Ghsr<i><sup>m1Mcwi</sup></i> (growth hormone secretagogue receptor; mutation 1, Medical College of Wisconsin) - Rat Genome Database

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Gene: Ghsrm1Mcwi (growth hormone secretagogue receptor; mutation 1, Medical College of Wisconsin) Rattus norvegicus
Symbol: Ghsrm1Mcwi
Name: growth hormone secretagogue receptor; mutation 1, Medical College of Wisconsin
RGD ID: 1578794
Description: mutation generated by ENU (N-ethyl-N-nitrourea); codon CAG/TAG mutation is generated which changes the AA Q343Stop
ASSOCIATED WITH abnormal gastrointestinal motility; abnormal locomotor behavior; abnormal locomotor response to cocaine
Type: allele  of Ghsr  
Previously known as: Ghsr^[m1Mcwi]; Ghsrm1Mcwi
Is Marker For: Strains:   FHH-Ghsrm1Mcwi  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Cytogenetic Map2 NCBI


References - curated
# Reference Title Reference Citation
1. Food intake and interdigestive gastrointestinal motility in ghrelin receptor mutant rats. Bülbül M, etal., J Gastroenterol. 2011 Apr;46(4):469-78. doi: 10.1007/s00535-010-0366-6. Epub 2011 Jan 22.
2. Attenuation of cocaine-induced locomotor sensitization in rats sustaining genetic or pharmacologic antagonism of ghrelin receptors. Clifford PS, etal., Addict Biol. 2012 Nov;17(6):956-63. doi: 10.1111/j.1369-1600.2011.00339.x. Epub 2011 Jul 25.
3. Rats with a truncated ghrelin receptor (GHSR) do not respond to ghrelin, and show reduced intake of palatable, high-calorie food. MacKay H, etal., Physiol Behav. 2016 Sep 1;163:88-96. doi: 10.1016/j.physbeh.2016.04.048. Epub 2016 Apr 27.
4. PhysGen Strains PhysGen strains


Related Rat Strains
The following Strains have been annotated to Ghsrm1Mcwi



Nucleotide Sequences
RefSeq Transcripts NM_032075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Additional Information

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-05-02 Ghsrm1Mcwi  growth hormone secretagogue receptor; mutation 1, Medical College of Wisconsin      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains Del AA343-364; 10th Prints Motif; multiple sites of PKC phosphorylation 629526