Abl1 (ABL proto-oncogene 1, non-receptor tyrosine kinase) - Rat Genome Database

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Gene: Abl1 (ABL proto-oncogene 1, non-receptor tyrosine kinase) Rattus norvegicus
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Symbol: Abl1
Name: ABL proto-oncogene 1, non-receptor tyrosine kinase
RGD ID: 1584969
Description: Enables delta-catenin binding activity; protein kinase activity; and protein kinase binding activity. Involved in several processes, including actin filament polymerization; cardiac muscle cell proliferation; and positive regulation of cellular component organization. Located in several cellular components, including growth cone; neuronal cell body; and ruffle. Is active in glutamatergic synapse and postsynaptic density. Biomarker of Parkinson's disease and ureteral obstruction. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple) and leukemia (multiple). Orthologous to human ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase); PARTICIPATES IN p53 signaling pathway; platelet-derived growth factor signaling pathway; cell cycle pathway, mitotic; INTERACTS WITH 1,2-dimethylhydrazine; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Abelson murine leukemia viral (v-abl) oncogene homolog 1; Abl; Abl1_mapped; c-abl oncogene 1, non-receptor tyrosine kinase; c-abl oncogene 1, receptor tyrosine kinase; LOC100909750; tyrosine-protein kinase ABL1; tyrosine-protein kinase ABL1-like; v-abl Abelson murine leukemia viral oncogene 1; v-abl Abelson murine leukemia viral oncogene homolog 1; v-abl Abelson murine leukemia viral oncogene homolog 1 (mapped)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8335,377,587 - 35,480,843 (+)NCBIGRCr8
mRatBN7.2314,979,853 - 15,083,065 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl314,979,853 - 15,083,065 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx318,053,160 - 18,156,546 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0326,638,164 - 26,741,549 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0324,885,255 - 24,988,906 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0310,041,820 - 10,145,076 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl310,041,826 - 10,144,388 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl39,410,661 - 9,448,167 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0315,401,182 - 15,504,438 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4310,804,594 - 10,907,162NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera39,728,420 - 9,830,777 (+)NCBICelera
Cytogenetic Map3p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (EXP,ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-nitroquinoline N-oxide  (ISO)
4-phenylcoumarin  (ISO)
5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole  (ISO)
acetaldehyde  (ISO)
AICA ribonucleotide  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (ISO)
alvocidib  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
androstane-3,17-dione  (ISO)
arsenous acid  (ISO)
ATP  (ISO)
atropine  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucan  (ISO)
beta-hexachlorocyclohexane  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol AF  (ISO)
bortezomib  (ISO)
bosutinib  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
capsaicin  (ISO)
CGP 52608  (ISO)
chloroquine  (ISO)
cilostazol  (ISO)
cisplatin  (EXP,ISO)
citalopram  (EXP)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumarin  (ISO)
crizotinib  (ISO)
Cuprizon  (EXP)
cyproconazole  (EXP)
cytochalasin D  (ISO)
daunorubicin  (ISO)
DDE  (ISO)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
epoxiconazole  (EXP)
escitalopram  (EXP)
FR900359  (ISO)
fulvestrant  (ISO)
gallic acid  (ISO)
gamma-hexachlorocyclohexane  (ISO)
genistein  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
histamine  (ISO)
hydrogen peroxide  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
mangiferin  (ISO)
meloxicam  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methylmercury chloride  (ISO)
myristicin  (ISO)
Myrtucommulone A  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-dimethylsphingosine  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
