Hus1b (HUS1 checkpoint clamp component B) - Rat Genome Database

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Gene: Hus1b (HUS1 checkpoint clamp component B) Rattus norvegicus
Analyze
Symbol: Hus1b
Name: HUS1 checkpoint clamp component B
RGD ID: 1585035
Description: Orthologous to human HUS1B (HUS1 checkpoint clamp component B); INTERACTS WITH bisphenol A; benzo[a]pyrene (ortholog); butanal (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: checkpoint protein HUS1B; HUS1 checkpoint homolog b; HUS1 checkpoint homolog b (S. pombe); LOC691382; similar to Hus1 checkpoint homolog b
RGD Orthologs
Human
Mouse
Bonobo
Squirrel
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21733,534,113 - 33,534,943 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1733,378,629 - 33,379,459 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01734,982,500 - 34,983,330 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01733,374,446 - 33,375,276 (+)NCBIRnor_WKY
Rnor_6.01735,424,018 - 35,424,848 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1735,424,011 - 35,425,104 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01738,707,452 - 38,708,282 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41739,978,923 - 39,979,753 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1733,078,922 - 33,079,752 (+)NCBICelera
Cytogenetic Map17p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15632090   PMID:21873635  


Genomics

Comparative Map Data
Hus1b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21733,534,113 - 33,534,943 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1733,378,629 - 33,379,459 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01734,982,500 - 34,983,330 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01733,374,446 - 33,375,276 (+)NCBIRnor_WKY
Rnor_6.01735,424,018 - 35,424,848 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1735,424,011 - 35,425,104 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01738,707,452 - 38,708,282 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41739,978,923 - 39,979,753 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1733,078,922 - 33,079,752 (+)NCBICelera
Cytogenetic Map17p12NCBI
HUS1B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386655,939 - 657,100 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl6655,939 - 657,100 (-)EnsemblGRCh38hg38GRCh38
GRCh376655,939 - 657,100 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366600,939 - 601,964 (-)NCBINCBI36Build 36hg18NCBI36
Build 346600,939 - 601,944NCBI
Celera61,883,309 - 1,884,334 (-)NCBICelera
Cytogenetic Map6p25.3NCBI
HuRef6526,023 - 527,048 (-)NCBIHuRef
CHM1_16658,066 - 659,091 (-)NCBICHM1_1
T2T-CHM13v2.06515,149 - 516,310 (-)NCBIT2T-CHM13v2.0
Hus1b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391331,130,559 - 31,131,744 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1331,130,556 - 31,131,742 (-)EnsemblGRCm39 Ensembl
GRCm381330,946,576 - 30,947,761 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1330,946,573 - 30,947,759 (-)EnsemblGRCm38mm10GRCm38
MGSCv371331,038,713 - 31,039,543 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361330,954,309 - 30,955,139 (-)NCBIMGSCv36mm8
Celera1331,159,693 - 31,160,523 (-)NCBICelera
Cytogenetic Map13A3.2NCBI
HUS1B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16601,123 - 602,138 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6601,288 - 602,124 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06466,508 - 469,590 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
Hus1b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494624,799,523 - 24,800,636 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049366331,820,063 - 1,821,150 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HUS1B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11771,502,951 - 71,504,134 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666044581,645 - 584,356 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Hus1b
8 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:323
Count of miRNA genes:129
Interacting mature miRNAs:139
Transcripts:ENSRNOT00000072505, ENSRNOT00000074097
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)171864018263640182Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318457246843Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
4889891Eae32Experimental allergic encephalomyelitis QTL 324.80.0002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)172702794936146731Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172702794956836890Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173136839162109574Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173199078450909196Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat

Markers in Region
RH131719  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21733,534,738 - 33,534,952 (+)MAPPERmRatBN7.2
Rnor_6.01735,424,644 - 35,424,857NCBIRnor6.0
Rnor_6.01734,694,230 - 34,694,443NCBIRnor6.0
Rnor_5.01736,739,684 - 36,739,897UniSTSRnor5.0
Rnor_5.01738,707,443 - 38,707,656UniSTSRnor5.0
RGSC_v3.41739,979,549 - 39,979,762UniSTSRGSC3.4
Celera1733,079,548 - 33,079,761UniSTS
Cytogenetic Map17p12UniSTS
UniSTS:493122  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21733,534,112 - 33,534,943 (+)MAPPERmRatBN7.2
Rnor_6.01735,424,018 - 35,424,848NCBIRnor6.0
Rnor_6.01734,693,604 - 34,694,434NCBIRnor6.0
Rnor_5.01736,739,058 - 36,739,888UniSTSRnor5.0
Rnor_5.01738,707,452 - 38,708,282UniSTSRnor5.0
RGSC_v3.41739,978,923 - 39,979,753UniSTSRGSC3.4
Celera1733,078,922 - 33,079,752UniSTS
Cytogenetic Map17p12UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000086985   ⟹   ENSRNOP00000069298
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1735,424,011 - 35,425,104 (+)Ensembl
RefSeq Acc Id: NM_001134846   ⟹   NP_001128318
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21733,534,113 - 33,534,943 (+)NCBI
Rnor_6.01735,424,018 - 35,424,848 (+)NCBI
Rnor_5.01738,707,452 - 38,708,282 (-)NCBI
RGSC_v3.41739,978,923 - 39,979,753 (+)RGD
Celera1733,078,922 - 33,079,752 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001128318 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL98362 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001128318   ⟸   NM_001134846
- Sequence:
RefSeq Acc Id: ENSRNOP00000069298   ⟸   ENSRNOT00000086985

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1585035 AgrOrtholog
BioCyc Gene G2FUF-9546 BioCyc
Ensembl Genes ENSRNOG00000055922 Ensembl
NCBI Gene 691382 ENTREZGENE
PhenoGen Hus1b PhenoGen


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-01 Hus1b  HUS1 checkpoint clamp component B  Hus1b  HUS1 checkpoint homolog b (S. pombe)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-17 Hus1b  HUS1 checkpoint homolog b (S. pombe)  LOC683826  similar to Hus1 checkpoint homolog b  Data Merged 1643240 APPROVED
2008-03-06 Hus1b  HUS1 checkpoint homolog b (S. pombe)  LOC691382  similar to Hus1 checkpoint homolog b  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC683826  similar to Hus1 checkpoint homolog b      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC691382  similar to Hus1 checkpoint homolog b      Symbol and Name status set to provisional 70820 PROVISIONAL