Cd274 (CD274 molecule) - Rat Genome Database

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Gene: Cd274 (CD274 molecule) Rattus norvegicus
Symbol: Cd274
Name: CD274 molecule
RGD ID: 1566211
Description: Predicted to enable transcription coactivator activity. Involved in positive regulation of T cell proliferation and positive regulation of cell migration. Located in cell surface. Biomarker of periodontitis and pre-eclampsia. Orthologous to human CD274 (CD274 molecule); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CD274 antigen; LOC499342; Pdcd1lg1; programmed cell death 1 ligand 1; RGD1566211; similar to PD-1-ligand precursor
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81236,526,215 - 236,549,956 (+)NCBIGRCr8
mRatBN7.21227,116,674 - 227,137,379 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1227,116,649 - 227,134,450 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1235,523,534 - 235,535,346 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01242,453,199 - 242,465,011 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01235,269,986 - 235,282,673 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01247,519,890 - 247,539,659 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1247,519,939 - 247,537,943 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01254,768,528 - 254,788,292 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41233,053,607 - 233,065,384 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1224,273,306 - 224,285,083 (+)NCBICelera
Cytogenetic Map1q52NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute myocarditis  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
allergic disease  (ISO)
alveolar echinococcosis  (ISO)
anti-basement membrane glomerulonephritis  (ISO)
asthma  (ISO)
autoimmune hepatitis  (ISO)
cervix uteri carcinoma in situ  (ISO)
Chlamydia pneumonia  (ISO)
chromosome 9p deletion syndrome  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
colon cancer  (ISO)
Corneal Graft Rejection  (IMP)
Coxsackievirus Infections  (ISO)
cryptococcal meningitis  (ISO)
cutaneous leishmaniasis  (ISO)
Disease Progression  (ISO)
Experimental Mammary Neoplasms  (IDA)
Fungemia  (ISO)
genetic disease  (ISO)
Hepatic Echinococcosis  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
herpes simplex  (ISO)
herpes simplex virus keratitis  (ISO)
histoplasmosis  (ISO)
human immunodeficiency virus infectious disease  (ISO)
influenza  (ISO)
invasive ductal carcinoma  (ISO)
Lung Neoplasms  (ISO)
Lymphatic Metastasis  (ISO)
lymphocytic choriomeningitis  (ISO)
lymphoma  (ISO)
melanoma  (ISO)
nasal type extranodal NK/T-cell lymphoma  (ISO)
Neoplasm Metastasis  (ISO)
ovarian cancer  (ISO)
Ovarian Neoplasms  (ISO)
papillomavirus infectious disease  (ISO)
periodontitis  (IEP)
pre-eclampsia  (IEP)
primary progressive multiple sclerosis  (ISO)
pulmonary tuberculosis  (ISO)
rabies  (ISO)
Radiation-Induced Neoplasms  (ISO)
Recurrence  (ISO)
Recurrent Respiratory Papillomatosis  (ISO)
respiratory syncytial virus infectious disease  (ISO)
Retroviridae Infections  (ISO)
Sepsis  (ISO)
Spinal Cord Injuries  (IEP)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
substance-related disorder  (ISO)
Thymus Neoplasms  (ISO)
toxic shock syndrome  (ISO)
Transplant Rejection  (ISO)
tuberculosis  (ISO)
Viral Bronchiolitis  (ISO)
viral encephalitis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3-phenylprop-2-enal  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
acetylsalicylic acid  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aripiprazole  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
buta-1,3-diene  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
carboplatin  (ISO)
CGP 52608  (ISO)
chloroquine  (ISO)
chlorpromazine  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diiodine  (ISO)
dioxygen  (ISO)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
estriol  (ISO)
ethyl methanesulfonate  (ISO)
etoposide  (ISO)
eugenol  (ISO)
ferric oxide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gemcitabine  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
imiquimod  (ISO)
indolin-2-one  (ISO)
isoeugenol  (ISO)
ketoconazole  (EXP)
kojic acid  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
LY294002  (ISO)
malathion  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
mocetinostat  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
oleanolic acid  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
pentanal  (ISO)
phenformin  (EXP)
phenobarbital  (ISO)
platycodin D  (ISO)
protein kinase inhibitor  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
sevoflurane  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
succimer  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
thyroxine  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
trans-isoeugenol  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
tubastatin A  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function


References - curated
# Reference Title Reference Citation
1. Roles of programmed death-1 (PD-1)/PD-1 ligands pathway in the development of murine acute myocarditis caused by coxsackievirus B3. null
2. PD-L1 on tumor cells is induced in ascites and promotes peritoneal dissemination of ovarian cancer through CTL dysfunction. Abiko K, etal., Clin Cancer Res. 2013 Mar 15;19(6):1363-74. doi: 10.1158/1078-0432.CCR-12-2199. Epub 2013 Jan 22.
