Serp2 (stress-associated endoplasmic reticulum protein family member 2) - Rat Genome Database

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Gene: Serp2 (stress-associated endoplasmic reticulum protein family member 2) Rattus norvegicus
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Symbol: Serp2
Name: stress-associated endoplasmic reticulum protein family member 2
RGD ID: 1566076
Description: Predicted to be involved in endoplasmic reticulum unfolded protein response. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human SERP2 (stress associated endoplasmic reticulum protein family member 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC498546; RGD1566076; similar to Chromosome 13 open reading frame 21; stress-associated endoplasmic reticulum protein 2
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81558,289,148 - 58,313,224 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1558,289,148 - 58,313,430 (-)EnsemblGRCr8
mRatBN7.21551,879,882 - 51,903,958 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1551,879,877 - 51,904,785 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1556,018,305 - 56,042,388 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01557,136,628 - 57,160,705 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01553,955,858 - 53,979,983 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01558,687,784 - 58,712,023 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1558,687,786 - 58,711,872 (-)Ensemblrn6Rnor6.0
Rnor_5.01562,376,859 - 62,400,913 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41557,532,189 - 57,556,372 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1551,497,304 - 51,521,471 (-)NCBICelera
Cytogenetic Map15q11NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Serp2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81558,289,148 - 58,313,224 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1558,289,148 - 58,313,430 (-)EnsemblGRCr8
mRatBN7.21551,879,882 - 51,903,958 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1551,879,877 - 51,904,785 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1556,018,305 - 56,042,388 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01557,136,628 - 57,160,705 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01553,955,858 - 53,979,983 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01558,687,784 - 58,712,023 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1558,687,786 - 58,711,872 (-)Ensemblrn6Rnor6.0
Rnor_5.01562,376,859 - 62,400,913 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41557,532,189 - 57,556,372 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1551,497,304 - 51,521,471 (-)NCBICelera
Cytogenetic Map15q11NCBI
SERP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381344,373,647 - 44,397,714 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1344,373,665 - 44,397,714 (+)Ensemblhg38GRCh38
GRCh371344,947,783 - 44,971,850 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361343,845,978 - 43,869,850 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341343,845,977 - 43,869,849NCBI
Celera1326,004,057 - 26,027,937 (+)NCBICelera
Cytogenetic Map13q14.11NCBI
HuRef1325,749,592 - 25,773,470 (+)NCBIHuRef
CHM1_11344,915,512 - 44,939,378 (+)NCBICHM1_1
T2T-CHM13v2.01343,593,406 - 43,617,488 (+)NCBIT2T-CHM13v2.0
Serp2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391476,770,252 - 76,794,518 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1476,770,254 - 76,794,329 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381476,532,812 - 76,557,074 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1476,532,814 - 76,556,889 (-)Ensemblmm10GRCm38
MGSCv371476,932,619 - 76,956,696 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361475,266,961 - 75,291,044 (-)NCBIMGSCv36mm8
Celera1474,033,480 - 74,057,543 (-)NCBICelera
Cytogenetic Map14D3NCBI
cM Map1440.44NCBI
SERP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21443,869,645 - 43,897,154 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11334,952,040 - 34,976,848 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01325,536,882 - 25,561,888 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13198,505,311 - 198,523,463 (-)NCBIPanPan1.1PanPan1.1panPan2
SERP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1226,540,055 - 6,560,980 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl226,540,050 - 6,561,034 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha226,529,537 - 6,550,448 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0226,658,321 - 6,679,231 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl226,658,725 - 6,679,298 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1226,440,549 - 6,461,456 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0226,502,456 - 6,523,353 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0226,509,433 - 6,530,343 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Serp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945154,730,036 - 154,746,575 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936791650,765 - 667,171 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936791650,604 - 667,143 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SERP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1122,672,240 - 22,700,675 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11122,672,235 - 22,700,895 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
SERP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1322,468,477 - 22,493,928 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl322,470,718 - 22,493,523 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605721,628,564 - 21,655,685 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Serp2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474810,620,872 - 10,643,604 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474810,606,441 - 10,643,883 (-)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Serp2
120 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:296
Count of miRNA genes:178
Interacting mature miRNAs:210
Transcripts:ENSRNOT00000058204
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)152788577486257085Rat
724545Niddm54Non-insulin dependent diabetes mellitus QTL 540.02blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)155079449473699215Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat

Markers in Region
RH130773  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21551,879,923 - 51,880,137 (+)MAPPERmRatBN7.2
Rnor_6.01558,687,826 - 58,688,039NCBIRnor6.0
Rnor_5.01562,376,901 - 62,377,114UniSTSRnor5.0
RGSC_v3.41557,532,229 - 57,532,442UniSTSRGSC3.4
Celera1551,497,344 - 51,497,557UniSTS
RH 3.4 Map15493.81UniSTS
Cytogenetic Map15q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 147 84 83 56 74 56 6 321 172 9 125 69 92 27 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000058204   ⟹   ENSRNOP00000055005
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1558,289,148 - 58,313,224 (-)Ensembl
mRatBN7.2 Ensembl1551,879,877 - 51,904,024 (-)Ensembl
Rnor_6.0 Ensembl1558,687,786 - 58,711,872 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097930   ⟹   ENSRNOP00000077119
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1551,879,877 - 51,904,785 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100358   ⟹   ENSRNOP00000076790
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1551,879,877 - 51,904,785 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117734   ⟹   ENSRNOP00000078821
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1551,895,118 - 51,903,965 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000169603   ⟹   ENSRNOP00000111969
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1558,289,501 - 58,313,430 (-)Ensembl
RefSeq Acc Id: NM_001394792   ⟹   NP_001381721
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81558,289,148 - 58,313,224 (-)NCBI
mRatBN7.21551,879,882 - 51,903,958 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001381721 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM02317 (Get FASTA)   NCBI Sequence Viewer  
  EDM02318 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000055005
  ENSRNOP00000055005.3
  ENSRNOP00000076790.1
  ENSRNOP00000077119.1
  ENSRNOP00000078821.1
Ensembl Acc Id: ENSRNOP00000055005   ⟸   ENSRNOT00000058204
Ensembl Acc Id: ENSRNOP00000076790   ⟸   ENSRNOT00000100358
Ensembl Acc Id: ENSRNOP00000077119   ⟸   ENSRNOT00000097930
Ensembl Acc Id: ENSRNOP00000078821   ⟸   ENSRNOT00000117734
RefSeq Acc Id: NP_001381721   ⟸   NM_001394792
- UniProtKB: A6HTV4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000111969   ⟸   ENSRNOT00000169603

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z8N0-F1-model_v2 AlphaFold D3Z8N0 1-92 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699840
Promoter ID:EPDNEW_R10363
Type:single initiation site
Name:Serp2_1
Description:stress-associated endoplasmic reticulum protein family member2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01558,711,865 - 58,711,925EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566076 AgrOrtholog
BioCyc Gene G2FUF-13048 BioCyc
Ensembl Genes ENSRNOG00000038228 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000058204 ENTREZGENE
  ENSRNOT00000058204.3 UniProtKB/TrEMBL
  ENSRNOT00000097930.1 UniProtKB/TrEMBL
  ENSRNOT00000100358.1 UniProtKB/TrEMBL
  ENSRNOT00000117734.1 UniProtKB/TrEMBL
InterPro RAMP4 UniProtKB/TrEMBL
NCBI Gene 498546 ENTREZGENE
PANTHER RAMP4 UniProtKB/TrEMBL
  STRESS-ASSOCIATED ENDOPLASMIC RETICULUM PROTEIN 2 UniProtKB/TrEMBL
Pfam RAMP4 UniProtKB/TrEMBL
PhenoGen Serp2 PhenoGen
RatGTEx ENSRNOG00000038228 RatGTEx
UniProt A0A8I5Y769_RAT UniProtKB/TrEMBL
  A0A8I5YBH1_RAT UniProtKB/TrEMBL
  A0A8I5ZLK3_RAT UniProtKB/TrEMBL
  A6HTV4 ENTREZGENE, UniProtKB/TrEMBL
  D3Z8N0_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-31 Serp2  stress-associated endoplasmic reticulum protein family member 2  RGD1566076_predicted  similar to Chromosome 13 open reading frame 21 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1566076_predicted  similar to Chromosome 13 open reading frame 21 (predicted)  LOC498546  similar to Chromosome 13 open reading frame 21  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498546  similar to Chromosome 13 open reading frame 21      Symbol and Name status set to provisional 70820 PROVISIONAL