Ryr1 (ryanodine receptor 1) - Rat Genome Database

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Gene: Ryr1 (ryanodine receptor 1) Rattus norvegicus
Analyze
Symbol: Ryr1
Name: ryanodine receptor 1
RGD ID: 1586637
Description: Enables ryanodine-sensitive calcium-release channel activity. Involved in several processes, including cellular response to ATP; negative regulation of transforming growth factor beta receptor signaling pathway; and release of sequestered calcium ion into cytosol by sarcoplasmic reticulum. Located in several cellular components, including sarcolemma; sarcomere; and sarcoplasmic reticulum. Is extrinsic component of cytoplasmic side of plasma membrane. Used to study myocardial infarction. Biomarker of osteochondrodysplasia and pulmonary hypertension. Human ortholog(s) of this gene implicated in congestive heart failure (multiple); intracranial vasospasm; and muscle tissue disease (multiple). Orthologous to human RYR1 (ryanodine receptor 1); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC686059; ryanodine receptor 1 (skeletal); ryanodine receptor 1, skeletal muscle; ryanodine receptor 1-like; ryanodine receptor 1-like, skeletal muscle; RYR-1; Ryr1l; similar to ryanodine receptor 1 (skeletal); skeletal muscle calcium release channel; skeletal muscle ryanodine receptor; skeletal muscle-type ryanodine receptor; type 1 ryanodine receptor
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8193,420,078 - 93,551,305 (-)NCBIGRCr8
mRatBN7.2184,292,578 - 84,423,824 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl184,292,578 - 84,423,812 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0187,959,596 - 88,066,252 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl187,959,712 - 88,066,101 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0189,135,622 - 89,241,311 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4184,116,098 - 84,254,503 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera178,682,691 - 78,812,242 (-)NCBICelera
Cytogenetic Map1q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
ankyloglossia  (ISO)
anterior segment dysgenesis  (ISO)
anterior segment dysgenesis 7  (ISO)
Aortic Coarctation  (ISO)
arthrogryposis multiplex congenita  (ISO)
atrial heart septal defect  (ISO)
autosomal dominant intellectual developmental disorder 26  (ISO)
autosomal recessive nonsyndromic deafness  (ISO)
Axial Myopathy, Late-Onset  (ISO)
Bronchomalacia  (ISO)
cardiomyopathy  (ISO)
caudal regression syndrome  (ISO)
centronuclear myopathy  (ISO)
clubfoot  (ISO)
congenital disorder of glycosylation Ii  (ISO)
Congenital Hip Dislocation  (ISO)
congenital muscular dystrophy  (ISO)
congenital myasthenic syndrome  (ISO)
congenital myasthenic syndrome 12  (ISO)
congenital myopathy  (ISO)
congenital myopathy 1A  (ISO,ISS)
congenital myopathy 1B  (ISO,ISS)
congenital myopathy 4A  (ISO)
Congenital Neuromuscular Disease, with Uniform Type 1 Fiber  (ISO)
congenital structural myopathy  (ISO)
congestive heart failure  (ISO)
Developmental Disabilities  (ISO)
distal arthrogryposis  (ISO)
Dwarfism  (ISO)
Dyskinesias  (ISO)
dystonia  (ISO)
fetal akinesia deformation sequence syndrome  (ISO)
fetal akinesia deformation sequence syndrome 1  (ISO)
gastroesophageal reflux disease  (ISO)
genetic disease  (ISO)
gestational diabetes  (ISO)
glaucoma  (ISO)
GNE myopathy  (ISO)
Hearing Loss  (ISO)
Heart Block  (ISO)
Heat Stroke  (ISO)
hereditary nonpolyposis colorectal cancer type 5  (ISO)
Hydrops Fetalis  (ISO)
intracranial vasospasm  (ISO)
isolated elevated serum creatine phosphokinase levels  (ISO)
King Denborough syndrome  (ISO)
Lead Poisoning  (ISO)