3. Expression of programmed death 1 and its ligands in the liver of autoimmune hepatitis C57BL/6 mice. Cao J, etal., Chin Med J (Engl). 2009 Aug 20;122(16):1941-6.
4. Blockade of the negative co-stimulatory molecules PD-1 and CTLA-4 improves survival in primary and secondary fungal sepsis. Chang KC, etal., Crit Care. 2013 May 11;17(3):R85. doi: 10.1186/cc12711.
5. In vitro and in vivo effect of PD-1/PD-L1 blockade on microglia/macrophage activation and T cell subset balance in cryptococcal meningitis. Che YM, etal., J Cell Biochem. 2018 Apr;119(4):3044-3057. doi: 10.1002/jcb.26432. Epub 2017 Dec 26.
6. CD72/CD100 and PD-1/PD-L1 markers are increased on T and B cells in HIV-1+ viremic individuals, and CD72/CD100 axis is correlated with T-cell exhaustion. Correa-Rocha R, etal., PLoS One. 2018 Aug 30;13(8):e0203419. doi: 10.1371/journal.pone.0203419. eCollection 2018.
7. CNS expression of B7-H1 regulates pro-inflammatory cytokine production and alters severity of Theiler's virus-induced demyelinating disease. Duncan DS and Miller SD, PLoS One. 2011 Apr 8;6(4):e18548.
8. Viral acute lower respiratory infections impair CD8+ T cells through PD-1. Erickson JJ, etal., J Clin Invest. 2012 Aug;122(8):2967-82. doi: 10.1172/JCI62860. Epub 2012 Jul 17.
9. Expression of PD-L1 on CD4+CD25+Foxp3+ Regulatory T Cells of Patients with Chronic HBV Infection and Its Correlation with Clinical Parameters. Feng C, etal., Viral Immunol. 2015 Oct;28(8):418-24. doi: 10.1089/vim.2015.0062. Epub 2015 Aug 12.
10. Programmed death 1 protects from fatal circulatory failure during systemic virus infection of mice. Frebel H, etal., J Exp Med. 2012 Dec 17;209(13):2485-99. doi: 10.1084/jem.20121015. Epub 2012 Dec 10.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Pre-treatment serum levels of soluble programmed cell death-ligand 1 predict prognosis in patients with hepatitis B-related hepatocellular carcinoma. Han X, etal., J Cancer Res Clin Oncol. 2019 Feb;145(2):303-312. doi: 10.1007/s00432-018-2758-6. Epub 2018 Sep 28.
13. Immune suppression in premalignant respiratory papillomas: enriched functional CD4+Foxp3+ regulatory T cells and PD-1/PD-L1/L2 expression. Hatam LJ, etal., Clin Cancer Res. 2012 Apr 1;18(7):1925-35. doi: 10.1158/1078-0432.CCR-11-2941. Epub 2012 Feb 9.
14. Dexmedetomidine Mitigates Microglia-Mediated Neuroinflammation through Upregulation of Programmed Cell Death Protein 1 in a Rat Spinal Cord Injury Model. He H, etal., J Neurotrauma. 2018 Nov 1;35(21):2591-2603. doi: 10.1089/neu.2017.5625. Epub 2018 Jun 7.
