Gpr15lg (G protein-coupled receptor 15 ligand) - Rat Genome Database

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Gene: Gpr15lg (G protein-coupled receptor 15 ligand) Rattus norvegicus
Analyze
Symbol: Gpr15lg
Name: G protein-coupled receptor 15 ligand
RGD ID: 1566160
Description: Enables receptor ligand activity. Predicted to be involved in several processes, including defense response to other organism; mast cell degranulation; and negative regulation of cell cycle G1/S phase transition. Predicted to be located in extracellular region. Orthologous to human GPR15LG (G protein-coupled receptor 15 ligand); INTERACTS WITH atrazine; arsane (ortholog); arsenic atom (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Gpr15l; hypothetical gene supported by AF152002; hypothetical protein LOC290595; LOC290595; putative uncharacterized protein C10orf99 homolog; secreted protein C10orf99 homolog; uncharacterized protein LOC290595
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81612,888,528 - 12,896,134 (-)NCBIGRCr8
mRatBN7.21612,868,270 - 12,875,876 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1612,868,270 - 12,875,876 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1612,812,472 - 12,820,076 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01613,957,213 - 13,964,817 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01612,804,984 - 12,812,590 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01614,352,998 - 14,360,604 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1614,353,459 - 14,360,555 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01614,255,516 - 14,263,122 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41613,308,805 - 13,316,412 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1613,126,436 - 13,134,041 (-)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
2. A natural ligand for the orphan receptor GPR15 modulates lymphocyte recruitment to epithelia. Suply T, etal., Sci Signal. 2017 Sep 12;10(496). pii: 10/496/eaal0180. doi: 10.1126/scisignal.aal0180.
Additional References at PubMed
PMID:25351403   PMID:25585381   PMID:28936214  


Genomics

Comparative Map Data
Gpr15lg
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81612,888,528 - 12,896,134 (-)NCBIGRCr8
mRatBN7.21612,868,270 - 12,875,876 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1612,868,270 - 12,875,876 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1612,812,472 - 12,820,076 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01613,957,213 - 13,964,817 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01612,804,984 - 12,812,590 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01614,352,998 - 14,360,604 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1614,353,459 - 14,360,555 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01614,255,516 - 14,263,122 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41613,308,805 - 13,316,412 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1613,126,436 - 13,134,041 (-)NCBICelera
Cytogenetic Map16p14NCBI
GPR15LG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381084,173,801 - 84,185,294 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1084,173,801 - 84,185,294 (+)EnsemblGRCh38hg38GRCh38
GRCh371085,933,557 - 85,945,050 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361085,923,534 - 85,935,030 (+)NCBINCBI36Build 36hg18NCBI36
Celera1079,928,477 - 79,940,052 (+)NCBICelera
Cytogenetic Map10q23.1NCBI
HuRef1079,779,540 - 79,800,292 (+)NCBIHuRef
CHM1_11086,215,322 - 86,226,818 (+)NCBICHM1_1
T2T-CHM13v2.01085,052,266 - 85,063,813 (+)NCBIT2T-CHM13v2.0
Gpr15lg
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391436,824,097 - 36,832,058 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1436,824,097 - 36,835,979 (-)EnsemblGRCm39 Ensembl
GRCm381437,102,140 - 37,110,101 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1437,102,140 - 37,114,022 (-)EnsemblGRCm38mm10GRCm38
MGSCv371437,915,326 - 37,927,208 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361436,013,532 - 36,021,841 (-)NCBIMGSCv36mm8
Celera1433,313,175 - 33,324,994 (-)NCBICelera
Cytogenetic Map14BNCBI
cM Map1421.29NCBI
Gpr15lg
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555103,697,163 - 3,703,108 (+)NCBIChiLan1.0ChiLan1.0
GPR15LG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2896,155,641 - 96,167,279 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11096,160,961 - 96,172,599 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01080,589,270 - 80,600,894 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11084,159,041 - 84,170,624 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1084,159,041 - 84,170,624 (+)Ensemblpanpan1.1panPan2
GPR15LG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1432,426,663 - 32,432,103 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha432,410,141 - 32,417,796 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0432,740,208 - 32,747,823 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl432,740,046 - 32,747,532 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1432,602,915 - 32,610,513 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0432,795,105 - 32,802,713 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0433,291,700 - 33,299,329 (+)NCBIUU_Cfam_GSD_1.0
Gpr15lg
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721346,290,683 - 46,298,780 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936767790,676 - 798,265 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936767790,152 - 798,265 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPR15LG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1485,404,074 - 85,421,467 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11485,404,074 - 85,421,474 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21492,208,927 - 92,226,347 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPR15LG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1947,645,479 - 47,658,029 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660487,823,327 - 7,834,440 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpr15lg
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248412,846,117 - 2,852,539 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248412,845,796 - 2,852,575 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gpr15lg
83 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:203
Count of miRNA genes:128
Interacting mature miRNAs:144
Transcripts:ENSRNOT00000065460
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)16122477621Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126727669Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126727669Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)16285170915884239Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338015021361552Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
737825Alc13Alcohol consumption QTL 134.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760916039848Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
61372Bp40Blood pressure QTL 402.2blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)16422773017696785Rat

