Proser2 (proline and serine rich 2) - Rat Genome Database

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Gene: Proser2 (proline and serine rich 2) Rattus norvegicus
Analyze
Symbol: Proser2
Name: proline and serine rich 2
RGD ID: 1586830
Description: Orthologous to human PROSER2 (proline and serine rich 2); INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: hypothetical protein LOC683460; LOC683460; proline and serine-rich protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21772,151,961 - 72,187,524 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1772,151,872 - 72,185,825 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1775,661,401 - 75,695,546 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01779,482,844 - 79,516,983 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01773,533,126 - 73,567,265 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01776,079,641 - 76,140,428 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1776,079,720 - 76,137,697 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01777,774,659 - 77,779,818 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1771,606,908 - 71,643,201 (+)NCBICelera
Cytogenetic Map17q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Proser2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21772,151,961 - 72,187,524 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1772,151,872 - 72,185,825 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1775,661,401 - 75,695,546 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01779,482,844 - 79,516,983 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01773,533,126 - 73,567,265 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01776,079,641 - 76,140,428 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1776,079,720 - 76,137,697 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01777,774,659 - 77,779,818 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1771,606,908 - 71,643,201 (+)NCBICelera
Cytogenetic Map17q12.3NCBI
PROSER2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381011,823,356 - 11,872,277 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1011,823,339 - 11,872,277 (+)EnsemblGRCh38hg38GRCh38
GRCh371011,865,355 - 11,914,276 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361011,905,403 - 11,954,282 (+)NCBINCBI36Build 36hg18NCBI36
Build 341011,905,402 - 11,954,280NCBI
Celera1011,793,985 - 11,842,841 (+)NCBICelera
Cytogenetic Map10p14NCBI
HuRef1011,783,248 - 11,831,931 (+)NCBIHuRef
CHM1_11011,865,406 - 11,914,260 (+)NCBICHM1_1
T2T-CHM13v2.01011,834,808 - 11,883,725 (+)NCBIT2T-CHM13v2.0
Proser2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3926,103,304 - 6,135,100 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl26,102,418 - 6,135,022 (-)EnsemblGRCm39 Ensembl
GRCm3826,098,493 - 6,130,291 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl26,097,607 - 6,130,211 (-)EnsemblGRCm38mm10GRCm38
MGSCv3726,019,546 - 6,051,231 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3626,017,297 - 6,047,418 (-)NCBIMGSCv36mm8
Celera26,038,847 - 6,070,436 (-)NCBICelera
Cytogenetic Map2A1NCBI
cM Map23.62NCBI
Proser2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542127,809,610 - 27,823,125 (+)NCBIChiLan1.0ChiLan1.0
PROSER2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11024,351,954 - 24,399,883 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01011,827,392 - 11,876,724 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11011,808,602 - 11,866,702 (+)NCBIpanpan1.1PanPan1.1panPan2
PROSER2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1224,510,659 - 24,550,712 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl224,512,531 - 24,550,709 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha221,541,078 - 21,581,124 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0224,882,935 - 24,922,002 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl224,880,962 - 24,921,881 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1222,007,770 - 22,048,187 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0222,850,859 - 22,891,486 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0223,566,158 - 23,606,397 (-)NCBIUU_Cfam_GSD_1.0
Proser2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934427,255,571 - 27,270,268 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364843,420,633 - 3,435,491 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049364843,423,530 - 3,435,505 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PROSER2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1060,033,531 - 60,058,496 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11060,033,509 - 60,077,360 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21065,735,098 - 65,761,136 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PROSER2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1911,874,999 - 11,918,916 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl911,875,406 - 11,919,031 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605117,377,567 - 17,422,794 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Proser2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247757,069,196 - 7,104,975 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247757,069,053 - 7,104,209 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Proser2
315 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:125
Count of miRNA genes:109
Interacting mature miRNAs:117
Transcripts:ENSRNOT00000073933
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173455084373951021Rat
2301412Kidm40Kidney mass QTL 400.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)173747984782479847Rat
2317054Aia12Adjuvant induced arthritis QTL 124.24joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)173828150983281509Rat
2317060Aia26Adjuvant induced arthritis QTL 263.22joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)173828150983281509Rat
1598871Memor5Memory QTL 55.3exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)174054004180387013Rat
