Srgap2 (SLIT-ROBO Rho GTPase activating protein 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Srgap2 (SLIT-ROBO Rho GTPase activating protein 2) Rattus norvegicus
Analyze
Symbol: Srgap2
Name: SLIT-ROBO Rho GTPase activating protein 2
RGD ID: 1566016
Description: Predicted to have GTPase activator activity; protein homodimerization activity; and small GTPase binding activity. Predicted to be involved in several processes, including negative regulation of neuron migration; plasma membrane bounded cell projection organization; and substrate adhesion-dependent cell spreading. Localizes to cytoplasm and nucleus. Orthologous to human SRGAP2 (SLIT-ROBO Rho GTPase activating protein 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC360840; MGC188551; RGD1566016; similar to KIAA0456 protein; SLIT-ROBO Rho GTPase-activating protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21342,745,956 - 42,967,083 (-)NCBI
Rnor_6.0 Ensembl1348,068,158 - 48,286,720 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01348,065,280 - 48,286,888 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01353,141,198 - 53,362,657 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41344,239,946 - 44,452,446 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1343,100,229 - 43,312,451 (-)NCBICelera
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

Additional References at PubMed
PMID:12477932   PMID:12865426   PMID:19737524   PMID:20810653   PMID:21148482   PMID:22559944   PMID:26365803   PMID:27748913   PMID:30685845  


Genomics

Comparative Map Data
Srgap2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21342,745,956 - 42,967,083 (-)NCBI
Rnor_6.0 Ensembl1348,068,158 - 48,286,720 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01348,065,280 - 48,286,888 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01353,141,198 - 53,362,657 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41344,239,946 - 44,452,446 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1343,100,229 - 43,312,451 (-)NCBICelera
Cytogenetic Map13q13NCBI
SRGAP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1206,203,345 - 206,464,443 (+)EnsemblGRCh38hg38GRCh38
GRCh381206,203,541 - 206,464,436 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371206,516,198 - 206,637,776 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361204,582,823 - 204,704,406 (+)NCBINCBI36hg18NCBI36
Celera1179,840,685 - 179,889,229 (+)NCBI
Cytogenetic Map1q32.1NCBI
HuRef1177,269,281 - 177,336,031 (+)NCBIHuRef
CHM1_11207,650,968 - 207,909,982 (+)NCBICHM1_1
Srgap2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391131,212,989 - 131,455,269 (-)NCBIGRCm39mm39
GRCm39 Ensembl1131,212,989 - 131,455,090 (-)Ensembl
GRCm381131,285,251 - 131,527,531 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1131,285,251 - 131,527,352 (-)EnsemblGRCm38mm10GRCm38
MGSCv371133,181,828 - 133,423,938 (-)NCBIGRCm37mm9NCBIm37
MGSCv361133,112,797 - 133,354,907 (-)NCBImm8
Celera1133,908,005 - 134,139,712 (-)NCBICelera
Cytogenetic Map1E4NCBI
Srgap2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540641,801,235 - 42,050,731 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540641,801,235 - 42,050,731 (+)NCBIChiLan1.0ChiLan1.0
SRGAP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11186,090,389 - 186,346,012 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1186,092,113 - 186,346,019 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01181,808,318 - 182,064,583 (+)NCBIMhudiblu_PPA_v0panPan3
SRGAP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1382,506,617 - 2,741,866 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha382,599,173 - 2,834,184 (+)NCBI
ROS_Cfam_1.0382,504,091 - 2,739,418 (+)NCBI
UMICH_Zoey_3.1382,497,737 - 2,732,688 (+)NCBI
UNSW_CanFamBas_1.0382,890,316 - 3,126,035 (+)NCBI
UU_Cfam_GSD_1.0383,090,840 - 3,326,253 (+)NCBI
Srgap2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934468,855,976 - 69,097,751 (-)NCBI
SpeTri2.0NW_0049365576,096,258 - 6,338,024 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SRGAP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1966,838,062 - 67,117,315 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2973,085,753 - 73,361,203 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SRGAP2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12522,897,699 - 23,147,097 (-)NCBI
ChlSab1.1 Ensembl2522,897,469 - 23,145,218 (-)Ensembl
Vero_WHO_p1.0NW_02366605523,596,464 - 23,848,743 (-)NCBI
Srgap2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248074,937,573 - 5,169,104 (-)NCBI