15. Prognostic Significance of PD-1, PD-L1 and CD8 Gene Expression Levels in Gastric Cancer. Ito S, etal., Oncology. 2020;98(7):501-511. doi: 10.1159/000506075. Epub 2020 May 7.
16. PD-L1/B7-H1 Inhibits Viral Clearance by Macrophages in HSV-1-Infected Corneas. Jeon S, etal., J Immunol. 2018 Jun 1;200(11):3711-3719. doi: 10.4049/jimmunol.1700417. Epub 2018 Apr 18.
17. Blocking of monocyte-associated B7-H1 (CD274) enhances HCV-specific T cell immunity in chronic hepatitis C infection. Jeong HY, etal., J Leukoc Biol. 2008 Mar;83(3):755-64. doi: 10.1189/jlb.0307168. Epub 2007 Dec 17.
18. Combination of an oncolytic virus with PD-L1 blockade keeps cancer in check. Jonas BA, Sci Transl Med. 2017 Apr 19;9(386). pii: 9/386/eaan2781. doi: 10.1126/scitranslmed.aan2781.
19. B7-H1 (CD274) inhibits the development of herpetic stromal keratitis (HSK). Jun H, etal., FEBS Lett. 2005 Nov 7;579(27):6259-64. doi: 10.1016/j.febslet.2005.09.098. Epub 2005 Oct 19.
20. Expression of programmed cell death ligand 1 (PD-L1) in advanced stage EBV-associated extranodal NK/T cell lymphoma is associated with better prognosis. Kim WY, etal., Virchows Arch. 2016 Nov;469(5):581-590. doi: 10.1007/s00428-016-2011-0. Epub 2016 Sep 5.
21. Upregulation of PD-1 on CD4⁺CD25⁺ T cells is associated with immunosuppression in liver of mice infected with Echinococcus multilocularis. La X, etal., Int Immunopharmacol. 2015 Jun;26(2):357-66. doi: 10.1016/j.intimp.2015.04.013. Epub 2015 Apr 20.
22. Detrimental contribution of the immuno-inhibitor B7-H1 to rabies virus encephalitis. Lafon M, etal., J Immunol. 2008 Jun 1;180(11):7506-15. doi: 10.4049/jimmunol.180.11.7506.
23. Blocking the monocyte chemoattractant protein-1/CCR2 chemokine pathway induces permanent survival of islet allografts through a programmed death-1 ligand-1-dependent mechanism. Lee I, etal., J Immunol. 2003 Dec 15;171(12):6929-35.
24. Increased levels of soluble co-stimulatory molecule PD-L1 (B7-H1) in the plasma of viraemic HIV-1+ individuals. León-Flores A, etal., Immunol Lett. 2018 Nov;203:70-79. doi: 10.1016/j.imlet.2018.09.007. Epub 2018 Sep 17.
25. PD-L1 and PD-L2 have distinct roles in regulating host immunity to cutaneous leishmaniasis. Liang SC, etal., Eur J Immunol. 2006 Jan;36(1):58-64. doi: 10.1002/eji.200535458.
26. High PD-L1 expression in gastric cancer (GC) patients and correlation with molecular features. Liu X, etal., Pathol Res Pract. 2020 Apr;216(4):152881. doi: 10.1016/j.prp.2020.152881. Epub 2020 Feb 13.
27. The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum. Lázár-Molnár E, etal., Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2658-63. doi: 10.1073/pnas.0711918105. Epub 2008 Feb 11.
28. Programmed death ligand 1 is over-expressed by neutrophils in the blood of patients with active tuberculosis. McNab FW, etal., Eur J Immunol. 2011 Jul;41(7):1941-7. doi: 10.1002/eji.201141421. Epub 2011 May 27.