learning disability  (ISO)
Left Ventricular Hypertrophy  (ISO)
long QT syndrome  (ISO)
Malignant Fever  (ISO)
malignant hyperthermia  (ISO,ISS)
Malignant Hypothermia  (ISO)
Mitochondrial Progressive Myopathy with Congenital Cataract, Hearing Loss, and Developmental Delay  (ISO)
Muscle Hypotonia  (ISO)
Muscle Weakness  (ISO)
muscular disease  (ISO)
Myalgia  (ISO)
myocardial infarction  (IDA)
myopathy  (ISO)
Myotonia  (ISO)
nephrotoxicity  (IEP)
neuromuscular disease  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
osteochondrodysplasia  (IEP)
osteogenesis imperfecta type 1  (ISO)
osteoporosis  (ISO)
panhypopituitarism  (ISO)
pre-eclampsia  (ISO)
primary pulmonary hypertension  (ISO)
ptosis  (ISO)
pulmonary hypertension  (IEP)
renal cell carcinoma  (ISO)
respiratory failure  (ISO)
Rhabdomyolysis  (ISO)
rigid spine muscular dystrophy 1  (ISO)
scoliosis  (ISO)
Sepsis  (IEP)
Spinal Cord Injuries  (IDA)
ventricular septal defect  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',3,3',6,6'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-chloro-m-cresol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
Ammothamnine  (ISO)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP,ISO)
baclofen  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bicuculline  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
chrysene  (ISO)
Cuprizon  (EXP)
dantrolene  (ISO)
DDE  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (EXP,ISO)
dextran sulfate  (ISO)
dimethylarsinic acid  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
ethanol  (ISO)
fenvalerate  (ISO)
flubendiamide  (ISO)
folic acid  (ISO)
graphite  (ISO)
halothane  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
menadione  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
methylarsonic acid  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
paracetamol  (ISO)
perfluorooctanoic acid  (EXP)
pioglitazone  (ISO)
raloxifene  (ISO)
ryanodine  (ISO)
SCH 23390  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
sotorasib  (ISO)
spermine  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
tetracaine  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
trichloroethene  (EXP)
triclosan  (ISO)
triptonide  (ISO)
valproic acid  (EXP,ISO)
vorinostat  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Skeletal muscle dysfunction in idiopathic pulmonary arterial hypertension. Batt J, etal., Am J Respir Cell Mol Biol. 2014 Jan;50(1):74-86. doi: 10.1165/rcmb.2012-0506OC.
2. Identification of functionally segregated sarcoplasmic reticulum calcium stores in pulmonary arterial smooth muscle. Clark JH, etal., J Biol Chem. 2010 Apr 30;285(18):13542-9. doi: 10.1074/jbc.M110.101485. Epub 2010 Feb 21.
3. The presence of a functional t-tubule network increases the sensitivity of RyR1 to agonists in skinned rat skeletal muscle fibres. Duke AM and Steele DS, Cell Calcium. 2008 Oct;44(4):411-21.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Stretch-induced Ca2+ signalling in vascular smooth muscle cells depends on Ca2+ store segregation. Gilbert G, etal., Cardiovasc Res. 2014 Jul 15;103(2):313-23. doi: 10.1093/cvr/cvu069. Epub 2014 Apr 1.
6. Common variants in RYR1 are associated with left ventricular hypertrophy assessed by electrocardiogram. Hong KW, etal., Eur Heart J. 2012 May;33(10):1250-6. doi: 10.1093/eurheartj/ehr267. Epub 2011 Aug 9.
7. Variation in expression of calcium-handling proteins is associated with inter-individual differences in mechanical performance of rat (Rattus norvegicus) skeletal muscle. James RS, etal., J Exp Biol. 2011 Nov 1;214(Pt 21):3542-8. doi: 10.1242/jeb.058305.