nilotinib  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
okadaic acid  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
platycodin D  (ISO)
ponatinib  (ISO)
potassium chloride  (EXP)
psoralen  (ISO)
purmorphamine  (ISO)
pyrethrins  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rottlerin  (ISO)
sodium arsenite  (ISO)
sorafenib  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IEA,ISO)
actin filament polymerization  (IMP)
activated T cell proliferation  (IEA,ISO)
activation of protein kinase C activity  (ISO)
alpha-beta T cell differentiation  (IEA,ISO)
associative learning  (IEP)
B cell proliferation  (IEA,ISO)
B cell proliferation involved in immune response  (IEA,ISO)
B cell receptor signaling pathway  (IEA,ISO)
B-1 B cell homeostasis  (IEA,ISO)
Bergmann glial cell differentiation  (IEA,ISO)
BMP signaling pathway  (IEA,ISO)
canonical NF-kappaB signal transduction  (IEA,ISO)
cardiac muscle cell proliferation  (IEP)
cell communication  (IEA)
cell-cell adhesion  (IEA,ISO)
cellular response to hydrogen peroxide  (IEA,ISO)
cellular response to lipopolysaccharide  (IEA,ISO)
cellular response to oxidative stress  (IEA,IEP,ISO)
cellular response to transforming growth factor beta stimulus  (IEP)
cellular senescence  (IEA,ISO)
cerebellum morphogenesis  (IEA,ISO)
circulatory system development  (IEA,ISO)
DN4 thymocyte differentiation  (IEA,ISO)
DNA conformation change  (IEA,ISO)
DNA damage response  (IEA,ISO)
endothelial cell migration  (IEA,ISO)
ephrin receptor signaling pathway  (IEA,ISO)
epidermal growth factor receptor signaling pathway  (IBA,IEA,ISO)
ERK1 and ERK2 cascade  (IEA,ISO)
establishment of localization in cell  (IEA,ISO)
integrin-mediated signaling pathway  (IBA,IEA,ISO)
intracellular signal transduction  (IEA,ISO)
learning or memory  (IMP)
microspike assembly  (IEA,ISO)
myoblast proliferation  (IEP)
negative regulation of BMP signaling pathway  (IEA,ISO)
negative regulation of cell-cell adhesion  (IEA,ISO)
negative regulation of cellular senescence  (IEA,ISO)
negative regulation of double-strand break repair via homologous recombination  (IEA,ISO)
negative regulation of endothelial cell apoptotic process  (IEA,ISO)
negative regulation of ERK1 and ERK2 cascade  (IEA,ISO)
negative regulation of long-term synaptic potentiation  (IEA,ISO)
negative regulation of mitotic cell cycle  (IEA,ISO)
negative regulation of ubiquitin-protein transferase activity  (ISO)
neural tube closure  (IEA,ISO)
neuroepithelial cell differentiation  (IEA,ISO)
neuromuscular process controlling balance  (IEA,ISO)
neuron apoptotic process  (IEA,ISO)
neuron differentiation  (IEA,ISO)
neuropilin signaling pathway  (IEA,ISO)
obsolete positive regulation of microtubule binding  (ISO)
peptidyl-tyrosine autophosphorylation  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
phagocytosis  (IEA,ISO)
phospholipase C-inhibiting G protein-coupled receptor signaling pathway  (IEA,ISO)
platelet-derived growth factor receptor signaling pathway  (IEA,ISO)
platelet-derived growth factor receptor-beta signaling pathway  (IEA,ISO)
podocyte apoptotic process  (IMP)
positive regulation of apoptotic process  (IEA,IMP,ISO)
positive regulation of blood vessel branching  (IEA,ISO)
positive regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (IEA,ISO)
positive regulation of cellular process  (IMP)
positive regulation of cytosolic calcium ion concentration  (IEA,ISO)
positive regulation of dendrite development  (IMP)
positive regulation of endothelial cell migration  (IBA,IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of establishment of T cell polarity  (IEA,ISO)
positive regulation of extracellular matrix organization  (IMP)
positive regulation of fibroblast proliferation  (IMP)
positive regulation of focal adhesion assembly  (IEA,ISO)
positive regulation of interleukin-2 production  (IEA,ISO)
positive regulation of mitotic cell cycle  (IEA,ISO)
positive regulation of neuron apoptotic process  (IEA,IMP,ISO)
positive regulation of osteoblast proliferation  (IEA,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of release of sequestered calcium ion into cytosol  (IEA,ISO)
