Ip6k3 (inositol hexakisphosphate kinase 3) - Rat Genome Database

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Gene: Ip6k3 (inositol hexakisphosphate kinase 3) Rattus norvegicus
Analyze
Symbol: Ip6k3
Name: inositol hexakisphosphate kinase 3
RGD ID: 1584104
Description: Predicted to enable inositol hexakisphosphate 6-kinase activity. Predicted to be involved in phosphatidylinositol metabolic process and protein phosphorylation. Predicted to act upstream of or within inositol phosphate biosynthetic process and locomotion. Predicted to be located in cytoplasm and nucleus. Orthologous to human IP6K3 (inositol hexakisphosphate kinase 3); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; cadmium dichloride.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Ihpk3; inositol hexaphosphate kinase 3; LOC688862; similar to inositol hexaphosphate kinase 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2205,223,863 - 5,245,443 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl205,224,120 - 5,245,428 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0205,733,485 - 5,754,859 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,733,482 - 5,754,773 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,797,347 - 7,818,363 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4205,379,966 - 5,425,313 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera206,803,479 - 6,816,940 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
cytoplasm  (ISO)
cytoplasm  (ISO)
nucleus  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11502751  


Genomics

Comparative Map Data
Ip6k3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2205,223,863 - 5,245,443 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl205,224,120 - 5,245,428 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0205,733,485 - 5,754,859 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,733,482 - 5,754,773 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,797,347 - 7,818,363 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4205,379,966 - 5,425,313 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera206,803,479 - 6,816,940 (-)NCBICelera
Cytogenetic Map20p12NCBI
IP6K3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38633,721,662 - 33,762,145 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl633,721,662 - 33,746,905 (-)EnsemblGRCh38hg38GRCh38
GRCh37633,689,439 - 33,714,682 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36633,797,421 - 33,822,660 (-)NCBINCBI36Build 36hg18NCBI36
Build 34633,797,424 - 33,822,660NCBI
Celera635,243,832 - 35,269,147 (-)NCBICelera
Cytogenetic Map6p21.31NCBI
HuRef633,430,917 - 33,456,232 (-)NCBIHuRef
CHM1_1633,691,716 - 33,717,039 (-)NCBICHM1_1
T2T-CHM13v2.0633,542,845 - 33,568,085 (-)NCBIT2T-CHM13v2.0
Ip6k3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391727,362,945 - 27,386,738 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1727,362,939 - 27,386,769 (-)EnsemblGRCm39 Ensembl
GRCm381727,143,971 - 27,167,764 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1727,143,965 - 27,167,795 (-)EnsemblGRCm38mm10GRCm38
MGSCv371727,280,916 - 27,304,709 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361726,871,560 - 26,895,353 (-)NCBIMGSCv36mm8
Celera1727,680,127 - 27,703,420 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
Ip6k3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554372,125,222 - 2,149,242 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554372,128,337 - 2,150,714 (-)NCBIChiLan1.0ChiLan1.0
IP6K3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1634,403,261 - 34,428,398 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl634,403,261 - 34,428,386 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0633,294,835 - 33,320,117 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
IP6K3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1123,072,052 - 3,095,659 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl123,072,975 - 3,086,057 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha123,087,670 - 3,111,516 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0123,403,737 - 3,427,603 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl123,404,946 - 3,418,032 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1123,070,435 - 3,094,284 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0123,152,016 - 3,176,318 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0123,249,802 - 3,273,649 (-)NCBIUU_Cfam_GSD_1.0
Ip6k3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494638,729,155 - 38,757,387 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647625,208,284 - 25,231,281 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493647625,208,332 - 25,231,236 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IP6K3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl729,931,925 - 29,961,466 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1729,938,779 - 29,961,520 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2734,546,566 - 34,560,420 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IP6K3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11738,331,107 - 38,356,590 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1738,332,601 - 38,356,828 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604433,616,370 - 33,640,570 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ip6k3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475423,195,787 - 23,207,754 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475423,191,793 - 23,212,581 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ip6k3
155 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:32
Count of miRNA genes:32
Interacting mature miRNAs:32
Transcripts:ENSRNOT00000035977
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
61474Eae1Experimental allergic encephalomyelitis QTL 13nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)2046066076691706Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat

Markers in Region
BF386248  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2205,273,781 - 5,273,984 (+)MAPPERmRatBN7.2
Rnor_6.0206,536,564 - 6,536,766NCBIRnor6.0
Rnor_6.0205,770,933 - 5,771,135NCBIRnor6.0
Rnor_5.0208,781,137 - 8,781,339UniSTSRnor5.0
RGSC_v3.4205,417,080 - 5,417,282UniSTSRGSC3.4
RH 3.4 Map2055.53UniSTS
Cytogenetic Map20p12UniSTS
AW534106  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2205,227,340 - 5,227,516 (+)MAPPERmRatBN7.2
Rnor_6.0205,736,703 - 5,736,878NCBIRnor6.0
Rnor_5.0207,800,406 - 7,800,581UniSTSRnor5.0
RGSC_v3.4205,382,528 - 5,382,703UniSTSRGSC3.4
Celera206,806,698 - 6,806,873UniSTS
RH 3.4 Map2054.53UniSTS
Cytogenetic Map20p12UniSTS
BI296025  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2205,232,072 - 5,232,232 (+)MAPPERmRatBN7.2
Rnor_6.0205,741,434 - 5,741,593NCBIRnor6.0
Rnor_5.0207,805,012 - 7,805,171UniSTSRnor5.0
RGSC_v3.4205,387,004 - 5,387,163UniSTSRGSC3.4
Celera206,811,539 - 6,811,698UniSTS
RH 3.4 Map2055.73UniSTS
Cytogenetic Map20p12UniSTS
RH139300  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2205,282,578 - 5,282,738 (+)MAPPERmRatBN7.2
Rnor_6.0206,545,107 - 6,545,266NCBIRnor6.0
Rnor_6.0205,779,766 - 5,779,925NCBIRnor6.0
Rnor_5.0208,789,680 - 8,789,839UniSTSRnor5.0
RGSC_v3.4205,425,713 - 5,425,872UniSTSRGSC3.4
Celera206,846,408 - 6,846,567UniSTS
RH 3.4 Map2057.14UniSTS
Cytogenetic Map20p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 7 4
Low 41 3 2 2 4 4 4 2 16 5 4
Below cutoff 1 2 21 8 16 8 46 32 23 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000035977   ⟹   ENSRNOP00000033439
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl205,224,120 - 5,245,428 (-)Ensembl
Rnor_6.0 Ensembl205,733,482 - 5,754,773 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092586   ⟹   ENSRNOP00000075784
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl205,734,352 - 5,745,964 (-)Ensembl
RefSeq Acc Id: XM_008772778   ⟹   XP_008771000
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2205,223,863 - 5,245,439 (-)NCBI
Rnor_6.0205,733,485 - 5,754,859 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005497460
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2205,227,727 - 5,245,443 (-)NCBI
Protein Sequences
Protein RefSeqs XP_008771000 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_008771000   ⟸   XM_008772778
- UniProtKB: D4AEE6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075784   ⟸   ENSRNOT00000092586
RefSeq Acc Id: ENSRNOP00000033439   ⟸   ENSRNOT00000035977

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AEE6-F1-model_v2 AlphaFold D4AEE6 1-401 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701431
Promoter ID:EPDNEW_R11951
Type:single initiation site
Name:Ip6k3_1
Description:inositol hexakisphosphate kinase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0205,754,785 - 5,754,845EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1584104 AgrOrtholog
BioCyc Gene G2FUF-4491 BioCyc
BioCyc Pathway PWY-6369 [inositol diphosphates biosynthesis] BioCyc
Ensembl Genes ENSRNOG00000025883 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000033439 ENTREZGENE
  ENSRNOP00000033439.5 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000035977 ENTREZGENE
  ENSRNOT00000035977.6 UniProtKB/TrEMBL
Gene3D-CATH 3.30.470.160 UniProtKB/TrEMBL
InterPro IPK UniProtKB/TrEMBL
  IPK_sf UniProtKB/TrEMBL
KEGG Report rno:688862 UniProtKB/TrEMBL
NCBI Gene 688862 ENTREZGENE
PANTHER INOSITOL HEXAKISPHOSPHATE KINASE 3 UniProtKB/TrEMBL
  PTHR12400 UniProtKB/TrEMBL
Pfam IPK UniProtKB/TrEMBL
PhenoGen Ip6k3 PhenoGen
Superfamily-SCOP SAICAR synthase-like UniProtKB/TrEMBL
UniProt D4AEE6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-02-26 Ip6k3  inositol hexakisphosphate kinase 3  Ihpk3  inositol hexaphosphate kinase 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Ihpk3  inositol hexaphosphate kinase 3  LOC688862  similar to inositol hexaphosphate kinase 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-19 LOC688862  similar to inositol hexaphosphate kinase 3      Symbol and Name status set to provisional 70820 PROVISIONAL