8. Altered inhibition of the rat skeletal ryanodine receptor/calcium release channel by magnesium in the presence of ATP. Jóna I, etal., Pflugers Arch. 2001 Mar;441(6):729-38.
9. Upregulation of the CaV 1.1-ryanodine receptor complex in a rat model of critical illness myopathy. Kraner SD, etal., Am J Physiol Regul Integr Comp Physiol. 2011 Jun;300(6):R1384-91. Epub 2011 Apr 6.
10. Ryanodine Receptor Calcium Leak in Circulating B-Lymphocytes as a Biomarker in Heart Failure. Kushnir A, etal., Circulation. 2018 Sep 11;138(11):1144-1154. doi: 10.1161/CIRCULATIONAHA.117.032703.
11. Ryanodine receptors: structure, expression, molecular details, and function in calcium release. Lanner JT, etal., Cold Spring Harb Perspect Biol. 2010 Nov;2(11):a003996. doi: 10.1101/cshperspect.a003996. Epub 2010 Oct 20.
12. Spinal Cord Injury Leads to Hyperoxidation and Nitrosylation of Skeletal Muscle Ryanodine Receptor-1 Associated with Upregulation of Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4. Liu XH, etal., J Neurotrauma. 2017 Jun 15;34(12):2069-2074. doi: 10.1089/neu.2016.4763. Epub 2017 Feb 27.
13. Malignant hyperthermia, environmental heat stress, and intracellular calcium dysregulation in a mouse model expressing the p.G2435R variant of RYR1. Lopez JR, etal., Br J Anaesth. 2018 Oct;121(4):953-961. doi: 10.1016/j.bja.2018.07.008. Epub 2018 Aug 10.
14. Both short intense and prolonged moderate in vitro stimulation reduce the mRNA expression of calcium-regulatory proteins in rat skeletal muscle. Mänttäri S, etal., Mol Cell Biochem. 2013 Jan;373(1-2):171-8. doi: 10.1007/s11010-012-1486-5. Epub 2012 Oct 31.
15. Vitamin D and calcium co-therapy mitigates pre-established cadmium nephropathy by regulating renal calcium homeostatic molecules and improving anti-oxidative and anti-inflammatory activities in rat. Obaid AA, etal., J Trace Elem Med Biol. 2023 May 24;79:127221. doi: 10.1016/j.jtemb.2023.127221.
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. DHPR activation underlies SR Ca2+ release induced by osmotic stress in isolated rat skeletal muscle fibers. Pickering JD, etal., J Gen Physiol. 2009 May;133(5):511-24. doi: 10.1085/jgp.200910191.
18. Characterization of ryanodine receptors in rat colonic epithelium. Prinz G and Diener M, Acta Physiol (Oxf). 2008 Jun;193(2):151-62. doi: 10.1111/j.1748-1716.2007.01802.x. Epub 2007 Nov 15.
19. Caloric restriction prevents age-related decline in skeletal muscle dihydropyridine receptor and ryanodine receptor expression. Renganathan M and Delbono O, FEBS Lett. 1998 Sep 4;434(3):346-50. doi: 10.1016/s0014-5793(98)01009-6.
20. Triadin (Trisk 95) overexpression blocks excitation-contraction coupling in rat skeletal myotubes. Rezgui SS, etal., J Biol Chem. 2005 Nov 25;280(47):39302-8. Epub 2005 Sep 21.
21. GOA pipeline RGD automated data pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Functional ryanodine receptors in the plasma membrane of RINm5F pancreatic beta-cells. Rosker C, etal., J Biol Chem. 2009 Feb 20;284(8):5186-94. doi: 10.1074/jbc.M805587200. Epub 2008 Dec 30.
25. Effects of chronic sepsis on contractile properties of fast twitch muscle in an experimental model of critical illness neuromyopathy in the rat. Rossignol B, etal., Crit Care Med. 2008 Jun;36(6):1855-63. doi: 10.1097/CCM.0b013e318176106b.