29. PD-L1 expression on neoplastic or stromal cells is respectively a poor or good prognostic factor for adult T-cell leukemia/lymphoma. Miyoshi H, etal., Blood. 2016 Sep 8;128(10):1374-81. doi: 10.1182/blood-2016-02-698936. Epub 2016 Jul 14.
30. Role of lentivirus-mediated overexpression of programmed death-ligand 1 on corneal allograft survival. Nosov M, etal., Am J Transplant. 2012 May;12(5):1313-22. doi: 10.1111/j.1600-6143.2011.03948.x. Epub 2012 Feb 2.
31. Notch Signaling Pathway Was Involved in Regulating Programmed Cell Death 1 Expression during Sepsis-Induced Immunosuppression. Pan T, etal., Mediators Inflamm. 2015;2015:539841. doi: 10.1155/2015/539841. Epub 2015 Apr 30.
32. Enhanced antiviral T cell function in the absence of B7-H1 is insufficient to prevent persistence but exacerbates axonal bystander damage during viral encephalomyelitis. Phares TW, etal., J Immunol. 2010 Nov 1;185(9):5607-18. Epub 2010 Sep 27.
33. Stimulation of the PD-1/PDL-1 T-cell co-inhibitory pathway is effective in treatment of experimental autoimmune glomerulonephritis. Reynolds J, etal., Nephrol Dial Transplant. 2012 Apr;27(4):1343-50. doi: 10.1093/ndt/gfr529. Epub 2011 Sep 29.
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. Comprehensive gene review and curation RGD comprehensive gene curation
36. Monocyte programmed death ligand-1 expression after 3-4 days of sepsis is associated with risk stratification and mortality in septic patients: a prospective cohort study. Shao R, etal., Crit Care. 2016 May 9;20(1):124. doi: 10.1186/s13054-016-1301-x.
37. Increased PD-L1 expression and PD-L1/CD86 ratio on dendritic cells were associated with impaired dendritic cells function in HCV infection. Shen T, etal., J Med Virol. 2010 Jul;82(7):1152-9. doi: 10.1002/jmv.21809.
38. PD-1 Dynamically Regulates Inflammation and Development of Brain-Resident Memory CD8 T Cells During Persistent Viral Encephalitis. Shwetank, etal., Front Immunol. 2019 Apr 17;10:783. doi: 10.3389/fimmu.2019.00783. eCollection 2019.
39. Inhibiting the programmed death 1 pathway rescues Mycobacterium tuberculosis-specific interferon γ-producing T cells from apoptosis in patients with pulmonary tuberculosis. Singh A, etal., J Infect Dis. 2013 Aug 15;208(4):603-15. doi: 10.1093/infdis/jit206. Epub 2013 May 9.
40. Programmed Death Ligand 1 Promotes Early-Life Chlamydia Respiratory Infection-Induced Severe Allergic Airway Disease. Starkey MR, etal., Am J Respir Cell Mol Biol. 2016 Apr;54(4):493-503. doi: 10.1165/rcmb.2015-0204OC.
41. The PD-1/PD-L1 inhibitory pathway is altered in pre-eclampsia and regulates T cell responses in pre-eclamptic rats. Tian M, etal., Sci Rep. 2016 Jun 9;6:27683. doi: 10.1038/srep27683.
42. PD-L1 expression induced by the 2009 pandemic influenza A(H1N1) virus impairs the human T cell response. Valero-Pacheco N, etal., Clin Dev Immunol. 2013;2013:989673. doi: 10.1155/2013/989673. Epub 2013 Sep 26.
43. Immunotherapy of alveolar echinococcosis via PD-1/PD-L1 immune checkpoint blockade in mice. Wang J, etal., Parasite Immunol. 2018 Dec;40(12):e12596. doi: 10.1111/pim.12596. Epub 2018 Nov 4.
44. Aberrant PD-1 ligand expression contributes to the myocardial inflammatory injury caused by Coxsackievirus B infection. Wang T, etal., Antiviral Res. 2019 Jun;166:1-10. doi: 10.1016/j.antiviral.2019.03.007. Epub 2019 Mar 20.