1358295Aocep1Aortic cell protein QTL 16.10.00000071thoracic aorta cellular protein amount (VT:0010598)aortic cell percentage174099000585990005Rat
7411575Bw140Body weight QTL 14030.20.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
8694181Bw151Body weight QTL 1514.360.001body mass (VT:0001259)body weight gain (CMO:0000420)174856093586533673Rat
2317038Ginf3Gastrointestinal inflammation QTL 32.890.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)174992015486533673Rat
2303580Gluco49Glucose level QTL 492blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)175004027186533673Rat
4889894Eae33Experimental allergic encephalomyelitis QTL 335.20.0001nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)175090909986022412Rat
1354588Bvd4Brain ventricular dilatation QTL 45.310.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)175349882882479847Rat
2302365Gluco40Glucose level QTL 404.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)175724684382046127Rat
7488963Bp369Blood pressure QTL 3690.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)175900564977910000Rat
2317045Aia11Adjuvant induced arthritis QTL 114.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)176078142686533673Rat
7411577Bw141Body weight QTL 1410.001body mass (VT:0001259)body weight gain (CMO:0000420)176261951686533673Rat
1300131Bp193Blood pressure QTL 1933.3arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)176364000973951021Rat
631502Cm26Cardiac mass QTL 263.71heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)176570358081153923Rat
1300129Rf25Renal function QTL 253.03blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)177100332581153923Rat
12904736Cm121Cardiac mass QTL 1210.043heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)177177462182479847Rat

Markers in Region
D17Mit6  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1771,624,153 - 71,624,253UniSTS
Cytogenetic Map17 RGD
D17Got90  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1771,624,156 - 71,624,312UniSTS
RH 3.4 Map17713.8UniSTS
RH 3.4 Map17713.8RGD
RH 2.0 Map17617.5RGD
RH130877  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21772,187,134 - 72,187,352 (+)MAPPERmRatBN7.2
Rnor_6.01776,139,155 - 76,139,372NCBIRnor6.0
Rnor_5.01777,779,572 - 77,779,789UniSTSRnor5.0
Celera1771,641,928 - 71,642,145UniSTS
RH 3.4 Map17713.7UniSTS
AU047786  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1771,623,451 - 71,623,635UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 1 1 8 6 10
Low 3 43 56 40 19 40 8 11 74 27 35 1 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000073933   ⟹   ENSRNOP00000066551
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1772,151,872 - 72,185,825 (+)Ensembl
Rnor_6.0 Ensembl1776,079,720 - 76,137,697 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000092710   ⟹   ENSRNOP00000075904
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1776,079,907 - 76,134,594 (+)Ensembl
RefSeq Acc Id: NM_001400808   ⟹   NP_001387737
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21772,151,981 - 72,187,378 (+)NCBI
RefSeq Acc Id: XM_008771898   ⟹   XP_008770120
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21772,152,393 - 72,187,381 (+)NCBI
Rnor_6.01776,079,848 - 76,140,428 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008771899   ⟹   XP_008770121
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21772,151,961 - 72,187,381 (+)NCBI
Rnor_6.01776,079,641 - 76,140,428 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039096511   ⟹   XP_038952439
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21772,166,070 - 72,187,524 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001387737 (Get FASTA)   NCBI Sequence Viewer  
  XP_008770120 (Get FASTA)   NCBI Sequence Viewer  
  XP_008770121 (Get FASTA)   NCBI Sequence Viewer  
  XP_038952439 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000066551
  ENSRNOP00000066551.1
Reference Protein Sequences
RefSeq Acc Id: XP_008770121   ⟸   XM_008771899
- Peptide Label: isoform X1
- UniProtKB: M0RAK0 (UniProtKB/TrEMBL),   A6JLX3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770120   ⟸   XM_008771898
- Peptide Label: isoform X1
- UniProtKB: M0RAK0 (UniProtKB/TrEMBL),   A6JLX3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075904   ⟸   ENSRNOT00000092710
RefSeq Acc Id: ENSRNOP00000066551   ⟸   ENSRNOT00000073933
RefSeq Acc Id: XP_038952439   ⟸   XM_039096511
- Peptide Label: isoform X1
- UniProtKB: M0RAK0 (UniProtKB/TrEMBL),   A6JLX3 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001387737   ⟸   NM_001400808
- UniProtKB: M0RAK0 (UniProtKB/TrEMBL),   A6JLX3 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RAK0-F1-model_v2 AlphaFold M0RAK0 1-471 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700568
Promoter ID:EPDNEW_R11089
Type:initiation region
Name:Proser2_1
Description:proline and serine rich 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01776,079,720 - 76,079,780EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1586830 AgrOrtholog
BioCyc Gene G2FUF-8711 BioCyc
Ensembl Genes ENSRNOG00000045553 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000073933 ENTREZGENE
  ENSRNOT00000073933.4 UniProtKB/TrEMBL
KEGG Report rno:683460 UniProtKB/TrEMBL
NCBI Gene 683460 ENTREZGENE
PANTHER PROLINE AND SERINE-RICH PROTEIN 2 UniProtKB/TrEMBL
  TRANSMEMBRANE PROTEIN 143 FAMILY MEMBER UniProtKB/TrEMBL
Pfam SARG UniProtKB/TrEMBL
PhenoGen Proser2 PhenoGen
RatGTEx ENSRNOG00000045553 RatGTEx
UniProt A6JLX3 ENTREZGENE, UniProtKB/TrEMBL
  M0RAK0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-13 Proser2  proline and serine rich 2  Proser2  proline and serine-rich protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-13 Proser2  proline and serine-rich protein 2  LOC683460  hypothetical protein LOC683460  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC683460  hypothetical protein LOC683460      Symbol and Name status set to provisional 70820 PROVISIONAL