positive regulation of stress fiber assembly  (IEA,ISO)
positive regulation of substrate adhesion-dependent cell spreading  (IEA,ISO)
positive regulation of T cell migration  (IEA,ISO)
positive regulation of type II interferon production  (IEA,ISO)
positive regulation of vasoconstriction  (IMP)
positive regulation of Wnt signaling pathway, planar cell polarity pathway  (IEA,ISO)
post-embryonic development  (IEA,ISO)
protein autophosphorylation  (IDA,ISO)
protein localization to cytoplasmic microtubule plus-end  (IEA,ISO)
protein phosphorylation  (ISO)
regulation of actin cytoskeleton organization  (IEA,ISO)
regulation of axon extension  (IEA,ISO)
regulation of Cdc42 protein signal transduction  (IEA,ISO)
regulation of cell cycle  (IEA,ISO)
regulation of cell population proliferation  (IEA,ISO)
regulation of cellular senescence  (IEA,ISO)
regulation of extracellular matrix organization  (IEA,ISO)
regulation of microtubule polymerization  (IEA,ISO)
regulation of modification of synaptic structure  (IEA,IGI,ISO)
regulation of postsynaptic specialization assembly  (EXP,IDA,IMP)
regulation of T cell differentiation  (IEA,ISO)
response to endoplasmic reticulum stress  (IDA)
response to epinephrine  (IEP)
response to oxidative stress  (IEA,ISO)
response to xenobiotic stimulus  (IEP)
signal transduction in response to DNA damage  (IEA,ISO)
signaling  (IEA)
spleen development  (IEA,ISO)
substrate adhesion-dependent cell spreading  (IEA,ISO)
T cell receptor signaling pathway  (IEA,ISO)
thymus development  (IEA,ISO)
transitional one stage B cell differentiation  (IEA,ISO)

Cellular Component
actin cytoskeleton  (IEA,ISO)
cell leading edge  (IEA,ISO)
cytoplasm  (IEA,ISO)
cytosol  (IEA,ISO)
dendrite  (IDA)
glutamatergic synapse  (EXP,IDA,IMP)
growth cone  (IDA)
neuronal cell body  (IDA)
nuclear body  (IEA,ISO)
nucleolus  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IDA,IEA,ISO)
perinuclear region of cytoplasm  (IEA,ISO)
plasma membrane  (IBA)
postsynaptic density  (EXP,IDA,IMP)
protein-containing complex  (IEA,ISO)
ruffle  (IDA)

References

References - curated
# Reference Title Reference Citation
1. Imatinib therapy blocks cerebellar apoptosis and improves neurological symptoms in a mouse model of Niemann-Pick type C disease. Alvarez AR, etal., FASEB J. 2008 Oct;22(10):3617-27. doi: 10.1096/fj.07-102715. Epub 2008 Jun 30.
2. Activation of the neuronal c-Abl tyrosine kinase by amyloid-beta-peptide and reactive oxygen species. Alvarez AR, etal., Neurobiol Dis. 2004 Nov;17(2):326-36.
3. Abl silencing inhibits CAS-mediated process and constriction in resistance arteries. Anfinogenova Y, etal., Circ Res. 2007 Aug 17;101(4):420-8. Epub 2007 Jul 5.
4. BCR/ABL p210, p190 and p230 fusion genes in 250 Mexican patients with chronic myeloid leukaemia (CML). Arana-Trejo RM, etal., Clin Lab Haematol. 2002 Jun;24(3):145-50.
5. Transcriptional regulation by p53. Beckerman R and Prives C, Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a000935. doi: 10.1101/cshperspect.a000935. Epub 2010 Apr 28.
6. Transferred BCR/ABL DNA from K562 extracellular vesicles causes chronic myeloid leukemia in immunodeficient mice. Cai J, etal., PLoS One. 2014 Aug 18;9(8):e105200. doi: 10.1371/journal.pone.0105200. eCollection 2014.
7. STI571 prevents apoptosis, tau phosphorylation and behavioural impairments induced by Alzheimer's beta-amyloid deposits. Cancino GI, etal., Brain. 2008 Sep;131(Pt 9):2425-42. doi: 10.1093/brain/awn125. Epub 2008 Jun 17.
8. c-Abl tyrosine kinase modulates tau pathology and Cdk5 phosphorylation in AD transgenic mice. Cancino GI, etal., Neurobiol Aging. 2011 Jul;32(7):1249-61. doi: 10.1016/j.neurobiolaging.2009.07.007. Epub 2009 Aug 22.
9. Conformational control inhibition of the BCR-ABL1 tyrosine kinase, including the gatekeeper T315I mutant, by the switch-control inhibitor DCC-2036. Chan WW, etal., Cancer Cell. 2011 Apr 12;19(4):556-68. doi: 10.1016/j.ccr.2011.03.003.
10. c-Abl mediates angiotensin II-induced apoptosis in podocytes. Chen X, etal., J Mol Histol. 2013 Oct;44(5):597-608. doi: 10.1007/s10735-013-9505-8. Epub 2013 Mar 21.