45. [Enhancement of antiviral immunity in HBV mouse model by blocking PD-1/PD-L1 signaling pathway]. Weng ZH, etal., Zhonghua Gan Zang Bing Za Zhi. 2010 Apr;18(4):263-6. doi: 10.3760/cma.j.issn.1007-3418.2010.04.007.
46. Lymphocyte subset expression and serum concentrations of PD-1/PD-L1 in sepsis - pilot study. Wilson JK, etal., Crit Care. 2018 Apr 17;22(1):95. doi: 10.1186/s13054-018-2020-2.
47. Immune Checkpoint Receptors Tim-3 and PD-1 Regulate Monocyte and T Lymphocyte Function in Septic Patients. Xia Q, etal., Mediators Inflamm. 2018 Nov 22;2018:1632902. doi: 10.1155/2018/1632902. eCollection 2018.
48. Inhibition of T-cell responses by intratumoral hepatic stellate cells contribute to migration and invasion of hepatocellular carcinoma. Xia Y, etal., Clin Exp Metastasis. 2011 Oct;28(7):661-74. doi: 10.1007/s10585-011-9399-3. Epub 2011 Jun 30.
49. The Protective and Immunomodulatory Effects of Fucoidan Against 7,12-Dimethyl benz[a]anthracene-Induced Experimental Mammary Carcinogenesis Through the PD1/PDL1 Signaling Pathway in Rats. Xue M, etal., Nutr Cancer. 2017 Nov-Dec;69(8):1234-1244. doi: 10.1080/01635581.2017.1362446. Epub 2017 Oct 18.
50. Increased expression of programmed death (PD)-1 and its ligand PD-L1 correlates with impaired cell-mediated immunity in high-risk human papillomavirus-related cervical intraepithelial neoplasia. Yang W, etal., Immunology. 2013 Aug;139(4):513-22. doi: 10.1111/imm.12101.
51. [Temporal expression of PD-1 and PD-L1 during the development of experimental periodontitis in rats and its implications]. Yang X, etal., Shanghai Kou Qiang Yi Xue. 2019 Dec;28(6):591-596.
52. Control of pathogenic effector T-cell activities in situ by PD-L1 expression on respiratory inflammatory dendritic cells during respiratory syncytial virus infection. Yao S, etal., Mucosal Immunol. 2015 Jul;8(4):746-59. doi: 10.1038/mi.2014.106. Epub 2014 Dec 3.
53. Upregulation of circulating PD-L1/PD-1 is associated with poor post-cryoablation prognosis in patients with HBV-related hepatocellular carcinoma. Zeng Z, etal., PLoS One. 2011;6(9):e23621. doi: 10.1371/journal.pone.0023621. Epub 2011 Sep 1.
54. Predictive Value of Soluble Programmed Death-1 for Severe Sepsis and Septic Shock During the First Week in an Intensive Care Unit. Zhao Y, etal., Shock. 2019 Mar;51(3):289-297. doi: 10.1097/SHK.0000000000001171.