Position Markers
BE108135  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21342,963,130 - 42,963,286 (+)MAPPER
Rnor_6.01348,282,793 - 48,282,948NCBIRnor6.0
Rnor_5.01353,358,711 - 53,358,866UniSTSRnor5.0
RGSC_v3.41344,448,519 - 44,448,674UniSTSRGSC3.4
Celera1343,308,524 - 43,308,679UniSTS
RH 3.4 Map13111.3UniSTS
Cytogenetic Map13q13UniSTS
BE109592  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21342,789,446 - 42,789,622 (+)MAPPER
Rnor_6.01348,108,771 - 48,108,946NCBIRnor6.0
Rnor_5.01353,184,689 - 53,184,864UniSTSRnor5.0
RGSC_v3.41344,274,793 - 44,274,968UniSTSRGSC3.4
Celera1343,135,071 - 43,135,246UniSTS
RH 3.4 Map13110.2UniSTS
Cytogenetic Map13q13UniSTS
AU046573  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21342,801,095 - 42,801,267 (+)MAPPER
Rnor_6.01348,120,419 - 48,120,590NCBIRnor6.0
Rnor_5.01353,196,337 - 53,196,508UniSTSRnor5.0
RGSC_v3.41344,286,441 - 44,286,612UniSTSRGSC3.4
Celera1343,146,719 - 43,146,890UniSTS
Cytogenetic Map13q13UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131107975663Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131107975663Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13901674250513953Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13901690682995569Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13901690682995569Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1312193394108478121Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)131409633059096330Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)131409633059096330Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131444158250799665Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131444158251577031Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131462463159624631Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131462463159624631Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131981081464810814Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)132005247765052477Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)132148248158537177Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1324502279108770533Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132800833873008338Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132858445273584452Rat
1558644Cm45Cardiac mass QTL 453.60.002heart mass (VT:0007028)heart wet weight (CMO:0000069)132907693474076934Rat
6893338Cm76Cardiac mass QTL 7600.99heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)132907693474076934Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1335301263107975663Rat
2301962Cm72Cardiac mass QTL 724.12heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)133614753364868393Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133614753399968921Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133614753399968921Rat
2303563Bw89Body weight QTL 896body mass (VT:0001259)body weight (CMO:0000012)133734634882346348Rat
61340Bp25Blood pressure QTL 254.20.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133937292784372927Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133950130093652524Rat
4889861Pur29Proteinuria QTL 2913.80.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)134231074486833540Rat
1331750Bp220Blood pressure QTL 2202.98arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)134231074487310744Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)134250834587508345Rat
61349Bp31Blood pressure QTL 315.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)134250834587508345Rat
1549897Stresp12Stress response QTL 123.35stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)134357571788575717Rat
619615Bp80Blood pressure QTL 800.0354arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134567662990676629Rat
2303032Bp328Blood pressure QTL 328arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134644457050799665Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:68
Count of miRNA genes:55
Interacting mature miRNAs:63
Transcripts:ENSRNOT00000008976
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 31 30 17 19 17 1 1 74 26 34 11 1
Low 2 12 27 24 24 7 10 9 7 7
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001134958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769480 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090885 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC113752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC168690 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213536 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000008976   ⟹   ENSRNOP00000008976
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1348,073,927 - 48,286,720 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085967   ⟹   ENSRNOP00000068925
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1348,068,158 - 48,284,408 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000086928   ⟹   ENSRNOP00000070956
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1348,070,362 - 48,284,990 (-)Ensembl
RefSeq Acc Id: NM_001134958   ⟹   NP_001128430
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21342,754,602 - 42,967,058 (-)NCBI
Rnor_6.01348,073,926 - 48,286,720 (-)NCBI
Rnor_5.01353,141,198 - 53,362,657 (-)NCBI
RGSC_v3.41344,239,946 - 44,452,446 (-)RGD
Celera1343,100,229 - 43,312,451 (-)RGD
Sequence:
RefSeq Acc Id: XM_006249782   ⟹   XP_006249844
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21342,745,956 - 42,967,083 (-)NCBI
Rnor_6.01348,065,280 - 48,286,888 (-)NCBI
Rnor_5.01353,141,198 - 53,362,657 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006249783   ⟹   XP_006249845
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21342,745,956 - 42,966,205 (-)NCBI
Rnor_6.01348,065,280 - 48,285,808 (-)NCBI
Rnor_5.01353,141,198 - 53,362,657 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006249785   ⟹   XP_006249847
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21342,745,956 - 42,877,914 (-)NCBI
Rnor_6.01348,065,280 - 48,197,183 (-)NCBI
Rnor_5.01353,141,198 - 53,362,657 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008769479   ⟹   XP_008767701
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01348,068,548 - 48,286,888 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008769480   ⟹   XP_008767702
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21342,745,956 - 42,854,748 (-)NCBI
Rnor_6.01348,065,280 - 48,136,806 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039090884   ⟹   XP_038946812
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21342,745,956 - 42,967,083 (-)NCBI
RefSeq Acc Id: XM_039090885   ⟹   XP_038946813
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21342,749,079 - 42,967,083 (-)NCBI
RefSeq Acc Id: XM_039090886   ⟹   XP_038946814
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21342,751,163 - 42,967,083 (-)NCBI
RefSeq Acc Id: XM_039090887   ⟹   XP_038946815
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21342,745,956 - 42,817,378 (-)NCBI
RefSeq Acc Id: XM_039090888   ⟹   XP_038946816
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21342,755,856 - 42,967,083 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001128430   ⟸   NM_001134958
- UniProtKB: B5DEJ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249844   ⟸   XM_006249782
- Peptide Label: isoform X1
- UniProtKB: D4A208 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006249845   ⟸   XM_006249783
- Peptide Label: isoform X1
- UniProtKB: D4A208 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006249847   ⟸   XM_006249785
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008767702   ⟸   XM_008769480
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_008767701   ⟸   XM_008769479
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000008976   ⟸   ENSRNOT00000008976
RefSeq Acc Id: ENSRNOP00000068925   ⟸   ENSRNOT00000085967
RefSeq Acc Id: ENSRNOP00000070956   ⟸   ENSRNOT00000086928
RefSeq Acc Id: XP_038946812   ⟸   XM_039090884
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038946815   ⟸   XM_039090887
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038946813   ⟸   XM_039090885
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038946814   ⟸   XM_039090886
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038946816   ⟸   XM_039090888
- Peptide Label: isoform X8
Protein Domains
F-BAR   Rho-GAP   SH3

