iresp3Immunoglobin response QTL316.2blood immunoglobulin E amount (VT:0002492)serum immunoglobulin E level (CMO:0002101)916094576Rat
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9121707400Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)949664545496645Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)949664545496645Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)9131250552Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)949664545496645Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9141763315Rat

Markers in Region
RH125746  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.291,731,137 - 1,731,387 (-)MAPPERmRatBN7.2
Rnor_6.0910,154,995 - 10,155,244NCBIRnor6.0
Rnor_5.099,154,191 - 9,154,440UniSTSRnor5.0
Celera96,785,733 - 6,785,982UniSTS
Cytogenetic Map9q11UniSTS
RH124646  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.291,731,249 - 1,731,436 (-)MAPPERmRatBN7.2
Rnor_6.0910,154,946 - 10,155,132NCBIRnor6.0
Rnor_5.099,154,142 - 9,154,328UniSTSRnor5.0
Celera96,785,684 - 6,785,870UniSTS
Cytogenetic Map9q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 160 91 90 59 92 59 6 356 192 11 139 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000071211   ⟹   ENSRNOP00000064141
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl91,818,204 - 1,863,089 (-)Ensembl
mRatBN7.2 Ensembl91,731,080 - 1,775,970 (-)Ensembl
Rnor_6.0 Ensembl910,110,389 - 10,155,302 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109046   ⟹   ENSRNOP00000092239
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl91,818,204 - 1,863,089 (-)Ensembl
mRatBN7.2 Ensembl91,731,080 - 1,775,970 (-)Ensembl
RefSeq Acc Id: NM_001106876   ⟹   NP_001100346
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,818,204 - 1,863,089 (-)NCBI
mRatBN7.291,731,080 - 1,775,970 (-)NCBI
Rnor_6.0910,110,389 - 10,155,302 (+)NCBI
Rnor_5.099,110,342 - 9,154,498 (+)NCBI
Celera96,741,249 - 6,786,040 (+)RGD
Sequence:
RefSeq Acc Id: XM_006244307   ⟹   XP_006244369
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,818,204 - 1,863,091 (-)NCBI
mRatBN7.291,731,077 - 1,775,985 (-)NCBI
Rnor_6.0910,110,394 - 10,155,305 (+)NCBI
Rnor_5.099,110,342 - 9,154,498 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039083136   ⟹   XP_038939064
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,818,204 - 1,854,370 (-)NCBI
mRatBN7.291,731,077 - 1,767,239 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001100346 (Get FASTA)   NCBI Sequence Viewer  
  XP_006244369 (Get FASTA)   NCBI Sequence Viewer  
  XP_038939064 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL83599 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000064141
  ENSRNOP00000064141.2
  ENSRNOP00000092239
  ENSRNOP00000092239.1
RefSeq Acc Id: NP_001100346   ⟸   NM_001106876
- UniProtKB: M0R462 (UniProtKB/TrEMBL),   A6KQU1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244369   ⟸   XM_006244307
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AH62 (UniProtKB/TrEMBL),   M0R462 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000064141   ⟸   ENSRNOT00000071211
RefSeq Acc Id: XP_038939064   ⟸   XM_039083136
- Peptide Label: isoform X2
- UniProtKB: M0R462 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000092239   ⟸   ENSRNOT00000109046
Protein Domains
YEATS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R462-F1-model_v2 AlphaFold M0R462 1-547 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696447
Promoter ID:EPDNEW_R6972
Type:initiation region
Name:Mllt1_1
Description:MLLT1, super elongation complex subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0910,110,432 - 10,110,492EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1588581 AgrOrtholog
BioCyc Gene G2FUF-28505 BioCyc
Ensembl Genes ENSRNOG00000048736 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000071211 ENTREZGENE
  ENSRNOT00000071211.2 UniProtKB/TrEMBL
  ENSRNOT00000109046 ENTREZGENE
  ENSRNOT00000109046.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1270.290 UniProtKB/TrEMBL
  2.60.40.1970 UniProtKB/TrEMBL
InterPro AF-9_AHD UniProtKB/TrEMBL
  YEAST_sf UniProtKB/TrEMBL
  YEATS_dom UniProtKB/TrEMBL
  YEATS_domain UniProtKB/TrEMBL
KEGG Report rno:301119 UniProtKB/TrEMBL
NCBI Gene 301119 ENTREZGENE
PANTHER AHD DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  PROTEIN ENL UniProtKB/TrEMBL
Pfam AHD UniProtKB/TrEMBL
  YEATS UniProtKB/TrEMBL
PhenoGen Mllt1 PhenoGen
PROSITE YEATS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000048736 RatGTEx
UniProt A0A8I6AH62 ENTREZGENE, UniProtKB/TrEMBL
  A6KQU1 ENTREZGENE, UniProtKB/TrEMBL
  M0R462 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-22 Mllt1  MLLT1, super elongation complex subunit  Mllt1  myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-01 Mllt1  myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1  Mllt1  myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-14 Mllt1  myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1  Mllt1  myeloid/lymphoid or mixed lineage leukemia translocation to 1 homolog (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Mllt1  myeloid/lymphoid or mixed lineage leukemia translocation to 1 homolog (Drosophila)  LOC301119  similar to myeloid/lymphoid or mixed lineage-leukemia translocation to 1 homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC301119  similar to myeloid/lymphoid or mixed lineage-leukemia translocation to 1 homolog      Symbol and Name status set to provisional 70820 PROVISIONAL