Nr4a1<i><sup>m1Mcwi</sup></i> (nuclear receptor subfamily 4, group A, member 1; mutation 1, Medical College of Wisconsin) - Rat Genome Database

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Gene: Nr4a1m1Mcwi (nuclear receptor subfamily 4, group A, member 1; mutation 1, Medical College of Wisconsin) Rattus norvegicus
Analyze
Symbol: Nr4a1m1Mcwi
Name: nuclear receptor subfamily 4, group A, member 1; mutation 1, Medical College of Wisconsin
RGD ID: 1578791
Description: mutation generated by ENU (N-ethyl-N-nitrourea); Y130Stop mutation is generated from the codon change TAC/TAA.
ASSOCIATED WITH abnormal involuntary movement; abnormal substantia nigra pars compacta morphology; decreased body weight; ASSOCIATED WITH Albuminuria; chronic kidney disease; Dyskinesias
Type: allele  of Nr4a1  
Previously known as: Nr4a1m1Mcwi
Is Marker For: Strains:   FHH-Nr4a1m1Mcwi  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Cytogenetic Map7 NCBI


References

References - curated
# Reference Title Reference Citation
1. PhysGen Strains PhysGen strains
2. Genetic disruption of the nuclear receptor Nur77 (Nr4a1) in rat reduces dopamine cell loss and l-Dopa-induced dyskinesia in experimental Parkinson's disease. Rouillard C, etal., Exp Neurol. 2018 Jun;304:143-153. doi: 10.1016/j.expneurol.2018.03.008. Epub 2018 Mar 9.
3. Genetic susceptibility and loss of Nr4a1 enhances macrophage-mediated renal injury in CKD. Westbrook L, etal., J Am Soc Nephrol. 2014 Nov;25(11):2499-510. doi: 10.1681/ASN.2013070786. Epub 2014 Apr 10.

Genomics


Related Rat Strains
The following Strains have been annotated to Nr4a1m1Mcwi


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_024388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-05-02 Nr4a1m1Mcwi  nuclear receptor subfamily 4, group A, member 1; mutation 1, Medical College of Wisconsin      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_domains Del AA130-597; Hormone receptor DNA binding and ligand binding 629526