Arhgef4 (Rho guanine nucleotide exchange factor 4) - Rat Genome Database

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Gene: Arhgef4 (Rho guanine nucleotide exchange factor 4) Rattus norvegicus
Analyze
Symbol: Arhgef4
Name: Rho guanine nucleotide exchange factor 4
RGD ID: 1586179
Description: Predicted to enable guanyl-nucleotide exchange factor activity and protein domain specific binding activity. Predicted to be involved in filopodium assembly and lamellipodium assembly. Predicted to be active in cytosol. Orthologous to human ARHGEF4 (Rho guanine nucleotide exchange factor 4); INTERACTS WITH 1,2-dimethylhydrazine; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC301334; Rho guanine nucleotide exchange factor (GEF) 4; similar to Rho guanine nucleotide exchange factor 4 isoform a
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8944,357,716 - 44,500,959 (+)NCBIGRCr8
mRatBN7.2936,861,800 - 37,005,079 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl936,861,835 - 37,005,075 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0941,160,562 - 41,305,015 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl941,295,909 - 41,302,501 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0940,829,962 - 40,973,783 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4933,395,974 - 33,539,597 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera934,646,792 - 34,790,632 (+)NCBICelera
Cytogenetic Map9q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10947987   PMID:17599059   PMID:30125942   PMID:34022264  


Genomics

Comparative Map Data
Arhgef4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8944,357,716 - 44,500,959 (+)NCBIGRCr8
mRatBN7.2936,861,800 - 37,005,079 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl936,861,835 - 37,005,075 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0941,160,562 - 41,305,015 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl941,295,909 - 41,302,501 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0940,829,962 - 40,973,783 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4933,395,974 - 33,539,597 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera934,646,792 - 34,790,632 (+)NCBICelera
Cytogenetic Map9q21NCBI
ARHGEF4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382130,836,914 - 131,047,253 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2130,836,914 - 131,047,263 (+)EnsemblGRCh38hg38GRCh38
GRCh372131,594,487 - 131,804,826 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362131,390,694 - 131,521,306 (+)NCBINCBI36Build 36hg18NCBI36
Build 342131,507,955 - 131,638,568NCBI
Celera2124,772,847 - 124,903,056 (-)NCBICelera
Cytogenetic Map2q21.1NCBI
HuRef2123,744,169 - 123,803,670 (+)NCBIHuRef
CHM1_12131,678,231 - 131,808,841 (+)NCBICHM1_1
T2T-CHM13v2.02131,271,158 - 131,481,546 (+)NCBIT2T-CHM13v2.0
Arhgef4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39134,717,263 - 34,851,819 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl134,717,269 - 34,852,390 (+)EnsemblGRCm39 Ensembl
GRCm38134,677,949 - 34,812,754 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl134,678,188 - 34,813,309 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl134,801,794 - 34,801,964 (+)EnsemblGRCm38mm10GRCm38
MGSCv37134,858,567 - 34,869,599 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36134,746,268 - 34,757,300 (+)NCBIMGSCv36mm8
Celera134,571,295 - 34,582,266 (+)NCBICelera
Cytogenetic Map1BNCBI
cM Map113.34NCBI
Arhgef4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955459321,683 - 534,108 (+)NCBIChiLan1.0ChiLan1.0
ARHGEF4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21344,598,671 - 44,805,585 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B44,613,644 - 44,820,559 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B29,583,389 - 29,716,630 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B131,669,743 - 131,800,705 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B131,594,345 - 131,800,705 (+)Ensemblpanpan1.1panPan2
ARHGEF4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11920,618,860 - 20,734,458 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1920,618,492 - 20,734,162 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1920,893,924 - 20,980,407 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01921,971,698 - 22,058,440 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11920,582,693 - 20,698,963 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01920,842,403 - 20,959,173 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01921,914,410 - 22,001,460 (+)NCBIUU_Cfam_GSD_1.0
Arhgef4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303100,150,254 - 100,308,313 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493646941,352,361 - 41,467,466 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGEF4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1557,115,853 - 57,374,612 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11557,260,772 - 57,378,634 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ARHGEF4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_023666037568,740 - 772,089 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgef4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473214,885,119 - 15,110,134 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Arhgef4
876 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:266
Count of miRNA genes:165
Interacting mature miRNAs:184
Transcripts:ENSRNOT00000018935
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91353377042791750Rat
724543Cm20Cardiac mass QTL 203.9heart mass (VT:0007028)calculated heart weight (CMO:0000073)91696139840594091Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)92213332249968732Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)92375402458157242Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat

