Acsbg2 (acyl-CoA synthetase bubblegum family member 2) - Rat Genome Database

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Gene: Acsbg2 (acyl-CoA synthetase bubblegum family member 2) Rattus norvegicus
Analyze
Symbol: Acsbg2
Name: acyl-CoA synthetase bubblegum family member 2
RGD ID: 1588580
Description: Predicted to enable arachidonate-CoA ligase activity and fatty acyl-CoA hydrolase activity. Predicted to be involved in long-chain fatty acid biosynthetic process. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be located in cytosol and mitochondrion. Predicted to be active in cytoplasm. Orthologous to human ACSBG2 (acyl-CoA synthetase bubblegum family member 2); PARTICIPATES IN eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; fatty acid metabolic pathway; INTERACTS WITH allethrin; alpha-Zearalanol; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: arachidonate--CoA ligase ACSBG2; bubblegum-related acyl-CoA synthetase 2; LOC301120; long-chain-fatty-acid--CoA ligase ACSBG2; MGC156748; similar to lipidosin
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,770,971 - 1,802,635 (-)NCBIGRCr8
mRatBN7.291,683,846 - 1,715,517 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,683,847 - 1,714,518 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx92,117,894 - 2,148,600 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,467,118 - 7,497,819 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,423,090 - 6,453,794 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0910,172,317 - 10,203,550 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,172,832 - 10,203,460 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.099,171,052 - 9,201,478 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera96,802,528 - 6,833,152 (+)NCBICelera
Cytogenetic Map9q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,ISO)
cytosol  (ISO)
membrane  (IEA)
mitochondrion  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12477932   PMID:16371355   PMID:16762313  


Genomics

Comparative Map Data
Acsbg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr891,770,971 - 1,802,635 (-)NCBIGRCr8
mRatBN7.291,683,846 - 1,715,517 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl91,683,847 - 1,714,518 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx92,117,894 - 2,148,600 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,467,118 - 7,497,819 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,423,090 - 6,453,794 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0910,172,317 - 10,203,550 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl910,172,832 - 10,203,460 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.099,171,052 - 9,201,478 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera96,802,528 - 6,833,152 (+)NCBICelera
Cytogenetic Map9q11NCBI
ACSBG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38196,135,633 - 6,193,091 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl196,135,247 - 6,193,094 (+)EnsemblGRCh38hg38GRCh38
GRCh37196,135,644 - 6,193,102 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36196,086,710 - 6,144,112 (+)NCBINCBI36Build 36hg18NCBI36
Celera196,074,482 - 6,131,888 (+)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef195,894,905 - 5,952,085 (+)NCBIHuRef
CHM1_1196,135,824 - 6,192,695 (+)NCBICHM1_1
T2T-CHM13v2.0196,124,368 - 6,181,277 (+)NCBIT2T-CHM13v2.0
Acsbg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391757,150,103 - 57,181,505 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1757,150,103 - 57,181,447 (-)EnsemblGRCm39 Ensembl
GRCm381756,843,103 - 56,874,505 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1756,843,103 - 56,874,447 (-)EnsemblGRCm38mm10GRCm38
MGSCv371756,982,527 - 57,013,870 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361756,528,228 - 56,559,571 (-)NCBIMGSCv36mm8
Celera1761,187,798 - 61,219,131 (-)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.54NCBI
ACSBG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22010,537,002 - 10,597,567 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1199,762,976 - 9,825,962 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0195,156,888 - 5,214,336 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1196,083,127 - 6,139,795 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl196,083,127 - 6,139,795 (+)Ensemblpanpan1.1panPan2
ACSBG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12053,952,497 - 53,991,606 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2053,952,540 - 53,991,367 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2053,697,131 - 53,736,279 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02054,604,643 - 54,643,812 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2054,604,694 - 54,643,560 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12053,671,156 - 53,710,293 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02054,120,074 - 54,159,234 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02054,349,850 - 54,389,013 (-)NCBIUU_Cfam_GSD_1.0
ACSBG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl272,879,252 - 72,920,468 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1272,879,252 - 72,910,311 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2273,441,581 - 73,485,239 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ACSBG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.165,778,036 - 5,824,597 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660812,213,200 - 2,255,894 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Acsbg2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248284,127,845 - 4,149,041 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Acsbg2
77 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:88
Count of miRNA genes:69
Interacting mature miRNAs:77
Transcripts:ENSRNOT00000071254, ENSRNOT00000074555
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
10054141Gmadr4Adrenal mass QTL 42.450.0074adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)9114209783Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 6 4 47 56 49 32 10 32 6 79 31 28 2 47 17