11. Proto-oncogene expression in proliferating and differentiating cardiac and skeletal muscle. Claycomb WC and Lanson NA, Biochem J. 1987 Nov 1;247(3):701-6. doi: 10.1042/bj2470701.
12. p73 participates in male germ cells apoptosis induced by etoposide. Codelia VA, etal., Mol Hum Reprod. 2010 Oct;16(10):734-42. doi: 10.1093/molehr/gaq045. Epub 2010 Jun 2.
13. Breakpoints on chromosomes 9 and 22 in Philadelphia chromosome-positive chronic myelogenous leukemia (CML). Amplification of rearranged c-abl oncogenes in CML blast crisis. Collins SJ J Clin Invest. 1986 Nov;78(5):1392-6.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. ABL1 in thalamus is associated with safety but not fear learning. Habib MR, etal., Front Syst Neurosci. 2013 Mar 26;7:5. doi: 10.3389/fnsys.2013.00005. eCollection 2013.
16. Reactive Oxygen Species Are Involved in the Development of Gastric Cancer and Gastric Cancer-Related Depression through ABL1-Mediated Inflammation Signaling Pathway. Huang T, etal., Oxid Med Cell Longev. 2019 Jul 15;2019:5813985. doi: 10.1155/2019/5813985. eCollection 2019.
17. Targeting of the c-Abl tyrosine kinase to mitochondria in endoplasmic reticulum stress-induced apoptosis. Ito Y, etal., Mol Cell Biol. 2001 Sep;21(18):6233-42.
18. Abl tyrosine kinase promotes dendrogenesis by inducing actin cytoskeletal rearrangements in cooperation with Rho family small GTPases in hippocampal neurons. Jones SB, etal., J Neurosci. 2004 Sep 29;24(39):8510-21.
19. Functional role for the c-Abl tyrosine kinase in meiosis I. Kharbanda S, etal., Oncogene. 1998 Apr 9;16(14):1773-7.
20. Oxidative stress activates the c-Abl/p73 proapoptotic pathway in Niemann-Pick type C neurons. Klein A, etal., Neurobiol Dis. 2011 Jan;41(1):209-18. doi: 10.1016/j.nbd.2010.09.008. Epub 2010 Sep 29.
21. Phosphorylation by the c-Abl protein tyrosine kinase inhibits parkin's ubiquitination and protective function. Ko HS, etal., Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16691-6. doi: 10.1073/pnas.1006083107. Epub 2010 Sep 7.
22. Clonal eosinophils are a morphologic hallmark of ETV6/ABL1 positive acute myeloid leukemia. La Starza R, etal., Haematologica. 2002 Aug;87(8):789-94.
23. Differential expression of protooncogenes related to transformation and cancer progression in rat myoblasts. Leibovitch SA, etal., Cancer Res. 1986 Aug;46(8):4097-103.
24. Mice deficient in Abl are osteoporotic and have defects in osteoblast maturation. Li B, etal., Nat Genet. 2000 Mar;24(3):304-8.
25. Array-comparative genomic hybridization to detect genomewide changes in microdissected primary and metastatic oral squamous cell carcinomas. Liu CJ, etal., Mol Carcinog. 2006 Oct;45(10):721-31. doi: 10.1002/mc.20213.
26. C1222C Deletion in Exon 8 of ABL1 Is Involved in Carcinogenesis and Cell Cycle Control of Colorectal Cancer Through IRS1/PI3K/Akt Pathway. Liu Y, etal., Front Oncol. 2020 Aug 11;10:1385. doi: 10.3389/fonc.2020.01385. eCollection 2020.
27. Brain armadillo protein delta-catenin interacts with Abl tyrosine kinase and modulates cellular morphogenesis in response to growth factors. Lu Q, etal., J Neurosci Res. 2002 Mar 1;67(5):618-24.
28. c-Abl phosphorylates alpha-synuclein and regulates its degradation: implication for alpha-synuclein clearance and contribution to the pathogenesis of Parkinson's disease. Mahul-Mellier AL, etal., Hum Mol Genet. 2014 Jun 1;23(11):2858-79. doi: 10.1093/hmg/ddt674. Epub 2014 Jan 9.
