![]()
Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-demecolcine | decreases expression | ISO | RGD:1321388 | 6480464 | Demecolcine results in decreased expression of KLHL14 mRNA | CTD | PMID:23649840 | 17alpha-ethynylestradiol | affects expression | ISO | RGD:1321388 | 6480464 | Ethinyl Estradiol affects the expression of KLHL14 mRNA | CTD | PMID:20170705, PMID:26865667 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | RGD:1321388 | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of KLHL14 mRNA | CTD | PMID:20106945, PMID:21632981 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of KLHL14 mRNA | CTD | PMID:32109520 | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | 3,4-methylenedioxymethamphetamine | decreases expression | ISO | RGD:1621344 | 6480464 | N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of KLHL14 mRNA | CTD | PMID:20188158 | 6-propyl-2-thiouracil | increases expression | EXP | | 6480464 | Propylthiouracil results in increased expression of KLHL14 mRNA | CTD | PMID:24780913 | 6-propyl-2-thiouracil | decreases expression | EXP | | 6480464 | Propylthiouracil results in decreased expression of KLHL14 mRNA | CTD | PMID:25825206, PMID:30047161 | aflatoxin B1 | increases expression | EXP | | 6480464 | Aflatoxin B1 results in increased expression of KLHL14 mRNA | CTD | PMID:23630614 | aflatoxin B1 | decreases methylation | ISO | RGD:1321388 | 6480464 | Aflatoxin B1 results in decreased methylation of KLHL14 gene | CTD | PMID:27153756 | all-trans-retinoic acid | increases expression | ISO | RGD:1321388 | 6480464 | Tretinoin results in increased expression of KLHL14 mRNA | CTD | PMID:21934132 | amitrole | decreases expression | EXP | | 6480464 | Amitrole results in decreased expression of KLHL14 mRNA | CTD | PMID:30047161 | aristolochic acid A | decreases expression | ISO | RGD:1321388 | 6480464 | aristolochic acid I results in decreased expression of KLHL14 mRNA | CTD | PMID:33212167 | arsenous acid | decreases expression | ISO | RGD:1321388 | 6480464 | Arsenic Trioxide results in decreased expression of KLHL14 mRNA | CTD | PMID:26705709 | arsenous acid | multiple interactions | ISO | RGD:1321388 | 6480464 | Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to KLHL14 protein] | CTD | PMID:26598702 | azathioprine | decreases expression | ISO | RGD:1321388 | 6480464 | Azathioprine results in decreased expression of KLHL14 mRNA | CTD | PMID:22623647 | benzo[a]pyrene | decreases expression | ISO | RGD:1321388 | 6480464 | Benzo(a)pyrene results in decreased expression of KLHL14 mRNA | CTD | PMID:20106945 more ... | benzo[a]pyrene | affects methylation | ISO | RGD:1321388 | 6480464 | Benzo(a)pyrene affects the methylation of KLHL14 5' UTR, Benzo(a)pyrene affects the methylation of KLHL14 promoter | CTD | PMID:27901495 | bis(2-ethylhexyl) phthalate | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of KLHL14 promoter | CTD | PMID:23359474 | bis(2-ethylhexyl) phthalate | decreases expression | ISO | RGD:1321388 | 6480464 | Diethylhexyl Phthalate results in decreased expression of KLHL14 mRNA | CTD | PMID:31163220 | bisphenol A | affects expression | ISO | RGD:1321388 | 6480464 | bisphenol A affects the expression of KLHL14 mRNA | CTD | PMID:20170705 | bisphenol A | decreases expression | ISO | RGD:1621344 | 6480464 | bisphenol A results in decreased expression of KLHL14 mRNA | CTD | PMID:32156529 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of KLHL14 mRNA | CTD | PMID:25181051 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of KLHL14 promoter | CTD | PMID:23359474 | buta-1,3-diene | decreases expression | ISO | RGD:1621344 | 6480464 | 1, 3-butadiene results in decreased expression of KLHL14 mRNA | CTD | PMID:29038090 | caffeine | decreases phosphorylation | ISO | RGD:1321388 | 6480464 | Caffeine results in decreased phosphorylation of KLHL14 protein | CTD | PMID:35688186 | calcitriol | increases expression | ISO | RGD:1321388 | 6480464 | Calcitriol results in increased expression of KLHL14 mRNA | CTD | PMID:16002434 | CGP 52608 | multiple interactions | ISO | RGD:1321388 | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to KLHL14 gene] | CTD | PMID:28238834 | chlordecone | increases expression | ISO | RGD:1621344 | 6480464 | Chlordecone results in increased expression of KLHL14 mRNA | CTD | PMID:33711761 | Cuprizon | decreases expression | EXP | | 6480464 | Cuprizone results in decreased expression of KLHL14 mRNA | CTD | PMID:26577399 | cyclosporin A | decreases expression | ISO | RGD:1321388 | 6480464 | Cyclosporine results in decreased expression of KLHL14 mRNA | CTD | PMID:25562108 | diarsenic trioxide | multiple interactions | ISO | RGD:1321388 | 6480464 | Arsenic Trioxide inhibits the reaction [4-aminophenylarsenoxide binds to KLHL14 protein] | CTD | PMID:26598702 | diarsenic trioxide | decreases expression | ISO | RGD:1321388 | 6480464 | Arsenic Trioxide results in decreased expression of KLHL14 mRNA | CTD | PMID:26705709 | dibutyl phthalate | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of