Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Thsd7a | Rat | 17beta-estradiol | multiple interactions | ISO | THSD7A (Homo sapiens) | 6480464 | [Progesterone co-treated with Estradiol] results in increased expression of THSD7A mRNA | CTD | PMID:17404688 | Thsd7a | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of THSD7A mRNA | CTD | PMID:32109520 and PMID:34747641 | Thsd7a | Rat | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | Thsd7a | Rat | 2-palmitoylglycerol | increases expression | ISO | THSD7A (Homo sapiens) | 6480464 | 2-palmitoylglycerol results in increased expression of THSD7A mRNA | CTD | PMID:37199045 | Thsd7a | Rat | 4-hydroxyphenyl retinamide | decreases expression | ISO | Thsd7a (Mus musculus) | 6480464 | Fenretinide results in decreased expression of THSD7A mRNA | CTD | PMID:28973697 | Thsd7a | Rat | 5-aza-2'-deoxycytidine | decreases methylation | ISO | Thsd7a (Mus musculus) | 6480464 | Decitabine results in decreased methylation of THSD7A gene | CTD | PMID:27923600 | Thsd7a | Rat | 5-fluorouracil | increases expression | ISO | THSD7A (Homo sapiens) | 6480464 | Fluorouracil results in increased expression of THSD7A mRNA | CTD | PMID:24737281 | Thsd7a | Rat | 6-propyl-2-thiouracil | affects expression | EXP | | 6480464 | Propylthiouracil affects the expression of THSD7A mRNA | CTD | PMID:24780913 | Thsd7a | Rat | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of THSD7A mRNA | CTD | PMID:30047161 | Thsd7a | Rat | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of THSD7A mRNA | CTD | PMID:36843608 | Thsd7a | Rat | acrylamide | decreases expression | ISO | THSD7A (Homo sapiens) | 6480464 | Acrylamide results in decreased expression of THSD7A mRNA | CTD | PMID:32763439 | Thsd7a | Rat | aflatoxin B1 | decreases expression | ISO | THSD7A (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased expression of THSD7A mRNA | CTD | PMID:22100608 and PMID:27153756 | Thsd7a | Rat | aflatoxin B1 | affects methylation | ISO | THSD7A (Homo sapiens) | 6480464 | Aflatoxin B1 affects the methylation of THSD7A intron | CTD | PMID:30157460 | Thsd7a | Rat | Aflatoxin B2 alpha | increases methylation | ISO | THSD7A (Homo sapiens) | 6480464 | aflatoxin B2 results in increased methylation of THSD7A intron | CTD | PMID:30157460 | Thsd7a | Rat | aldehydo-D-glucose | increases expression | ISO | Thsd7a (Mus musculus) | 6480464 | Glucose results in increased expression of THSD7A mRNA | CTD | PMID:33448797 | Thsd7a | Rat | aldehydo-D-glucose | multiple interactions | ISO | Thsd7a (Mus musculus) | 6480464 | fucoxanthin inhibits the reaction [Glucose results in increased expression of THSD7A mRNA] | CTD | PMID:33448797 | Thsd7a | Rat | all-trans-retinoic acid | increases expression | ISO | THSD7A (Homo sapiens) | 6480464 | Tretinoin results in increased expression of THSD7A mRNA | CTD | PMID:21934132 | Thsd7a | Rat | all-trans-retinoic acid | decreases expression | ISO | THSD7A (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of THSD7A mRNA | CTD | PMID:23724009 | Thsd7a | Rat | atrazine | affects methylation | EXP | | 6480464 | Atrazine affects the methylation of THSD7A gene | CTD | PMID:35440735 | Thsd7a | Rat | benzo[a]pyrene | increases mutagenesis | ISO | THSD7A (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased mutagenesis of THSD7A gene | CTD | PMID:25435355 | Thsd7a | Rat | benzo[a]pyrene | decreases expression | ISO | THSD7A (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of THSD7A mRNA | CTD | PMID:32234424 | Thsd7a | Rat | benzo[a]pyrene | increases methylation | ISO | THSD7A (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of THSD7A 5' UTR | CTD | PMID:27901495 | Thsd7a | Rat | benzo[a]pyrene | affects methylation | ISO | THSD7A (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of THSD7A intron and Benzo(a)pyrene affects the methylation of THSD7A promoter | CTD | PMID:27901495 and PMID:30157460 | Thsd7a | Rat | benzo[a]pyrene | decreases methylation | ISO | THSD7A (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of THSD7A 3' UTR | CTD | PMID:27901495 | Thsd7a | Rat | benzo[a]pyrene | multiple interactions | ISO | Thsd7a (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of THSD7A mRNA | CTD | PMID:27858113 | Thsd7a | Rat | benzo[b]fluoranthene | multiple interactions | ISO | Thsd7a (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of THSD7A mRNA | CTD | PMID:27858113 | Thsd7a | Rat | benzo[e]pyrene | increases methylation | ISO | THSD7A (Homo sapiens) | 6480464 | benzo(e)pyrene results in increased methylation of THSD7A intron | CTD | PMID:30157460 | Thsd7a | Rat | beryllium sulfate | decreases expression | ISO | THSD7A (Homo sapiens) | 6480464 | beryllium sulfate results in decreased expression of THSD7A mRNA | CTD | PMID:35679967 | Thsd7a | Rat | beryllium sulfate | increases expression | ISO | THSD7A (Homo sapiens) | 6480464 | beryllium sulfate results in increased expression of THSD7A mRNA | CTD | PMID:35679967 | Thsd7a | Rat | bis(2-ethylhexyl) phthalate | increases expression | ISO | THSD7A (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in increased expression of THSD7A mRNA | CTD | PMID:31163220 | Thsd7a | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of THSD7A mRNA | CTD | PMID:25181051 | Thsd7a | Rat | bisphenol A | multiple interactions | ISO | THSD7A (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of THSD7A gene | CTD | PMID:31601247 | Thsd7a | Rat | bisphenol A | increases expression | ISO | Thsd7a (Mus musculus) | 6480464 | bisphenol A results in increased expression of THSD7A mRNA | CTD | PMID:30951980 and PMID:35598803 | Thsd7a | Rat | butanal | decreases expression | ISO | THSD7A (Homo sapiens) | 6480464 | butyraldehyde results in decreased expression of THSD7A mRNA | CTD | PMID:26079696 | Thsd7a | Rat | chrysene | decreases expression | ISO | Thsd7a (Mus musculus) | 6480464 | chrysene results in decreased expression of THSD7A mRNA | CTD | PMID:26377693 | Thsd7a | Rat | chrysene | multiple interactions | ISO | Thsd7a (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of THSD7A mRNA | CTD | PMID:27858113 | Thsd7a | Rat | cobalt dichloride | decreases expression | ISO | THSD7A (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of THSD7A mRNA | CTD | PMID:19376846 | Thsd7a | Rat | CU-O LINKAGE | decreases expression | ISO | THSD7A (Homo sapiens) | 6480464 | cupric oxide results in decreased expression of THSD7A mRNA | CTD | PMID:22077320 | Thsd7a | Rat | cyclosporin A | increases expression | ISO | THSD7A (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of THSD7A mRNA | CTD | PMID:20106945 | Thsd7a | Rat | cyclosporin A | decreases expression | ISO | THSD7A (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of THSD7A mRNA | CTD | PMID:27989131 | Thsd7a | Rat | D-glucose | increases expression | ISO | Thsd7a (Mus musculus) | 6480464 | Glucose results in increased expression of THSD7A mRNA | CTD | PMID:33448797 | Thsd7a | Rat | D-glucose | multiple interactions | ISO | Thsd7a (Mus musculus) | 6480464 | fucoxanthin inhibits the reaction [Glucose results in increased expression of THSD7A mRNA] | CTD | PMID:33448797 | Thsd7a | Rat | DDT | decreases expression | EXP | | 6480464 | DDT results in decreased expression of THSD7A mRNA | CTD | PMID:30207508 | Thsd7a | Rat | dorsomorphin | multiple interactions | ISO | THSD7A (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Thsd7a | Rat | elemental selenium | decreases expression | ISO | THSD7A (Homo sapiens) | 6480464 | Selenium results in decreased expression of THSD7A mRNA | CTD | PMID:19244175 | Thsd7a | Rat | entinostat | decreases expression | ISO | THSD7A (Homo sapiens) | 6480464 | entinostat results in decreased expression of THSD7A mRNA | CTD | PMID:27188386 | Thsd7a | Rat | entinostat | multiple interactions | ISO | THSD7A (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THSD7A mRNA | CTD | PMID:27188386 | Thsd7a | Rat | entinostat | increases expression | ISO | THSD7A (Homo sapiens) | 6480464 | entinostat results in increased expression of THSD7A mRNA | CTD | PMID:26272509 | Thsd7a | Rat | flutamide | decreases expression | EXP | | 6480464 | Flutamide results in decreased expression of THSD7A mRNA | CTD | PMID:24136188 | Thsd7a | Rat | folic acid | decreases expression | ISO | Thsd7a (Mus musculus) | 6480464 | Folic Acid results in decreased expression of THSD7A mRNA | CTD | PMID:25629700 | Thsd7a | Rat | fucoxanthin | multiple interactions | ISO | Thsd7a (Mus musculus) | 6480464 | fucoxanthin inhibits the reaction [Glucose results in increased expression of THSD7A mRNA] | CTD | PMID:33448797 | Thsd7a | Rat | fulvestrant | multiple interactions | ISO | THSD7A (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of THSD7A gene | CTD | PMID:31601247 | Thsd7a | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of THSD7A mRNA | CTD | PMID:33387578 | Thsd7a | Rat | glucose | increases expression | ISO | Thsd7a (Mus musculus) | 6480464 | Glucose results in increased expression of THSD7A mRNA | CTD | PMID:33448797 | Thsd7a | Rat | glucose | multiple interactions | ISO | Thsd7a (Mus musculus) | 6480464 | fucoxanthin inhibits the reaction [Glucose results in increased expression of THSD7A mRNA] | CTD | PMID:33448797 | Thsd7a | Rat | inulin | multiple interactions | ISO | Thsd7a (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of THSD7A mRNA | CTD | PMID:36331819 | Thsd7a | Rat | mercury dibromide | increases expression | ISO | THSD7A (Homo sapiens) | 6480464 | mercuric bromide results in increased expression of THSD7A mRNA | CTD | PMID:26272509 | Thsd7a | Rat | mercury dibromide | multiple interactions | ISO | THSD7A (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THSD7A mRNA | CTD | PMID:27188386 | Thsd7a | Rat | methapyrilene | increases methylation | ISO | THSD7A (Homo sapiens) | 6480464 | Methapyrilene results in increased methylation of THSD7A intron | CTD | PMID:30157460 | Thsd7a | Rat | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of THSD7A mRNA | CTD | PMID:30047161 | Thsd7a | Rat | methoxychlor | affects methylation | EXP | | 6480464 | Methoxychlor affects the methylation of THSD7A gene | CTD | PMID:35440735 | Thsd7a | Rat | methylmercury chloride | increases expression | ISO | THSD7A (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of THSD7A mRNA | CTD | PMID:28001369 | Thsd7a | Rat | N,N-diethyl-m-toluamide | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in increased methylation of THSD7A gene | CTD | PMID:33148267 | Thsd7a | Rat | O-methyleugenol | decreases expression | ISO | THSD7A (Homo sapiens) | 6480464 | methyleugenol results in decreased expression of THSD7A mRNA | CTD | PMID:32234424 | Thsd7a | Rat | p-chloromercuribenzoic acid | increases expression | ISO | THSD7A (Homo sapiens) | 6480464 | p-Chloromercuribenzoic Acid results in increased expression of THSD7A mRNA | CTD | PMID:26272509 | Thsd7a | Rat | p-chloromercuribenzoic acid | multiple interactions | ISO | THSD7A (Homo sapiens) | 6480464 | [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THSD7A mRNA | CTD | PMID:27188386 | Thsd7a | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of THSD7A mRNA | CTD | PMID:33387578 | Thsd7a | Rat | perfluorohexanesulfonic acid | increases expression | ISO | Thsd7a (Mus musculus) | 6480464 | perfluorohexanesulfonic acid results in increased expression of THSD7A mRNA | CTD | PMID:37995155 | Thsd7a | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Thsd7a (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of THSD7A mRNA | CTD | PMID:36331819 | Thsd7a | Rat | permethrin | multiple interactions | EXP | | 6480464 | [Permethrin co-treated with DEET] results in increased methylation of THSD7A gene | CTD | PMID:33148267 | Thsd7a | Rat | phenylmercury acetate | increases expression | ISO | THSD7A (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in increased expression of THSD7A mRNA | CTD | PMID:26272509 | Thsd7a | Rat | phenylmercury acetate | multiple interactions | ISO | THSD7A (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of THSD7A mRNA | CTD | PMID:27188386 | Thsd7a | Rat | pirinixic acid | multiple interactions | ISO | THSD7A (Homo sapiens) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of THSD7A mRNA | CTD | PMID:19710929 | Thsd7a | Rat | progesterone | multiple interactions | ISO | THSD7A (Homo sapiens) | 6480464 | [Progesterone co-treated with Estradiol] results in increased expression of THSD7A mRNA | CTD | PMID:17404688 | Thsd7a | Rat | progesterone | increases expression | ISO | THSD7A (Homo sapiens) | 6480464 | Progesterone results in increased expression of THSD7A mRNA | CTD | PMID:17404688 and PMID:20864642 | Thsd7a | Rat | SB 431542 | multiple interactions | ISO | THSD7A (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Thsd7a | Rat | selenium atom | decreases expression | ISO | THSD7A (Homo sapiens) | 6480464 | Selenium results in decreased expression of THSD7A mRNA | CTD | PMID:19244175 | Thsd7a | Rat | silicon dioxide | decreases expression | ISO | THSD7A (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of THSD7A mRNA | CTD | PMID:25895662 | Thsd7a | Rat | silver atom | decreases expression | ISO | Thsd7a (Mus musculus) | 6480464 | Silver results in decreased expression of THSD7A mRNA | CTD | PMID:27131904 | Thsd7a | Rat | silver(0) | decreases expression | ISO | Thsd7a (Mus musculus) | 6480464 | Silver results in decreased expression of THSD7A mRNA | CTD | PMID:27131904 | Thsd7a | Rat | sunitinib | increases expression | ISO | THSD7A (Homo sapiens) | 6480464 | Sunitinib results in increased expression of THSD7A mRNA | CTD | PMID:31533062 | Thsd7a | Rat | tetrachloromethane | affects expression | ISO | Thsd7a (Mus musculus) | 6480464 | Carbon Tetrachloride affects the expression of THSD7A mRNA | CTD | PMID:17484886 | Thsd7a | Rat | tetraphene | multiple interactions | ISO | Thsd7a (Mus musculus) | 6480464 | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of THSD7A mRNA | CTD | PMID:27858113 | Thsd7a | Rat | trichostatin A | decreases expression | ISO | THSD7A (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of THSD7A mRNA | CTD | PMID:24935251 | Thsd7a | Rat | trichostatin A | increases expression | ISO | THSD7A (Homo sapiens) | 6480464 | trichostatin A results in increased expression of THSD7A mRNA | CTD | PMID:24935251 | Thsd7a | Rat | triclosan | decreases expression | ISO | THSD7A (Homo sapiens) | 6480464 | Triclosan results in decreased expression of THSD7A mRNA | CTD | PMID:30510588 | Thsd7a | Rat | trimellitic anhydride | decreases expression | ISO | Thsd7a (Mus musculus) | 6480464 | trimellitic anhydride results in decreased expression of THSD7A mRNA | CTD | PMID:19042947 | Thsd7a | Rat | valproic acid | affects expression | ISO | THSD7A (Homo sapiens) | 6480464 | Valproic Acid affects the expression of THSD7A mRNA | CTD | PMID:25979313 | Thsd7a | Rat | valproic acid | decreases expression | EXP | | 6480464 | Valproic Acid results in decreased expression of THSD7A mRNA | CTD | PMID:29427782 | Thsd7a | Rat | valproic acid | affects splicing | EXP | | 6480464 | Valproic Acid affects the splicing of THSD7A mRNA | CTD | PMID:29427782 | Thsd7a | Rat | valproic acid | increases expression | ISO | THSD7A (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of THSD7A mRNA | CTD | PMID:19101580 more ... | Thsd7a | Rat | valproic acid | decreases expression | ISO | THSD7A (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of THSD7A mRNA | CTD | PMID:24935251 | Thsd7a | Rat | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of THSD7A mRNA | CTD | PMID:19015723 | Thsd7a | Rat | vitamin E | decreases expression | ISO | THSD7A (Homo sapiens) | 6480464 | Vitamin E results in decreased expression of THSD7A mRNA | CTD | PMID:19244175 | |