Markers in Region
D9Rat76  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2936,962,359 - 36,962,591 (+)MAPPERmRatBN7.2
Rnor_6.0941,261,034 - 41,261,265NCBIRnor6.0
Rnor_5.0940,929,725 - 40,929,956UniSTSRnor5.0
RGSC_v3.4933,496,795 - 33,497,026UniSTSRGSC3.4
RGSC_v3.4933,496,794 - 33,497,026RGDRGSC3.4
RGSC_v3.1933,498,209 - 33,498,440RGD
Celera934,746,702 - 34,746,933UniSTS
RH 3.4 Map9352.2RGD
RH 3.4 Map9352.2UniSTS
RH 2.0 Map9356.8RGD
SHRSP x BN Map932.0698RGD
FHH x ACI Map924.71RGD
Cytogenetic Map9q21UniSTS
D9Rat58  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2936,919,457 - 36,919,672 (+)MAPPERmRatBN7.2
Rnor_6.0941,218,155 - 41,218,369NCBIRnor6.0
Rnor_5.0940,887,557 - 40,887,771UniSTSRnor5.0
RGSC_v3.4933,453,530 - 33,453,744UniSTSRGSC3.4
RGSC_v3.4933,453,529 - 33,453,744RGDRGSC3.4
RGSC_v3.1933,454,944 - 33,455,158RGD
Celera934,704,373 - 34,704,587UniSTS
RH 3.4 Map9352.9RGD
RH 3.4 Map9352.9UniSTS
RH 2.0 Map9353.5RGD
FHH x ACI Map924.71RGD
Cytogenetic Map9q21UniSTS
D9Got46  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2936,865,773 - 36,865,913 (+)MAPPERmRatBN7.2
Rnor_6.0941,164,475 - 41,164,614NCBIRnor6.0
Rnor_5.0940,833,877 - 40,834,016UniSTSRnor5.0
RGSC_v3.4933,399,848 - 33,399,988RGDRGSC3.4
RGSC_v3.4933,399,849 - 33,399,988UniSTSRGSC3.4
RGSC_v3.1933,401,263 - 33,401,402RGD
Celera934,650,705 - 34,650,844UniSTS
RH 3.4 Map9348.0UniSTS
RH 3.4 Map9348.0RGD
RH 2.0 Map9352.4RGD
Cytogenetic Map9q21UniSTS
BG381432  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2937,001,257 - 37,001,418 (+)MAPPERmRatBN7.2
Rnor_6.0941,299,598 - 41,299,758NCBIRnor6.0
Rnor_5.0940,968,286 - 40,968,446UniSTSRnor5.0
RGSC_v3.4933,535,791 - 33,535,951UniSTSRGSC3.4
Celera934,785,215 - 34,785,375UniSTS
RH 3.4 Map9353.2UniSTS
Cytogenetic Map9q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 64 9
Low 3 19 30 14 19 14 6 7 10 35 32 11 6
Below cutoff 24 21 21 21 2 3 2

Sequence


RefSeq Acc Id: ENSRNOT00000018935   ⟹   ENSRNOP00000018935
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl936,861,835 - 37,005,075 (+)Ensembl
Rnor_6.0 Ensembl941,295,909 - 41,302,501 (+)Ensembl
RefSeq Acc Id: NM_001427642   ⟹   NP_001414571
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8944,357,758 - 44,500,959 (+)NCBI
RefSeq Acc Id: XM_017596787   ⟹   XP_017452276
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8944,357,716 - 44,499,976 (+)NCBI
mRatBN7.2936,861,800 - 37,003,508 (+)NCBI
Rnor_6.0941,160,562 - 41,302,437 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039084525   ⟹   XP_038940453
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8944,357,716 - 44,500,959 (+)NCBI
mRatBN7.2936,861,800 - 37,005,079 (+)NCBI
RefSeq Acc Id: XM_063266889   ⟹   XP_063122959
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8944,357,716 - 44,493,548 (+)NCBI
RefSeq Acc Id: XM_063266890   ⟹   XP_063122960
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8944,357,716 - 44,500,959 (+)NCBI
RefSeq Acc Id: XM_063266891   ⟹   XP_063122961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8944,434,115 - 44,500,959 (+)NCBI
RefSeq Acc Id: XP_017452276   ⟸   XM_017596787
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000018935   ⟸   ENSRNOT00000018935
RefSeq Acc Id: XP_038940453   ⟸   XM_039084525
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063122960   ⟸   XM_063266890
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063122959   ⟸   XM_063266889
- Peptide Label: isoform X3
RefSeq Acc Id: NP_001414571   ⟸   NM_001427642
RefSeq Acc Id: XP_063122961   ⟸   XM_063266891
- Peptide Label: isoform X5
Protein Domains
DH   PH   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZKB4-F1-model_v2 AlphaFold D3ZKB4 1-484 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1586179 AgrOrtholog
BioCyc Gene G2FUF-27851 BioCyc
Ensembl Genes ENSRNOG00000014035 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018935.8 UniProtKB/TrEMBL
Gene3D-CATH 1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  GDS_CDC24_CS UniProtKB/TrEMBL
  PH_type UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
  SH3-like_dom UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
KEGG Report rno:301334 UniProtKB/TrEMBL
NCBI Gene 301334 ENTREZGENE
PANTHER RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR (GEF) 4 UniProtKB/TrEMBL
  RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4 UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PhenoGen Arhgef4 PhenoGen
PROSITE DH_1 UniProtKB/TrEMBL
  DH_2 UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014035 RatGTEx
SMART RhoGEF UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP DH-domain UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
UniProt A6INA8_RAT UniProtKB/TrEMBL
  D3ZKB4_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-19 Arhgef4  Rho guanine nucleotide exchange factor 4  Arhgef4  Rho guanine nucleotide exchange factor (GEF) 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Arhgef4  Rho guanine nucleotide exchange factor (GEF) 4  LOC301334  similar to Rho guanine nucleotide exchange factor 4 isoform a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC301334  similar to Rho guanine nucleotide exchange factor 4 isoform a      Symbol and Name status set to provisional 70820 PROVISIONAL