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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Spx | Rat | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in increased expression of SPX mRNA and [Testosterone co-treated with Estradiol] results in increased expression of SPX mRNA | CTD | PMID:26496021 and PMID:32741896 | Spx | Rat | 2,2',4,4'-Tetrabromodiphenyl ether | increases expression | ISO | SPX (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31173147 | Spx | Rat | 2-palmitoylglycerol | increases expression | ISO | SPX (Homo sapiens) | 6480464 | 2-palmitoylglycerol results in increased expression of SPX mRNA | CTD | PMID:37199045 | Spx | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | SPX (Homo sapiens) | 6480464 | bisphenol S results in increased expression of SPX mRNA | CTD | PMID:25912373 | Spx | Rat | acrolein | multiple interactions | ISO | SPX (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of SPX mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased expression of SPX mRNA | CTD | PMID:32699268 | Spx | Rat | aflatoxin B1 | decreases methylation | ISO | SPX (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of SPX gene | CTD | PMID:27153756 | Spx | Rat | all-trans-retinoic acid | increases expression | ISO | SPX (Homo sapiens) | 6480464 | Tretinoin results in increased expression of SPX mRNA | CTD | PMID:21934132 | Spx | Rat | alpha-pinene | multiple interactions | ISO | SPX (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of SPX mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased expression of SPX mRNA | CTD | PMID:32699268 | Spx | Rat | belinostat | decreases expression | ISO | SPX (Homo sapiens) | 6480464 | belinostat results in decreased expression of SPX mRNA | CTD | PMID:27188386 | Spx | Rat | benzo[a]pyrene | decreases methylation | ISO | SPX (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of SPX promoter | CTD | PMID:27901495 | Spx | Rat | beta-lapachone | increases expression | ISO | SPX (Homo sapiens) | 6480464 | beta-lapachone results in increased expression of SPX mRNA | CTD | PMID:38218311 | Spx | Rat | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in increased expression of SPX mRNA | CTD | PMID:26496021 | Spx | Rat | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of SPX gene | CTD | PMID:28505145 | Spx | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of SPX mRNA | CTD | PMID:25181051 | Spx | Rat | cadmium dichloride | decreases expression | ISO | SPX (Homo sapiens) | 6480464 | Cadmium Chloride results in decreased expression of SPX mRNA | CTD | PMID:38382870 | Spx | Rat | cisplatin | decreases expression | ISO | SPX (Homo sapiens) | 6480464 | Cisplatin results in decreased expression of SPX mRNA | CTD | PMID:27392435 | Spx | Rat | cisplatin | multiple interactions | ISO | SPX (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in decreased expression of SPX mRNA | CTD | PMID:27392435 | Spx | Rat | copper atom | multiple interactions | ISO | SPX (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of SPX mRNA | CTD | PMID:20971185 | Spx | Rat | copper(0) | multiple interactions | ISO | SPX (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in increased expression of SPX mRNA | CTD | PMID:20971185 | Spx | Rat | cyclosporin A | increases expression | ISO | SPX (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of SPX mRNA | CTD | PMID:20106945 more ... | Spx | Rat | decabromodiphenyl ether | affects expression | ISO | SPX (Homo sapiens) | 6480464 | decabromobiphenyl ether affects the expression of SPX mRNA | CTD | PMID:24834073 | Spx | Rat | dorsomorphin | multiple interactions | ISO | SPX (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Spx | Rat | entinostat | decreases expression | ISO | SPX (Homo sapiens) | 6480464 | entinostat results in decreased expression of SPX mRNA | CTD | PMID:27188386 | Spx | Rat | genistein | decreases expression | ISO | Spx (Mus musculus) | 6480464 | Genistein results in decreased expression of SPX mRNA | CTD | PMID:32186404 | Spx | Rat | lipopolysaccharide | multiple interactions | ISO | SPX (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in increased expression of SPX mRNA | CTD | PMID:35811015 | Spx | Rat | N-Nitrosopyrrolidine | increases expression | ISO | SPX (Homo sapiens) | 6480464 | N-Nitrosopyrrolidine results in increased expression of SPX mRNA | CTD | PMID:32234424 | Spx | Rat | ozone | multiple interactions | ISO | SPX (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of SPX mRNA more ... | CTD | PMID:32699268 | Spx | Rat | paracetamol | increases expression | ISO | SPX (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of SPX mRNA | CTD | PMID:29067470 | Spx | Rat | perfluorononanoic acid | increases expression | ISO | SPX (Homo sapiens) | 6480464 | perfluoro-n-nonanoic acid results in increased expression of SPX mRNA | CTD | PMID:25812627 and PMID:32588087 | Spx | Rat | perfluorooctane-1-sulfonic acid | increases expression | ISO | SPX (Homo sapiens) | 6480464 | perfluorooctane sulfonic acid results in increased expression of SPX mRNA | CTD | PMID:25812627 | Spx | Rat | perfluorooctanoic acid | increases expression | ISO | SPX (Homo sapiens) | 6480464 | perfluorooctanoic acid results in increased expression of SPX mRNA | CTD | PMID:25812627 and PMID:36326898 | Spx | Rat | phenylmercury acetate | increases expression | ISO | SPX (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of SPX mRNA | CTD | PMID:26272509 | Spx | Rat | phenylmercury acetate | multiple interactions | ISO | SPX (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPX mRNA | CTD | PMID:27188386 | Spx | Rat | potassium chromate | increases expression | ISO | SPX (Homo sapiens) | 6480464 | potassium chromate(VI) results in increased expression of SPX mRNA | CTD | PMID:22714537 | Spx | Rat | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | SPX (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in increased expression of SPX mRNA | CTD | PMID:35811015 | Spx | Rat | SB 431542 | multiple interactions | ISO | SPX (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Spx | Rat | silicon dioxide | decreases expression | ISO | SPX (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of SPX mRNA | CTD | PMID:25895662 | Spx | Rat | silicon dioxide | increases expression | ISO | SPX (Homo sapiens) | 6480464 | Silicon Dioxide analog results in increased expression of SPX mRNA | CTD | PMID:23806026 | Spx | Rat | sodium arsenite | increases expression | ISO | SPX (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of SPX mRNA | CTD | PMID:38568856 | Spx | Rat | sodium arsenite | decreases expression | ISO | SPX (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of SPX mRNA | CTD | PMID:34032870 | Spx | Rat | testosterone | multiple interactions | EXP | | 6480464 | [Testosterone co-treated with Estradiol] results in increased expression of SPX mRNA | CTD | PMID:32741896 | Spx | Rat | Theaflavin 3,3'-digallate | affects expression | ISO | SPX (Homo sapiens) | 6480464 | theaflavin-3 and 3'-digallate affects the expression of SPX mRNA | CTD | PMID:34925699 | Spx | Rat | thiram | increases expression | ISO | SPX (Homo sapiens) | 6480464 | Thiram results in increased expression of SPX mRNA | CTD | PMID:38568856 | Spx | Rat | titanium dioxide | decreases expression | ISO | Spx (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of SPX mRNA | CTD | PMID:29264374 | Spx | Rat | triphenyl phosphate | affects expression | ISO | SPX (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of SPX mRNA | CTD | PMID:37042841 | Spx | Rat | triptonide | increases expression | ISO | Spx (Mus musculus) | 6480464 | triptonide results in increased expression of SPX mRNA | CTD | PMID:33045310 | Spx | Rat | valproic acid | affects expression | ISO | SPX (Homo sapiens) | 6480464 | Valproic Acid affects the expression of SPX mRNA | CTD | PMID:25979313 | Spx | Rat | valproic acid | increases expression | ISO | SPX (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of SPX mRNA | CTD | PMID:23179753 more ... | Spx | Rat | valproic acid | multiple interactions | ISO | SPX (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPX mRNA | CTD | PMID:27188386 | Spx | Rat | valproic acid | decreases expression | ISO | SPX (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of SPX mRNA | CTD | PMID:23179753 and PMID:27188386 | Spx | Rat | vorinostat | multiple interactions | ISO | SPX (Homo sapiens) | 6480464 | [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPX mRNA | CTD | PMID:27188386 | Spx | Rat | vorinostat | increases expression | ISO | SPX (Homo sapiens) | 6480464 | vorinostat results in increased expression of SPX mRNA | CTD | PMID:26272509 | Spx | Rat | zoledronic acid | increases expression | ISO | SPX (Homo sapiens) | 6480464 | zoledronic acid results in increased expression of SPX mRNA | CTD | PMID:24714768 | |