Ccl26 (C-C motif chemokine ligand 26) - Rat Genome Database

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Gene: Ccl26 (C-C motif chemokine ligand 26) Rattus norvegicus
Analyze
Symbol: Ccl26
Name: C-C motif chemokine ligand 26
RGD ID: 1587817
Description: Predicted to enable CCR3 chemokine receptor binding activity; CX3C chemokine receptor binding activity; and chemokine activity. Predicted to be involved in several processes, including leukocyte chemotaxis; positive regulation of GTPase activity; and positive regulation of actin filament polymerization. Predicted to be located in extracellular space. Used to study asthma. Human ortholog(s) of this gene implicated in asthma; eosinophilic esophagitis; and rhinitis. Orthologous to human CCL26 (C-C motif chemokine ligand 26); PARTICIPATES IN interleukin-4 signaling pathway; chemokine mediated signaling pathway; INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; 1-nitropyrene (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-C motif chemokine 26; chemokine (C-C motif) ligand 26; LOC685958; similar to eotaxin 3-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81226,745,972 - 26,750,924 (+)NCBIGRCr8
mRatBN7.21221,109,384 - 21,114,336 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1221,109,421 - 21,114,335 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1222,251,193 - 22,256,123 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01222,863,537 - 22,868,467 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01221,930,001 - 21,934,931 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01224,157,182 - 24,161,870 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1224,158,766 - 24,161,869 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01226,154,496 - 26,159,229 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41222,265,430 - 22,268,793 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1222,873,373 - 22,876,736 (+)NCBICelera
Cytogenetic Map12q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Comparison of the nasal release of IL-4, IL-10, IL-17, CCL13/MCP-4, and CCL26/eotaxin-3 in allergic rhinitis during season and after allergen challenge. Baumann R, etal., Am J Rhinol Allergy. 2013 Jul-Aug;27(4):266-72. doi: 10.2500/ajra.2013.27.3913.
2. Increased expression of eotaxin-3 distinguishes between eosinophilic esophagitis and gastroesophageal reflux disease. Bhattacharya B, etal., Hum Pathol. 2007 Dec;38(12):1744-53. Epub 2007 Sep 27.
3. Histologic eosinophilic gastritis is a systemic disorder associated with blood and extragastric eosinophilia, TH2 immunity, and a unique gastric transcriptome. Caldwell JM, etal., J Allergy Clin Immunol. 2014 Nov;134(5):1114-24. doi: 10.1016/j.jaci.2014.07.026. Epub 2014 Sep 15.
4. Analysis of the polymorphisms in eotaxin gene family and their association with asthma, IgE, and eosinophil. Chae SC, etal., Biochem Biophys Res Commun. 2004 Jul 16;320(1):131-7.
5. The suggestive association of eotaxin-2 and eotaxin-3 gene polymorphisms in Korean population with allergic rhinitis. Chae SC, etal., Immunogenetics. 2005 Jan;56(10):760-4. Epub 2004 Dec 4.
6. Nasal fluid release of eotaxin-3 and eotaxin-2 in persistent sinonasal eosinophilic inflammation. De Corso E, etal., Int Forum Allergy Rhinol. 2014 Aug;4(8):617-24. doi: 10.1002/alr.21348. Epub 2014 Jul 2.
7. Markers of eosinophilic inflammation and risk prediction in patients with coronary artery disease. Falcone C, etal., Eur J Clin Invest. 2006 Apr;36(4):211-7.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Expression and role of acidic mammalian chitinase and eotaxin-3 in chronic rhinosinusitis with nasal polyps. Gu Z, etal., J Otolaryngol Head Neck Surg. 2011 Feb;40(1):64-9.
10. AcCystatin, an immunoregulatory molecule from Angiostrongylus cantonensis, ameliorates the asthmatic response in an aluminium hydroxide/ovalbumin-induced rat model of asthma. Ji P, etal., Parasitol Res. 2015 Feb;114(2):613-24. doi: 10.1007/s00436-014-4223-z. Epub 2014 Nov 18.
11. Significant elevation of serum levels of eotaxin-3/CCL26, but not of eotaxin-2/CCL24, in patients with atopic dermatitis: serum eotaxin-3/CCL26 levels reflect the disease activity of atopic dermatitis. Kagami S, etal., Clin Exp Immunol. 2003 Nov;134(2):309-13.
12. High levels of CCL26 in blister fluid and sera of patients with bullous pemphigoid. Kagami S, etal., J Invest Dermatol. 2012 Jan;132(1):249-51. doi: 10.1038/jid.2011.251. Epub 2011 Sep 1.
13. Eotaxin-3 and interleukin-5 pleural fluid levels are associated with pleural fluid eosinophilia in post-coronary artery bypass grafting pleural effusions. Kalomenidis I, etal., Chest. 2005 Jun;127(6):2094-100.
14. Correlation between CCL26 production by human bronchial epithelial cells and airway eosinophils: Involvement in patients with severe eosinophilic asthma. Larose MC, etal., J Allergy Clin Immunol. 2015 Oct;136(4):904-13. doi: 10.1016/j.jaci.2015.02.039. Epub 2015 May 1.
15. Genetic interactions model among Eotaxin gene polymorphisms in asthma. Lee JH, etal., J Hum Genet. 2008;53(10):867-75. Epub 2008 Aug 20.
16. Treatment with topical steroids downregulates IL-5, eotaxin-1/CCL11, and eotaxin-3/CCL26 gene expression in eosinophilic esophagitis. Lucendo AJ, etal., Am J Gastroenterol. 2008 Sep;103(9):2184-93. doi: 10.1111/j.1572-0241.2008.01937.x.
17. Comparison of plasma eotaxin family level in aspirin-induced and aspirin-tolerant asthma patients. Min JW, etal., Chest. 2005 Nov;128(5):3127-32.
18. Eotaxins and CCR3 interaction regulates the Th2 environment of cutaneous T-cell lymphoma. Miyagaki T, etal., J Invest Dermatol. 2010 Sep;130(9):2304-11. doi: 10.1038/jid.2010.128. Epub 2010 May 27.
19. PGD2 induces eotaxin-3 via PPARgamma from sebocytes: a possible pathogenesis of eosinophilic pustular folliculitis. Nakahigashi K, etal., J Allergy Clin Immunol. 2012 Feb;129(2):536-43. doi: 10.1016/j.jaci.2011.11.034. Epub 2011 Dec 28.
20. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
21. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Comprehensive gene review and curation RGD comprehensive gene curation
24. Mucosal cytokine profiles in paediatric eosinophilic oesophagitis: a case-control study. Romano C, etal., Dig Liver Dis. 2014 Jul;46(7):590-5. doi: 10.1016/j.dld.2014.03.003. Epub 2014 Apr 3.
25. Puerarin attenuates airway inflammation by regulation of eotaxin-3. Wang J, etal., Immunol Lett. 2015 Feb;163(2):173-8. doi: 10.1016/j.imlet.2014.12.002. Epub 2014 Dec 19.
26. Eotaxin-1, -2, and -3 immunoreactivity and protein concentration in the nasal polyps of eosinophilic chronic rhinosinusitis patients. Yao T, etal., Laryngoscope. 2009 Jun;119(6):1053-9.
27. Eotaxin-3 in Churg-Strauss syndrome: a clinical and immunogenetic study. Zwerina J, etal., Rheumatology (Oxford). 2011 Oct;50(10):1823-7. doi: 10.1093/rheumatology/keq445. Epub 2011 Jan 25.
Additional References at PubMed
PMID:10373330   PMID:11425309   PMID:19525930   PMID:31151084  


