Tes (testin LIM domain protein) - Rat Genome Database

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Gene: Tes (testin LIM domain protein) Rattus norvegicus
Analyze
Symbol: Tes
Name: testin LIM domain protein
RGD ID: 1566346
Description: Predicted to enable zinc ion binding activity. Predicted to be involved in negative regulation of cell population proliferation. Predicted to be located in cytoplasm. Predicted to be part of protein-containing complex. Human ortholog(s) of this gene implicated in childhood acute lymphocytic leukemia; gastrointestinal system cancer (multiple); high grade glioma; lung non-small cell carcinoma; and uterine cancer (multiple). Orthologous to human TES (testin LIM domain protein); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC500040; similar to Testis derived transcript; testin; testis derived transcript
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8446,331,257 - 46,369,782 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl446,331,257 - 46,369,780 (+)EnsemblGRCr8
mRatBN7.2445,365,304 - 45,403,829 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl445,365,285 - 45,403,829 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx450,366,261 - 50,412,536 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0446,287,252 - 46,333,519 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0444,704,633 - 44,743,227 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0444,321,883 - 44,360,407 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl444,321,883 - 44,360,405 (+)Ensemblrn6Rnor6.0
Rnor_5.0444,929,781 - 44,968,305 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4442,680,722 - 42,719,246 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera440,655,536 - 40,694,015 (+)NCBICelera
Cytogenetic Map4q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-schisandrin B  (EXP)
(-)-anisomycin  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-acetamidofluorene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrolein  (ISO)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
amphetamine  (EXP)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
C60 fullerene  (EXP)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
decabromodiphenyl ether  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
diethyl malate  (ISO)
dioxygen  (EXP)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
furfural  (ISO)
glutathione  (EXP)
GSK-J4  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
indole-3-methanol  (EXP)
iron atom  (ISO)
iron(0)  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury(0)  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodimethylamine  (EXP)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function
metal ion binding  (IEA)
protein binding  (IPI,ISO)
zinc ion binding  (IEA,ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Molecular recognition of the Tes LIM2-3 domains by the actin-related protein Arp7A. Boeda B, etal., J Biol Chem. 2011 Apr 1;286(13):11543-54. doi: 10.1074/jbc.M110.171264. Epub 2011 Jan 29.
2. TESTIN suppresses tumor growth and invasion via manipulating cell cycle progression in endometrial carcinoma. Gu Z, etal., Med Sci Monit. 2014 Jun 14;20:980-7. doi: 10.12659/MSM.890544.
3. TES inhibits colorectal cancer progression through activation of p38. Li H, etal., Oncotarget. 2016 Jul 19;7(29):45819-45836. doi: 10.18632/oncotarget.9961.
4. Extensive analysis of D7S486 in primary gastric cancer supports TESTIN as a candidate tumor suppressor gene. Ma H, etal., Mol Cancer. 2010 Jul 13;9:190. doi: 10.1186/1476-4598-9-190.
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Adenoviral transduction of TESTIN gene into breast and uterine cancer cell lines promotes apoptosis and tumor reduction in vivo. Sarti M, etal., Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):806-13.
8. Differential expression of testin and survivin in breast cancer subtypes. Sarti M, etal., Oncol Rep. 2013 Aug;30(2):824-32. doi: 10.3892/or.2013.2502. Epub 2013 May 28.
9. Testin (TES) as a candidate tumour suppressor and prognostic marker in human astrocytoma. Steponaitis G, etal., Oncol Lett. 2016 Nov;12(5):3305-3311. doi: 10.3892/ol.2016.5077. Epub 2016 Sep 1.
10. TES functions as a Mena-dependent tumor suppressor in gastric cancer carcinogenesis and metastasis. Wang DD, etal., Cancer Commun (Lond). 2019 Feb 6;39(1):3. doi: 10.1186/s40880-019-0347-y.
11. Testin is a tumor suppressor in non-small cell lung cancer. Wang M, etal., Oncol Rep. 2017 Feb;37(2):1027-1035. doi: 10.3892/or.2016.5316. Epub 2016 Dec 14.
12. Silencing of TESTIN by dense biallelic promoter methylation is the most common molecular event in childhood acute lymphoblastic leukaemia. Weeks RJ, etal., Mol Cancer. 2010 Jun 24;9:163. doi: 10.1186/1476-4598-9-163.
13. Testin is a tumor suppressor and prognostic marker in breast cancer. Zhu J, etal., Cancer Sci. 2012 Dec;103(12):2092-101. doi: 10.1111/cas.12020. Epub 2012 Oct 22.
Additional References at PubMed
PMID:11420696   PMID:12477932   PMID:12917688   PMID:15489334   PMID:15656790   PMID:21423176   PMID:21630459   PMID:22658674   PMID:25468996  


