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Gene: Trip6 (thyroid hormone receptor interactor 6) Rattus norvegicus

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Symbol:

Trip6

Name:

thyroid hormone receptor interactor 6

RGD ID:

1583180

Description:

Predicted to enable interleukin-1 receptor binding activity and kinase binding activity. Predicted to be involved in several processes, including chordate embryonic development; positive regulation of cell migration; and positive regulation of non-canonical NF-kappaB signal transduction. Predicted to be located in cytoskeleton and nucleus. Predicted to be active in cytoplasm; focal adhesion; and stress fiber. Orthologous to human TRIP6 (thyroid hormone receptor interactor 6); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; Cuprizon.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

hypothetical protein LOC686323; LOC686323; similar to thyroid receptor-interacting protein 6; thyroid receptor-interacting protein 6; uncharacterized protein LOC686323

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	25,022,959 - 25,027,366 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	25,022,909 - 25,027,363 (+)	Ensembl				GRCr8
mRatBN7.2	12	19,386,212 - 19,390,619 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	19,386,014 - 19,390,618 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	20,541,275 - 20,545,688 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	21,153,979 - 21,158,391 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	20,218,536 - 20,222,949 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	22,451,596 - 22,456,003 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	22,451,596 - 22,456,003 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	24,466,257 - 24,470,664 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Celera	12	21,188,206 - 21,192,613 (+)	NCBI		Celera
Cytogenetic Map	12	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dimethoxyphenol (ISO)

2-bromohexadecanoic acid (ISO)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

Butylbenzyl phthalate (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

chloropicrin (ISO)

chlorpyrifos (ISO)

chromium(6+) (ISO)

clofibrate (ISO)

cobalt dichloride (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

dibutyl phthalate (ISO)

diethylstilbestrol (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

enzyme inhibitor (ISO)

ethyl methanesulfonate (ISO)

fenthion (ISO)

flutamide (EXP)

formaldehyde (ISO)

FR900359 (ISO)

furfural (ISO)

gentamycin (EXP)

glyphosate (EXP)

hydralazine (ISO)

ivermectin (ISO)

methidathion (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

N-methyl-N-nitrosourea (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

pentachlorophenol (ISO)

phenylmercury acetate (ISO)

SB 431542 (ISO)

selenium atom (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium chloride (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

thiram (ISO)

topotecan (EXP)

triphenyl phosphate (ISO)

triptonide (ISO)

troglitazone (ISO)

valproic acid (ISO)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell adhesion (IEA)

chordate embryonic development (IEA,ISO)

positive regulation of cell migration (IEA,ISO)

positive regulation of non-canonical NF-kappaB signal transduction (IBA,IEA,ISO)

signal transduction (IBA)

Cellular Component

anchoring junction (IEA)

cytoplasm (IBA,IEA)

cytoskeleton (IEA,ISO)

cytosol (IEA,ISO)

focal adhesion (IBA,IEA,ISO)

nucleus (IEA,ISO)

plasma membrane (IEA,ISO)

stress fiber (IBA)

Molecular Function

interleukin-1 receptor binding (IEA,ISO)

kinase binding (IEA,ISO)

metal ion binding (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10826496	PMID:12477932	PMID:14688263	PMID:15657077	PMID:16624523	PMID:21423176	PMID:22658674	PMID:31730275

Genomics

Comparative Map Data

Trip6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	25,022,959 - 25,027,366 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	25,022,909 - 25,027,363 (+)	Ensembl				GRCr8
mRatBN7.2	12	19,386,212 - 19,390,619 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	19,386,014 - 19,390,618 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	20,541,275 - 20,545,688 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	21,153,979 - 21,158,391 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	20,218,536 - 20,222,949 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	22,451,596 - 22,456,003 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	22,451,596 - 22,456,003 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	24,466,257 - 24,470,664 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
Celera	12	21,188,206 - 21,192,613 (+)	NCBI		Celera
Cytogenetic Map	12	q12	NCBI