26. Search for genetic variants in the ryanodine receptor 1 gene in patients with symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Rueffert H, etal., Neurocrit Care. 2011 Dec;15(3):410-5. doi: 10.1007/s12028-011-9542-7.
27. Identification of novel ryanodine receptor 1 (RyR1) protein interaction with calcium homeostasis endoplasmic reticulum protein (CHERP). Ryan T, etal., J Biol Chem. 2011 May 13;286(19):17060-8. doi: 10.1074/jbc.M110.197186. Epub 2011 Mar 14.
28. Acute Skeletal Muscle Contractions Orchestrate Signaling Mechanisms to Trigger Nuclear NFATc1 Shuttling and Epigenetic Histone Modifications. Suhr F, etal., Cell Physiol Biochem. 2019;52(3):633-652. doi: 10.33594/000000045.
29. Oxygen-coupled redox regulation of the skeletal muscle ryanodine receptor-Ca2+ release channel by NADPH oxidase 4. Sun QA, etal., Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16098-103. doi: 10.1073/pnas.1109546108. Epub 2011 Sep 6.
30. Disrupted placental vitamin D metabolism and calcium signaling in gestational diabetes and pre-eclampsia patients. Varshney S, etal., Endocrine. 2023 Apr;80(1):191-200. doi: 10.1007/s12020-022-03272-9. Epub 2022 Dec 8.
31. Decreased intracellular [Ca2+ ] coincides with reduced expression of Dhprα1s, RyR1, and diaphragmatic dysfunction in a rat model of sepsis. Wang MM, etal., Muscle Nerve. 2017 Dec;56(6):1128-1136. doi: 10.1002/mus.25554. Epub 2017 Mar 23.
32. Ryanodine receptor 1 mediated dexamethasone-induced chondrodysplasia in fetal rats. Wang YZ, etal., Biochim Biophys Acta Mol Cell Res. 2020 Oct;1867(10):118791. doi: 10.1016/j.bbamcr.2020.118791. Epub 2020 Jun 30.
33. Defects in ryanodine receptor calcium release in skeletal muscle from post-myocardial infarct rats. Ward CW, etal., FASEB J. 2003 Aug;17(11):1517-9. doi: 10.1096/fj.02-1083fje. Epub 2003 Jun 3.
34. ECG conduction disturbances and ryanodine receptor expression levels in occupational lead exposure workers. Xie J, etal., Occup Environ Med. 2019 Mar;76(3):151-156. doi: 10.1136/oemed-2018-105463. Epub 2019 Jan 19.
35. A novel RyR1-selective inhibitor prevents and rescues sudden death in mouse models of malignant hyperthermia and heat stroke. Yamazawa T, etal., Nat Commun. 2021 Jul 13;12(1):4293. doi: 10.1038/s41467-021-24644-1.
36. [Therapeutic effects of novel type1 ryanodine receptor inhibitor on skeletal muscle diseases]. Yamazawa T, etal., Nihon Yakurigaku Zasshi. 2022;157(1):15-22. doi: 10.1254/fpj.21068.
37. [Estrogen reduces the expressions of ryanodine receptor type 1 and Cav1.3 L-type calcium channel in the vaginal smooth muscle cells of rats]. Zhou QG, etal., Zhonghua Nan Ke Xue. 2009 Jun;15(6):511-6.
38. Moderate intensity continuous training reverses the detrimental effects of ovariectomy on RyR1 phosphorylation in rat skeletal muscle. Zügel M, etal., Mol Cell Endocrinol. 2019 Feb 5;481:1-7. doi: 10.1016/j.mce.2018.11.003. Epub 2018 Nov 19.