Markers in Region
AI716200  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21612,868,376 - 12,868,519 (+)MAPPERmRatBN7.2
Rnor_6.01614,353,105 - 14,353,247NCBIRnor6.0
Rnor_5.01614,255,623 - 14,255,765UniSTSRnor5.0
RGSC_v3.41613,308,910 - 13,309,052UniSTSRGSC3.4
Celera1613,126,543 - 13,126,685UniSTS
RH 3.4 Map16114.4UniSTS
Cytogenetic Map16p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 2
Medium 1 12 8 10 2 2
Low 29 20 17 8 17 54 25 19 8
Below cutoff 1 11 9 9 2 2 17 6 11 1 2

Sequence


RefSeq Acc Id: ENSRNOT00000065460   ⟹   ENSRNOP00000060855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1612,868,270 - 12,875,876 (-)Ensembl
Rnor_6.0 Ensembl1614,353,459 - 14,360,555 (-)Ensembl
RefSeq Acc Id: NM_001106063   ⟹   NP_001099533
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81612,888,528 - 12,896,134 (-)NCBI
mRatBN7.21612,868,270 - 12,875,876 (-)NCBI
Rnor_6.01614,352,998 - 14,360,604 (-)NCBI
Rnor_5.01614,255,516 - 14,263,122 (-)NCBI
RGSC_v3.41613,308,805 - 13,316,412 (-)RGD
Celera1613,126,436 - 13,134,041 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001099533 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D3ZKM3 (Get FASTA)   NCBI Sequence Viewer  
  EDL90896 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000060855
  ENSRNOP00000060855.2
  ENSRNOP00055014187
  ENSRNOP00060014665
  ENSRNOP00065028024
RefSeq Acc Id: NP_001099533   ⟸   NM_001106063
- Peptide Label: precursor
- UniProtKB: D3ZKM3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000060855   ⟸   ENSRNOT00000065460

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZKM3-F1-model_v2 AlphaFold D3ZKM3 1-77 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699967
Promoter ID:EPDNEW_R10489
Type:multiple initiation site
Name:LOC290595_1
Description:hypothetical gene supported by AF152002
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01614,360,605 - 14,360,665EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566160 AgrOrtholog
BioCyc Gene G2FUF-11993 BioCyc
Ensembl Genes ENSRNOG00000043342 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055010418 UniProtKB/Swiss-Prot
  ENSRNOG00060011121 UniProtKB/Swiss-Prot
  ENSRNOG00065020601 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000065460 ENTREZGENE
  ENSRNOT00000065460.4 UniProtKB/Swiss-Prot
  ENSRNOT00055017625 UniProtKB/Swiss-Prot
  ENSRNOT00060018809 UniProtKB/Swiss-Prot
  ENSRNOT00065034885 UniProtKB/Swiss-Prot
InterPro GPR15L UniProtKB/Swiss-Prot
KEGG Report rno:290595 UniProtKB/Swiss-Prot
NCBI Gene 290595 ENTREZGENE
Pfam GPR15L UniProtKB/Swiss-Prot
PhenoGen Gpr15lg PhenoGen
RatGTEx ENSRNOG00000043342 RatGTEx
  ENSRNOG00055010418 RatGTEx
  ENSRNOG00060011121 RatGTEx
  ENSRNOG00065020601 RatGTEx
UniProt D3ZKM3 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-17 Gpr15lg  G protein-coupled receptor 15 ligand  LOC290595  hypothetical gene supported by AF152002  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-02-09 LOC290595  hypothetical gene supported by AF152002      Symbol and Name status set to provisional 70820 PROVISIONAL