29. Does a rise in the BCR-ABL1 transcript level identify chronic phase CML patients responding to imatinib who have a high risk of cytogenetic relapse? Marin D, etal., Br J Haematol. 2009 May;145(3):373-5. doi: 10.1111/j.1365-2141.2009.07646.x. Epub 2009 Mar 12.
30. BCR-ABL1 kinase domain mutation analysis in an Irish cohort of chronic myeloid leukemia patients. McCarron SL, etal., Genet Test Mol Biomarkers. 2013 Feb;17(2):170-3. doi: 10.1089/gtmb.2012.0272. Epub 2013 Jan 5.
31. Two novel c-abl mRNAs are expressed in rat parotid salivary glands during in vivo beta-adrenergic receptor stimulation. Mertz PM, etal., Biochim Biophys Acta. 1990 Jul 30;1049(3):272-7.
32. Detection of hypermethylation of the c-abl genomic locus in the spleen of juvenile LE rats. Mihara K, etal., Biochem Biophys Res Commun 1988 Aug 15;154(3):1061-6.
33. Abl kinase interacts with and phosphorylates vinexin. Mitsushima M, etal., FEBS Lett. 2006 Jul 24;580(17):4288-95. Epub 2006 Jul 5.
34. Synaptic clustering of PSD-95 is regulated by c-Abl through tyrosine phosphorylation. Perez de Arce K, etal., J Neurosci. 2010 Mar 10;30(10):3728-38. doi: 10.1523/JNEUROSCI.2024-09.2010.
35. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
36. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
37. GOA pipeline RGD automated data pipeline
38. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
39. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
40. Outcomes of children with BCR-ABL1-like acute lymphoblastic leukemia treated with risk-directed therapy based on the levels of minimal residual disease. Roberts KG, etal., J Clin Oncol. 2014 Sep 20;32(27):3012-20.
41. ABL1 promoter methylation can exist independently of BCR-ABL transcription in chronic myeloid leukemia hematopoietic progenitors. Sun B, etal., Cancer Res. 2001 Sep 15;61(18):6931-7.
42. Secondary activation of c-abl may be related to translocation to the nucleolar organizer region in an in vitro cultured rat leukemia cell line (K3D). Takahashi R, etal., Proc Natl Acad Sci U S A 1986 Feb;83(4):1079-83.
43. Somatically mutated ABL1 is an actionable and essential NSCLC survival gene. Testoni E, etal., EMBO Mol Med. 2016 Feb 1;8(2):105-16. doi: 10.15252/emmm.201505456.
44. cAbl tyrosine kinase mediates reactive oxygen species- and caveolin-dependent AT1 receptor signaling in vascular smooth muscle: role in vascular hypertrophy. Ushio-Fukai M, etal., Circ Res. 2005 Oct 14;97(8):829-36. Epub 2005 Sep 8.
45. EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-ß oligomers. Vargas LM, etal., PLoS One. 2014 Mar 21;9(3):e92309. doi: 10.1371/journal.pone.0092309. eCollection 2014.
46. ABL1, Overexpressed in Hepatocellular Carcinomas, Regulates Expression of NOTCH1 and Promotes Development of Liver Tumors in Mice. Wang F, etal., Gastroenterology. 2020 Jul;159(1):289-305.e16. doi: 10.1053/j.gastro.2020.03.013. Epub 2020 Jun 24.
47. Noncanonical TGF-beta pathways, mTORC1 and Abl, in renal interstitial fibrogenesis. Wang S, etal., Am J Physiol Renal Physiol. 2010 Jan;298(1):F142-9. doi: 10.1152/ajprenal.00320.2009. Epub 2009 Oct 21.
48. Imatinib mesylate blocks a non-Smad TGF-beta pathway and reduces renal fibrogenesis in vivo. Wang S, etal., FASEB J. 2005 Jan;19(1):1-11.
49. Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma. Wu IC, etal., Neoplasia. 2011 Apr;13(4):386-92. doi: 10.1593/neo.101722.
50. The c-Abl-MST1 signaling pathway mediates oxidative stress-induced neuronal cell death. Xiao L, etal., J Neurosci. 2011 Jun 29;31(26):9611-9. doi: 10.1523/JNEUROSCI.0035-11.2011.
51. Association of the Abl tyrosine kinase with the Trk nerve growth factor receptor. Yano H, etal., J Neurosci Res. 2000 Feb 1;59(3):356-64.