KLHL14 promoter | CTD | PMID:23359474 | dorsomorphin | multiple interactions | ISO | RGD:1321388 | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | entinostat | increases expression | ISO | RGD:1321388 | 6480464 | entinostat results in increased expression of KLHL14 mRNA | CTD | PMID:26272509 | entinostat | multiple interactions | ISO | RGD:1321388 | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLHL14 mRNA | CTD | PMID:27188386 | epoxiconazole | increases expression | ISO | RGD:1621344 | 6480464 | epoxiconazole results in increased expression of KLHL14 mRNA | CTD | PMID:35436446 | ethyl methanesulfonate | decreases expression | ISO | RGD:1321388 | 6480464 | Ethyl Methanesulfonate results in decreased expression of KLHL14 mRNA | CTD | PMID:23649840 | formaldehyde | decreases expression | ISO | RGD:1321388 | 6480464 | Formaldehyde results in decreased expression of KLHL14 mRNA | CTD | PMID:23649840 | genistein | decreases expression | ISO | RGD:1321388 | 6480464 | Genistein results in decreased expression of KLHL14 mRNA | CTD | PMID:26865667 | GW 4064 | decreases expression | ISO | RGD:1621344 | 6480464 | GW 4064 results in decreased expression of KLHL14 mRNA | CTD | PMID:26655953 | leflunomide | decreases expression | ISO | RGD:1321388 | 6480464 | leflunomide results in decreased expression of KLHL14 mRNA | CTD | PMID:28988120 | methimazole | decreases expression | EXP | | 6480464 | Methimazole results in decreased expression of KLHL14 mRNA | CTD | PMID:30047161 | methyl methanesulfonate | decreases expression | ISO | RGD:1321388 | 6480464 | Methyl Methanesulfonate results in decreased expression of KLHL14 mRNA | CTD | PMID:23649840 | methylmercury chloride | decreases expression | ISO | RGD:1321388 | 6480464 | methylmercuric chloride results in decreased expression of KLHL14 mRNA | CTD | PMID:26272509, PMID:28001369 | panobinostat | increases expression | ISO | RGD:1321388 | 6480464 | panobinostat results in increased expression of KLHL14 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | RGD:1321388 | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of KLHL14 mRNA | CTD | PMID:27188386 | pirinixic acid | multiple interactions | ISO | RGD:1621344 | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of KLHL14 mRNA | CTD | PMID:19710929 | progesterone | decreases expression | ISO | RGD:1621344 | 6480464 | Progesterone results in decreased expression of KLHL14 mRNA | CTD | PMID:22238285 | quercetin | decreases expression | ISO | RGD:1321388 | 6480464 | Quercetin results in decreased expression of KLHL14 mRNA | CTD | PMID:21632981 | SB 431542 | multiple interactions | ISO | RGD:1321388 | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | silver atom | decreases expression | ISO | RGD:1321388 | 6480464 | Silver results in decreased expression of KLHL14 mRNA | CTD | PMID:26014281 | silver(0) | decreases expression | ISO | RGD:1321388 | 6480464 | Silver results in decreased expression of KLHL14 mRNA | CTD | PMID:26014281 | sodium arsenate | increases expression | ISO | RGD:1621344 | 6480464 | sodium arsenate results in increased expression of KLHL14 mRNA | CTD | PMID:21795629 | sulfadimethoxine | decreases expression | EXP | | 6480464 | Sulfadimethoxine results in decreased expression of KLHL14 mRNA | CTD | PMID:30047161 | trichostatin A | increases expression | ISO | RGD:1321388 | 6480464 | trichostatin A results in increased expression of KLHL14 mRNA | CTD | PMID:24935251 | trichostatin A | multiple interactions | ISO | RGD:1321388 | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KLHL14 mRNA | CTD | PMID:27188386 | trichostatin A | decreases expression | ISO | RGD:1321388 | 6480464 | trichostatin A results in decreased expression of KLHL14 mRNA | CTD | PMID:24935251, PMID:26272509 | triclosan | decreases expression | ISO | RGD:1321388 | 6480464 | Triclosan results in decreased expression of KLHL14 mRNA | CTD | PMID:30510588 | tris(2-butoxyethyl) phosphate | affects expression | ISO | RGD:1321388 | 6480464 | tris(2-butoxyethyl) phosphate affects the expression of KLHL14 mRNA | CTD | PMID:29024780 | tungsten | decreases expression | ISO | RGD:1621344 | 6480464 | Tungsten results in decreased expression of KLHL14 mRNA | CTD | PMID:30912803 | urethane | decreases expression | ISO | RGD:1321388 | 6480464 | Urethane results in decreased expression of KLHL14 mRNA | CTD | PMID:28818685 | valproic acid | decreases expression | ISO | RGD:1321388 | 6480464 | Valproic Acid results in decreased expression of KLHL14 mRNA | CTD | PMID:23179753, PMID:26272509 | valproic acid | increases expression | ISO | RGD:1321388 | 6480464 | Valproic Acid results in increased expression of KLHL14 mRNA | CTD | PMID:23179753 more ... | valproic acid | multiple interactions | ISO | RGD:1321388 | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of KLHL14 mRNA | CTD | PMID:27188386 | vincristine | decreases expression | ISO | RGD:1321388 | 6480464 | Vincristine results in decreased expression of KLHL14 mRNA | CTD | PMID:23649840 | |