Nxf7 (nuclear RNA export factor 7) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Nxf7 (nuclear RNA export factor 7) Rattus norvegicus
Analyze
Symbol: Nxf7
Name: nuclear RNA export factor 7
RGD ID: 1566170
Description: Predicted to enable mRNA binding activity. Predicted to be involved in poly(A)+ mRNA export from nucleus. Predicted to be located in cytoplasm. Predicted to be part of nuclear pore. Predicted to be active in nucleus. Orthologous to several human genes including NXF2 (nuclear RNA export factor 2) and NXF2B (nuclear RNA export factor 2B); PARTICIPATES IN influenza A pathway; mRNA decay pathway; ribosome biogenesis pathway; INTERACTS WITH bisphenol A; fenvalerate; trichloroethene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC501621; MGC114500; similar to nuclear RNA export factor 7
RGD Orthologs
Human
Mouse
Bonobo
Squirrel
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X102,828,592 - 102,845,799 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX102,828,592 - 102,845,696 (-)EnsemblGRCr8
mRatBN7.2X98,535,374 - 98,552,562 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX98,535,375 - 98,552,526 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX100,196,722 - 100,213,805 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X103,712,746 - 103,729,829 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X101,222,664 - 101,239,768 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X106,049,075 - 106,066,334 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX106,049,075 - 106,066,227 (-)Ensemblrn6Rnor6.0
Rnor_5.0X105,934,946 - 105,952,143 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X122,897,820 - 122,914,925 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX99,552,583 - 99,569,687 (-)NCBICelera
Cytogenetic MapXq32NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA,ISO)
cytoplasmic stress granule  (IEA)
nuclear pore  (IEA)
nucleoplasm  (IEA)
nucleus  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:11566096   PMID:15820316   PMID:16027110   PMID:19182904   PMID:22082260   PMID:30361391  


Genomics

Comparative Map Data
Nxf7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X102,828,592 - 102,845,799 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 EnsemblX102,828,592 - 102,845,696 (-)EnsemblGRCr8
mRatBN7.2X98,535,374 - 98,552,562 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX98,535,375 - 98,552,526 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_UtxX100,196,722 - 100,213,805 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X103,712,746 - 103,729,829 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X101,222,664 - 101,239,768 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X106,049,075 - 106,066,334 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX106,049,075 - 106,066,227 (-)Ensemblrn6Rnor6.0
Rnor_5.0X105,934,946 - 105,952,143 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4X122,897,820 - 122,914,925 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
CeleraX99,552,583 - 99,569,687 (-)NCBICelera
Cytogenetic MapXq32NCBI
NXF5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X101,832,112 - 101,857,577 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX101,832,537 - 101,843,278 (-)Ensemblhg38GRCh38
GRCh38.p14 EnsemblX101,832,112 - 101,857,577 (-)Ensemblhg38GRCh38
GRCh37X101,087,085 - 101,112,549 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X100,973,741 - 100,999,205 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34X100,893,229 - 100,918,694NCBI
CeleraX101,607,687 - 101,633,150 (-)NCBICelera
Cytogenetic MapXq22.1NCBI
HuRefX90,894,346 - 90,920,212 (-)NCBIHuRef
CHM1_1X100,981,153 - 101,006,521 (-)NCBICHM1_1
T2T-CHM13v2.0X100,276,716 - 100,302,189 (-)NCBIT2T-CHM13v2.0
Nxf7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X134,480,304 - 134,499,530 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX134,480,304 - 134,499,526 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38X135,579,555 - 135,598,781 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX135,579,555 - 135,598,777 (-)Ensemblmm10GRCm38
MGSCv37X132,114,326 - 132,128,394 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36X130,926,151 - 130,940,219 (-)NCBIMGSCv36mm8
CeleraX118,900,122 - 118,914,212 (-)NCBICelera
Cytogenetic MapXF1NCBI
cM MapX57.25NCBI
LOC100978865
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X101,850,372 - 101,931,250 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X101,853,974 - 101,934,854 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X91,029,232 - 91,040,710 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X101,162,023 - 101,168,749 (-)NCBIPanPan1.1PanPan1.1panPan2
Nxf5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X62,598,818 - 62,741,717 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936813733,393 - 874,254 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100153087
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1X83,338,757 - 83,361,973 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X97,200,538 - 97,224,518 (-)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Nxf7
52 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:168
Count of miRNA genes:125
Interacting mature miRNAs:130
Transcripts:ENSRNOT00000033752
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X75294106120294106Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between duration of physical contact or close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat

Markers in Region
RH139714  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X98,535,417 - 98,535,634 (+)MAPPERmRatBN7.2
Rnor_6.0X106,049,119 - 106,049,335NCBIRnor6.0
Rnor_5.0X105,934,990 - 105,935,206UniSTSRnor5.0
RGSC_v3.4X122,914,665 - 122,914,881UniSTSRGSC3.4
CeleraX99,552,627 - 99,552,843UniSTS
Cytogenetic MapXq35UniSTS