Genomics

Comparative Map Data
Ccl26
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81226,745,972 - 26,750,924 (+)NCBIGRCr8
mRatBN7.21221,109,384 - 21,114,336 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1221,109,421 - 21,114,335 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1222,251,193 - 22,256,123 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01222,863,537 - 22,868,467 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01221,930,001 - 21,934,931 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01224,157,182 - 24,161,870 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1224,158,766 - 24,161,869 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01226,154,496 - 26,159,229 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41222,265,430 - 22,268,793 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1222,873,373 - 22,876,736 (+)NCBICelera
Cytogenetic Map12q12NCBI
CCL26
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38775,769,524 - 75,791,597 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl775,769,533 - 75,789,896 (-)EnsemblGRCh38hg38GRCh38
GRCh37775,398,842 - 75,420,915 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36775,236,778 - 75,257,000 (-)NCBINCBI36Build 36hg18NCBI36
Build 34775,043,492 - 75,063,715NCBI
Celera770,266,590 - 70,286,812 (-)NCBICelera
Cytogenetic Map7q11.23NCBI
HuRef770,484,790 - 70,505,408 (-)NCBIHuRef
CHM1_1775,328,822 - 75,349,108 (-)NCBICHM1_1
T2T-CHM13v2.0777,056,596 - 77,078,673 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2774,731,906 - 74,752,128 (-)NCBI
Ccl26
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395135,589,302 - 135,592,423 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5135,589,302 - 135,592,423 (-)EnsemblGRCm39 Ensembl
GRCm385135,560,448 - 135,563,569 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5135,560,448 - 135,563,569 (-)EnsemblGRCm38mm10GRCm38
MGSCv375136,036,318 - 136,039,439 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365135,845,075 - 135,848,196 (-)NCBIMGSCv36mm8
Celera5132,571,981 - 132,575,102 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map575.27NCBI
Ccl26
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545614,554,583 - 14,558,967 (-)NCBIChiLan1.0ChiLan1.0
CCL26
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2694,180,602 - 94,184,888 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17142,445,240 - 142,449,526 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0768,230,804 - 68,251,369 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1782,221,846 - 82,242,874 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl782,221,846 - 82,242,874 (-)Ensemblpanpan1.1panPan2
CCL26
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.167,151,352 - 7,154,509 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl67,151,212 - 7,154,726 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha68,848,112 - 8,851,272 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.066,971,954 - 6,975,124 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl66,971,814 - 6,981,222 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.166,941,498 - 6,944,666 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.066,904,900 - 6,908,069 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.067,068,177 - 7,071,344 (-)NCBIUU_Cfam_GSD_1.0
Ccl26
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344131,619,608 - 131,626,877 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365432,414,850 - 2,416,953 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365432,414,948 - 2,416,922 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCL26
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl310,381,306 - 10,385,677 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1310,381,306 - 10,385,677 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CCL26
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12810,036,177 - 10,038,962 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2810,036,337 - 10,038,875 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660706,400,433 - 6,403,167 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Ccl26
7 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:123
Count of miRNA genes:98
Interacting mature miRNAs:102
Transcripts:ENSRNOT00000001963
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961088935682913Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
11530002Bss119Bone structure and strength QTL 11916.394e-17lumbar vertebra area (VT:0010570)lumbar vertebra area (CMO:0001688)122087341921346740Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382528064557Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121983578938193007Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)121961087024139202Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121107382524234895Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121363552330827399Rat
631521Pia12Pristane induced arthritis QTL 128.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)122025941723672083Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12136247923Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat

Markers in Region
BF390551  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21221,114,097 - 21,114,257 (+)MAPPERmRatBN7.2
Rnor_6.01224,161,632 - 24,161,791NCBIRnor6.0
Rnor_5.01226,158,935 - 26,159,094UniSTSRnor5.0
RGSC_v3.41222,268,556 - 22,268,715UniSTSRGSC3.4
Celera1222,876,499 - 22,876,658UniSTS
RH 3.4 Map12340.51UniSTS
Cytogenetic Map12q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
2 4 9 26 41 35 21 11 21 1 72 36 12 11 33 14

Sequence


Ensembl Acc Id: ENSRNOT00000001963   ⟹   ENSRNOP00000001963
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1221,109,421 - 21,114,335 (+)Ensembl
Rnor_6.0 Ensembl1224,158,766 - 24,161,869 (+)Ensembl
RefSeq Acc Id: NM_001109488   ⟹   NP_001102958
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81226,745,972 - 26,750,924 (+)NCBI
mRatBN7.21221,109,384 - 21,114,336 (+)NCBI
Rnor_6.01224,158,766 - 24,161,869 (+)NCBI
Rnor_5.01226,154,496 - 26,159,229 (+)NCBI
RGSC_v3.41222,265,430 - 22,268,793 (+)RGD
Celera1222,873,373 - 22,876,736 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001102958 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM13366 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001963.5
RefSeq Acc Id: NP_001102958   ⟸   NM_001109488
- Peptide Label: precursor
- UniProtKB: A6J0C7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001963   ⟸   ENSRNOT00000001963
Protein Domains
Chemokine interleukin-8-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZQG2-F1-model_v2 AlphaFold D3ZQG2 1-94 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1587817 AgrOrtholog
BioCyc Gene G2FUF-19625 BioCyc
Ensembl Genes ENSRNOG00000001444 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001963.6 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.40 UniProtKB/TrEMBL
InterPro Chemokine_b/g/d UniProtKB/TrEMBL
  Chemokine_IL8 UniProtKB/TrEMBL
  Interleukin_8-like_sf UniProtKB/TrEMBL
KEGG Report rno:685958 UniProtKB/TrEMBL
NCBI Gene 685958 ENTREZGENE
PANTHER C-C MOTIF CHEMOKINE 26 UniProtKB/TrEMBL
  PTHR12015 UniProtKB/TrEMBL
Pfam IL8 UniProtKB/TrEMBL
PhenoGen Ccl26 PhenoGen
RatGTEx ENSRNOG00000001444 RatGTEx
SMART SCY UniProtKB/TrEMBL
Superfamily-SCOP Chemokine_IL8 UniProtKB/TrEMBL
UniProt A6J0C7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZQG2_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-08 Ccl26  C-C motif chemokine ligand 26  Ccl26  chemokine (C-C motif) ligand 26  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-07-08 Ccl26  chemokine (C-C motif) ligand 26  LOC687177  similar to eotaxin 3-like  Data merged from RGD:1588909 1643240 APPROVED
2008-06-27     Ccl26  chemokine (C-C motif) ligand 26  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Ccl26  chemokine (C-C motif) ligand 26  LOC685958  similar to eotaxin 3-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC685958  similar to eotaxin 3-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC687177  similar to eotaxin 3-like      Symbol and Name status set to provisional 70820 PROVISIONAL