Additional References at PubMed
PMID:2065352   PMID:7565706   PMID:7590236   PMID:7671324   PMID:8438166   PMID:8612582   PMID:8663064   PMID:8806812   PMID:9037071   PMID:9109492   PMID:9144171   PMID:9168116  
PMID:9461559   PMID:9558345   PMID:9636171   PMID:9883720   PMID:10518561   PMID:10713049   PMID:10805805   PMID:10825157   PMID:10970852   PMID:11120811   PMID:11121037   PMID:11279004  
PMID:11390389   PMID:11809706   PMID:11864995   PMID:11971963   PMID:12167702   PMID:12379650   PMID:12384576   PMID:12672821   PMID:12893824   PMID:12944467   PMID:15657060   PMID:15657136  
PMID:17515907   PMID:17626041   PMID:17888034   PMID:18025176   PMID:18280240   PMID:18305217   PMID:18827006   PMID:19228876   PMID:19805123   PMID:20417104   PMID:20585028   PMID:20610769  
PMID:20624904   PMID:20837657   PMID:20980600   PMID:21690296   PMID:22301057   PMID:22665498   PMID:22729085   PMID:23006999   PMID:23100514   PMID:23840065   PMID:24367707   PMID:24520051  
PMID:24700464   PMID:24863063   PMID:26051942   PMID:27226592   PMID:28288113   PMID:28428613   PMID:32399753   PMID:32498644   PMID:33786723  


Genomics

Comparative Map Data
Abl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8335,377,587 - 35,480,843 (+)NCBIGRCr8
mRatBN7.2314,979,853 - 15,083,065 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl314,979,853 - 15,083,065 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx318,053,160 - 18,156,546 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0326,638,164 - 26,741,549 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0324,885,255 - 24,988,906 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0310,041,820 - 10,145,076 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl310,041,826 - 10,144,388 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl39,410,661 - 9,448,167 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0315,401,182 - 15,504,438 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4310,804,594 - 10,907,162NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera39,728,420 - 9,830,777 (+)NCBICelera
Cytogenetic Map3p12NCBI
ABL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389130,713,043 - 130,887,675 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9130,713,043 - 130,887,675 (+)EnsemblGRCh38hg38GRCh38
GRCh379133,588,430 - 133,763,062 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369132,579,089 - 132,752,883 (+)NCBINCBI36Build 36hg18NCBI36
Build 349130,619,260 - 130,792,614NCBI
Celera9104,127,800 - 104,301,349 (+)NCBICelera
Cytogenetic Map9q34.12NCBI
HuRef9103,075,969 - 103,249,725 (+)NCBIHuRef
CHM1_19133,738,310 - 133,911,675 (+)NCBICHM1_1
T2T-CHM13v2.09142,917,999 - 143,092,548 (+)NCBIT2T-CHM13v2.0
Abl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39231,578,256 - 31,697,105 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl231,578,388 - 31,694,239 (+)EnsemblGRCm39 Ensembl
GRCm38231,688,244 - 31,807,093 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl231,688,376 - 31,804,227 (+)EnsemblGRCm38mm10GRCm38
MGSCv37231,544,076 - 31,659,747 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36231,581,991 - 31,626,236 (+)NCBIMGSCv36mm8
Celera231,389,208 - 31,506,940 (+)NCBICelera
Cytogenetic Map2BNCBI
cM Map221.86NCBI
Abl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955513653,252 - 799,239 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955513652,048 - 799,182 (+)NCBIChiLan1.0ChiLan1.0
ABL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2118,467,889 - 8,639,598 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan198,470,232 - 8,640,648 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09101,834,189 - 102,005,811 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19130,482,852 - 130,652,941 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9130,484,333 - 130,652,941 (+)Ensemblpanpan1.1panPan2
ABL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1953,118,462 - 53,262,092 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl953,119,641 - 53,261,307 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha952,318,603 - 52,461,396 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0954,019,016 - 54,162,127 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl954,019,025 - 54,161,522 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1952,796,621 - 52,939,392 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0953,117,155 - 53,260,443 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0953,210,098 - 53,353,656 (-)NCBIUU_Cfam_GSD_1.0