Additional References at PubMed
PMID:7515481   PMID:7556644   PMID:7621815   PMID:7832748   PMID:8943043   PMID:10427100   PMID:10444070   PMID:10444400   PMID:11206130   PMID:11590243   PMID:11694536   PMID:11741831  
PMID:11784029   PMID:12207911   PMID:12223488   PMID:12704193   PMID:12937085   PMID:12954602   PMID:14592808   PMID:15536090   PMID:16163667   PMID:16186498   PMID:17074386   PMID:18003898  
PMID:18076146   PMID:18676612   PMID:19009018   PMID:19056867   PMID:19120137   PMID:19198614   PMID:20089138   PMID:20112737   PMID:20218309   PMID:21524998   PMID:21781462   PMID:22355118  
PMID:22480578   PMID:23454728   PMID:23695157   PMID:23943510   PMID:24124188   PMID:24233561   PMID:24431430   PMID:26115329   PMID:27499186   PMID:32916280  


Genomics

Comparative Map Data
Ryr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8193,420,078 - 93,551,305 (-)NCBIGRCr8
mRatBN7.2184,292,578 - 84,423,824 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl184,292,578 - 84,423,812 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0187,959,596 - 88,066,252 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl187,959,712 - 88,066,101 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0189,135,622 - 89,241,311 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4184,116,098 - 84,254,503 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera178,682,691 - 78,812,242 (-)NCBICelera
Cytogenetic Map1q21NCBI
RYR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381938,433,691 - 38,587,564 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1938,433,691 - 38,595,273 (+)EnsemblGRCh38hg38GRCh38
GRCh371938,924,331 - 39,078,204 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361943,616,180 - 43,770,044 (+)NCBINCBI36Build 36hg18NCBI36
Build 341943,616,179 - 43,770,012NCBI
Celera1935,726,452 - 35,880,238 (+)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1935,371,495 - 35,526,332 (+)NCBIHuRef
CHM1_11938,924,701 - 39,079,134 (+)NCBICHM1_1
T2T-CHM13v2.01941,235,876 - 41,391,545 (+)NCBIT2T-CHM13v2.0
Ryr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,702,765 - 28,824,599 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl728,702,769 - 28,824,604 (-)EnsemblGRCm39 Ensembl
GRCm38729,003,340 - 29,125,179 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl729,003,344 - 29,125,179 (-)EnsemblGRCm38mm10GRCm38
MGSCv37729,788,359 - 29,910,170 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36728,712,104 - 28,833,911 (-)NCBIMGSCv36mm8
Celera723,565,768 - 23,695,212 (-)NCBICelera
Cytogenetic Map7B1NCBI
cM Map716.94NCBI
Ryr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955468879,951 - 1,000,036 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955468879,807 - 1,000,118 (-)NCBIChiLan1.0ChiLan1.0
RYR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22044,724,700 - 44,882,541 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11946,595,023 - 46,752,872 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01935,527,466 - 35,685,446 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11944,099,196 - 44,256,470 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1944,106,036 - 44,256,327 (+)Ensemblpanpan1.1panPan2
RYR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11114,461,350 - 114,579,577 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1114,461,348 - 114,579,493 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1113,865,988 - 113,983,252 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01115,063,307 - 115,181,223 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1115,063,305 - 115,204,391 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11114,636,271 - 114,754,225 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01114,253,994 - 114,371,830 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01115,292,565 - 115,410,455 (-)NCBIUU_Cfam_GSD_1.0
Ryr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934913,020,295 - 13,133,060 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368011,185,733 - 1,298,289 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049368011,185,615 - 1,298,416 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RYR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl647,343,768 - 47,458,458 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1647,339,759 - 47,458,457 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2642,840,240 - 42,960,110 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6q1.2NCBI