TRIP6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	100,867,387 - 100,873,454 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	100,867,126 - 100,873,524 (+)	Ensembl			hg38	GRCh38
GRCh37	7	100,465,009 - 100,471,076 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	100,302,886 - 100,309,012 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	7	100,109,695 - 100,115,726	NCBI
Celera	7	95,195,527 - 95,201,655 (+)	NCBI		Celera
Cytogenetic Map	7	q22.1	NCBI
HuRef	7	95,095,162 - 95,101,455 (+)	NCBI		HuRef
CHM1_1	7	100,395,560 - 100,401,686 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	102,107,487 - 102,113,558 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	99,824,555 - 99,830,681 (+)	NCBI

Trip6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	137,308,160 - 137,312,469 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	137,307,916 - 137,312,666 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	137,309,898 - 137,314,480 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	137,309,654 - 137,314,404 (-)	Ensembl			mm10	GRCm38
MGSCv37	5	137,751,127 - 137,755,469 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	137,539,687 - 137,544,029 (-)	NCBI		MGSCv36	mm8
Celera	5	134,292,906 - 134,297,238 (-)	NCBI		Celera
Cytogenetic Map	5	G2	NCBI
cM Map	5	76.34	NCBI

Trip6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955573	102,639 - 107,047 (-)	Ensembl
ChiLan1.0	NW_004955573	102,649 - 107,047 (-)	NCBI	ChiLan1.0	ChiLan1.0

TRIP6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	8,894,390 - 8,898,397 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	8,894,390 - 8,898,173 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	10,600,459 - 10,604,466 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	8,830,218 - 8,834,229 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	6	8,830,220 - 8,834,260 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	6	8,682,766 - 8,686,770 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	8,660,837 - 8,664,852 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	8,842,588 - 8,846,600 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Trip6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	133,194,817 - 133,198,245 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936543	838,209 - 841,913 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936543	838,266 - 841,705 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TRIP6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	8,713,215 - 8,716,871 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	3	8,713,221 - 8,716,891 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	8,139,936 - 8,143,799 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TRIP6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	28	12,352,310 - 12,358,530 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	28	12,352,448 - 12,358,131 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666070	3,970,555 - 3,976,753 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Trip6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624740	16,292,912 - 16,296,982 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624740	16,292,909 - 16,297,042 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Trip6
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	16	16,716,864 - 16,721,090 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Trip6
35 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	113
Count of miRNA genes:	92
Interacting mature miRNAs:	98
Transcripts:	ENSRNOT00000072838
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2312418	Kidm41	Kidney mass QTL 41	3.7	0.0001	kidney mass (VT:0002707)	single kidney wet weight to body weight ratio (CMO:0000622)	12	5921918	25247790	Rat
631560	Apr1	Acute phase response QTL 1	6.1		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	24805022	52308831	Rat
61443	Btemp2	Thermal response to stress QTL 2	3.3	0.000094	body temperature trait (VT:0005535)	core body temperature (CMO:0001036)	12	20139028	26430640	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	11200494	52308831	Rat
2306789	Ean6	Experimental allergic neuritis QTL 6	4.9		nervous system integrity trait (VT:0010566)	experimental autoimmune neuritis severity score (CMO:0001528)	12	1	29775522	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	3489416	48489416	Rat
1331739	Hrtrt14	Heart rate QTL 14	3.56232		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	12	1	38687564	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	18473041	52308831	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200497	52308831	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	15264248	52308831	Rat
61331	Eau2	Experimental allergic uveoretinitis QTL 2		0.0005	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	12	1	33700600	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	11743528	52308831	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
2293684	Bmd26	Bone mineral density QTL 26	4.4	0.0002	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	12	1	38635130	Rat
6893681	Bw109	Body weight QTL 109	2.3	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	12	1	28133365	Rat
1302792	Scl21	Serum cholesterol level QTL 21	3.8	0.0011	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	12	12233000	30490641	Rat
61404	Bw120	Body weight QTL 120	5.1		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	12	17464979	46784661	Rat
1300174	Bw15	Body weight QTL 15	2.93		body mass (VT:0001259)	body weight loss (CMO:0001399)	12	1	28606299	Rat
1331786	Kidm11	Kidney mass QTL 11	3.571		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	12	16187438	52308831	Rat
1331787	Rf41	Renal function QTL 41	2.998		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	12	1	33700556	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	16135029	52308831	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	51213550	Rat
1331763	Wbc2	White blood cell count QTL 2	3.162		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	12	11200494	52308831	Rat
61416	Pia4	Pristane induced arthritis QTL 4	8.4		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	12	18749469	36488809	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	11200494	52308831	Rat
7387292	Kidm42	Kidney mass QTL 42	3.03	0.0004	kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	12	1	41361854	Rat
61421	Cia12	Collagen induced arthritis QTL 12	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	18749469	34312613	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	2747694	47747694	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	18473041	52308831	Rat
2303568	Bw88	Body weight QTL 88	3		body mass (VT:0001259)	body weight (CMO:0000012)	12	1	28606299	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	3087180	48087180	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7243862	Mcs30	Mammary carcinoma susceptibility QTL 30	8.62		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	12	5633306	50633306	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	16135029	52308831	Rat
2293086	Iddm30	Insulin dependent diabetes mellitus QTL 30	3.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	7901625	33938215	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
1331755	Bp219	Blood pressure QTL 219	3.041		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	33700556	Rat