Expression

RNA-SEQ Expression

appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 7 16 9 23 5 1 5 1 35 10 13 17 57 18

Sequence


Ensembl Acc Id: ENSRNOT00000033752   ⟹   ENSRNOP00000038474
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 EnsemblX102,828,592 - 102,845,696 (-)Ensembl
mRatBN7.2 EnsemblX98,535,375 - 98,552,494 (-)Ensembl
Rnor_6.0 EnsemblX106,049,075 - 106,066,227 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107546   ⟹   ENSRNOP00000095740
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX98,535,375 - 98,552,526 (-)Ensembl
RefSeq Acc Id: NM_001037216   ⟹   NP_001032293
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X102,828,592 - 102,845,696 (-)NCBI
mRatBN7.2X98,535,374 - 98,552,478 (-)NCBI
Rnor_6.0X106,049,075 - 106,066,227 (-)NCBI
Rnor_5.0X105,934,946 - 105,952,143 (-)NCBI
RGSC_v3.4X122,897,820 - 122,914,925 (+)RGD
CeleraX99,552,583 - 99,569,687 (-)RGD
Sequence:
RefSeq Acc Id: XM_006257254   ⟹   XP_006257316
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X102,828,592 - 102,845,799 (-)NCBI
mRatBN7.2X98,535,374 - 98,552,562 (-)NCBI
Rnor_6.0X106,049,075 - 106,066,334 (-)NCBI
Rnor_5.0X105,934,946 - 105,952,143 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039099981   ⟹   XP_038955909
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X102,828,592 - 102,845,489 (-)NCBI
mRatBN7.2X98,535,374 - 98,552,276 (-)NCBI
RefSeq Acc Id: NP_001032293   ⟸   NM_001037216
- UniProtKB: Q498M8 (UniProtKB/TrEMBL),   F7FPN7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257316   ⟸   XM_006257254
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000038474   ⟸   ENSRNOT00000033752
RefSeq Acc Id: XP_038955909   ⟸   XM_039099981
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000095740   ⟸   ENSRNOT00000107546
Protein Domains
NTF2   TAP-C

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q498M8-F1-model_v2 AlphaFold Q498M8 1-614 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566170 AgrOrtholog
BioCyc Gene G2FUF-1655 BioCyc
Ensembl Genes ENSRNOG00000023256 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000033752 ENTREZGENE
  ENSRNOT00000033752.5 UniProtKB/TrEMBL
  ENSRNOT00000107546.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.450.50 UniProtKB/TrEMBL
  3.30.70.330 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
  DNA helicase RuvA subunit, C-terminal domain UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7456178 IMAGE-MGC_LOAD
InterPro L_dom-like UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  NTF2 UniProtKB/TrEMBL
  NTF2-like_dom UniProtKB/TrEMBL
  Nuclear_transport_factor_2_euk UniProtKB/TrEMBL
  Nucleotide-bd_a/b_plait_sf UniProtKB/TrEMBL
  NXF_fam UniProtKB/TrEMBL
  RBD_domain_sf UniProtKB/TrEMBL
  TAP_C UniProtKB/TrEMBL
  Tap_RNA_bd UniProtKB/TrEMBL
  UBA-like UniProtKB/TrEMBL
KEGG Report rno:501621 UniProtKB/TrEMBL
MGC_CLONE MGC:114500 IMAGE-MGC_LOAD
NCBI Gene 501621 ENTREZGENE
PANTHER NUCLEAR RNA EXPORT FACTOR 7 UniProtKB/TrEMBL
  PTHR10662 UniProtKB/TrEMBL
Pfam LRR_NXF1-5 UniProtKB/TrEMBL
  NXF_NTF2 UniProtKB/TrEMBL
  Tap-RNA_bind UniProtKB/TrEMBL
  TAP_C UniProtKB/TrEMBL
PhenoGen Nxf7 PhenoGen
PROSITE LRR UniProtKB/TrEMBL
  NTF2_DOMAIN UniProtKB/TrEMBL
  TAP_C UniProtKB/TrEMBL
RatGTEx ENSRNOG00000023256 RatGTEx
SMART TAP_C UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
  SSF54427 UniProtKB/TrEMBL
  SSF54928 UniProtKB/TrEMBL
  UBA_like UniProtKB/TrEMBL
UniProt F7FPN7 ENTREZGENE, UniProtKB/TrEMBL
  Q498M8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-05 Nxf7  nuclear RNA export factor 7  LOC501621  similar to nuclear RNA export factor 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC501621  similar to nuclear RNA export factor 7      Symbol and Name status set to provisional 70820 PROVISIONAL