Additional References at PubMed
PMID:10581077   PMID:12538684   PMID:15568026   PMID:17016562   PMID:17076679   PMID:17489864   PMID:21855860   PMID:23716698   PMID:24691993   PMID:25310899   PMID:25902191   PMID:28196545  
PMID:28458101   PMID:28813410   PMID:28813417   PMID:30092337   PMID:31733200   PMID:32631356   PMID:38203304  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81236,526,215 - 236,549,956 (+)NCBIGRCr8
mRatBN7.21227,116,674 - 227,137,379 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1227,116,649 - 227,134,450 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1235,523,534 - 235,535,346 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01242,453,199 - 242,465,011 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01235,269,986 - 235,282,673 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01247,519,890 - 247,539,659 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1247,519,939 - 247,537,943 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01254,768,528 - 254,788,292 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41233,053,607 - 233,065,384 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1224,273,306 - 224,285,083 (+)NCBICelera
Cytogenetic Map1q52NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3895,450,542 - 5,470,554 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl95,450,503 - 5,470,566 (+)EnsemblGRCh38hg38GRCh38
GRCh3795,450,542 - 5,470,554 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3695,440,559 - 5,458,477 (+)NCBINCBI36Build 36hg18NCBI36
Celera95,376,139 - 5,396,204 (+)NCBICelera
Cytogenetic Map9p24.1NCBI
HuRef95,406,210 - 5,426,274 (+)NCBIHuRef
CHM1_195,450,664 - 5,470,759 (+)NCBICHM1_1
T2T-CHM13v2.095,455,669 - 5,475,674 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391929,339,428 - 29,365,495 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1929,344,855 - 29,365,495 (+)EnsemblGRCm39 Ensembl
GRCm381929,362,107 - 29,388,095 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1929,367,455 - 29,388,095 (+)EnsemblGRCm38mm10GRCm38
MGSCv371929,441,928 - 29,462,585 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361929,433,452 - 29,454,092 (+)NCBIMGSCv36mm8
Celera1930,144,050 - 30,164,685 (+)NCBICelera
Cytogenetic Map19C1NCBI
cM Map1923.88NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554349,487,315 - 9,505,904 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554349,487,309 - 9,508,366 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v211119,102,245 - 119,122,611 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19119,108,194 - 119,128,540 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v095,269,270 - 5,289,629 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.195,454,391 - 5,474,452 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl95,454,391 - 5,474,402 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1193,461,735 - 93,605,772 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl193,585,518 - 93,603,522 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha193,993,732 - 94,011,736 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0194,015,405 - 94,159,596 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl194,139,343 - 94,159,596 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1193,771,527 - 93,789,533 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0193,496,313 - 93,514,317 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0194,260,510 - 94,278,519 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024404947141,675,278 - 141,693,582 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936539132,868 - 143,602 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936539132,870 - 145,288 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1216,660,041 - 216,792,724 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11216,646,378 - 216,792,731 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21242,395,402 - 242,416,220 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11274,038,844 - 74,060,662 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1274,041,767 - 74,056,806 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603862,428,363 - 62,448,555 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046247369,996,156 - 10,013,814 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247369,991,851 - 10,017,047 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Cd274
171 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:47
Interacting mature miRNAs:51
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
1358292Cm37Cardiac mass QTL 376.20.00000081heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1197697768238755659Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1201554356246554356Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1201554356246554356Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1201554356246554356Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1201554356246554356Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1201554356246554356Rat
10059587Bw173Body weight QTL 1733.230.025body mass (VT:0001259)body weight (CMO:0000012)1202069611247069611Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1203995416244113296Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1206081677251081677Rat
1357399Bw45Body weight QTL 453.05body mass (VT:0001259)body mass index (BMI) (CMO:0000105)1206329708251329708Rat