RYR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1633,080,443 - 33,234,478 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl633,080,758 - 33,213,788 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607311,024,332 - 11,181,890 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ryr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479411,888,289 - 12,004,314 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479411,888,211 - 12,004,457 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ryr1
1142 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:37
Count of miRNA genes:37
Interacting mature miRNAs:37
Transcripts:ENSRNOT00000027893
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)14939317294393172Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
1300121Hrtrt1Heart rate QTL 13.7heart pumping trait (VT:2000009)heart rate (CMO:0000002)165789093115540829Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)166023617118608521Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)17219768090508767Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)177876254106047988Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)182174743118944897Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)180592172125592172Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)15673266898773277Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)178350581123350581Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)177494165122494165Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)15386304190532583Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)156949932101949932Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)183547917128547917Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)177857876122857876Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)178430536123430536Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)17843075491209302Rat

Markers in Region
D1Got388  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2184,388,001 - 84,388,149 (+)MAPPERmRatBN7.2
Rnor_6.0188,030,428 - 88,030,575NCBIRnor6.0
Rnor_5.0189,205,586 - 89,205,733UniSTSRnor5.0
RGSC_v3.4184,218,566 - 84,218,713UniSTSRGSC3.4
Celera178,777,328 - 78,777,475UniSTS
Cytogenetic Map1q21UniSTS
RH130025  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2184,292,313 - 84,292,466 (+)MAPPERmRatBN7.2
Rnor_6.0187,959,332 - 87,959,484NCBIRnor6.0
Rnor_5.0189,135,358 - 89,135,510UniSTSRnor5.0
RGSC_v3.4184,115,836 - 84,115,988UniSTSRGSC3.4
Celera178,682,427 - 78,682,579UniSTS
RH 3.4 Map1841.0UniSTS
Cytogenetic Map1q21UniSTS
RH133862  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2184,292,598 - 84,293,015 (+)MAPPERmRatBN7.2
Rnor_6.0187,959,617 - 87,960,033NCBIRnor6.0
Rnor_5.0189,135,643 - 89,136,059UniSTSRnor5.0
RGSC_v3.4184,116,121 - 84,116,537UniSTSRGSC3.4
Celera178,682,712 - 78,683,128UniSTS
RH 3.4 Map1828.9UniSTS
Cytogenetic Map1q21UniSTS
AI528790  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2184,292,607 - 84,292,748 (+)MAPPERmRatBN7.2
Rnor_6.0187,959,626 - 87,959,766NCBIRnor6.0
Rnor_5.0189,135,652 - 89,135,792UniSTSRnor5.0
RGSC_v3.4184,116,130 - 84,116,270UniSTSRGSC3.4
Celera178,682,721 - 78,682,861UniSTS
Cytogenetic Map1q21UniSTS
AW534727  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2184,360,847 - 84,361,386 (+)MAPPERmRatBN7.2
Rnor_6.0188,003,266 - 88,003,804NCBIRnor6.0
Rnor_5.0189,178,424 - 89,178,962UniSTSRnor5.0
RGSC_v3.4184,190,303 - 84,190,841UniSTSRGSC3.4
Celera178,750,182 - 78,750,720UniSTS
RH 3.4 Map1839.9UniSTS
Cytogenetic Map1q21UniSTS
AU049008  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2184,374,014 - 84,375,397 (+)MAPPERmRatBN7.2
Rnor_6.0188,016,436 - 88,017,818NCBIRnor6.0
Rnor_5.0189,191,594 - 89,192,976UniSTSRnor5.0
RGSC_v3.4184,203,476 - 84,204,858UniSTSRGSC3.4
Celera178,763,348 - 78,764,730UniSTS
Cytogenetic Map1q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000027893   ⟹   ENSRNOP00000027893
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl184,292,578 - 84,423,812 (-)Ensembl
Rnor_6.0 Ensembl187,975,997 - 88,066,101 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000079473   ⟹   ENSRNOP00000073446
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl184,292,578 - 84,423,812 (-)Ensembl
Rnor_6.0 Ensembl187,959,712 - 88,066,101 (-)Ensembl
RefSeq Acc Id: NM_001419537   ⟹   NP_001406466
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,420,078 - 93,551,305 (-)NCBI
mRatBN7.2184,292,578 - 84,423,824 (-)NCBI
RefSeq Acc Id: XM_039100852   ⟹   XP_038956780
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,420,078 - 93,551,300 (-)NCBI
mRatBN7.2184,292,578 - 84,423,799 (-)NCBI
RefSeq Acc Id: XM_039100853   ⟹   XP_038956781
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,420,078 - 93,551,300 (-)NCBI
mRatBN7.2184,292,578 - 84,423,799 (-)NCBI
RefSeq Acc Id: XM_039100854   ⟹   XP_038956782
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8193,420,078 - 93,551,300 (-)NCBI