Markers in Region

RH140457

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	19,385,449 - 19,385,636 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	22,450,834 - 22,451,020	NCBI	Rnor6.0
Rnor_5.0	12	24,465,495 - 24,465,681	UniSTS	Rnor5.0
Celera	12	21,187,444 - 21,187,630	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	162	91	90	59	92	59	6	356	192	11	141	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001127570	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC161996	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000072838 ⟹ ENSRNOP00000064918

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	25,022,909 - 25,024,448 (+)	Ensembl
mRatBN7.2 Ensembl	12	19,386,240 - 19,390,616 (+)	Ensembl
Rnor_6.0 Ensembl	12	22,451,596 - 22,456,003 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000076244 ⟹ ENSRNOP00000068301

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	19,386,014 - 19,390,486 (+)	Ensembl
Rnor_6.0 Ensembl	12	22,452,075 - 22,453,940 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000077058

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	25,022,952 - 25,027,363 (+)	Ensembl
mRatBN7.2 Ensembl	12	19,386,014 - 19,390,486 (+)	Ensembl
Rnor_6.0 Ensembl	12	22,452,605 - 22,453,959 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000116476 ⟹ ENSRNOP00000084948

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	19,386,014 - 19,390,618 (+)	Ensembl

RefSeq Acc Id:

NM_001127570 ⟹ NP_001121042

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	25,022,959 - 25,027,366 (+)	NCBI
mRatBN7.2	12	19,386,212 - 19,390,619 (+)	NCBI
Rnor_6.0	12	22,451,596 - 22,456,003 (+)	NCBI
Rnor_5.0	12	24,466,257 - 24,470,664 (+)	NCBI
Celera	12	21,188,206 - 21,192,613 (+)	RGD

Sequence:

show sequence

GGAAGAAAAAAAAAGCCAGAAAAAGTTTCTTTGCTGGAGTCCCAAACGGGGCGTGGGGCCGAAA
GGGAGGGAAGGGGCTCAAGGGCCCGGCCGCTGGGCTTGTGGGGGTCCTGACCTCTGTCTGGAGT
GGAGCAACCCTATTCCAGACCATGTCCGGGCCCACCTGGCTTCCCCCGAAGCAGCCAGAGCCCT
CCAGAGTCCCTCAGGGGAGAGCGCTGCCCAGAGGAACCCTGGGTCCGCCAACGGCCCATGGAGC
AACGCTCCAGCCTCACCCCAGGGTCAACTTTTGCCCCCTCCCACCTGAACAATGTTATCAGCCT
CCGGGGGTACCGGAAGATCGGGGGCCTACTTGGGTGGGATCCCATGGAGCAGCCCAGCGCCTGC
AGGGGCTCCCTCCAGACCGGGGAGTCATCCACCCTGGAAGTCTGGACGCTGAGATAGATTCGCT
CACCAGCATGCTGGCTGATCTGGACGGGAGTCGCAGTCATGCACCTAGGCGACCAGACAGACAG
GCTTTTGAGGCTCCTCCACCCCATGCTTACCGTGGAGGCTCCCTGAAACCCAGCGGAGGTGCTG
TTCCAGCCCCGATGCTCCCAGCATCTCCCTATGGTGGACCTACTCCAGCCTCTTATGCTACCGC
GAGCACTCCAGCTGGTCCTGCTTTCCCTGTTCAAGTGAAGGTGGCTCAACCCGTGAGAGGCTGT
GGACTGCCCAGGCGGGGGGCTTCGCAGGCCTCTGGACCTCTTCCAGGCCCCCACTTTCCTCTGA
CAGGTCGTGGTGAAGTCTGGGGAGCTGGCTATAGGAGCCACCGAGAGCCAGGACCAGGGGTTAA
GGAGGGAGCTGCTGGAGTTCATAACCCTGCAGGAGGAGGAAGAAGAGGTGGGCATGAGCCTCAG
GGCCCCTTGAGCCAGCCTCCAGAGGAGGAGCTGGAGAGACTGACCAAGAAGTTGGTGCATGACA
TGAACCACCCGCCCAGTGGGGAGTACTTTGGTCGGTGTGGTGGCTGTGGCGACGATGTGGTTGG
TGATGGAGCTGGGGTTGTGGCCCTGGACCGTGTCTTCCATACTGGTTGCTTCGTGTGTTCTACC
TGTCGGGCCCAGCTCCGAGGCCAGCACTTCTATGCCGTGGAGAGGCGGGCGTATTGTGAGAGCT
GCTATGTGGCCACACTGGAGAAATGTTCCACATGCTCTGAACCCATCCTGGACCGAATCCTGAG
GGCTATGGGGAAGGCTTACCATCCTGGTTGCTTCACCTGTGTGGTGTGCCACCGTGGCCTCGAT
GGCATCCCTTTCACAGTGGATGCCACCAGCCAGATCCACTGCATTGAAGATTTCCACAGGAAAT
TTGCCCCACGGTGCTCAGTGTGTGGTGGGGCCATCATGCCAGAGCCAGGTCAGGAGGAGACAGT
GAGAATTGTTGCTCTGGATAGAAGTTTCCACATTGGCTGCTACAAGTGTGAGGAGTGTGGGCTG
CTGCTGTCCTCTGAGGGAGAGTGTCAAGGCTGCTACCCGCTGGATGGGCATATCTTGTGCAAGG
CTTGTAGTGCCTGGCGCATTCAAGAGCTCTCAGCCACCGTCACCACCGACTGTTGACTGCTCTA
AGAAGGACCTGCTGGGATCTCAGTCCCCCTCTGTTACCTCCCCTGACATCTACCCTTAGTGTTT
GCACCAAATGCTGTCTCTTCTTCCTCCCTTCATGCAATAATAATCAGTGGAGTGTTTAAAAGCT
AAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001121042	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI61996	(Get FASTA)	NCBI Sequence Viewer
	EDM13274	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000064918.2
	ENSRNOP00000094729
	ENSRNOP00000094729.2

RefSeq Acc Id:

NP_001121042 ⟸ NM_001127570

- UniProtKB:

B1WC42 (UniProtKB/TrEMBL), A0A8I6AS72 (UniProtKB/TrEMBL), A0A096MJX8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSGPTWLPPKQPEPSRVPQGRALPRGTLGPPTAHGATLQPHPRVNFCPLPPEQCYQPPGVPEDR
GPTWVGSHGAAQRLQGLPPDRGVIHPGSLDAEIDSLTSMLADLDGSRSHAPRRPDRQAFEAPPP
HAYRGGSLKPSGGAVPAPMLPASPYGGPTPASYATASTPAGPAFPVQVKVAQPVRGCGLPRRGA
SQASGPLPGPHFPLTGRGEVWGAGYRSHREPGPGVKEGAAGVHNPAGGGRRGGHEPQGPLSQPP
EEELERLTKKLVHDMNHPPSGEYFGRCGGCGDDVVGDGAGVVALDRVFHTGCFVCSTCRAQLRG
QHFYAVERRAYCESCYVATLEKCSTCSEPILDRILRAMGKAYHPGCFTCVVCHRGLDGIPFTVD
ATSQIHCIEDFHRKFAPRCSVCGGAIMPEPGQEETVRIVALDRSFHIGCYKCEECGLLLSSEGE
CQGCYPLDGHILCKACSAWRIQELSATVTTDC

hide sequence

Ensembl Acc Id:

ENSRNOP00000064918 ⟸ ENSRNOT00000072838

Ensembl Acc Id:

ENSRNOP00000068301 ⟸ ENSRNOT00000076244

Ensembl Acc Id:

ENSRNOP00000084948 ⟸ ENSRNOT00000116476

Protein Domains

LIM zinc-binding

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-B1WC42-F1-model_v2	AlphaFold	B1WC42	1-480	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698521

Promoter ID:

EPDNEW_R9046

Type:

multiple initiation site

Name:

Trip6_2

Description:

thyroid hormone receptor interactor 6

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R9047

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	22,451,631 - 22,451,691	EPDNEW

RGD ID:

13698526

Promoter ID:

EPDNEW_R9047

Type:

single initiation site

Name:

Trip6_1

Description:

thyroid hormone receptor interactor 6

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R9046

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	22,452,514 - 22,452,574	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1583180	AgrOrtholog
BioCyc Gene	G2FUF-19696	BioCyc
Ensembl Genes	ENSRNOG00000048580	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000072838.5	UniProtKB/TrEMBL
	ENSRNOT00000077058	ENTREZGENE
	ENSRNOT00000077058.3	UniProtKB/TrEMBL
Gene3D-CATH	Cysteine Rich Protein	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:9034684	IMAGE-MGC_LOAD
InterPro	Znf_LIM	UniProtKB/TrEMBL
KEGG Report	rno:686323	UniProtKB/TrEMBL
MGC_CLONE	MGC:187834	IMAGE-MGC_LOAD
NCBI Gene	686323	ENTREZGENE
PANTHER	THYROID RECEPTOR-INTERACTING PROTEIN 6	UniProtKB/TrEMBL
	ZYXIN/TRIP6	UniProtKB/TrEMBL
Pfam	LIM	UniProtKB/TrEMBL
PhenoGen	Trip6	PhenoGen
PROSITE	LIM_DOMAIN_1	UniProtKB/TrEMBL
	LIM_DOMAIN_2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000048580	RatGTEx
SMART	LIM	UniProtKB/TrEMBL
Superfamily-SCOP	Glucocorticoid receptor-like (DNA-binding domain)	UniProtKB/TrEMBL
UniProt	A0A096MJX8	ENTREZGENE
	A0A8I6AS72	ENTREZGENE, UniProtKB/TrEMBL
	B1WC42	ENTREZGENE, UniProtKB/TrEMBL
	M0R678_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-08-16	Trip6	thyroid hormone receptor interactor 6	LOC686323	similar to thyroid receptor-interacting protein 6	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-19	LOC686323	similar to thyroid receptor-interacting protein 6			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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