Sequence


Ensembl Acc Id: ENSRNOT00000074555   ⟹   ENSRNOP00000066937
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl91,683,847 - 1,714,518 (-)Ensembl
Rnor_6.0 Ensembl910,172,832 - 10,203,460 (+)Ensembl
RefSeq Acc Id: NM_001080096   ⟹   NP_001073565
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,770,971 - 1,801,642 (-)NCBI
mRatBN7.291,683,846 - 1,714,518 (-)NCBI
Rnor_6.0910,172,832 - 10,203,461 (+)NCBI
Rnor_5.099,171,052 - 9,201,478 (+)NCBI
Celera96,802,528 - 6,833,152 (+)RGD
Sequence:
RefSeq Acc Id: XM_006244311   ⟹   XP_006244373
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,770,971 - 1,802,629 (-)NCBI
mRatBN7.291,683,846 - 1,715,511 (-)NCBI
Rnor_6.0910,172,320 - 10,203,550 (+)NCBI
Rnor_5.099,171,052 - 9,201,478 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063266825   ⟹   XP_063122895
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,773,082 - 1,802,631 (-)NCBI
RefSeq Acc Id: XR_001839650
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr891,770,971 - 1,802,635 (-)NCBI
mRatBN7.291,683,846 - 1,715,517 (-)NCBI
Rnor_6.0910,172,317 - 10,203,550 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001073565   ⟸   NM_001080096
- UniProtKB: A1L1K7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006244373   ⟸   XM_006244311
- Peptide Label: isoform X1
- UniProtKB: A6KQU4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000066937   ⟸   ENSRNOT00000074555
RefSeq Acc Id: XP_063122895   ⟸   XM_063266825
- Peptide Label: isoform X1
- UniProtKB: A6KQU4 (UniProtKB/TrEMBL)
Protein Domains
AMP-dependent synthetase/ligase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A1L1K7-F1-model_v2 AlphaFold A1L1K7 1-667 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696448
Promoter ID:EPDNEW_R6973
Type:initiation region
Name:Acsbg2_1
Description:acyl-CoA synthetase bubblegum family member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0910,172,819 - 10,172,879EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1588580 AgrOrtholog
BioCyc Gene G2FUF-28507 BioCyc
Ensembl Genes ENSRNOG00000045947 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055014186 UniProtKB/Swiss-Prot
  ENSRNOG00060021553 UniProtKB/Swiss-Prot
  ENSRNOG00065013883 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000074555.3 UniProtKB/Swiss-Prot
  ENSRNOT00055024401 UniProtKB/Swiss-Prot
  ENSRNOT00060037457 UniProtKB/Swiss-Prot
  ENSRNOT00065022892 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.12780 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7111052 IMAGE-MGC_LOAD
InterPro AMP-binding_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AMP-dep_Synth/Lig UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AMP-dep_Synthh-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:301120 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156748 IMAGE-MGC_LOAD
NCBI Gene 301120 ENTREZGENE
PANTHER LONG-CHAIN-FATTY-ACID--COA LIGASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LONG-CHAIN-FATTY-ACID--COA LIGASE ACSBG2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AMP-binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Acsbg2 PhenoGen
PROSITE AMP_BINDING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000045947 RatGTEx
  ENSRNOG00055014186 RatGTEx
  ENSRNOG00060021553 RatGTEx
  ENSRNOG00065013883 RatGTEx
Superfamily-SCOP Acetyl-CoA synthetase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A1L1K7 ENTREZGENE
  A6KQU4 ENTREZGENE, UniProtKB/TrEMBL
  ACBG2_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-04 Acsbg2  acyl-CoA synthetase bubblegum family member 2  LOC301120  similar to lipidosin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC301120  similar to lipidosin      Symbol and Name status set to provisional 70820 PROVISIONAL