mRatBN7.2184,292,578 - 84,423,799 (-)NCBI
Ensembl Acc Id: ENSRNOP00000073446   ⟸   ENSRNOT00000079473
Ensembl Acc Id: ENSRNOP00000027893   ⟸   ENSRNOT00000027893
RefSeq Acc Id: XP_038956782   ⟸   XM_039100854
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K5J1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038956780   ⟸   XM_039100852
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K5J1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038956781   ⟸   XM_039100853
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K5J1 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001406466   ⟸   NM_001419537
- UniProtKB: A0A0G2K5J1 (UniProtKB/TrEMBL),   V9GZ83 (UniProtKB/TrEMBL)
Protein Domains
B30.2/SPRY   EF-hand   MIR

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1586637 AgrOrtholog
BioCyc Gene G2FUF-60201 BioCyc
Ensembl Genes ENSRNOG00000020557 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027893.7 UniProtKB/TrEMBL
  ENSRNOT00000079473.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.10.490.160 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.120.920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.80.10.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.20.350.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IP3 receptor type 1 binding core, RIH domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro B30.2/SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  B30.2/SPRY_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ins145_P3_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIR_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIH_assoc-dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ryan_recept UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ryanodine_IP3_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ryanodine_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ryanrecept_TM4-6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RYDR_Jsol UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RyR/IP3R_RIH_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY1_RyR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY2_RyR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY3_RyR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene Ryr1 ENTREZGENE
PANTHER B30.2/SPRY DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RYANODINE RECEPTOR 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ins145_P3_rec UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ion_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIH_assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RR_TM4-6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RYDR_ITPR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RYDR_Jsol UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RyR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB RYR1 RGD
PhenoGen Ryr1 PhenoGen
PRINTS RYANODINER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE B302_SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020557 RatGTEx
SMART MIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF100909 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF82109 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K5J1 ENTREZGENE, UniProtKB/TrEMBL
  F1LMY4 ENTREZGENE, UniProtKB/Swiss-Prot
  V9GZ83 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary O35208 UniProtKB/Swiss-Prot
  Q9R1G1 UniProtKB/Swiss-Prot
  Q9R272 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-03 Ryr1  ryanodine receptor 1  Ryr1  ryanodine receptor 1 (skeletal)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-15 Ryr1  ryanodine receptor 1 (skeletal)  Ryr1l  ryanodine receptor 1-like  Data merged from RGD:620313 737654 APPROVED
2008-09-18 Ryr1  ryanodine receptor 1 (skeletal)  Ryr1  ryanodine receptor 1, skeletal muscle  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-14 Ryr1l  ryanodine receptor 1-like, skeletal muscle  Ryr1  ryanodine receptor 1, skeletal muscle  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-14 Ryr1l  ryanodine receptor 1-like  Ryr1l  ryanodine receptor 1-like, skeletal muscle  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-14 Ryr1  ryanodine receptor 1, skeletal muscle  LOC686059  similar to ryanodine receptor 1 (skeletal)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC686059  similar to ryanodine receptor 1 (skeletal)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 Ryr1  ryanodine receptor 1, skeletal muscle    ryanodine receptor 1 (skeletal)  Name updated 1299863 APPROVED
2002-08-07 Ryr1  ryanodine receptor 1 (skeletal)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation channel activated by cyclic ADP-ribose in skeletal muscle 724691