Prl5a2 (prolactin family 5, subfamily A, member 2) - Rat Genome Database

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Gene: Prl5a2 (prolactin family 5, subfamily A, member 2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Prl5a2
Name: prolactin family 5, subfamily A, member 2
RGD ID: 1583904
Description: Predicted to enable hormone activity and prolactin receptor binding activity. Predicted to be involved in several processes, including female pregnancy; positive regulation of lactation; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be active in extracellular space; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,7-dihydropurine-6-thione; atrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ghd2; growth hormone d2; Prlpp; prolactin-like protein P; similar to prolactin-like protein L
RGD Orthologs
Alliance Genes
More Info homologs ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21736,452,712 - 36,459,054 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1736,452,718 - 36,459,054 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1736,298,782 - 36,381,618 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01737,902,782 - 37,985,622 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01736,264,443 - 36,270,785 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01738,456,016 - 38,462,358 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1738,456,073 - 38,462,352 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01740,318,162 - 40,324,504 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41742,984,933 - 42,991,275 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1735,960,205 - 35,966,546 (-)NCBICelera
Cytogenetic Map17p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16897344   PMID:26697363   PMID:26862561  


Genomics

Variants

.
Variants in Prl5a2
175 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:91
Count of miRNA genes:79
Interacting mature miRNAs:82
Transcripts:ENSRNOT00000059757
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
2303561Bw91Body weight QTL 912body mass (VT:0001259)body weight (CMO:0000012)17886846253868462Rat
2300002Iddm36Insulin dependent diabetes mellitus QTL 361.98blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)17999128640540197Rat
1331765Hrtrt15Heart rate QTL 154.094heart pumping trait (VT:2000009)heart rate (CMO:0000002)171533061355836425Rat
1354640Scl32Serum cholesterol level QTL 325.4blood HDL cholesterol amount (VT:0000184)blood high density lipoprotein cholesterol level (CMO:0000052)171578159260781592Rat
1354659Scl68Serum cholesterol level QTL 683.9blood VLDL cholesterol amount (VT:0005144)blood very low density lipoprotein cholesterol level (CMO:0000648)171578159260781592Rat
7394837Memor18Memory QTL 18exploratory behavior trait (VT:0010471)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)171864018263640182Rat
1354628Stl13Serum triglyceride level QTL 133.8blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)172129303960781592Rat
70157Niddm32Non-insulin dependent diabetes mellitus QTL 324.34blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)172245492450909196Rat
61394Bp8Blood pressure QTL 82.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172308056759555013Rat
7488966Bp370Blood pressure QTL 3700.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318457246843Rat
12903978Cm118Cardiac mass QTL 1180.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)172365318468653184Rat
12903979Cm119Cardiac mass QTL 1190.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172365318468653184Rat
12903980Cm120Cardiac mass QTL 1200.002heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)172365318468653184Rat
12903981Am17Aortic mass QTL 170.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)172365318468653184Rat
1559055Bp278Blood pressure QTL 2780.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)172365318468653184Rat
12903982Kidm70Kidney mass QTL 700.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)172365318470974005Rat
1354619Bp242Blood pressure QTL 2426.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)172459934069599340Rat
1581512Cm55Cardiac mass QTL 552.80.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)172702794956836890Rat
4889955Bss93Bone structure and strength QTL 934.4tibia size trait (VT:0100001)tibia cortical bone volume to tibia total bone volume ratio (CMO:0001727)172702794960463643Rat
2302377Scl61Serum cholesterol level QTL 614.36blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)172738994653481766Rat
8552928Pigfal9Plasma insulin-like growth factor 1 level QTL 99blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)172840914773409147Rat
9590107Sffal7Serum free fatty acids level QTL 74.810.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)172840914773409147Rat
10450503Bp386Blood pressure QTL 3860.28arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)173136839162109574Rat
2324621Coatc5Coat color QTL 5coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)173136839173951021Rat
2313854Bp343Blood pressure QTL 3433.9life span trait (VT:0005372)age at time of death (CMO:0001193)173199078450909196Rat
724549Niddm56Non-insulin dependent diabetes mellitus QTL 560.03blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)173199078476990784Rat
1354663Bvd5Brain ventricular dilatation QTL 53.510.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)173199078481292925Rat
1300148Bp192Blood pressure QTL 1923.47arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)173455084373951021Rat
724528Uae4Urinary albumin excretion QTL 44.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)173583708569599340Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system appendage
High
Medium
Low 2
Below cutoff 9 3 6 3 1 1 2 7 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000059757   ⟹   ENSRNOP00000056509
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1736,452,718 - 36,459,054 (-)Ensembl
Rnor_6.0 Ensembl1738,457,783 - 38,462,352 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000088228   ⟹   ENSRNOP00000074214
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1738,456,073 - 38,462,195 (+)Ensembl
RefSeq Acc Id: NM_001044702   ⟹   NP_001038167
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21736,452,712 - 36,459,054 (-)NCBI
Rnor_6.01738,456,016 - 38,462,358 (+)NCBI
Rnor_5.01740,318,162 - 40,324,504 (+)NCBI
RGSC_v3.41742,984,933 - 42,991,275 (-)RGD
Celera1735,960,205 - 35,966,546 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001038167 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABC59295 (Get FASTA)   NCBI Sequence Viewer  
  CDW51442 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_001038167   ⟸   NM_001044702
- Peptide Label: precursor
- UniProtKB: Q1KZI1 (UniProtKB/TrEMBL),   F7F7K9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000056509   ⟸   ENSRNOT00000059757
RefSeq Acc Id: ENSRNOP00000074214   ⟸   ENSRNOT00000088228

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q1KZI1-F1-model_v2 AlphaFold Q1KZI1 1-232 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1583904 AgrOrtholog
BioCyc Gene G2FUF-9479 BioCyc
Ensembl Genes ENSRNOG00000039075 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000056509 ENTREZGENE
  ENSRNOP00000056509.4 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000059757 ENTREZGENE
  ENSRNOT00000059757.4 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/TrEMBL
  Somatotropin UniProtKB/TrEMBL
KEGG Report rno:691469 UniProtKB/TrEMBL
NCBI Gene 691469 ENTREZGENE
PANTHER PROLACTIN-5A1 UniProtKB/TrEMBL
  Somatotropin UniProtKB/TrEMBL
Pfam Hormone_1 UniProtKB/TrEMBL
PhenoGen Prl5a2 PhenoGen
Superfamily-SCOP 4_helix_cytokine UniProtKB/TrEMBL
UniProt F7F7K9 ENTREZGENE
  Q1KZI1 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F7F7K9 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-04-07 Prl5a2  prolactin family 5, subfamily A, member 2  Prl5a2  prolactin family 5, subfamily a, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-05-24 Prl5a2  prolactin family 5, subfamily a, member 2  LOC684042  similar to prolactin-like protein L  Data Merged 1643240 APPROVED
2007-05-04 Prl5a2  prolactin family 5, subfamily a, member 2  Prlpp  prolactin-like protein P  Symbol and Name updated 1624237 APPROVED
2006-11-20 LOC684042  similar to prolactin-like protein L      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 Prlpp  prolactin-like protein P      Symbol and Name status set to provisional 70820 PROVISIONAL