1357404Bw42Body weight QTL 424.490.0001body mass (VT:0001259)body weight (CMO:0000012)1206329708251329708Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1207702246228581766Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1210702053240947965Rat
1358890Bp259Blood pressure QTL 2593.06arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1210702053260522016Rat
2292216Bw80Body weight QTL 803.230.0019body mass (VT:0001259)body weight (CMO:0000012)1213533809243914901Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1213707201252085212Rat
734768Niddm59Non-insulin dependent diabetes mellitus QTL 59body mass (VT:0001259)body weight (CMO:0000012)1213843987258843987Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1214537555238757011Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1214647894259647894Rat
1549910Bw54Body weight QTL 540.05body mass (VT:0001259)body weight (CMO:0000012)1214647894259647894Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1216255568260522016Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1216255568260522016Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1218748008257976495Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1218753689245907899Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1218753816256448513Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1221264111259647894Rat
10053715Scort24Serum corticosterone level QTL 242.130.0088blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1221414816260522016Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1222363780260522016Rat
1600392Bw123Body weight QTL 1230.001body mass (VT:0001259)body weight (CMO:0000012)1223201027260522016Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1224054293243747962Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1224054293243747962Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1224054293260122809Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1224054293260122809Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1224569538260122809Rat
6480786Bw97Body weight QTL 975.03body mass (VT:0001259)body weight (CMO:0000012)1225126575227604520Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1225126575260522016Rat


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 8 19 9
Low 3 31 35 27 27 8 11 50 35 38 2 8
Below cutoff 10 14 14 14 24 3


RefSeq Acc Id: ENSRNOT00000034421   ⟹   ENSRNOP00000029992
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1227,116,649 - 227,134,450 (+)Ensembl
Rnor_6.0 Ensembl1247,519,939 - 247,537,943 (+)Ensembl
RefSeq Acc Id: NM_001191954   ⟹   NP_001178883
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr81236,530,232 - 236,549,956 (+)NCBI
mRatBN7.21227,116,674 - 227,136,399 (+)NCBI
Rnor_6.01247,525,151 - 247,536,928 (+)NCBI
Rnor_5.01254,768,528 - 254,788,292 (+)NCBI
Celera1224,273,306 - 224,285,083 (+)NCBI
RefSeq Acc Id: XM_039088029   ⟹   XP_038943957
Rat AssemblyChrPosition (strand)Source
GRCr81236,530,298 - 236,549,956 (+)NCBI
mRatBN7.21227,116,740 - 227,137,379 (+)NCBI
RefSeq Acc Id: XM_039088034   ⟹   XP_038943962
Rat AssemblyChrPosition (strand)Source
GRCr81236,530,236 - 236,549,956 (+)NCBI
mRatBN7.21227,116,689 - 227,137,379 (+)NCBI
RefSeq Acc Id: XM_063271728   ⟹   XP_063127798
Rat AssemblyChrPosition (strand)Source
GRCr81236,526,215 - 236,549,956 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001178883 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943957 (Get FASTA)   NCBI Sequence Viewer  
  XP_038943962 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127798 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM13095 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000029992
RefSeq Acc Id: NP_001178883   ⟸   NM_001191954
- Peptide Label: precursor
- UniProtKB: D4AE25 (UniProtKB/TrEMBL),   A6I0W4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000029992   ⟸   ENSRNOT00000034421
RefSeq Acc Id: XP_038943962   ⟸   XM_039088034
- Peptide Label: isoform X1
- UniProtKB: D4AE25 (UniProtKB/TrEMBL),   A6I0W4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038943957   ⟸   XM_039088029
- Peptide Label: isoform X1
- UniProtKB: D4AE25 (UniProtKB/TrEMBL),   A6I0W4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127798   ⟸   XM_063271728
- Peptide Label: isoform X1
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AE25-F1-model_v2 AlphaFold D4AE25 1-290 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690846
Promoter ID:EPDNEW_R1371
Type:single initiation site
Description:CD274 molecule
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01247,519,934 - 247,519,994EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566211 AgrOrtholog
BioCyc Gene G2FUF-55968 BioCyc
Ensembl Genes ENSRNOG00000016112 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000034421 ENTREZGENE
  ENSRNOT00000034421.7 UniProtKB/TrEMBL
InterPro CD80_C2-set UniProtKB/TrEMBL
  Ig-like UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
KEGG Report rno:499342 UniProtKB/TrEMBL
Pfam C2-set_2 UniProtKB/TrEMBL
  V-set UniProtKB/TrEMBL
PhenoGen Cd274 PhenoGen
RatGTEx ENSRNOG00000016112 RatGTEx
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-06-27 Cd274  CD274 molecule  Cd274  CD274 antigen  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Cd274  CD274 antigen  RGD1566211_predicted  similar to PD-1-ligand precursor (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1566211_predicted  similar to PD-1-ligand precursor (predicted)  LOC499342  similar to PD-1-ligand precursor  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC499342  similar to PD-1-ligand precursor      Symbol and Name status set to provisional 70820 PROVISIONAL