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698796
Promoter ID:EPDNEW_R9321
Type:initiation region
Name:Srgap2_1
Description:SLIT-ROBO Rho GTPase activating protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01348,286,702 - 48,286,762EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1566016 AgrOrtholog
Ensembl Genes ENSRNOG00000006733 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000008976 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000068925 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000070956 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008976 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000085967 UniProtKB/Swiss-Prot
  ENSRNOT00000086928 UniProtKB/TrEMBL
Gene3D-CATH 1.10.555.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AH/BAR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  F_BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FCH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  srGAP1/2/3_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  srGAP2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:360840 UniProtKB/TrEMBL
NCBI Gene 360840 ENTREZGENE
PANTHER PTHR14166:SF6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Srgap2 PhenoGen
PROSITE F_BAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHOGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FCH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF103657 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JZ92_RAT UniProtKB/TrEMBL
  B5DEJ1 ENTREZGENE, UniProtKB/TrEMBL
  D4A208 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-02 Srgap2   SLIT-ROBO Rho GTPase activating protein 2   RGD1566016  similar to KIAA0456 protein   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1566016  similar to KIAA0456 protein   RGD1566016_predicted  similar to KIAA0456 protein (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1566016_predicted  similar to KIAA0456 protein (predicted)  LOC360840  similar to KIAA0456 protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC360840  similar to KIAA0456 protein      Symbol and Name status set to provisional 70820 PROVISIONAL