Abl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947197,921,710 - 198,051,040 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648717,690,968 - 17,819,669 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648717,690,206 - 17,819,619 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1270,761,668 - 270,906,708 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11270,761,641 - 270,906,708 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21304,684,385 - 304,829,654 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ABL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1127,258,932 - 7,435,658 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl127,256,648 - 7,312,734 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660798,028,989 - 8,209,295 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247604,878,556 - 5,031,491 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247604,878,811 - 5,032,719 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Abl1
436 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:193
Count of miRNA genes:142
Interacting mature miRNAs:154
Transcripts:ENSRNOT00000042495
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
6893355Bw101Body weight QTL 1010.40.38body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
8693641Alc30Alcohol consumption QTL 3020.739drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)31043430624512004Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
1558657Cm43Cardiac mass QTL 436.63e-08heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
6893363Bw105Body weight QTL 1052.60.0036body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
1558647Cm46Cardiac mass QTL 465.40.0000055heart mass (VT:0007028)heart wet weight (CMO:0000069)31077882330356773Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
1558654Bw56Body weight QTL 564.50.0000171body mass (VT:0001259)body weight (CMO:0000012)31077870430357018Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)31077882330356773Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat

Markers in Region
D3Rat58  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8335,403,199 - 35,403,344 (+)Marker Load Pipeline
mRatBN7.2315,005,422 - 15,005,567 (-)MAPPERmRatBN7.2
Rnor_6.0310,119,318 - 10,119,462NCBIRnor6.0
Rnor_5.0315,478,680 - 15,478,824UniSTSRnor5.0
RGSC_v3.4310,829,503 - 10,829,729RGDRGSC3.4
RGSC_v3.4310,829,519 - 10,829,663UniSTSRGSC3.4
RGSC_v3.1310,725,672 - 10,725,816RGD
Celera39,753,732 - 9,753,876UniSTS
RH 3.4 Map353.9RGD
RH 3.4 Map353.9UniSTS
RH 2.0 Map30.0RGD
SHRSP x BN Map33.4899RGD
FHH x ACI Map36.9RGD
Cytogenetic Map3p12UniSTS
AU028664  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8335,409,308 - 35,409,496 (+)Marker Load Pipeline
mRatBN7.2315,011,531 - 15,011,721 (-)MAPPERmRatBN7.2
Rnor_6.0310,113,166 - 10,113,353NCBIRnor6.0
Rnor_5.0315,472,528 - 15,472,715UniSTSRnor5.0
RGSC_v3.4310,835,628 - 10,835,815UniSTSRGSC3.4
Celera39,759,841 - 9,760,031UniSTS
Cytogenetic Map3p12UniSTS
RH128159  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2315,082,670 - 15,082,851 (-)MAPPERmRatBN7.2
Rnor_6.0310,042,034 - 10,042,214NCBIRnor6.0
Rnor_6.039,409,407 - 9,409,587NCBIRnor6.0
Rnor_5.0315,401,396 - 15,401,576UniSTSRnor5.0
Rnor_5.0314,769,202 - 14,769,382UniSTSRnor5.0
RGSC_v3.4310,906,768 - 10,906,948UniSTSRGSC3.4
Celera39,830,388 - 9,830,568UniSTS
RH 3.4 Map359.0UniSTS
Cytogenetic Map3p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 11 43 82 57 60 41 19 41 160 73 74 35 41 19

Sequence


Ensembl Acc Id: ENSRNOT00000012617   ⟹   ENSRNOP00000012617
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl39,410,661 - 9,448,167 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000042495   ⟹   ENSRNOP00000044534
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl314,979,853 - 15,083,065 (+)Ensembl
Rnor_6.0 Ensembl310,041,826 - 10,144,388 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000043661   ⟹   ENSRNOP00000042940
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl39,410,661 - 9,447,813 (-)Ensembl
RefSeq Acc Id: NM_001100850   ⟹   NP_001094320
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8335,377,587 - 35,480,843 (+)NCBI
mRatBN7.2314,979,853 - 15,083,065 (+)NCBI
Rnor_6.0310,041,820 - 10,145,076 (-)NCBI
Rnor_5.0315,401,182 - 15,504,438 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006233918   ⟹   XP_006233980
