Krt6c (keratin 6c) - Rat Genome Database

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Gene: Krt6c (keratin 6c) Rattus norvegicus
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Symbol: Krt6c
Name: keratin 6c
RGD ID: 1588056
Description: Predicted to be a structural constituent of skin epidermis. Predicted to be involved in several processes, including intermediate filament organization; keratinization; and wound healing. Predicted to be active in keratin filament. Human ortholog(s) of this gene implicated in focal or diffuse nonepidermolytic palmoplantar keratoderma and pachyonychia congenita. Orthologous to human KRT6B (keratin 6B) and KRT6C (keratin 6C); INTERACTS WITH lead diacetate; 1-chloro-2,4-dinitrobenzene (ortholog); 17beta-estradiol (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CK 6A; CK-6A; cytokeratin-6A; K6a keratin; keratin K6; keratin, type II cytoskeletal 5; keratin, type II cytoskeletal 5-like; keratin, type II cytoskeletal 6A; keratin-6A; Krt6a; LOC102551453; LOC683313; similar to keratin complex 2, basic, gene 6a; type-II keratin Kb6
RGD Orthologs
Human
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,678,316 - 134,682,753 (-)NCBIGRCr8
mRatBN7.27132,799,608 - 132,804,045 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,799,616 - 132,804,045 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7134,592,867 - 134,597,269 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,822,398 - 136,826,800 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,731,890 - 136,736,327 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,290,296 - 143,317,563 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,312,546 - 143,317,707 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.07141,116,410 - 141,117,049 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Cytogenetic Map7q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1384967   PMID:12477932   PMID:26316108  


Genomics

Comparative Map Data
Krt6c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,678,316 - 134,682,753 (-)NCBIGRCr8
mRatBN7.27132,799,608 - 132,804,045 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,799,616 - 132,804,045 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7134,592,867 - 134,597,269 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,822,398 - 136,826,800 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,731,890 - 136,736,327 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,290,296 - 143,317,563 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,312,546 - 143,317,707 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.07141,116,410 - 141,117,049 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Cytogenetic Map7q36NCBI
KRT6C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381252,468,516 - 52,473,805 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1252,468,516 - 52,473,805 (-)EnsemblGRCh38hg38GRCh38
GRCh371252,862,300 - 52,867,589 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361251,148,567 - 51,153,836 (-)NCBINCBI36Build 36hg18NCBI36
Build 341251,148,861 - 51,153,824NCBI
Celera1252,508,540 - 52,513,809 (-)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1249,906,198 - 49,911,468 (-)NCBIHuRef
CHM1_11252,829,152 - 52,834,426 (-)NCBICHM1_1
T2T-CHM13v2.01252,433,115 - 52,438,404 (-)NCBIT2T-CHM13v2.0

Variants

.
Variants in Krt6c
104 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7119513385135012528Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)796670164135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
2306821Bp335Blood pressure QTL 3350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7106571501135012528Rat
631663Bw6Body weight QTL 63.4body mass (VT:0001259)body weight (CMO:0000012)7111075573134976056Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
731174Uae23Urinary albumin excretion QTL 232.40.0042urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)7104603555135012528Rat
1357339Stl14Serum triglyceride level QTL 143.450.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7112729683133492707Rat
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7112308254133492884Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat
2299163Iddm34Insulin dependent diabetes mellitus QTL 342.71blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)791281130135012528Rat
70173Niddm19Non-insulin dependent diabetes mellitus QTL 194.330.00005blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)764002457135012528Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)790482196135012528Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)783591953134666232Rat

Markers in Region
RH131737  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27132,787,458 - 132,787,668 (+)MAPPERmRatBN7.2
mRatBN7.27132,812,816 - 132,813,026 (+)MAPPERmRatBN7.2
mRatBN7.27132,799,807 - 132,800,017 (+)MAPPERmRatBN7.2
mRatBN7.27132,799,806 - 132,800,017 (+)MAPPERmRatBN7.2
Rnor_6.07143,290,492 - 143,290,701NCBIRnor6.0
Rnor_6.0142,966,967 - 42,967,175NCBIRnor6.0
Rnor_5.07141,088,725 - 141,088,934UniSTSRnor5.0
Celera7129,241,045 - 129,241,254UniSTS
Celera7129,269,978 - 129,270,187UniSTS
RH 3.4 Map71055.9UniSTS
BI289674  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera7129,272,345 - 129,272,530UniSTS
RH 3.4 Map71065.8UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000093088
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7143,312,546 - 143,317,707 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102479   ⟹   ENSRNOP00000087976
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7132,799,616 - 132,804,045 (-)Ensembl
RefSeq Acc Id: NM_001101007   ⟹   NP_001094477
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,678,316 - 134,682,753 (-)NCBI
mRatBN7.27132,799,608 - 132,804,045 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001094477 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA99994 (Get FASTA)   NCBI Sequence Viewer  
  AAH99121 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000087976
  ENSRNOP00000087976.1
GenBank Protein Q4FZU2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001094477   ⟸   NM_001101007
- UniProtKB: Q4FZU2 (UniProtKB/Swiss-Prot)
Ensembl Acc Id: ENSRNOP00000087976   ⟸   ENSRNOT00000102479
Protein Domains
IF rod

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4FZU2-F1-model_v2 AlphaFold Q4FZU2 1-552 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1588056 AgrOrtholog
BioCyc Gene G2FUF-31970 BioCyc
Ensembl Genes ENSRNOG00000062119 Ensembl
  ENSRNOG00000070470 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000102479 ENTREZGENE
  ENSRNOT00000102479.1 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot
  Single helix bin UniProtKB/Swiss-Prot
  Vasodilator-stimulated phosphoprotein UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7462749 IMAGE-MGC_LOAD
InterPro IF_conserved UniProtKB/Swiss-Prot
  IF_rod_dom UniProtKB/Swiss-Prot
  Keratin_2_head UniProtKB/Swiss-Prot
  Keratin_II UniProtKB/Swiss-Prot
KEGG Report rno:683313 UniProtKB/Swiss-Prot
MGC_CLONE MGC:116262 IMAGE-MGC_LOAD
NCBI Gene 683313 ENTREZGENE
PANTHER GATA-TYPE DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
  KERATIN, TYPE II CYTOSKELETAL 6A-RELATED UniProtKB/Swiss-Prot
Pfam Filament UniProtKB/Swiss-Prot
  Keratin_2_head UniProtKB/Swiss-Prot
PhenoGen Krt6c PhenoGen
PRINTS TYPE2KERATIN UniProtKB/Swiss-Prot
PROSITE IF_ROD_1 UniProtKB/Swiss-Prot
  IF_ROD_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000062119 RatGTEx
  ENSRNOG00000070470 RatGTEx
SMART Filament UniProtKB/Swiss-Prot
Superfamily-SCOP Intermediate filament protein, coiled coil region UniProtKB/Swiss-Prot
UniProt K2C6A_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-09-19 Krt6c  keratin 6c  LOC683313  similar to keratin complex 2, basic, gene 6a  Symbol and Name Changed 1299863 APPROVED
2021-03-09 LOC683313  similar to keratin complex 2, basic, gene 6a  LOC102551453  keratin, type II cytoskeletal 5-like  Data merged from RGD:7499194 737654 PROVISIONAL
2013-12-17 LOC102551453  keratin, type II cytoskeletal 5-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC683313  similar to keratin complex 2, basic, gene 6a      Symbol and Name status set to provisional 70820 PROVISIONAL