Genomics

Comparative Map Data
Tes
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8446,331,257 - 46,369,782 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl446,331,257 - 46,369,780 (+)EnsemblGRCr8
mRatBN7.2445,365,304 - 45,403,829 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl445,365,285 - 45,403,829 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx450,366,261 - 50,412,536 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0446,287,252 - 46,333,519 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0444,704,633 - 44,743,227 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0444,321,883 - 44,360,407 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl444,321,883 - 44,360,405 (+)Ensemblrn6Rnor6.0
Rnor_5.0444,929,781 - 44,968,305 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4442,680,722 - 42,719,246 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera440,655,536 - 40,694,015 (+)NCBICelera
Cytogenetic Map4q22NCBI
TES
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387116,210,539 - 116,258,783 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7116,210,493 - 116,258,789 (+)Ensemblhg38GRCh38
GRCh377115,850,593 - 115,898,837 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367115,637,817 - 115,686,073 (+)NCBIBuild 36Build 36hg18NCBI36
Celera7110,657,947 - 110,706,196 (+)NCBICelera
Cytogenetic Map7q31.2NCBI
HuRef7110,216,624 - 110,264,907 (+)NCBIHuRef
CHM1_17115,783,744 - 115,832,054 (+)NCBICHM1_1
T2T-CHM13v2.07117,525,529 - 117,573,770 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27115,245,942 - 115,294,229 (+)NCBI
Tes
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39617,065,148 - 17,105,824 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl617,065,148 - 17,105,827 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38617,065,149 - 17,105,825 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl617,065,149 - 17,105,828 (+)Ensemblmm10GRCm38
MGSCv37617,015,149 - 17,055,825 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36617,015,200 - 17,055,825 (+)NCBIMGSCv36mm8
Celera617,137,949 - 17,178,804 (+)NCBICelera
Cytogenetic Map6A2NCBI
cM Map67.67NCBI
Tes
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543222,014,444 - 22,035,636 (+)Ensembl
ChiLan1.0NW_00495543221,992,708 - 22,035,441 (+)NCBIChiLan1.0ChiLan1.0
TES
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26153,035,730 - 153,084,220 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan175,044,942 - 5,094,479 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07108,176,519 - 108,224,816 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17120,873,407 - 120,922,333 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7120,873,762 - 120,922,333 (+)EnsemblpanPan2panpan1.1
TES
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11455,217,768 - 55,240,668 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1455,177,375 - 55,240,668 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1454,588,694 - 54,636,021 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01455,231,813 - 55,279,332 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1455,231,648 - 55,279,332 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11455,263,314 - 55,310,657 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01454,952,074 - 54,999,418 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01455,322,418 - 55,369,952 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tes
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511843,893,609 - 43,933,961 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365892,755,903 - 2,796,308 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365892,755,905 - 2,796,244 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TES
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1829,895,882 - 29,936,233 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11829,895,878 - 29,936,248 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21831,991,868 - 32,012,667 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TES
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12184,913,067 - 84,963,290 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2184,913,093 - 84,963,303 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604218,799,132 - 18,844,419 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tes
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248273,206,196 - 3,249,025 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248273,208,246 - 3,248,942 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tes
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v16121,870,830 - 121,908,820 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tes
189 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:102
Count of miRNA genes:86
Interacting mature miRNAs:93
Transcripts:ENSRNOT00000049102
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)41308014658080146Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41564430960644309Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)43511329080113290Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44140057786400577Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44442502489425024Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41103870656038706Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1331807Rf31Renal function QTL 312.988urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)44049044275726188Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41103870656038706Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4589457557613242Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41103870656038706Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41890069763900697Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)43726957782269577Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41103870656038706Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
61475Aia2Adjuvant induced arthritis QTL 25.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)44047145375939996Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44140060386400603Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42228845363245191Rat
8552807Vie4Viral induced encephalitis QTL 47.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)41890069763900697Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41103870656038706Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)43044896182336920Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4588999950889999Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
7387227Uae40Urinary albumin excretion QTL 402.90.0052urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)41891315163913151Rat
6909122Insul22Insulin level QTL 224.63blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)42786220462997402Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)44140057786400577Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42192515166925151Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)4163900697Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41103870656038706Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat
11530004Niddm71Non-insulin dependent diabetes mellitus QTL 710.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)43353881653719714Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat

Markers in Region
RH142926  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2445,398,333 - 45,398,633 (+)MAPPERmRatBN7.2
Rnor_6.0444,354,912 - 44,355,211NCBIRnor6.0
Rnor_5.0444,962,810 - 44,963,109UniSTSRnor5.0
RGSC_v3.4442,713,751 - 42,714,050UniSTSRGSC3.4
Celera440,688,520 - 40,688,819UniSTS
RH 3.4 Map4299.1UniSTS
Cytogenetic Map4q21UniSTS
RH139200  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2445,403,405 - 45,403,612 (+)MAPPERmRatBN7.2
Rnor_6.0444,359,984 - 44,360,190NCBIRnor6.0
Rnor_5.0444,967,882 - 44,968,088UniSTSRnor5.0
RGSC_v3.4442,718,823 - 42,719,029UniSTSRGSC3.4
Celera440,693,592 - 40,693,798UniSTS
RH 3.4 Map4285.0UniSTS
Cytogenetic Map4q21UniSTS
AI236772  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8446,369,347 - 46,369,565 (+)Marker Load Pipeline
mRatBN7.2445,403,394 - 45,403,612 (+)MAPPERmRatBN7.2
Rnor_6.0444,359,973 - 44,360,190NCBIRnor6.0
Rnor_5.0444,967,871 - 44,968,088UniSTSRnor5.0
RGSC_v3.4442,718,812 - 42,719,029UniSTSRGSC3.4
Celera440,693,581 - 40,693,798UniSTS
RH 3.4 Map4285.0UniSTS
Cytogenetic Map4q21UniSTS
Tes  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2445,395,165 - 45,395,377 (+)MAPPERmRatBN7.2
Rnor_6.0444,351,744 - 44,351,955NCBIRnor6.0
Rnor_5.0444,959,642 - 44,959,853UniSTSRnor5.0
RGSC_v3.4442,710,583 - 42,710,794UniSTSRGSC3.4
Celera440,685,352 - 40,685,563UniSTS
Cytogenetic Map4q21UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000091095   ⟹   ENSRNOP00000070338
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl446,331,257 - 46,369,780 (+)Ensembl
mRatBN7.2 Ensembl445,365,285 - 45,403,829 (+)Ensembl
Rnor_6.0 Ensembl444,321,883 - 44,360,405 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094881   ⟹   ENSRNOP00000096525
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl446,350,723 - 46,369,780 (+)Ensembl
mRatBN7.2 Ensembl445,384,770 - 45,403,829 (+)Ensembl
RefSeq Acc Id: NM_001039344   ⟹   NP_001034433
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8446,331,257 - 46,369,782 (+)NCBI
mRatBN7.2445,365,304 - 45,403,829 (+)NCBI
Rnor_6.0444,321,883 - 44,360,407 (+)NCBI
Rnor_5.0444,929,781 - 44,968,305 (+)NCBI
RGSC_v3.4442,680,722 - 42,719,246 (+)RGD
Celera440,655,536 - 40,694,015 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001034433 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI29070 (Get FASTA)   NCBI Sequence Viewer  
  ABC68418 (Get FASTA)   NCBI Sequence Viewer  
  ABC87757 (Get FASTA)   NCBI Sequence Viewer  
  EDM15102 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000070338
  ENSRNOP00000070338.1
GenBank Protein Q2LAP6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001034433   ⟸   NM_001039344
- UniProtKB: Q2LAP6 (UniProtKB/Swiss-Prot),   A6IE14 (UniProtKB/TrEMBL),   A0A8I6AV73 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070338   ⟸   ENSRNOT00000091095
Ensembl Acc Id: ENSRNOP00000096525   ⟸   ENSRNOT00000094881
Protein Domains
LIM zinc-binding   PET

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q2LAP6-F1-model_v2 AlphaFold Q2LAP6 1-419 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692890
Promoter ID:EPDNEW_R3414
Type:initiation region
Name:Tes_1
Description:testin LIM domain protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0444,321,861 - 44,321,921EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566346 AgrOrtholog
BioCyc Gene G2FUF-45582 BioCyc
Ensembl Genes ENSRNOG00000051952 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000091095 ENTREZGENE
  ENSRNOT00000091095.2 UniProtKB/Swiss-Prot
Gene3D-CATH Cysteine Rich Protein UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7100907 IMAGE-MGC_LOAD
InterPro LIM1_Testin UniProtKB/Swiss-Prot
  LIM2_Testin UniProtKB/Swiss-Prot
  LIM3_Testin UniProtKB/Swiss-Prot
  PET_domain UniProtKB/Swiss-Prot
  PET_testin UniProtKB/Swiss-Prot
  Pk/Esn/Tes UniProtKB/Swiss-Prot
  Znf_LIM UniProtKB/Swiss-Prot
KEGG Report rno:500040 UniProtKB/Swiss-Prot
MGC_CLONE MGC:156466 IMAGE-MGC_LOAD
NCBI Gene 500040 ENTREZGENE
PANTHER LIM DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
  PTHR24211:SF1 UniProtKB/Swiss-Prot
Pfam LIM UniProtKB/Swiss-Prot
  PET UniProtKB/Swiss-Prot
PhenoGen Tes PhenoGen
PROSITE LIM_DOMAIN_1 UniProtKB/Swiss-Prot
  LIM_DOMAIN_2 UniProtKB/Swiss-Prot
  PET UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000051952 RatGTEx
SMART LIM UniProtKB/Swiss-Prot
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot
UniProt A0A8I6AV73 ENTREZGENE, UniProtKB/TrEMBL
  A6IE14 ENTREZGENE, UniProtKB/TrEMBL
  Q2LAP6 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-03-16 Tes  testin LIM domain protein  Tes  testis derived transcript  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Tes  testis derived transcript  LOC500040  similar to Testis derived transcript  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC500040  similar to Testis derived transcript      Symbol and Name status set to provisional 70820 PROVISIONAL