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8335,441,764 - 35,480,837 (+)NCBI
mRatBN7.2315,043,987 - 15,083,060 (+)NCBI
Rnor_6.0310,041,826 - 10,080,881 (-)NCBI
Rnor_5.0315,401,182 - 15,504,438 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001094320 (Get FASTA)   NCBI Sequence Viewer  
  XP_006233980 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABC46642 (Get FASTA)   NCBI Sequence Viewer  
  ABC46643 (Get FASTA)   NCBI Sequence Viewer  
  EDL93267 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000044534
  ENSRNOP00000044534.3
  ENSRNOP00000102019
RefSeq Acc Id: NP_001094320   ⟸   NM_001100850
- UniProtKB: E9PT20 (UniProtKB/TrEMBL),   Q2PYT4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233980   ⟸   XM_006233918
- Peptide Label: isoform X1
- UniProtKB: Q2PYT4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000044534   ⟸   ENSRNOT00000042495
Ensembl Acc Id: ENSRNOP00000012617   ⟸   ENSRNOT00000012617
Ensembl Acc Id: ENSRNOP00000042940   ⟸   ENSRNOT00000043661
Protein Domains
Protein kinase   SH2   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-E9PT20-F1-model_v2 AlphaFold E9PT20 1-1143 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1584969 AgrOrtholog
BioCyc Gene G2FUF-50172 BioCyc
Ensembl Genes ENSRNOG00000009371 Ensembl
  ENSRNOG00000047356 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000042495 ENTREZGENE
  ENSRNOT00000042495.6 UniProtKB/TrEMBL
  ENSRNOT00000173177 ENTREZGENE
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
  Nucleotidyltransferases domain 2 UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro ABL_SH2 UniProtKB/TrEMBL
  F-actin_binding UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Non-receptor_tyrosine_kinases UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr-Pkinase UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  Tyr_Pkinase_cat_dom UniProtKB/TrEMBL
  Tyr_prot_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:311860 UniProtKB/TrEMBL
NCBI Gene 311860 ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE UniProtKB/TrEMBL
Pfam F_actin_bind UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PharmGKB ABL1 RGD
PhenoGen Abl1 PhenoGen
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009371 RatGTEx
  ENSRNOG00000047356 RatGTEx
SMART FABD UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A6JU30_RAT UniProtKB/TrEMBL
  E9PT20 ENTREZGENE, UniProtKB/TrEMBL
  Q2PYT4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Abl1  ABL proto-oncogene 1, non-receptor tyrosine kinase  LOC100909750  tyrosine-protein kinase ABL1-like  Data merged from RGD:6502032 737654 PROVISIONAL
2014-07-09 Abl1  ABL proto-oncogene 1, non-receptor tyrosine kinase  Abl1  c-abl oncogene 1, non-receptor tyrosine kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100909750  tyrosine-protein kinase ABL1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2011-07-28 Abl1  c-abl oncogene 1, non-receptor tyrosine kinase  Abl1  c-abl oncogene 1, receptor tyrosine kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-09-17 Abl1  c-abl oncogene 1, receptor tyrosine kinase  Abl1  c-abl oncogene 1, non-receptor tyrosine kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-08-23 Abl1  c-abl oncogene 1, non-receptor tyrosine kinase  Abl1  c-abl oncogene 1, receptor tyrosine kinase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-10 Abl1  c-abl oncogene 1, receptor tyrosine kinase  Abl1  v-abl Abelson murine leukemia viral oncogene 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-26 Abl1  v-abl Abelson murine leukemia viral oncogene 1  Abl1  v-abl Abelson murine leukemia viral oncogene homolog 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-05 Abl1  v-abl Abelson murine leukemia viral oncogene homolog 1  Abl1  v-abl Abelson murine leukemia viral oncogene homolog 1 (mapped)  Name updated 737654 APPROVED
2007-04-05 Abl1  v-abl Abelson murine leukemia viral oncogene homolog 1 (mapped)  Abl1_mapped  v-abl Abelson murine leukemia viral oncogene homolog 1 (mapped)  Data merged from RGD:2008 737654 APPROVED
2005-11-17 Abl1_mapped  v-abl Abelson murine leukemia viral oncogene homolog 1 (mapped)  Abl1  Abelson murine leukemia viral (v-abl) oncogene homolog 1  Symbol and Name updated 1556543 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease may be associated with chronic myeloid leukemia 1298612
gene_expression mRNA levels elevated during the preleukemic stage in the spleen of juvenile LE rats 1298613